{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:08:33Z","timestamp":1785265713784,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s10238-016-0431-4","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T08:52:15Z","timestamp":1468918335000},"page":"371-381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Methotrexate treatment provokes apoptosis of proliferating keratinocyte in psoriasis patients"],"prefix":"10.1007","volume":"17","author":[{"given":"Tamilselvi","family":"Elango","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Thirupathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapna","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purushoth","family":"Ethiraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haripriya","family":"Dayalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpa","family":"Gnanaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"issue":"5\u20136","key":"431_CR1","first-page":"337","volume":"30","author":"S Gonzalez","year":"1999","unstructured":"Gonzalez S, Rajadhyaksha M, Rubinstein G, Anderson RR. Characterization of psoriasis in vivo by reflectance confocal microscopy. J Med. 1999;30(5\u20136):337\u201356.","journal-title":"J Med"},{"issue":"3","key":"431_CR2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1600-0560.2007.00800.x","volume":"35","author":"B Werner","year":"2008","unstructured":"Werner B, Bresch M, Brenner FM, Lima HC. Comparative study of histopathological and immunohistochemical findings in skin biopsies from patients with psoriasis before and after treatment with acitretin. J Cutan Pathol. 2008;35(3):302\u201310.","journal-title":"J Cutan Pathol"},{"key":"431_CR3","first-page":"413","volume":"9","author":"Y Teraki","year":"1999","unstructured":"Teraki Y, Shiohara T. Apoptosis and skin. Eur J Dermatol. 1999;9:413\u201326.","journal-title":"Eur J Dermatol"},{"issue":"2","key":"431_CR4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/sj.jid.5700008","volume":"126","author":"D Raj","year":"2006","unstructured":"Raj D, Brash DE, Grossman D. Keratinocyte apoptosis in epidermal development and disease. J Invest Dermatol. 2006;126(2):243\u201357.","journal-title":"J Invest Dermatol"},{"key":"431_CR5","doi-asserted-by":"crossref","first-page":"8247","DOI":"10.1128\/MCB.21.24.8247-8254.2001","volume":"21","author":"A Krueger","year":"2001","unstructured":"Krueger A, Baumann S, Krammer PH, Kirchhoff S. FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol Cell Biol. 2001;21:8247\u201354.","journal-title":"Mol Cell Biol"},{"key":"431_CR6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/35095508","volume":"1","author":"M Thome","year":"2001","unstructured":"Thome M, Tschopp J. Regulation of lymphocyte proliferation and death by FLIP. Nat Rev Immunol. 2001;1:50\u20138.","journal-title":"Nat Rev Immunol"},{"key":"431_CR7","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0960-9822(00)00512-1","volume":"10","author":"T Kataoka","year":"2000","unstructured":"Kataoka T, Budd RC, Holler N, et al. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr Biol. 2000;10:640\u20138.","journal-title":"Curr Biol"},{"issue":"4","key":"431_CR8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000018394","volume":"200","author":"M Laporte","year":"2000","unstructured":"Laporte M, Galand P, Fokan D, de Graef C, Heenen M. Apoptosis in established and healing psoriasis. Dermatology. 2000;200(4):314\u20136.","journal-title":"Dermatology"},{"issue":"3","key":"431_CR9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1365-2133.2005.07078.x","volume":"154","author":"S Kruger-Krasagakis","year":"2006","unstructured":"Kruger-Krasagakis S, Galanopoulos VK, Giannikaki L, Stefanidou M, Tosca AD. Programmed cell death of keratinocytes in infliximab-treated plaque-type psoriasis. Br J Dermatol. 2006;154(3):460\u20136.","journal-title":"Br J Dermatol"},{"issue":"4","key":"431_CR10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000211146","volume":"6","author":"A Er-raki","year":"1993","unstructured":"Er-raki A, Charveron M, Bonaf\u00e9 JL. Increased superoxide anion production in dermal fibroblasts of psoriatic patients. Skin Pharmacol. 1993;6(4):253\u20138.","journal-title":"Skin Pharmacol"},{"key":"431_CR11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2230.1996.tb00142.x","volume":"21","author":"M Boffa","year":"1996","unstructured":"Boffa M, Chalmers R. Methotrexate for psoriasis. Clin Exp Dermatol. 1996;21:399\u2013408.","journal-title":"Clin Exp Dermatol"},{"key":"431_CR12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00011-005-1355-8","volume":"54","author":"S Herman","year":"2005","unstructured":"Herman S, Zurgil N, Deutsch M. Low dose methotrexate induces apoptosis with reactive oxygen species involvement in T lymphocytic cell lines to a greater extent than in monocytic lines. Inflamm Res. 2005;54:273\u201380.","journal-title":"Inflamm Res"},{"key":"431_CR13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00403-005-0602-8","volume":"297","author":"AC Yazici","year":"2005","unstructured":"Yazici AC, T\u00fcrsen U, Apa DD, et al. The changes in expression of ICAM-3, Ki-67, PCNA, and CD31 in psoriatic lesions before and after methotrexate treatment. Arch Dermatol Res. 2005;297:249\u201355.","journal-title":"Arch Dermatol Res"},{"issue":"19\u201320","key":"431_CR14","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.cca.2012.05.007","volume":"413","author":"T Elango","year":"2012","unstructured":"Elango T, Dayalan H, Subramanian S, Gnanaraj P, Malligarjunan H. Serum interleukin-6 levels in response to methotrexate treatment in psoriatic patients. Clin Chim Acta. 2012;413(19\u201320):1652\u201366.","journal-title":"Clin Chim Acta"},{"issue":"6","key":"431_CR15","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/sji.12117","volume":"78","author":"E Tamilselvi","year":"2013","unstructured":"Tamilselvi E, Haripriya D, Hemamalini M, Pushpa G, Swapna S. Association of disease severity with IL-1 levels in methotrexate-treated psoriasis patients. Scand J Immunol. 2013;78(6):545\u201353.","journal-title":"Scand J Immunol"},{"issue":"4","key":"431_CR16","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10238-013-0252-7","volume":"14","author":"T Elango","year":"2014","unstructured":"Elango T, Dayalan H, Gnanraj P, Malligarjunan H, Subramanian S. Impact of methotrexate on oxidative stress and apoptosis markers in psoriatic patients. Clin Exp Med. 2014;14(4):431\u20137.","journal-title":"Clin Exp Med"},{"issue":"6","key":"431_CR17","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4103\/0378-6323.72443","volume":"76","author":"S Dogra","year":"2010","unstructured":"Dogra S, Yadav S. Psoriasis in India: prevalence and pattern. Indian J Dermatol Venereol Leprol. 2010;76(6):595\u2013601.","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"4","key":"431_CR18","doi-asserted-by":"crossref","first-page":"G1115","DOI":"10.1152\/ajpgi.2001.281.4.G1115","volume":"281","author":"J Soeda","year":"2001","unstructured":"Soeda J, Miyagawa S, Sano K, Masumoto J, Taniguchi S, Kawasaki S. Cytochrome c release into cytosol with subsequent caspase activation during warm ischemia in rat liver. Am J Physiol Gastrointest Liver Physiol. 2001;281(4):G1115\u201323.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"431_CR19","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.4049\/jimmunol.176.3.1431","volume":"176","author":"C Johansen","year":"2006","unstructured":"Johansen C, Funding AT, Otkjaer K, et al. Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2. J Immunol. 2006;176(3):1431\u20138.","journal-title":"J Immunol"},{"issue":"4","key":"431_CR20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402\u20138.","journal-title":"Methods"},{"issue":"3","key":"431_CR21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00000372-200406000-00001","volume":"26","author":"AR Bowen","year":"2004","unstructured":"Bowen AR, Hanks AN, Murphy KJ, Florell SR, Grossman D. Proliferation, apoptosis, and survivin expression in keratinocytic neoplasms and hyperplasias. Am J Dermatopathol. 2004;26(3):177\u201381.","journal-title":"Am J Dermatopathol"},{"issue":"6","key":"431_CR22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00403-012-1230-8","volume":"304","author":"SA Gabr","year":"2012","unstructured":"Gabr SA, Al-Ghadir AH. Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis. Arch Dermatol Res. 2012;304(6):451.","journal-title":"Arch Dermatol Res"},{"issue":"3","key":"431_CR23","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1053\/jhep.2000.9774","volume":"32","author":"I Fabregat","year":"2000","unstructured":"Fabregat I, Herrera B, Fern\u00e1ndez M, et al. Epidermal growth factor impairs the cytochrome C\/caspase-3 apoptotic pathway induced by transforming growth factor beta in rat fetal hepatocytes via a phosphoinositide 3-kinase-dependent pathway. Hepatology. 2000;32(3):528\u201335.","journal-title":"Hepatology"},{"issue":"6","key":"431_CR24","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/BF00791161","volume":"115","author":"AT Kagramanova","year":"1993","unstructured":"Kagramanova AT, Tishchenko LD, Berezov TT. The ornithine decarboxylase activity of the epidermis in psoriasis as a biochemical index of the hyperproliferative process. Biull Eksp Biol Med. 1993;115(6):618\u201320.","journal-title":"Biull Eksp Biol Med"},{"issue":"3","key":"431_CR25","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s10495-005-1891-2","volume":"10","author":"GY Liu","year":"2005","unstructured":"Liu GY, Hung YC, Hsu PC, et al. Ornithine decarboxylase prevents tumor necrosis factor alpha-induced apoptosis by decreasing intracellular reactive oxygen species. Apoptosis. 2005;10(3):569\u201381.","journal-title":"Apoptosis"},{"issue":"4","key":"431_CR26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s10238-004-0055-y","volume":"4","author":"RJ Gibson","year":"2005","unstructured":"Gibson RJ, Bowen JM, Cummins AG, Keefe DM. Relationship between dose of methotrexate, apoptosis, p53\/p21 expression and intestinal crypt proliferation in the rat. Clin Exp Med. 2005;4(4):188\u201395.","journal-title":"Clin Exp Med"},{"key":"431_CR27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nchembio.1177","volume":"9","author":"LD Walensky","year":"2013","unstructured":"Walensky LD. Protein-protein interactions: a PUMA mechanism unfolds. Nat Chem Biol. 2013;9:141\u20133.","journal-title":"Nat Chem Biol"},{"issue":"13","key":"431_CR28","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1073\/pnas.94.13.6939","volume":"94","author":"S Kharbanda","year":"1997","unstructured":"Kharbanda S, Pandey P, Schofield L, et al. Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci USA. 1997;94(13):6939\u201342.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"431_CR29","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s00403-001-0280-0","volume":"293","author":"Y Fukuya","year":"2002","unstructured":"Fukuya Y, Higaki M, Higaki Y, Kawashima M. Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis. Arch Dermatol Res. 2002;293(12):620\u20135.","journal-title":"Arch Dermatol Res"},{"key":"431_CR30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.acthis.2006.09.002","volume":"108","author":"P Oztas","year":"2006","unstructured":"Oztas P, Lortlar N, Oztas MO, Omeroglu S, Gurer MA, Alli N. Caspase 9 is decreased in psoriatic epidermis. Acta Histochem. 2006;108:497\u20139.","journal-title":"Acta Histochem"},{"key":"431_CR31","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1001\/archderm.133.12.1606","volume":"133","author":"A Orem","year":"1997","unstructured":"Orem A, Aliyazicioglu R, Kiran E. The relationship between nitric oxide production and activity of the disease in patients with psoriasis. Arch Dermatol. 1997;133:1606\u20137.","journal-title":"Arch Dermatol"},{"key":"431_CR32","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.185.4.601","volume":"185","author":"S Dimmeler","year":"1997","unstructured":"Dimmeler S, Haendeler J, Nehls M, et al. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1-beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J Exp Med. 1997;185:601\u20137.","journal-title":"J Exp Med"},{"issue":"3","key":"431_CR33","doi-asserted-by":"crossref","first-page":"16043","DOI":"10.1155\/MI\/2006\/16043","volume":"2006","author":"NS Tekin","year":"2006","unstructured":"Tekin NS, Ilter N, Sancak B, Ozden MG, Gurer MA. Nitric oxide levels in patients with psoriasis treated with methotrexate. Mediators Inflamm. 2006;2006(3):16043.","journal-title":"Mediators Inflamm"},{"issue":"5","key":"431_CR34","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/rheumatology\/37.5.502","volume":"37","author":"RJ Dolhain","year":"1998","unstructured":"Dolhain RJ, Tak PP, Dijkmans BA, De Kuiper P, Breedveld FC, Miltenburg AM. Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis. Br J Rheumatol. 1998;37(5):502\u20138.","journal-title":"Br J Rheumatol"},{"key":"431_CR35","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.4049\/jimmunol.167.5.2911","volume":"167","author":"S Majumdar","year":"2001","unstructured":"Majumdar S, Aggarwal BB. Methotrexate suppresses NfkappaB activation through inhibition of IkappaBalpha phosphorylation and degradation. J Immunol. 2001;167:2911\u201320.","journal-title":"J Immunol"},{"key":"431_CR36","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1074\/jbc.M108171200","volume":"277","author":"M Madesh","year":"2002","unstructured":"Madesh M, Antonsson B, Srinivasula SM, Alnemri ES, Hajn\u00f3czky G. Rapid kinetics of tBid-induced cytochrome c and Smac\/DIABLO release and mitochondrial depolarization. J Biol Chem. 2002;277:5651\u20139.","journal-title":"J Biol Chem"},{"issue":"1","key":"431_CR37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2500\/ajra.2013.27.3849","volume":"27","author":"HW Cho","year":"2013","unstructured":"Cho HW, Park SK, Heo KW, Hur DY. Methotrexate induces apoptosis in nasal polyps via caspase cascades and both mitochondria-mediated and p38 mitogen-activated protein kinases\/Jun N-terminal kinase pathways. Am J Rhinol Allergy. 2013;27(1):26\u201331.","journal-title":"Am J Rhinol Allergy"},{"issue":"38","key":"431_CR38","doi-asserted-by":"crossref","first-page":"32856","DOI":"10.1074\/jbc.M506119200","volume":"280","author":"E Calautti","year":"2005","unstructured":"Calautti E, Li J, Saoncella S, Brissette JL, Goetinck PF. Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death. J Biol Chem. 2005;280(38):32856\u201365.","journal-title":"J Biol Chem"},{"issue":"6","key":"431_CR39","first-page":"413","volume":"42","author":"Z Xiao-Yan","year":"2009","unstructured":"Xiao-Yan Z, Beng Z. Increased activities of Akt in psoriatic epidermis. Chin J Dermatol. 2009;42(6):413\u20136.","journal-title":"Chin J Dermatol"},{"issue":"12","key":"431_CR40","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1002\/1521-4141(200212)32:12<3689::AID-IMMU3689>3.0.CO;2-X","volume":"32","author":"D Neumann","year":"2002","unstructured":"Neumann D, Lienenklaus S, Rosati O, Martin U. IL-1beta-induced phosphorylation of PKB\/Akt depends on the presence of IRAK-1. Eur J Immunol. 2002;32(12):3689\u201398.","journal-title":"Eur J Immunol"},{"key":"431_CR41","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jdermsci.2004.05.008","volume":"35","author":"H Kawashima Doi","year":"2004","unstructured":"Kawashima Doi H, Ito Y, Shibata MA. Evaluation of cell death and proliferation in psoriatic epidermis. J Dermatol Sci. 2004;35:207\u201314.","journal-title":"J Dermatol Sci"},{"issue":"11","key":"431_CR42","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.1073\/pnas.1135239100","volume":"100","author":"AM Winter-Vann","year":"2003","unstructured":"Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ, et al. Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proc Natl Acad Sci. 2003;100(11):6529\u201334.","journal-title":"Proc Natl Acad Sci"},{"key":"431_CR43","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4103\/1110-6530.123929","volume":"33","author":"AA Imam","year":"2013","unstructured":"Imam AA, El-Hefnawy AH, El-Sayed SB, Ibrahim SH. The expression pattern of antiapoptotic protein c-FLIP in psoriatic epidermis. Egypt J Dermatol Venereol. 2013;33:46\u201350.","journal-title":"Egypt J Dermatol Venereol"},{"issue":"1","key":"431_CR44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1684\/ejd.2008.0571","volume":"19","author":"J Yang","year":"2009","unstructured":"Yang J, Li Y, Liu YQ, Long JW, Tian F, Dong J, Shen GX, Tu YT, Tao J. Expression of antiapoptotic protein c-FLIP is upregulated in psoriasis epidermis. Eur J Dermatol. 2009;19(1):29\u201333.","journal-title":"Eur J Dermatol"},{"issue":"3","key":"431_CR45","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1172\/JCI7630","volume":"105","author":"CS Seitz","year":"2000","unstructured":"Seitz CS, Freiberg RA, Hinata K, Khavari PA. NF-kappaB determines localization and features of cell death in epidermis. J Clin Invest. 2000;105(3):253\u201360.","journal-title":"J Clin Invest"},{"issue":"5","key":"431_CR46","first-page":"1321","volume":"151","author":"T Wrone-Smith","year":"1997","unstructured":"Wrone-Smith T, Mitra RS, Thompson CB, Jasty R, Castle VP, Nickoloff BJ. Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin. Am J Pathol. 1997;151(5):1321\u20139.","journal-title":"Am J Pathol"},{"key":"431_CR47","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1600-0560.2006.00719.x","volume":"34","author":"FK Doger","year":"2007","unstructured":"Doger FK, Dikicioglu E, Ergin F, Unal E, Sendur N, Uslu M. Nature of cell kinetics in psoriatic epidermis. J Cutan Pathol. 2007;34:257.","journal-title":"J Cutan Pathol"},{"issue":"5","key":"431_CR48","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1600-0560.2007.00841.x","volume":"35","author":"AG Abdou","year":"2008","unstructured":"Abdou AG, Hanout HM. Evaluation of survivin and NF-kappaB in psoriasis, an immunohistochemical study. J Cutan Pathol. 2008;35(5):445\u201351.","journal-title":"J Cutan Pathol"},{"key":"431_CR49","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","volume":"132","author":"MS Hayden","year":"2008","unstructured":"Hayden MS, Ghosh S. Shared principles in NF-kappa B signaling. Cell. 2008;132:344\u201362.","journal-title":"Cell"},{"key":"431_CR50","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/excr.1999.4733","volume":"254","author":"J Inoue","year":"2000","unstructured":"Inoue J, Ishida T, Tsukamoto N, et al. Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling. Exp Cell Res. 2000;254:14\u201324.","journal-title":"Exp Cell Res"},{"issue":"1","key":"431_CR51","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/187221309787158399","volume":"3","author":"D Tsuruta","year":"2009","unstructured":"Tsuruta D. NF-kappaB links keratinocytes and lymphocytes in the pathogenesis of psoriasis. Recent Pat Inflamm Allergy Drug Discov. 2009;3(1):40\u20138.","journal-title":"Recent Pat Inflamm Allergy Drug Discov."}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10238-016-0431-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-016-0431-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-016-0431-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-016-0431-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T08:53:06Z","timestamp":1718700786000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10238-016-0431-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,19]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["431"],"URL":"https:\/\/doi.org\/10.1007\/s10238-016-0431-4","relation":{},"ISSN":["1591-8890","1591-9528"],"issn-type":[{"value":"1591-8890","type":"print"},{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,19]]}}}