{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:17:48Z","timestamp":1785410268724,"version":"3.56.0"},"reference-count":140,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100022015","name":"Fakultas Teknik Universitas Indonesia","doi-asserted-by":"publisher","award":["NKB-3409\/UN2.F4.D\/PPM.00.00\/2024"],"award-info":[{"award-number":["NKB-3409\/UN2.F4.D\/PPM.00.00\/2024"]}],"id":[{"id":"10.13039\/501100022015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomech Model Mechanobiol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10237-025-02032-8","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T03:58:10Z","timestamp":1765857490000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Engineering the human tympanic membrane: lessons from mechanics, modelling, and materials"],"prefix":"10.1007","volume":"25","author":[{"given":"Sylvi F. R.","family":"Irnadiastputri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasna M.","family":"Tiurma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti F.","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buntara S.","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puspita A.","family":"Katili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"2032_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/J.HEARES.2012.05.001","volume":"290","author":"J Aernouts","year":"2012","unstructured":"Aernouts J, Aerts JRM, Dirckx JJJ (2012) Mechanical properties of human tympanic membrane in the quasi-static regime from in situ point indentation measurements. Hear Res 290:45\u201354. https:\/\/doi.org\/10.1016\/J.HEARES.2012.05.001","journal-title":"Hear Res"},{"key":"2032_CR63","unstructured":"Aernouts J (2012) Mechanical Properties of the Tympanic Membrane: Measurement and Modeling-Mechanische Eigenschapen van het Trom-melvlies: Meting en Modellering."},{"key":"2032_CR2","doi-asserted-by":"publisher","unstructured":"A\u011fr\u0131 \u0130, A\u011fr\u0131 AE, \u00d6zdemir D, \u00d6zg\u00fcr A (2018) CAPE and tympanosclerosis. Polyphenols: Mechanisms of Action in Human Health and Disease 421\u201330. https:\/\/doi.org\/10.1016\/B978-0-12-813006-3.00031-3.","DOI":"10.1016\/B978-0-12-813006-3.00031-3"},{"key":"2032_CR3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/J.EJENTA.2016.12.002","volume":"18","author":"R Ahmad","year":"2017","unstructured":"Ahmad R, Beigh Z, Maqbool T (2017) Revised grading system of tympanosclerosis. Egypt J Ear Nose Throat Allied Sci 18:23\u201325. https:\/\/doi.org\/10.1016\/J.EJENTA.2016.12.002","journal-title":"Egypt J Ear Nose Throat Allied Sci"},{"key":"2032_CR4","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/00129492-198907000-00007","volume":"10","author":"LS Alvord","year":"1989","unstructured":"Alvord LS, Doxey GP, Smith DM (1989) Hearing aids worn with tympanic membrane perforation: complications and solutions. Otol Neurotol 10:277\u2013280. https:\/\/doi.org\/10.1097\/00129492-198907000-00007","journal-title":"Otol Neurotol"},{"key":"2032_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/ADHM.202002082","volume":"10","author":"S Anand","year":"2021","unstructured":"Anand S, Stoppe T, Lucena M, Rademakers T, Neudert M, Danti S, Moroni L, Mota C (2021) Mimicking the human tympanic membrane: the significance of scaffold geometry. Adv Healthc Mater 10:2002082. https:\/\/doi.org\/10.1002\/ADHM.202002082","journal-title":"Adv Healthc Mater"},{"key":"2032_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/J.PMATSCI.2022.100942","volume":"127","author":"S Anand","year":"2022","unstructured":"Anand S, Danti S, Moroni L, Mota C (2022) Regenerative therapies for tympanic membrane. Prog Mater Sci 127:100942. https:\/\/doi.org\/10.1016\/J.PMATSCI.2022.100942","journal-title":"Prog Mater Sci"},{"key":"2032_CR7","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1017\/S0022215100157937","volume":"113","author":"S Asiri","year":"1999","unstructured":"Asiri S, Hasham A, Al Anazy F, Zakzouk S, Banjar A (1999) Tympanosclerosis: review of literature and incidence among patients with middle-ear infection. J Laryngol Otol 113:1076\u20131080. https:\/\/doi.org\/10.1017\/S0022215100157937","journal-title":"J Laryngol Otol"},{"key":"2032_CR8","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/S00405-009-1099-0","volume":"267","author":"H Aslan","year":"2010","unstructured":"Aslan H, Katmilmi\u015f H, \u00d6zt\u00fcrkcan S, Ilknur AE, Ba\u015fo\u01e7lu Vs (2010) Tympanosclerosis and our surgical results. Eur Arch Otorhinolaryngol 267:673\u2013677. https:\/\/doi.org\/10.1007\/S00405-009-1099-0","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2032_CR9","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/J.CIRP.2022.06.001","volume":"71","author":"P Bartolo","year":"2022","unstructured":"Bartolo P, Malshe A, Ferraris E, Koc B (2022) 3D bioprinting: materials, processes, and applications. CIRP Ann 71:577\u2013597. https:\/\/doi.org\/10.1016\/J.CIRP.2022.06.001","journal-title":"CIRP Ann"},{"key":"2032_CR10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/J.JOTO.2020.01.001","volume":"15","author":"A Bayram","year":"2020","unstructured":"Bayram A, Bayar Muluk N, Cingi C, Bafaqeeh SA (2020) Success rates for various graft materials in tympanoplasty \u2013 a review. J Otol 15:107. https:\/\/doi.org\/10.1016\/J.JOTO.2020.01.001","journal-title":"J Otol"},{"key":"2032_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/NANO14070563","author":"T Bedir","year":"2024","unstructured":"Bedir T, Baykara D, Yildirim R, Calikoglu Koyuncu AC, Sahin A, Kaya E, Tinaz GB, Insel MA, Topuzogullar\u0131 M, Gunduz O, Ustundag CB, Narayan R (2024) Three-dimensional-printed GelMA-KerMA composite patches as an innovative platform for potential tissue engineering of tympanic membrane perforations. Nanomaterials. https:\/\/doi.org\/10.3390\/NANO14070563","journal-title":"Nanomaterials"},{"key":"2032_CR12","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1121\/1.1906501","volume":"21","author":"GV B\u00e9k\u00e9sy","year":"1949","unstructured":"B\u00e9k\u00e9sy GV (1949) The structure of the middle ear and the hearing of one\u2019s own voice by bone conduction. J Acoust Soc Am 21:217\u2013232. https:\/\/doi.org\/10.1121\/1.1906501","journal-title":"J Acoust Soc Am"},{"key":"2032_CR13","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1097\/00005537-200109000-00007","volume":"111","author":"J Benecke","year":"2001","unstructured":"Benecke J (2001) Tympanic membrane grafting with alloderm. Laryngoscope 111:1525\u20131527. https:\/\/doi.org\/10.1097\/00005537-200109000-00007","journal-title":"Laryngoscope"},{"key":"2032_CR14","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1039\/D1BM01815A","volume":"10","author":"L Benecke","year":"2022","unstructured":"Benecke L, Chen Z, Zeidler-Rentzsch I, von Witzleben M, Bornitz M, Zahnert T, Neudert M, Cherif C, Aibibu D (2022) Development of electrospun, biomimetic tympanic membrane implants with tunable mechanical and oscillatory properties for myringoplasty. Biomater Sci 10:2287\u20132301. https:\/\/doi.org\/10.1039\/D1BM01815A","journal-title":"Biomater Sci"},{"key":"2032_CR15","doi-asserted-by":"publisher","first-page":"3399","DOI":"10.1007\/S00405-021-07078-9","volume":"279","author":"N Bevis","year":"2021","unstructured":"Bevis N, Sackmann B, Effertz T, Lauxmann M, Beutner D (2021) The impact of tympanic membrane perforations on middle ear transfer function. Eur Arch Otorhinolaryngol 279:3399. https:\/\/doi.org\/10.1007\/S00405-021-07078-9","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"3","key":"2032_CR16","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1177\/019459989310900305","volume":"109","author":"MH Bhaya","year":"1993","unstructured":"Bhaya MH, Schachern PA, Morizono T, Paparella MM (1993) Pathogenesis of tympanosclerosis. Otolaryngol Head Neck Surg 109(3):413\u2013420. https:\/\/doi.org\/10.1177\/019459989310900305","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2032_CR17","unstructured":"Biodesign\u00ae\u2014Otologic Tissue Repair Graft\u2014CCMed n.d. https:\/\/www.ccmed.co.uk\/product\/biodesign-oto\/ (accessed April 10, 2025)."},{"key":"2032_CR18","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1007\/s00405-016-3959-8","volume":"273","author":"S Biskin","year":"2016","unstructured":"Biskin S, Damar M, Oktem SN, Sakalli E, Erdem D, Pakir O (2016) A new graft material for myringoplasty: bacterial cellulose. Eur Arch Otorhinolaryngol 273:3561\u20133565. https:\/\/doi.org\/10.1007\/s00405-016-3959-8","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2032_CR19","unstructured":"Black NL (2020) Biomimetic Tympanic Membrane Grafts."},{"key":"2032_CR20","doi-asserted-by":"publisher","first-page":"80","DOI":"10.17159\/2309-8988\/2021\/V37A9","volume":"37","author":"FH Bresler","year":"2021","unstructured":"Bresler FH, M\u00fcller JH, Venter G (2021) Investigating an inverse finite element approach for characterising soft materials. R&D J 37:80\u201388. https:\/\/doi.org\/10.17159\/2309-8988\/2021\/V37A9","journal-title":"R&D J"},{"key":"2032_CR21","first-page":"9","volume":"99","author":"WE Brownell","year":"1997","unstructured":"Brownell WE, Alford BR (1997) How the ear works - nature\u2019s solutions for listening. Volta Rev 99:9","journal-title":"Volta Rev"},{"key":"2032_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1736957","author":"L Caminos","year":"2018","unstructured":"Caminos L, Garcia-Manrique J, Lima-Rodriguez A, Gonzalez-Herrera A (2018a) Analysis of the mechanical properties of the human tympanic membrane and its influence on the dynamic behaviour of the human hearing system. Appl Bionics Biomech. https:\/\/doi.org\/10.1155\/2018\/1736957","journal-title":"Appl Bionics Biomech"},{"key":"2032_CR23","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1736957","volume":"2018","author":"L Caminos","year":"2018","unstructured":"Caminos L, Garcia-Manrique J, Lima-Rodriguez A, Gonzalez-Herrera A (2018b) Analysis of the mechanical properties of the human tympanic membrane and its influence on the dynamic behaviour of the human hearing system. Appl Bionics Biomech 2018:1736957. https:\/\/doi.org\/10.1155\/2018\/1736957","journal-title":"Appl Bionics Biomech"},{"key":"2032_CR24","doi-asserted-by":"publisher","first-page":"e1047","DOI":"10.1097\/MAO.0000000000001997","volume":"39","author":"GC Casazza","year":"2018","unstructured":"Casazza GC, Thomas AJ, Gurgel RK, Shelton C, Meier JD (2018) Variation in tympanoplasty cost in a multihospital network. Otol Neurotol 39:e1047\u2013e1053. https:\/\/doi.org\/10.1097\/MAO.0000000000001997","journal-title":"Otol Neurotol"},{"key":"2032_CR25","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/S10439-006-9227-0\/METRICS","volume":"35","author":"T Cheng","year":"2007","unstructured":"Cheng T, Dai C, Gan RZ (2007) Viscoelastic properties of human tympanic membrane. Ann Biomed Eng 35:305\u2013314. https:\/\/doi.org\/10.1007\/S10439-006-9227-0\/METRICS","journal-title":"Ann Biomed Eng"},{"key":"2032_CR26","doi-asserted-by":"crossref","unstructured":"Cheng T (2007) Mechanical properties of human middle ear tissues.","DOI":"10.1115\/1.2800837"},{"key":"2032_CR27","unstructured":"Chronic Otitis Media: Pathogenesis-oriented Therapeutic Management\u2014Google Books n.d. https:\/\/books.google.co.id\/books?hl=en&lr=&id=GQyElmnS6qsC&oi=fnd&pg=PR5&ots=5w70vyQSC6&sig=Bl7gvHeQlQpr16QsOhyEoVEPcuU&redir_esc=y#v=onepage&q&f=false (accessed April 24, 2025)."},{"key":"2032_CR28","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S0377-1237(17)30165-X","volume":"56","author":"L Col","year":"2017","unstructured":"Col L, Mahajan SB, Capt G, Kochhar L (2017) Surgical management of tympanosclerosis-our experience. Med J Armed Forces India 56:198. https:\/\/doi.org\/10.1016\/S0377-1237(17)30165-X","journal-title":"Med J Armed Forces India"},{"key":"2032_CR29","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/J.JMBBM.2008.05.008","volume":"2","author":"NP Daphalapurkar","year":"2009","unstructured":"Daphalapurkar NP, Dai C, Gan RZ, Lu H (2009) Characterization of the linearly viscoelastic behavior of human tympanic membrane by nanoindentation. J Mech Behav Biomed Mater 2:82\u201392. https:\/\/doi.org\/10.1016\/J.JMBBM.2008.05.008","journal-title":"J Mech Behav Biomed Mater"},{"key":"2032_CR30","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/J.BJORL.2014.05.018","volume":"80","author":"MR de Freitas","year":"2014","unstructured":"de Freitas MR, de Oliveira TC (2014) The role of different types of grafts in tympanoplasty. Braz J Otorhinolaryngol 80:275\u2013276. https:\/\/doi.org\/10.1016\/J.BJORL.2014.05.018","journal-title":"Braz J Otorhinolaryngol"},{"key":"2032_CR31","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/J.HEARES.2017.01.015","volume":"349","author":"A De Paolis","year":"2017","unstructured":"De Paolis A, Bikson M, Nelson JT, de Ru JA, Packer M, Cardoso L (2017) Analytical and numerical modeling of the hearing system: advances towards the assessment of hearing damage. Hear Res 349:111\u2013128. https:\/\/doi.org\/10.1016\/J.HEARES.2017.01.015","journal-title":"Hear Res"},{"key":"2032_CR32","unstructured":"Deafness and hearing loss n.d. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/deafness-and-hearing-loss (accessed March 13, 2025)."},{"key":"2032_CR33","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/0021-9290(80)90056-1","volume":"13","author":"WF Decraemer","year":"1980","unstructured":"Decraemer WF, Maes MA, Vanhuyse VJ, Vanpeperstraete P (1980) A non-linear viscoelastic constitutive equation for soft biological tissues, based upon a structural model. J Biomech 13:559\u2013564. https:\/\/doi.org\/10.1016\/0021-9290(80)90056-1","journal-title":"J Biomech"},{"key":"2032_CR34","unstructured":"Dolhi N, Weimer AD (2023) Tympanic Membrane Perforation. StatPearls."},{"key":"2032_CR35","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1097\/00005537-200311000-00002","volume":"113","author":"J Dornhoffer","year":"2003","unstructured":"Dornhoffer J (2003) Cartilage tympanoplasty: indications, techniques, and outcomes in a 1,000-patient series. Laryngoscope 113:1844\u20131856. https:\/\/doi.org\/10.1097\/00005537-200311000-00002","journal-title":"Laryngoscope"},{"key":"2032_CR36","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1121\/10.0020273","volume":"154","author":"A Ebrahimian","year":"2023","unstructured":"Ebrahimian A, Mohammadi H, Maftoon N (2023) Relative importance and interactions of parameters of finite-element models of human middle ear. J Acoust Soc Am 154:619\u2013634. https:\/\/doi.org\/10.1121\/10.0020273","journal-title":"J Acoust Soc Am"},{"key":"2032_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/J.JMBBM.2024.106478","volume":"153","author":"A Ebrahimian","year":"2024","unstructured":"Ebrahimian A, Mohammadi H, Maftoon N (2024) Material characterization of human middle ear using machine-learning-based surrogate models. J Mech Behav Biomed Mater 153:106478. https:\/\/doi.org\/10.1016\/J.JMBBM.2024.106478","journal-title":"J Mech Behav Biomed Mater"},{"key":"2032_CR38","unstructured":"EpiPatch\u2014https:\/\/iosgroup.net n.d. https:\/\/iosgroup.net\/brands\/biomed\/myringoplasty-solutions\/epipatch\/ (accessed April 10, 2025)."},{"key":"2032_CR39","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1016\/J.JBIOMECH.2004.08.022","volume":"38","author":"J Fay","year":"2005","unstructured":"Fay J, Puria S, Decraemer WF, Steele C (2005) Three approaches for estimating the elastic modulus of the tympanic membrane. J Biomech 38:1807\u20131815. https:\/\/doi.org\/10.1016\/J.JBIOMECH.2004.08.022","journal-title":"J Biomech"},{"key":"2032_CR40","doi-asserted-by":"publisher","first-page":"19743","DOI":"10.1073\/PNAS.0603898104","volume":"103","author":"JP Fay","year":"2006","unstructured":"Fay JP, Puria S, Steele CR (2006) The discordant eardrum. Proc Natl Acad Sci U S A 103:19743\u201319748. https:\/\/doi.org\/10.1073\/PNAS.0603898104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2032_CR41","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1121\/1.381892","volume":"63","author":"WRJ Funnell","year":"1978","unstructured":"Funnell WRJ, Laszlo CA (1978) Modeling of the cat eardrum as a thin shell using the finite-element method. J Acoust Soc Am 63:1461\u20131467. https:\/\/doi.org\/10.1121\/1.381892","journal-title":"J Acoust Soc Am"},{"key":"2032_CR42","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1159\/000013867","volume":"5","author":"M Gaihede","year":"2000","unstructured":"Gaihede M, Koefoed-Nielsen B (2000) Mechanics of the middle ear system: age-related changes in viscoelastic properties. Audiol Neurootol 5:53\u201358. https:\/\/doi.org\/10.1159\/000013867","journal-title":"Audiol Neurootol"},{"key":"2032_CR43","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/00129492-200205000-00008","volume":"23","author":"RZ Gan","year":"2002","unstructured":"Gan RZ, Sun Q, Dyer RK, Chang KH, Dormer KJ (2002) Three-dimensional modeling of middle ear biomechanics and its applications. Otol Neurotol 23:271\u2013280. https:\/\/doi.org\/10.1097\/00129492-200205000-00008","journal-title":"Otol Neurotol"},{"key":"2032_CR44","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1023\/B:ABME.0000030260.22737.53","volume":"32","author":"RZ Gan","year":"2004","unstructured":"Gan RZ, Feng B, Sun Q (2004) Three-dimensional finite element modeling of human ear for sound transmission. Ann Biomed Eng 32:847\u2013859. https:\/\/doi.org\/10.1023\/B:ABME.0000030260.22737.53","journal-title":"Ann Biomed Eng"},{"key":"2032_CR45","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/J.ACTBIO.2023.01.048","volume":"159","author":"J Garcia-Manrique","year":"2023","unstructured":"Garcia-Manrique J, Furlong C, Gonzalez-Herrera A, Cheng JT (2023) Numerical model characterization of the sound transmission mechanism in the tympanic membrane from a high-speed digital holographic experiment in transient regime. Acta Biomater 159:63\u201373. https:\/\/doi.org\/10.1016\/J.ACTBIO.2023.01.048","journal-title":"Acta Biomater"},{"issue":"3","key":"2032_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/APP13031665","volume":"13","author":"F Gentil","year":"2023","unstructured":"Gentil F, Parente M, Santos C, Areias B, Jorge RN (2023) Numerical study of tympanosclerosis including its effect on human hearing. Appl Sci 13(3):1665. https:\/\/doi.org\/10.3390\/APP13031665","journal-title":"Appl Sci"},{"key":"2032_CR47","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1002\/LARY.28914","volume":"131","author":"I Ghanad","year":"2021","unstructured":"Ghanad I, Polanik MD, Trakimas DR, Knoll RM, Castillo-Bustamante M, Black NL, Kozin ED, Remenschneider AK (2021) A systematic review of nonautologous graft materials used in human tympanoplasty. Laryngoscope 131:392\u2013400. https:\/\/doi.org\/10.1002\/LARY.28914","journal-title":"Laryngoscope"},{"key":"2032_CR48","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1007\/S00405-014-3373-Z","volume":"272","author":"E Guder","year":"2015","unstructured":"Guder E, Lankenau E, Fleischhauer F, Schulz-Hildebrandt H, H\u00fcttmann G, Pau HW, Just T (2015) Microanatomy of the tympanic membrane in chronic myringitis obtained with optical coherence tomography. Eur Arch Otorhinolaryngol 272:3217\u20133223. https:\/\/doi.org\/10.1007\/S00405-014-3373-Z","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2032_CR1302","doi-asserted-by":"publisher","unstructured":"Gurr A, Hildmann H, Stark T, Dazert S (2008) Die Therapie der Tympanosklerose. HNO 56(6):651\u2013658. https:\/\/doi.org\/10.1007\/s00106-008-1749-3","DOI":"10.1007\/s00106-008-1749-3"},{"key":"2032_CR49","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1007\/S12070-018-1369-5","volume":"71","author":"A Hajela","year":"2018","unstructured":"Hajela A, Kumar S, Singh HP, Verma V (2018) Comparison of ossiculoplasty using autograft ossicle versus allograft (Teflon). Indian J Otolaryngol Head Neck Surg 71:1309. https:\/\/doi.org\/10.1007\/S12070-018-1369-5","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"2032_CR50","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/J.HEARES.2010.02.005","volume":"263","author":"SM Hesabgar","year":"2010","unstructured":"Hesabgar SM, Marshall H, Agrawal SK, Samani A, Ladak HM (2010) Measuring the quasi-static Young\u2019s modulus of the eardrum using an indentation technique. Hear Res 263:168\u2013176. https:\/\/doi.org\/10.1016\/J.HEARES.2010.02.005","journal-title":"Hear Res"},{"key":"2032_CR51","doi-asserted-by":"publisher","unstructured":"Hidayat, Sudarsono, Othman R (2020) Dynamic Behavior of Human Tympanic Membrane Perforation Using Finite Element Method. IOP Conf Ser Mater Sci Eng 797:012025. https:\/\/doi.org\/10.1088\/1757-899X\/797\/1\/012025.","DOI":"10.1088\/1757-899X\/797\/1\/012025"},{"key":"2032_CR52","doi-asserted-by":"publisher","DOI":"10.3389\/FBIOE.2022.967475\/FULL","volume":"10","author":"M Hirabayashi","year":"2022","unstructured":"Hirabayashi M, Kurihara S, Ito R, Kurashina Y, Motegi M, Okano HJ, Yamamoto Y, Kojima H, Asakura T (2022) Combined analysis of finite element model and audiometry provides insights into the pathogenesis of conductive hearing loss. Front Bioeng Biotechnol 10:967475. https:\/\/doi.org\/10.3389\/FBIOE.2022.967475\/FULL","journal-title":"Front Bioeng Biotechnol"},{"key":"2032_CR54","doi-asserted-by":"publisher","DOI":"10.1115\/1.2838034","author":"G Huang","year":"2008","unstructured":"Huang G, Daphalapurkar NP, Gan RZ, Lu H (2008) A method for measuring linearly viscoelastic properties of human tympanic membrane using nanoindentation. J Biomech Eng. https:\/\/doi.org\/10.1115\/1.2838034","journal-title":"J Biomech Eng"},{"key":"2032_CR97","unstructured":"How Do We Hear?|NIDCD n.d. https:\/\/www.nidcd.nih.gov\/health\/how-do-we-hear (accessed March 13, 2025)."},{"key":"2032_CR55","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3978\/J.ISSN.2223-4292.2014.11.32","volume":"5","author":"Z Hubler","year":"2015","unstructured":"Hubler Z, Shemonski ND, Shelton RL, Monroy GL, Nolan RM, Boppart SA (2015) Real-time automated thickness measurement of the in vivo human tympanic membrane using optical coherence tomography. Quant Imaging Med Surg 5:69\u201377. https:\/\/doi.org\/10.3978\/J.ISSN.2223-4292.2014.11.32","journal-title":"Quant Imaging Med Surg"},{"key":"2032_CR56","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5152\/IAO.2019.5280","volume":"16","author":"A H\u00fcseyino\u011flu","year":"2019","unstructured":"H\u00fcseyino\u011flu A, Uzun C, Koder A, Ya\u011f\u0131z R, Benlier E, Bulut E (2019) The effect of auricular graft donor site on morbidity and cosmetic appearance in cartilage tympanoplasties. J Int Adv Otol 16:67. https:\/\/doi.org\/10.5152\/IAO.2019.5280","journal-title":"J Int Adv Otol"},{"key":"2032_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/J.JMBBM.2020.104219","author":"E Ilhan","year":"2021","unstructured":"Ilhan E, Ulag S, Sahin A, Yilmaz BK, Ekren N, Kilic O, Sengor M, Kalaskar DM, Oktar FN, Gunduz O (2021) Fabrication of tissue-engineered tympanic membrane patches using 3D-printing technology. J Mech Behav Biomed Mater. https:\/\/doi.org\/10.1016\/J.JMBBM.2020.104219","journal-title":"J Mech Behav Biomed Mater"},{"key":"2032_CR58","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/J.MSEC.2016.12.007","volume":"73","author":"APS Immich","year":"2017","unstructured":"Immich APS, Pennacchi PC, Naves AF, Felisbino SL, Boemo RL, Maria-Engler SS, Catalani LH (2017) Improved tympanic membrane regeneration after myringoplastic surgery using an artificial biograft. Mater Sci Eng C Mater Biol Appl 73:48\u201358. https:\/\/doi.org\/10.1016\/J.MSEC.2016.12.007","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"2032_CR59","unstructured":"Incidence of Tympanosclerosis in Chronic Suppurative Otitis Media Patients in a Tertiary Care Hospital K Arumugam. 2019."},{"key":"2032_CR60","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.msec.2016.11.094","volume":"72","author":"CH Jang","year":"2017","unstructured":"Jang CH, Ahn SH, Lee JW, Lee BH, Lee H, Kim GH (2017) Mesenchymal stem cell-laden hybrid scaffold for regenerating subacute tympanic membrane perforation. Mater Sci Eng C Mater Biol 72:456\u2013463. https:\/\/doi.org\/10.1016\/j.msec.2016.11.094","journal-title":"Mater Sci Eng C Mater Biol"},{"key":"2032_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13287-015-0273-0","volume":"7","author":"ZM Jessop","year":"2016","unstructured":"Jessop ZM, Javed M, Otto IA, Combellack EJ, Morgan S, Breugem CC, Archer CW, Khan IM, Lineaweaver WC, Kon M, Malda J, Whitaker IS (2016) Combining regenerative medicine strategies to provide durable reconstructive options: auricular cartilage tissue engineering. Stem Cell Res Therapy 7:1\u201312. https:\/\/doi.org\/10.1186\/S13287-015-0273-0","journal-title":"Stem Cell Res Therapy"},{"key":"2032_CR62","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1097\/MAO.0B013E318064E912","volume":"28","author":"A Johnson","year":"2007","unstructured":"Johnson A, Mixson C, Munday J (2007) Suitability of formaldehyde-treated acellular dermis for tympanic membrane repair in chinchillas. Otol Neurotol 28:778\u2013781. https:\/\/doi.org\/10.1097\/MAO.0B013E318064E912","journal-title":"Otol Neurotol"},{"key":"2032_CR64","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S1361-8415(02)00085-3","volume":"6","author":"M Kauer","year":"2002","unstructured":"Kauer M, Vuskovic V, Dual J, Szekely G, Bajka M (2002) Inverse finite element characterization of soft tissues. Med Image Anal 6:275\u2013287. https:\/\/doi.org\/10.1016\/S1361-8415(02)00085-3","journal-title":"Med Image Anal"},{"key":"2032_CR65","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/BF03050766","volume":"58","author":"K Kaur","year":"2006","unstructured":"Kaur K, Sonkhya N, Bapna AS (2006) Tympanosclerosis revisited. Indian J Otolaryngol Head Neck Surg 58:128. https:\/\/doi.org\/10.1007\/BF03050766","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"2032_CR67","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/J.1524-475X.2009.00565.X","volume":"18","author":"J Kim","year":"2010","unstructured":"Kim J, Kim CH, Park CH, Seo JN, Kweon H, Kang SW, Lee KG (2010) Comparison of methods for the repair of acute tympanic membrane perforations: silk patch vs. paper patch. Wound Repair Regen 18:132\u2013138. https:\/\/doi.org\/10.1111\/J.1524-475X.2009.00565.X","journal-title":"Wound Repair Regen"},{"key":"2032_CR68","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1089\/TEN.TEA.2010.0533","volume":"17","author":"J Kim","year":"2011","unstructured":"Kim J, Kim SW, Choi SJ, Lim KT, Lee JB, Seonwoo H, Choung PH, Park K, Cho CS, Choung YH, Chung JH (2011) A healing method of tympanic membrane perforations using three-dimensional porous chitosan scaffolds. Tissue Eng Part A 17:2763\u20132772. https:\/\/doi.org\/10.1089\/TEN.TEA.2010.0533","journal-title":"Tissue Eng Part A"},{"key":"2032_CR69","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3349\/YMJ.2023.0444","volume":"65","author":"M Kim","year":"2024","unstructured":"Kim M, Kim YJ, Kim YS, Roh TS, Lee EJ, Shim JH, Kang EH, Kim MJ, Yun IS (2024) One-year results of ear reconstruction with 3D printed implants. Yonsei Med J 65:456\u2013462. https:\/\/doi.org\/10.3349\/YMJ.2023.0444","journal-title":"Yonsei Med J"},{"key":"2032_CR1301","unstructured":"Kirikae I (1960) The structure and function of the middle ear. University of Tokyo Press"},{"key":"2032_CR70","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1121\/1.1451073","volume":"111","author":"T Koike","year":"2002","unstructured":"Koike T, Wada H, Kobayashi T (2002) Modeling of the human middle ear using the finite-element method. J Acoust Soc Am 111:1306\u20131317. https:\/\/doi.org\/10.1121\/1.1451073","journal-title":"J Acoust Soc Am"},{"key":"2032_CR71","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.heares.2016.03.005","volume":"340","author":"ED Kozin","year":"2016","unstructured":"Kozin ED, Black NL, Cheng JT, Cotler MJ, McKenna MJ, Lee DJ, Lewis JA, Rosowski JJ, Remenschneider AK (2016) Design, fabrication, and in vitro testing of novel three-dimensionally printed tympanic membrane grafts. Hear Res 340:191\u2013203. https:\/\/doi.org\/10.1016\/j.heares.2016.03.005","journal-title":"Hear Res"},{"key":"2032_CR72","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1089\/ten.tea.2017.0246","volume":"24","author":"CY Kuo","year":"2018","unstructured":"Kuo CY, Wilson E, Fuson A, Gandhi N, Monfaredi R, Jenkins A, Romero M, Santoro M, Fisher JP, Cleary K, Reilly B (2018) Repair of tympanic membrane perforations with customized bioprinted ear grafts using chinchilla models. Tissue Eng Part A 24:527\u2013535. https:\/\/doi.org\/10.1089\/ten.tea.2017.0246","journal-title":"Tissue Eng Part A"},{"key":"2032_CR73","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1097\/00005537-200104000-00025","volume":"111","author":"DW Laidlaw","year":"2001","unstructured":"Laidlaw DW, Costantino PD, Govindaraj S, Hiltzik DH, Catalano PJ (2001) Tympanic membrane repair with a dermal allograft. Laryngoscope 111:702\u2013707. https:\/\/doi.org\/10.1097\/00005537-200104000-00025","journal-title":"Laryngoscope"},{"key":"2032_CR74","doi-asserted-by":"publisher","first-page":"5153","DOI":"10.1007\/S00405-023-08170-Y","volume":"280","author":"GB Lajdam","year":"2023","unstructured":"Lajdam GB, Alahmadi RA, Alhakami M, Ghaddaf AA, Abdulhamid AS, Alahmadi A, Abdelsamad Y, Hagr A (2023) Comparison of temporalis muscle fascia and cartilage grafts for primary type 1 tympanoplasty: a meta-analysis of randomized controlled trials. Eur Arch Otorhinolaryngol 280:5153\u20135165. https:\/\/doi.org\/10.1007\/S00405-023-08170-Y","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2032_CR75","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1039\/C4TB00213J","volume":"2","author":"H Lee","year":"2014","unstructured":"Lee H, Jang CH, Kim GH (2014) A polycaprolactone\/silk-fibroin nanofibrous composite combined with human umbilical cord serum for subacute tympanic membrane perforation; an in vitro and in vivo study. J Mater Chem B 2:2703\u20132713. https:\/\/doi.org\/10.1039\/C4TB00213J","journal-title":"J Mater Chem B"},{"key":"2032_CR76","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-1839","volume":"38","author":"JM Lee","year":"2018","unstructured":"Lee JM, Seo YJ, Shim DB, Lee HJ, Kim SH (2018) Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study. Acta Otorhinolaryngol Ital 38:554. https:\/\/doi.org\/10.14639\/0392-100X-1839","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"2032_CR77","doi-asserted-by":"publisher","DOI":"10.1007\/S00405-024-09166-Y","author":"HSH Lee","year":"2024","unstructured":"Lee HSH, Kwok HHC, Xiao MLQ, Wai CKC (2024a) Biosynthetic graft versus autologous graft tympanoplasty: a prospective randomized controlled trial. Eur Arch Otorhinolaryngol. https:\/\/doi.org\/10.1007\/S00405-024-09166-Y","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"6","key":"2032_CR78","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.1007\/S00405-024-09166-Y\/METRICS","volume":"282","author":"HSH Lee","year":"2024","unstructured":"Lee HSH, Kwok HHC, Xiao MLQ, Wai CKC (2024b) Biosynthetic graft versus autologous graft tympanoplasty: a prospective randomized controlled trial. Eur Arch Oto-Rhino-Laryngol 282(6):2971\u20132975. https:\/\/doi.org\/10.1007\/S00405-024-09166-Y\/METRICS","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"key":"2032_CR79","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.heares.2018.10.010","volume":"370","author":"J Liang","year":"2018","unstructured":"Liang J, Smith KD, Lu H, Seale TW, Gan RZ (2018) Mechanical properties of the Papio anubis tympanic membrane: change significantly from infancy to adulthood. Hear Res 370:143\u2013154. https:\/\/doi.org\/10.1016\/j.heares.2018.10.010","journal-title":"Hear Res"},{"key":"2032_CR80","doi-asserted-by":"publisher","DOI":"10.1007\/S10162-020-00765-0","volume":"21","author":"J Liang","year":"2020","unstructured":"Liang J, Engles WG, Smith KD, Dai C, Gan RZ (2020) Mechanical properties of baboon tympanic membrane from young to adult. J Assoc Res Otolaryngol 21:395. https:\/\/doi.org\/10.1007\/S10162-020-00765-0","journal-title":"J Assoc Res Otolaryngol"},{"key":"2032_CR81","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3109\/00016487009181875","volume":"70","author":"DJ Lim","year":"1970","unstructured":"Lim DJ (1970) Human tympanic membrane. An ultrastructural observation. Acta Otolaryngol 70:176\u2013186. https:\/\/doi.org\/10.3109\/00016487009181875","journal-title":"Acta Otolaryngol"},{"key":"2032_CR82","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3390\/GELS9020103","volume":"9","author":"K Loukelis","year":"2023","unstructured":"Loukelis K, Helal ZA, Mikos AG, Chatzinikolaidou M (2023) Nanocomposite bioprinting for tissue engineering applications. Gels 9:103. https:\/\/doi.org\/10.3390\/GELS9020103","journal-title":"Gels"},{"key":"2032_CR83","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/JOA.12389","volume":"228","author":"JC Luers","year":"2015","unstructured":"Luers JC, H\u00fcttenbrink KB (2015) Surgical anatomy and pathology of the middle ear. J Anat 228:338. https:\/\/doi.org\/10.1111\/JOA.12389","journal-title":"J Anat"},{"key":"2032_CR84","doi-asserted-by":"publisher","DOI":"10.1115\/1.3118770","author":"H Luo","year":"2009","unstructured":"Luo H, Dai C, Gan RZ, Lu H (2009) Measurement of young\u2019s modulus of human tympanic membrane at high strain rates. J Biomech Eng. https:\/\/doi.org\/10.1115\/1.3118770","journal-title":"J Biomech Eng"},{"key":"2032_CR85","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S0377-1237(17)30165-X","volume":"56","author":"S Mahajan","year":"2017","unstructured":"Mahajan S, Kochhar L (2017) Surgical management of tympanosclerosis-our experience. Med J Armed Forces India 56:198. https:\/\/doi.org\/10.1016\/S0377-1237(17)30165-X","journal-title":"Med J Armed Forces India"},{"key":"2032_CR87","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/01.MAO.0000176177.17636.53","volume":"27","author":"RP Mehta","year":"2006","unstructured":"Mehta RP, Rosowski JJ, Voss SE, O\u2019Neil E, Merchant SN (2006) Determinants of hearing loss in perforations of the tympanic membrane. Otol Neurotol 27:136. https:\/\/doi.org\/10.1097\/01.MAO.0000176177.17636.53","journal-title":"Otol Neurotol"},{"issue":"3","key":"2032_CR88","doi-asserted-by":"publisher","first-page":"249","DOI":"10.5281\/ZENODO.55396","volume":"13","author":"GI Mikhasev","year":"2015","unstructured":"Mikhasev GI, Bosiakov Mihailovich S, Petrova LG, Maisyuk MM (2015) Finite-element modelling of the tympanic membrane retraction pocket under negative pressure in the tympanic cavity. Facta Universitatis, Series: Mech Eng 13(3):249\u2013257. https:\/\/doi.org\/10.5281\/ZENODO.55396","journal-title":"Facta Universitatis, Series: Mech Eng"},{"key":"2032_CR89","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/j.jbiomech.2009.02.016","volume":"42","author":"KM Moerman","year":"2009","unstructured":"Moerman KM, Holt CA, Evans SL, Simms CK (2009) Digital image correlation and finite element modelling as a method to determine mechanical properties of human soft tissue in vivo. J Biomech 42:1150\u20131153. https:\/\/doi.org\/10.1016\/j.jbiomech.2009.02.016","journal-title":"J Biomech"},{"key":"2032_CR90","doi-asserted-by":"publisher","DOI":"10.1016\/J.HEARES.2024.109092","volume":"452","author":"H Mohammadi","year":"2024","unstructured":"Mohammadi H, Ebrahimian A, Maftoon N (2024) Finite-element modelling of interactions of needle with tympanic membrane and middle ear. Hear Res 452:109092. https:\/\/doi.org\/10.1016\/J.HEARES.2024.109092","journal-title":"Hear Res"},{"key":"2032_CR91","doi-asserted-by":"publisher","first-page":"E276","DOI":"10.1002\/LARY.25141","volume":"125","author":"GL Monroy","year":"2015","unstructured":"Monroy GL, Shelton RL, Nolan RM, Nguyen CT, Novak MA, Hill MC, McCormick DT, Boppart SA (2015) Noninvasive depth-resolved optical measurements of the tympanic membrane and middle ear for differentiating otitis media. Laryngoscope 125:E276. https:\/\/doi.org\/10.1002\/LARY.25141","journal-title":"Laryngoscope"},{"key":"2032_CR92","doi-asserted-by":"publisher","first-page":"E256","DOI":"10.1097\/MAO.0000000000004132","volume":"45","author":"J Morgenstern","year":"2024","unstructured":"Morgenstern J, Kreusch T, Golde J, Steuer S, Ossmann S, Kirsten L, Walther J, Zahnert T, Koch E, Neudert M (2024) In vivo thickness of the healthy tympanic membrane determined by optical coherence tomography. Otol Neurotol 45:E256\u2013E262. https:\/\/doi.org\/10.1097\/MAO.0000000000004132","journal-title":"Otol Neurotol"},{"key":"2032_CR93","doi-asserted-by":"publisher","DOI":"10.1007\/S10162-017-0630-Z","volume":"18","author":"H Motallebzadeh","year":"2017","unstructured":"Motallebzadeh H, Maftoon N, Pitaro J, Funnell WRJ, Daniel SJ (2017) Fluid-structure finite-element modelling and clinical measurement of the wideband acoustic input admittance of the newborn ear canal and middle ear. J Assoc Res Otolaryngol 18:671. https:\/\/doi.org\/10.1007\/S10162-017-0630-Z","journal-title":"J Assoc Res Otolaryngol"},{"key":"2032_CR94","doi-asserted-by":"publisher","DOI":"10.1101\/2024.10.15.618553","author":"H Motallebzadeh","year":"2024","unstructured":"Motallebzadeh H, Deistler M, Sch\u00f6nleitner FM, Macke JH, Puria S (2024) From simulations to inference: using machine learning to tune patient-specific finite-element models of the middle ear towards objective diagnosis. BioRxiv. https:\/\/doi.org\/10.1101\/2024.10.15.618553","journal-title":"BioRxiv"},{"key":"2032_CR95","doi-asserted-by":"publisher","DOI":"10.1002\/DVG.23348","volume":"58","author":"M Mozaffari","year":"2019","unstructured":"Mozaffari M, Jiang D, Tucker AS (2019) Developmental aspects of the tympanic membrane: shedding light on function and disease. Genesis 58:e23348. https:\/\/doi.org\/10.1002\/DVG.23348","journal-title":"Genesis"},{"key":"2032_CR96","unstructured":"MyringoPatch\u2014BioMed ENT n.d. https:\/\/biomed-ent.com\/tympanic-membrane-perforations\/ (accessed April 10, 2025)."},{"key":"2032_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOADV.2024.213827","volume":"159","author":"O Nobus","year":"2024","unstructured":"Nobus O, Parmentier L, Livens P, Muyshondt P, Szewcyk K, Jacobs C, Verdoodt D, Pieters L, Thijssen Q, Van Durme B, Vral A, Dirckx J, Van Rompaey V, Van Vlierberghe S (2024) The importance of mechanical and biological cues of tympanic membrane grafts to ensure optimal regeneration. Biomater Adv 159:213827. https:\/\/doi.org\/10.1016\/J.BIOADV.2024.213827","journal-title":"Biomater Adv"},{"key":"2032_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/J.MTCHEM.2024.102016","volume":"37","author":"S Norouzi","year":"2024","unstructured":"Norouzi S, Saveh Shemshaki N, Norouzi E, Latifi M, Azimi B, Danti S, Qiao X, Miao Y, Yang S, Gorji M, Petrovic V, Aboudzadeh MA, Bagherzadeh R (2024) Recent advances in biomaterials for tissue-engineered constructs: essential factors and engineering techniques. Mater Today Chem 37:102016. https:\/\/doi.org\/10.1016\/J.MTCHEM.2024.102016","journal-title":"Mater Today Chem"},{"key":"2032_CR86","unstructured":"Novozhilov AA, Shilyagin PA, Novozhilova VA, Smirnova DD, Slepanov AA, Dilenjan AL, Klimycheva MB, Gelikonov GG, Gelikonov VM, Shakov AV (2023) Measuring the Tympanic Membrane Thickness Using Optical Coherence Tomography|Opera Medica et Physiologica. https:\/\/operamedphys.org\/node\/498\/abstract"},{"key":"2032_CR101","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1121\/1.5008741","volume":"142","author":"KN O\u2019Connor","year":"2017","unstructured":"O\u2019Connor KN, Cai H, Puria S (2017) The effects of varying tympanic-membrane material properties on human middle-ear sound transmission in a three-dimensional finite-element model. J Acoust Soc Am 142:2836\u20132853. https:\/\/doi.org\/10.1121\/1.5008741","journal-title":"J Acoust Soc Am"},{"key":"2032_CR102","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.3390\/S21041388","volume":"21","author":"D Oboe","year":"2021","unstructured":"Oboe D, Colombo L, Sbarufatti C, Giglio M (2021) Shape sensing of a complex aeronautical structure with inverse finite element method. Sensors 21:1388. https:\/\/doi.org\/10.3390\/S21041388","journal-title":"Sensors"},{"key":"2032_CR103","unstructured":"PhonoGraft: 3D Printed Tympanic Membrane Graft n.d. https:\/\/wyss.harvard.edu\/technology\/phonograft-3d-printed-tympanic-membrane-graft\/ (accessed April 10, 2025)."},{"key":"2032_CR104","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1159\/000013839","volume":"4","author":"PJ Prendergast","year":"1999","unstructured":"Prendergast PJ, Ferris P, Rice HJ, Blayney AW (1999) Vibro-acoustic modelling of the outer and middle ear using the finite-element method. Audiol Neurootol 4:185\u2013191. https:\/\/doi.org\/10.1159\/000013839","journal-title":"Audiol Neurootol"},{"key":"2032_CR105","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2991\/MATHI.K.201218.001","volume":"2","author":"D Ranglani","year":"2021","unstructured":"Ranglani D, Agiwal S, More N, Parkale R, Shitole V, Hiray AR, Kapusetti G (2021a) Review on tympanic membrane and auditory canal regeneration by biomaterial intervention. Mater Highl 2:7\u201317. https:\/\/doi.org\/10.2991\/MATHI.K.201218.001","journal-title":"Mater Highl"},{"key":"2032_CR106","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2991\/mathi.k.201218.001","volume":"2","author":"D Ranglani","year":"2021","unstructured":"Ranglani D, Agiwal S, More N, Parkale R, Shitole V, Hiray AR, Kapusetti G (2021b) Review on tympanic membrane and auditory canal regeneration by biomaterial intervention. Mater Highlights 2:7. https:\/\/doi.org\/10.2991\/mathi.k.201218.001","journal-title":"Mater Highlights"},{"key":"2032_CR107","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.heares.2017.01.002","volume":"345","author":"SA Rohani","year":"2017","unstructured":"Rohani SA, Ghomashchi S, Agrawal SK, Ladak HM (2017) Estimation of the Young\u2019s modulus of the human pars tensa using in-situ pressurization and inverse finite-element analysis. Hear Res 345:69\u201378. https:\/\/doi.org\/10.1016\/j.heares.2017.01.002","journal-title":"Hear Res"},{"key":"2032_CR108","unstructured":"Rosario DC, Mendez MD (2023) Chronic Suppurative Otitis. StatPearls."},{"key":"2032_CR109","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomc.2021.100205","author":"AA Rostam-Alilou","year":"2021","unstructured":"Rostam-Alilou AA, Jafari H, Zolfagharian A, Serjouei A, Bodaghi M (2021) Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: a vibro-acoustic analysis. Compos Part C: Open Access. https:\/\/doi.org\/10.1016\/j.jcomc.2021.100205","journal-title":"Compos Part C: Open Access"},{"key":"2032_CR110","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1001\/ARCHOTOL.1991.01870180063013","volume":"117","author":"CB Ruah","year":"1991","unstructured":"Ruah CB, Schachern PA, Zelterman D, Paparella MM, Yoon TH (1991) Age-related morphologic changes in the human tympanic membrane. A light and electron microscopic study. Arch Otolaryngol Head Neck Surg 117:627\u2013634. https:\/\/doi.org\/10.1001\/ARCHOTOL.1991.01870180063013","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2032_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBIOSY.2022.100046","volume":"6","author":"E Sainsbury","year":"2022","unstructured":"Sainsbury E, Amaral R, Blayney AW, Walsh RMC, O\u2019Brien FJ, O\u2019Leary C (2022) Tissue engineering and regenerative medicine strategies for the repair of tympanic membrane perforations. Biomater Biosyst 6:100046. https:\/\/doi.org\/10.1016\/J.BBIOSY.2022.100046","journal-title":"Biomater Biosyst"},{"key":"2032_CR113","unstructured":"Schuster-Bruce J, Gosnell E (2022) Conventional Hearing Aid Indications and Selection. StatPearls."},{"key":"2032_CR114","unstructured":"Sensorineural hearing loss after ossicular manipulation and drill-generated acoustic trauma in type I tympanoplasty with and without mastoidectomy: A series of 51 cases\u2014PubMed n.d. https:\/\/pubmed.ncbi.nlm.nih.gov\/26401668\/ (accessed April 10, 2025)."},{"key":"2032_CR115","doi-asserted-by":"publisher","unstructured":"Sheikh A, Bint-e-Zainab, Shabbir K, Imtiaz A, Sheikh A, Bint-e-Zainab, Shabbir K, Imtiaz A (2022) Structure and Physiology of Human Ear Involved in Hearing. Auditory System\u2014Function and Disorders. https:\/\/doi.org\/10.5772\/INTECHOPEN.105466.","DOI":"10.5772\/INTECHOPEN.105466"},{"key":"2032_CR116","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.bjps.2008.11.046","volume":"62","author":"A Sterodimas","year":"2009","unstructured":"Sterodimas A, de Faria J, Correa WE, Pitanguy I (2009) Tissue engineering and auricular reconstruction: a review. J Plast Reconstr Aesthet Surg 62:447\u2013452. https:\/\/doi.org\/10.1016\/j.bjps.2008.11.046","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"2032_CR117","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/S10237-002-0014-Z\/METRICS","volume":"1","author":"Q Sun","year":"2002","unstructured":"Sun Q, Gan RZ, Chang K-H, Dormer KJ (2002) Computer-integrated finite element modeling of human middle ear. Biomech Model Mechanobiol 1:109\u2013122. https:\/\/doi.org\/10.1007\/S10237-002-0014-Z\/METRICS","journal-title":"Biomech Model Mechanobiol"},{"key":"2032_CR118","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3390\/POLYM16020248","volume":"16","author":"M Svistushkin","year":"2024","unstructured":"Svistushkin M, Kotova S, Zolotova A, Fayzullin A, Antoshin A, Serejnikova N, Shekhter A, Voloshin S, Giliazova A, Istranova E, Nikiforova G, Khlytina A, Shevchik E, Nikiforova A, Selezneva L, Shpichka A, Timashev PS (2024) Collagen matrix to restore the tympanic membrane: developing a novel platform to treat perforations. Polymers 16:248. https:\/\/doi.org\/10.3390\/POLYM16020248","journal-title":"Polymers"},{"key":"2032_CR119","unstructured":"Szymanski A, Toth J, Ogorevc M, Geiger Z (2023) Anatomy, Head and Neck, Ear Tympanic Membrane. StatPearls."},{"key":"2032_CR120","doi-asserted-by":"publisher","DOI":"10.28920\/DHM51.1.10-17","volume":"51","author":"D\u00dc Talas","year":"2021","unstructured":"Talas D\u00dc, Beger O, \u00c7\u00f6meleko\u011flu \u00dc, \u00c7ak\u0131r S, Taghipour P, Vayiso\u011flu Y (2021) An insight to tympanic membrane perforation pressure through morphometry: a cadaver study. Diving Hyperb Med 51:10. https:\/\/doi.org\/10.28920\/DHM51.1.10-17","journal-title":"Diving Hyperb Med"},{"key":"2032_CR121","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2021.108335","author":"H Tang","year":"2021","unstructured":"Tang H, Psota P, Rosowski JJ, Furlong C, Cheng JT (2021) Analyses of the tympanic membrane impulse response measured with high-speed holography. Hear Res. https:\/\/doi.org\/10.1016\/j.heares.2021.108335","journal-title":"Hear Res"},{"key":"2032_CR122","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/J.JBIOMECH.2014.12.019","volume":"48","author":"M Taylor","year":"2015","unstructured":"Taylor M, Prendergast PJ (2015) Four decades of finite element analysis of orthopaedic devices: where are we now and what are the opportunities? J Biomech 48:767\u2013778. https:\/\/doi.org\/10.1016\/J.JBIOMECH.2014.12.019","journal-title":"J Biomech"},{"key":"2032_CR123","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1067\/mhn.2002.122701","volume":"126","author":"KB Teufert","year":"2002","unstructured":"Teufert KB, De La Cruz A (2002) Tympanosclerosis: long-term hearing results after ossicular reconstruction. Otolaryngol Head Neck Surg 126:264\u2013272. https:\/\/doi.org\/10.1067\/mhn.2002.122701","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2032_CR125","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/J.PROCIR.2019.04.156","volume":"82","author":"B Thimm","year":"2019","unstructured":"Thimm B, Steden J, Reuber M, Christ HJ (2019) Using digital image correlation measurements for the inverse identification of constitutive material parameters applied in metal cutting simulations. Procedia CIRP 82:95\u2013100. https:\/\/doi.org\/10.1016\/J.PROCIR.2019.04.156","journal-title":"Procedia CIRP"},{"key":"2032_CR126","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1097\/00006534-200104150-00024","volume":"107","author":"CH Thorne","year":"2001","unstructured":"Thorne CH, Brecht LE, Bradley JP, Levine JP, Hammerschlag P, Longaker MT (2001) Auricular reconstruction: indications for autogenous and prosthetic techniques. Plast Reconstr Surg 107:1241\u20131252. https:\/\/doi.org\/10.1097\/00006534-200104150-00024","journal-title":"Plast Reconstr Surg"},{"key":"2032_CR129","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1288\/00005537-199206000-00016","volume":"102","author":"AC Urquhart","year":"1992","unstructured":"Urquhart AC, McIntosh WA, Bodenstein NP (1992) Drill-generated sensorineural hearing loss following mastoid surgery. Laryngoscope 102:689\u2013692. https:\/\/doi.org\/10.1288\/00005537-199206000-00016","journal-title":"Laryngoscope"},{"key":"2032_CR130","doi-asserted-by":"publisher","DOI":"10.1007\/S10162-013-0394-Z","volume":"14","author":"S Van Der Jeught","year":"2013","unstructured":"Van Der Jeught S, Dirckx JJJ, Aerts JRM, Bradu A, Podoleanu AG, Buytaert JAN (2013) Full-field thickness distribution of human tympanic membrane obtained with optical coherence tomography. J Assoc Res Otolaryngol 14:483. https:\/\/doi.org\/10.1007\/S10162-013-0394-Z","journal-title":"J Assoc Res Otolaryngol"},{"key":"2032_CR131","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1109\/JBHI.2015.2406883","volume":"19","author":"M Viceconti","year":"2015","unstructured":"Viceconti M, Hunter P, Hose R (2015) Big data, big knowledge: big data for personalized healthcare. IEEE J Biomed Health Inform 19:1209\u20131215. https:\/\/doi.org\/10.1109\/JBHI.2015.2406883","journal-title":"IEEE J Biomed Health Inform"},{"key":"2032_CR1300","unstructured":"Von B\u00e9k\u00e9sy G (1960) Experiments in hearing. McGraw Hill, New York. https:\/\/psycnet.apa.org\/record\/1961-01618-000"},{"key":"2032_CR132","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.actbio.2023.09.005","volume":"170","author":"M von Witzleben","year":"2023","unstructured":"von Witzleben M, Stoppe T, Zeinalova A, Chen Z, Ahlfeld T, Bornitz M, Bernhardt A, Neudert M, Gelinsky M (2023) Multimodal additive manufacturing of biomimetic tympanic membrane replacements with near tissue-like acousto-mechanical and biological properties. Acta Biomater 170:124\u2013141. https:\/\/doi.org\/10.1016\/j.actbio.2023.09.005","journal-title":"Acta Biomater"},{"key":"2032_CR133","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1097\/01.MLG.0000172042.73024.AD","volume":"115","author":"JD Vos","year":"2005","unstructured":"Vos JD, Latev MD, Labadie RF, Cohen SM, Werkhaven JA, Haynes DS (2005) Use of AlloDerm in type I tympanoplasty: a comparison with native tissue grafts. Laryngoscope 115:1599\u20131602. https:\/\/doi.org\/10.1097\/01.MLG.0000172042.73024.AD","journal-title":"Laryngoscope"},{"key":"2032_CR134","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1121\/1.2749417","volume":"122","author":"X Wang","year":"2007","unstructured":"Wang X, Cheng T, Gan RZ (2007) Finite-element analysis of middle-ear pressure effects on static and dynamic behavior of human ear. J Acoust Soc Am 122:906\u2013917. https:\/\/doi.org\/10.1121\/1.2749417","journal-title":"J Acoust Soc Am"},{"key":"2032_CR135","doi-asserted-by":"publisher","DOI":"10.1016\/J.CEJ.2021.129536","volume":"419","author":"B Wang","year":"2021","unstructured":"Wang B, Xin T, Shen L, Zhang K, Zhang D, Zhang H, Liu J, Chen B, Cui W, Shu Y (2021) Acoustic transmitted electrospun fibrous membranes for tympanic membrane regeneration. Chem Eng J 419:129536. https:\/\/doi.org\/10.1016\/J.CEJ.2021.129536","journal-title":"Chem Eng J"},{"key":"2032_CR136","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAOTO.2025.0043","author":"J Wang","year":"2025","unstructured":"Wang J, Couvreur F, Farrell JD, Ghedia R, Shoman N, Morris DP, Adamson RBA (2025) Fusion of middle ear optical coherence tomography and computed tomography. JAMA Otolaryngol Head Neck Surg. https:\/\/doi.org\/10.1001\/JAMAOTO.2025.0043","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"2032_CR138","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1001\/ARCHOTOL.1997.01900060020003","volume":"123","author":"JD Williams","year":"1997","unstructured":"Williams JD, Romo T, Sclafani AP, Cho H (1997) Porous high-density polyethylene implants in auricular reconstruction. Arch Otolaryngol Head Neck Surg 123:578\u2013583. https:\/\/doi.org\/10.1001\/ARCHOTOL.1997.01900060020003","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2032_CR139","doi-asserted-by":"publisher","first-page":"5298","DOI":"10.1021\/ACS.CHEMREV.8B00593","volume":"119","author":"J Xue","year":"2019","unstructured":"Xue J, Wu T, Dai Y, Xia Y (2019) Electrospinning and Electrospun Nanofibers: methods, materials, and applications. Chem Rev 119:5298. https:\/\/doi.org\/10.1021\/ACS.CHEMREV.8B00593","journal-title":"Chem Rev"},{"key":"2032_CR140","doi-asserted-by":"publisher","DOI":"10.3389\/FBIOE.2024.1439499","volume":"12","author":"H Xue","year":"2024","unstructured":"Xue H, Chen S, Hu Y, Huang J, Shen Y (2024) Advances in 3D printing for the repair of tympanic membrane perforation: a comprehensive review. Front Bioeng Biotechnol 12:1439499. https:\/\/doi.org\/10.3389\/FBIOE.2024.1439499","journal-title":"Front Bioeng Biotechnol"},{"key":"2032_CR141","doi-asserted-by":"publisher","DOI":"10.1115\/1.4030410","author":"Z Yokell","year":"2015","unstructured":"Yokell Z, Wang X, Gan RZ (2015) Dynamic properties of tympanic membrane in a chinchilla otitis media model measured with acoustic loading. J Biomech Eng. https:\/\/doi.org\/10.1115\/1.4030410","journal-title":"J Biomech Eng"},{"key":"2032_CR142","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2022.106619","author":"YC Yu","year":"2022","unstructured":"Yu YC, Wang TC, Shih TC (2022) Effects of age-related tympanic-membrane material properties on sound transmission in the middle ear in a three-dimensional finite-element model. Comput Methods Programs Biomed. https:\/\/doi.org\/10.1016\/j.cmpb.2022.106619","journal-title":"Comput Methods Programs Biomed"},{"key":"2032_CR143","doi-asserted-by":"publisher","DOI":"10.3390\/MEDICINA59122114","volume":"59","author":"M Zeppieri","year":"2023","unstructured":"Zeppieri M, Marsili S, Enaholo ES, Shuaibu AO, Uwagboe N, Salati C, Spadea L, Musa M (2023) Optical coherence tomography (OCT): a brief look at the uses and technological evolution of ophthalmology. Medicina (b Aires) 59:2114. https:\/\/doi.org\/10.3390\/MEDICINA59122114","journal-title":"Medicina (b Aires)"},{"key":"2032_CR144","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1504\/IJECB.2010.035260","volume":"1","author":"X Zhang","year":"2010","unstructured":"Zhang X, Gan RZ (2010) Dynamic properties of human tympanic membrane &ndash; experimental measurement and modelling analysis. Int J Exp Comput Biomech 1:252. https:\/\/doi.org\/10.1504\/IJECB.2010.035260","journal-title":"Int J Exp Comput Biomech"},{"key":"2032_CR145","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/S10439-012-0624-2","volume":"41","author":"X Zhang","year":"2012","unstructured":"Zhang X, Gan RZ (2012) Dynamic properties of human tympanic membrane based on frequency-temperature superposition. Ann Biomed Eng 41:205. https:\/\/doi.org\/10.1007\/S10439-012-0624-2","journal-title":"Ann Biomed Eng"}],"container-title":["Biomechanics and Modeling in Mechanobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-025-02032-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10237-025-02032-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10237-025-02032-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:02:26Z","timestamp":1772748146000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10237-025-02032-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,16]]},"references-count":140,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["2032"],"URL":"https:\/\/doi.org\/10.1007\/s10237-025-02032-8","relation":{},"ISSN":["1617-7959","1617-7940"],"issn-type":[{"value":"1617-7959","type":"print"},{"value":"1617-7940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,16]]},"assertion":[{"value":"3 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"7"}}