{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:29:36Z","timestamp":1786980576142,"version":"build-2736575974"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T00:00:00Z","timestamp":1440806400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001870","name":"Fundacja na rzecz Nauki Polskiej (PL)","doi-asserted-by":"publisher","award":["FNP FOCUS 01\/08"],"award-info":[{"award-number":["FNP FOCUS 01\/08"]}],"id":[{"id":"10.13039\/501100001870","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s10238-015-0385-y","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T09:31:05Z","timestamp":1440754265000},"page":"503-509","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Accumulation of CD5+CD19+ B lymphocytes expressing PD-1 and PD-1L in hypertrophied pharyngeal tonsils"],"prefix":"10.1007","volume":"16","author":[{"given":"Paulina","family":"Wlasiuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Niedzielski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Skorka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Karczmarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Zaleska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Zajac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Putowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Pac-Kozuchowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Giannopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,29]]},"reference":[{"key":"385_CR1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000342329","volume":"75","author":"G Gysin","year":"2013","unstructured":"Gysin G. Indications of pediatric tonsillectomy. ORL. 2013;75:193\u2013202.","journal-title":"ORL"},{"key":"385_CR2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000024354","volume":"122","author":"MJ Kempen van","year":"2000","unstructured":"van Kempen MJ, Rijkers GT, Van Cauwenberge PB. The immune response in adenoids and tonsils. Int Arch Allergy Immunol. 2000;122:8\u201319.","journal-title":"Int Arch Allergy Immunol"},{"key":"385_CR3","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2008-02-078071","volume":"112","author":"TW LeBien","year":"2008","unstructured":"LeBien TW, Tedder TF. B lymphocytes: how they develop and function. Blood. 2008;112:1570\u201380.","journal-title":"Blood"},{"key":"385_CR4","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.biocel.2004.05.017","volume":"36","author":"M Dono","year":"2004","unstructured":"Dono M, Cerruti G, Zupo S. The CD5+ B-cell. Int J Biochem Cell Biol. 2004;36:2105\u201311.","journal-title":"Int J Biochem Cell Biol"},{"key":"385_CR5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cyto.2014.11.024","volume":"71","author":"MY Balkhi","year":"2015","unstructured":"Balkhi MY, Qiangzhong M, Ahmad S, Junghans RP. T cell exhaustion and interleukin 2 downregulation. Cytokine. 2015;71:339\u201347.","journal-title":"Cytokine"},{"key":"385_CR6","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1006\/geno.1994.1562","volume":"23","author":"T Shinohara","year":"1994","unstructured":"Shinohara T, Taniwaki M, Ishida Y, Kawaichi M, Honjo T. Structure and chromosomal localization of the human PD-1 gene (PDCD1). Genomics. 1994;23:704\u20136.","journal-title":"Genomics"},{"key":"385_CR7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-065X.2010.00923.x","volume":"236","author":"LM Francisco","year":"2010","unstructured":"Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010;236:219\u201342.","journal-title":"Immunol Rev"},{"key":"385_CR8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1365-2249.2012.04573.x","volume":"168","author":"I Sada-Ovalle","year":"2012","unstructured":"Sada-Ovalle I, Talayero A, Chav\u00e9z-Gal\u00e1n L, et al. Functionality of CD4+ and CD8+ T cells from tonsillar tissue. Clin Exp Immunol. 2012;168:200\u20136.","journal-title":"Clin Exp Immunol"},{"key":"385_CR9","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/sj.gene.6364223","volume":"6","author":"ES James","year":"2005","unstructured":"James ES, Harney S, Wordsworth BP, Cookson WO, Davis SJ, Moffatt MF. PDCD1: tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 2005;6:430\u20137.","journal-title":"Genes Immun"},{"key":"385_CR10","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-065X.2009.00767.x","volume":"229","author":"JL Riley","year":"2009","unstructured":"Riley JL. PD-1 signaling in primary T cells. Immunol Rev. 2009;229:114\u201325.","journal-title":"Immunol Rev"},{"key":"385_CR11","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/ca.22373","volume":"27","author":"I Brambilla","year":"2014","unstructured":"Brambilla I, Pusateri A, Pagella F, et al. Adenoids in children: advances in immunology, diagnosis and surgery. Clin Anat. 2014;27:346\u201352.","journal-title":"Clin Anat"},{"key":"385_CR12","first-page":"1416","volume":"143","author":"F Graeme-Cook","year":"1993","unstructured":"Graeme-Cook F, Bhan AK, Harris NL. Immunohistochemical characterization of intraepithelial and subepithelial mononuclear cells of the upper airways. Am J Pathol. 1993;143:1416\u201321.","journal-title":"Am J Pathol"},{"key":"385_CR13","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.autrev.2008.11.007","volume":"8","author":"A Dalloul","year":"2009","unstructured":"Dalloul A. CD5: a safeguard against autoimmunity and a shield for cancer cells. Autoimmun Rev. 2009;8:349\u201353.","journal-title":"Autoimmun Rev"},{"key":"385_CR14","doi-asserted-by":"publisher","unstructured":"Hayakawa K, Formica AM, Colombo MJ, Ichikawa D, Shinton SA, Brill-Dashoff J, Hardy RR. B cells generated by B-1 development can progress to chronic lymphocytic leukemia. Ann N Y Acad Sci. 2015. doi: 10.1111\/nyas.12768 .","DOI":"10.1111\/nyas.12768"},{"key":"385_CR15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-065X.2008.00661.x","volume":"224","author":"JD Bouaziz","year":"2008","unstructured":"Bouaziz JD, Yanaba K, Tedder TF. Regulatory B cells as inhibitors of immune responses and inflammation. Immunol Rev. 2008;224:201\u201314.","journal-title":"Immunol Rev"},{"key":"385_CR16","doi-asserted-by":"crossref","unstructured":"Mauri C, Menon M. The expanding family of regulatory B cells. Int Immunol. 2015. pii: dxv038.","DOI":"10.1093\/intimm\/dxv038"},{"key":"385_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084185","author":"KJ Nicholas","year":"2013","unstructured":"Nicholas KJ, Zern EK, Barnett L, et al. B cell responses to HIV antigen are a potent correlate of viremia in HIV-1 infection and improve with PD-1 blockade. PLoS ONE. 2013;. doi: 10.1371\/journal.pone.0084185 .","journal-title":"PLoS ONE"},{"key":"385_CR18","doi-asserted-by":"crossref","first-page":"e92934","DOI":"10.1371\/journal.pone.0092934","volume":"9","author":"B Siewe","year":"2014","unstructured":"Siewe B, Wallace J, Rygielski S, et al. Regulatory B cells inhibit cytotoxic T lymphocyte (CTL) activity and elimination of infected CD4 T cells after in vitro reactivation of HIV latent reservoirs. PLoS ONE. 2014;9:e92934.","journal-title":"PLoS ONE"},{"key":"385_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035178","author":"M Grzywnowicz","year":"2012","unstructured":"Grzywnowicz M, Zaleska J, Mertens D, et al. Programmed death-1 and its ligand are novel immunotolerant molecules expressed on leukemic B cells in chronic lymphocytic leukemia. PLoS ONE. 2012;. doi: 10.1371\/journal.pone.0035178 .","journal-title":"PLoS ONE"},{"key":"385_CR20","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.imlet.2014.09.001","volume":"1","author":"G Zhang","year":"2014","unstructured":"Zhang G, Li N, Zhang P, et al. PD-1 mRNA expression is associated with clinical and viral profile and PD1 3\u2032-untranslated region polymorphism in patients with chronic HBV infection. Immunol Lett. 2014;1:212\u20136.","journal-title":"Immunol Lett"},{"key":"385_CR21","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nm0902-1039c","volume":"8","author":"H Dong","year":"2002","unstructured":"Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med. 2002;8:793\u2013800.","journal-title":"Nat Med"},{"key":"385_CR22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0165-2478(02)00142-6","volume":"84","author":"M Ishida","year":"2002","unstructured":"Ishida M, Iwai Y, Tanaka Y, et al. Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol Lett. 2002;84:57\u201362.","journal-title":"Immunol Lett"},{"key":"385_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/nri3740","author":"DE Speiser","year":"2014","unstructured":"Speiser DE, Utzschneider DT, Oberle SG, M\u00fcnz C, Romero P, Zehn D. T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion? Nat Rev Immunol. 2014;. doi: 10.1038\/nri3740 .","journal-title":"Nat Rev Immunol"},{"key":"385_CR24","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1158\/0008-5472.CAN-12-2384","volume":"73","author":"S Lyford-Pike","year":"2013","unstructured":"Lyford-Pike S, Peng S, Young GD, et al. Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Res. 2013;73:1733\u201341.","journal-title":"Cancer Res"},{"key":"385_CR25","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/bjc.2014.416","volume":"111","author":"X Wu","year":"2014","unstructured":"Wu X, Zhang H, Xing Q, et al. PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients. Br J Cancer. 2014;111:1391\u20139.","journal-title":"Br J Cancer"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-015-0385-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10238-015-0385-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-015-0385-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-015-0385-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T18:52:33Z","timestamp":1553626353000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10238-015-0385-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,29]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["385"],"URL":"https:\/\/doi.org\/10.1007\/s10238-015-0385-y","relation":{},"ISSN":["1591-8890","1591-9528"],"issn-type":[{"value":"1591-8890","type":"print"},{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,29]]}}}