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This idealized computational study evaluated associations of donor-to-recipient (\n                    <jats:italic>D<\/jats:italic>\n                    \/\n                    <jats:italic>R<\/jats:italic>\n                    ) thickness ratio, absolute stiffness, stiffness contrast, and depth-dependent stiffness with interface-local strain. Two-dimensional axisymmetric finite element models were subjected to a spatially uniform nominal pressure of 1.00\u00a0MPa. Nine\n                    <jats:italic>D<\/jats:italic>\n                    \/\n                    <jats:italic>R<\/jats:italic>\n                    ratios (0.33\u20133.25) and eleven homogeneous donor\/recipient (DC\/RC) Young\u2019s modulus combinations (2.50-7.00\u00a0MPa) yielded 99 homogeneous cases; nine functionally graded material (FGM) cases were evaluated. Primary outcomes were 95th percentile (P95) values of the nodewise compressive strain magnitude and tensor maximum shear strain within a fixed 0.25-mm local interface region of interest (ROI). This robust upper-tail measure is less sensitive than a single nodal maximum. In the matched homogeneous control, P95 values were 0.031 and 0.015. The largest homogeneous values were 0.412 and 0.347 at\n                    <jats:italic>D<\/jats:italic>\n                    \/\n                    <jats:italic>R<\/jats:italic>\n                    =3.25 and DC\/RC=7.0\/2.5\u00a0MPa. Same-side concentration factors normalized local P95 to median strain in the same model\u2019s 0.75-1.00\u00a0mm far-field band. Pooled factors were 3.71 \u00b1 2.04 for compression and 6.03 \u00b1 3.79 for maximum shear in homogeneous cases (\n                    <jats:italic>n<\/jats:italic>\n                    = 198 model-sides), and 3.51 \u00b1 2.17 and 5.69 \u00b1 4.03 in FGM cases (\n                    <jats:italic>n<\/jats:italic>\n                    = 18). FGM values were lower than both extreme homogeneous mismatch references at every\n                    <jats:italic>D<\/jats:italic>\n                    \/\n                    <jats:italic>R<\/jats:italic>\n                    ratio. Across formulations, thickness disparity remained associated with interface-local upper-tail strain. These results support evaluating donor-recipient cartilage thickness and material compatibility alongside surface congruity and osseous integration in future experimental and patient-specific modeling studies.\n                  <\/jats:p>","DOI":"10.1007\/s10237-026-02128-9","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:31:04Z","timestamp":1789191064000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined cartilage thickness and mechanical property mismatch drives local strain amplification at the patellar osteochondral allograft interface"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8335-3060","authenticated-orcid":false,"given":"Michael A. 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