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A key feature of the proposed framework is its analytical tractability, which allows the governing poroelastic equations to be solved in closed form under appropriate mechanical and hydraulic boundary conditions. Within this setting, linearity is used to capture the reversible component of the tissue response, providing a baseline description of the coupled solid\u2013fluid feedback on which more complex time-dependent phenomena, such as viscoelastic effects and remodelling, may build. The results indicate that both strain and stress measures (in the form of shear strain and deviatoric stress measures) peak in the peripheral region of the LC, which is currently suspected to be the initial site of glaucomatous damage. These quantities increase with IOP, suggesting a pressure-dependent mechanical insult to the retinal ganglion cell (RGC) axons. In parallel, the model predicts a monotonic reduction in fluid content as IOP rises, which may contribute to ischemic phenomena and disc haemorrhages. The influence of material anisotropy was also examined, revealing that isotropic assumptions tend to overestimate the fluid content while underestimating shear strain. Given the current experimental challenges in measuring blood flow within the LC, the proposed model provides a valuable framework for exploring the coupled mechanical\u2013hemodynamic behavior of the tissue and for inverse estimation of its mechanical parameters, such as the stiffness of the opening for the central retinal vessels.<\/jats:p>","DOI":"10.1007\/s10237-026-02083-5","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:46:19Z","timestamp":1782135979000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stresses and fluid flow in lamina cribrosa through anisotropic poroelasticity"],"prefix":"10.1007","volume":"25","author":[{"given":"Riccardo","family":"Cavuoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Damian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Deseri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Fraldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Siesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Verticchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Guidoboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"issue":"2","key":"2083_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s40135-015-0067-7","volume":"3","author":"RY Abe","year":"2015","unstructured":"Abe RY, Gracitelli CP, Diniz-Filho A, Tatham AJ, Medeiros FA (2015) Lamina cribrosa in glaucoma: diagnosis and monitoring. 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Professor Alon Harris holds an ownership interest in AdOM, Oxymap, Qlaris, SlitLed, and AEYE Health. If you have questions regarding paid relationships that your physician\/researcher may have with industry, you are encouraged to talk with your physician\/researcher, or check for industry relationships posted on individual faculty pages on our website at\n                      \n                      .","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"72"}}