{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:55:22Z","timestamp":1789736122335,"version":"4.0.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["5380"],"award-info":[{"award-number":["5380"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s10238-017-0463-4","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T09:22:48Z","timestamp":1496222568000},"page":"45-50","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Enhanced liver fibrosis test using ELISA assay accurately discriminates advanced stage of liver fibrosis as determined by transient elastography fibroscan in treatment na\u00efve chronic HCV patients"],"prefix":"10.1007","volume":"18","author":[{"given":"Dalia","family":"Omran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Yosry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar K.","family":"Darweesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed M.","family":"Nabeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"El-Beshlawey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh","family":"Saif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza","family":"Fared","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Hassany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania A.","family":"Zayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,31]]},"reference":[{"key":"463_CR1","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.hep.2003.09.022","volume":"38","author":"P Bedossa","year":"2003","unstructured":"Bedossa P, Darg\u00e8re D, Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology. 2003;38:1449\u201357.","journal-title":"Hepatology"},{"key":"463_CR2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jhep.2007.02.010","volume":"47","author":"A Lawson","year":"2007","unstructured":"Lawson A, Hagan S, Rye K, et al. The natural history of hepatitis C with severe hepatic fibrosis. J Hepatol. 2007;47:37\u201345.","journal-title":"J Hepatol"},{"key":"463_CR3","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/hep.22759","volume":"49","author":"MG Ghany","year":"2009","unstructured":"Ghany MG, Strader DB, Thomas DL, Seeff LB. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology. 2009;49:1335\u201374.","journal-title":"Hepatology"},{"key":"463_CR4","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/hep.23315","volume":"51","author":"JE Everhart","year":"2010","unstructured":"Everhart JE, Wright EC, Goodman ZD, et al. Prognostic value of Ishak fibrosis stage: findings from the hepatitis C antiviral long-term treatment against cirrhosis trial. Hepatology. 2010;51:585\u201394.","journal-title":"Hepatology"},{"key":"463_CR5","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0140-6736(86)90883-4","volume":"1","author":"B Maharaj","year":"1986","unstructured":"Maharaj B, Maharaj RJ, Leary WP, et al. Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver. Lancet. 1986;1:523\u20135.","journal-title":"Lancet"},{"key":"463_CR6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1056\/NEJM200102153440706","volume":"344","author":"AA Bravo","year":"2001","unstructured":"Bravo AA, Sheth SG, Chopra S. Liver biopsy. N Engl J Med. 2001;344:495\u2013500.","journal-title":"N Engl J Med"},{"key":"463_CR7","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1111\/j.1572-0241.2002.06038.x","volume":"97","author":"A Regev","year":"2002","unstructured":"Regev A, Berho M, Jeffers LJ, et al. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol. 2002;97:2614\u20138.","journal-title":"Am J Gastroenterol"},{"key":"463_CR8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/hep.20535","volume":"41","author":"MC Rousselet","year":"2005","unstructured":"Rousselet MC, Michalak S, Dupr\u00e9 F, et al. Sources of variability in histological scoring of chronic viral hepatitis. Hepatology. 2005;41:257\u201364.","journal-title":"Hepatology"},{"key":"463_CR9","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1373\/clinchem.2004.032227","volume":"50","author":"T Poynard","year":"2004","unstructured":"Poynard T, Munteanu M, Imbert-Bismut F. Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Clin Chem. 2004;50:1344\u201355.","journal-title":"Clin Chem"},{"key":"463_CR10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jhep.2008.07.039","volume":"50","author":"SH Mehta","year":"2009","unstructured":"Mehta SH, Lau B, Afdhal NH, Thomas DL. Exceeding the limits of liver histology markers. J Hepatol. 2009;50:36\u201341.","journal-title":"J Hepatol"},{"key":"463_CR11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/hep.23190","volume":"50","author":"S Anna","year":"2009","unstructured":"Anna S, Brian J. Chronic hepatitis B: update 2009. Hepatology. 2009;50:661\u20132.","journal-title":"Hepatology"},{"issue":"3","key":"463_CR12","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/hep.22742","volume":"49","author":"DC Rockey","year":"2009","unstructured":"Rockey DC, Caldwell SH, Goodman ZD, Nelson RC, Smith AD. American association for the study of liver diseases. Liver biopsy. Hepatol. 2009;49(3):1017\u201344.","journal-title":"Liver biopsy. Hepatol."},{"issue":"Suppl 1","key":"463_CR13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1478-3231.2010.02380.x","volume":"31","author":"L Castera","year":"2011","unstructured":"Castera L, Bedossa P. How to assess liver fibrosis in chronic hepatitis C: serum markers or transient elastography vs. liver biopsy? Liver Int. 2011;31(Suppl 1):13\u20137.","journal-title":"Liver Int"},{"key":"463_CR14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0399-8320(08)73994-0","volume":"32","author":"V Ledinghen","year":"2008","unstructured":"Ledinghen V, Vergniol J. Transient elastography (FibroScan). Gastroenterol Clin Bio. 2008;32:58\u201367.","journal-title":"Gastroenterol Clin Bio"},{"key":"463_CR15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/jvh.12296","volume":"22","author":"JA Carrion","year":"2015","unstructured":"Carrion JA, Puigvehi M, Coll S, et al. Applicability and accuracy improvement of transient elastography using the M and XL probes by experienced operators. J Viral Hepat. 2015;22:297\u2013306.","journal-title":"J Viral Hepat"},{"key":"463_CR16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1053\/j.gastro.2004.11.018","volume":"128","author":"L Cast\u00e9ra","year":"2005","unstructured":"Cast\u00e9ra L, Vergniol J, Foucher J, et al. Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology. 2005;128:343\u201350.","journal-title":"Gastroenterology"},{"key":"463_CR17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/hep.20506","volume":"41","author":"M Ziol","year":"2005","unstructured":"Ziol M, Handra-Luca A, Kettaneh A, et al. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C. Hepatology. 2005;41:48\u201354.","journal-title":"Hepatology"},{"key":"463_CR18","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1136\/gut.2008.149708","volume":"57","author":"U Arena","year":"2008","unstructured":"Arena U, Vizzutti F, Abraldes JG, et al. Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C. Gut. 2008;57:1288\u201393.","journal-title":"Gut"},{"key":"463_CR19","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.gcb.2008.09.018","volume":"32","author":"J Vergniol","year":"2008","unstructured":"Vergniol J, Foucher J, Mamou K, et al. Non-invasive evaluation of liver fibrosis using FibroScan in long-term sustained-virological responder patients after HCV treatment. Gastroenterol Clin Biol. 2008;32:1061\u20133.","journal-title":"Gastroenterol Clin Biol"},{"key":"463_CR20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.antiviral.2009.04.002","volume":"83","author":"E Ogawa","year":"2009","unstructured":"Ogawa E, Furusyo N, Toyoda K, et al. The longitudinal quantitative assessment by transient elastography of chronic hepatitis C patients treated with pegylated interferon alpha-2b and ribavirin. Antiviral Res. 2009;83:127\u201334.","journal-title":"Antiviral Res"},{"key":"463_CR21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1365-2893.2008.01055.x","volume":"16","author":"J Vergniol","year":"2009","unstructured":"Vergniol J, Foucher J, Castera L, et al. Changes of non-invasive markers and FibroScan values during HCV treatment. J Viral Hepatitis. 2009;16:132\u201340.","journal-title":"J Viral Hepatitis"},{"key":"463_CR22","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/gut.2005.069153","volume":"55","author":"J Foucher","year":"2006","unstructured":"Foucher J, Chanteloup E, Vergniol J, et al. Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut. 2006;55:403\u20138.","journal-title":"Gut"},{"key":"463_CR23","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1053\/j.gastro.2004.08.052","volume":"127","author":"WM Rosenberg","year":"2004","unstructured":"Rosenberg WM, Voelker M, Thiel R, et al. Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology. 2004;127:1704\u201313.","journal-title":"Gastroenterology"},{"key":"463_CR24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jhep.2013.03.016","volume":"59","author":"R Lichtinghagen","year":"2013","unstructured":"Lichtinghagen R, Pietsch D, Bantel H, Manns MP, Brand K, Bahr MJ. The enhanced liver fibrosis (ELF) score: normal values, influence factors and proposed cut-off values. J Hepatol. 2013;59:236\u201342.","journal-title":"J Hepatol"},{"key":"463_CR25","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0399-8320(07)89420-6","volume":"31","author":"H Fontaine","year":"2007","unstructured":"Fontaine H, Petitprez K, Roudot-Thoraval F, Trinchet JC. Guidelines for the diagnosis of uncomplicated cirrhosis. Gastroenterol Clin Biol. 2007;31:504\u20139.","journal-title":"Gastroenterol Clin Biol"},{"key":"463_CR26","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1872-034X.2009.00500.x","volume":"39","author":"Y Nitta","year":"2009","unstructured":"Nitta Y, Kawabe N, Hashimoto S, et al. Liver stiffness measured by transient elastography correlates with fibrosis area in liver biopsy in patients with chronic hepatitis C. Hepatology Research. 2009;39:675\u201384.","journal-title":"Hepatology Research."},{"key":"463_CR27","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jhep.2005.10.019","volume":"44","author":"J Parkes","year":"2006","unstructured":"Parkes J, Guha IN, Roderick P, Rosenberg W. Performance of serum marker panels for liver fibrosis in chronic hepatitis C. J Hepatol. 2006;44:462\u201374.","journal-title":"J Hepatol"},{"key":"463_CR28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1471-230X-10-103","volume":"10","author":"M Friedrich-Rust","year":"2010","unstructured":"Friedrich-Rust M, Rosenberg W, Parkes J, Herrmann E, Zeuzem S, Sarrazin C. Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis. BMC Gastroenterol. 2010;10:103\u201310.","journal-title":"BMC Gastroenterol"},{"key":"463_CR29","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1136\/gut.2006.111302","volume":"56","author":"M Fraquelli","year":"2007","unstructured":"Fraquelli M, Rigamonti C, Casazza G, et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. Gut. 2007;56:968\u201373.","journal-title":"Gut"},{"key":"463_CR30","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.cgh.2008.07.006","volume":"6","author":"J Boursier","year":"2008","unstructured":"Boursier J, Konate A, Gorea G, et al. Reproducibility of liver stiffness measurement by ultrasonographic elastometry. Clin Gastroenterol Hepatol. 2008;6:1263\u20139.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"463_CR31","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/hep.23425","volume":"51","author":"L Castera","year":"2010","unstructured":"Castera L, Foucher J, Bernard PH, et al. Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology. 2010;51:828\u201335.","journal-title":"Hepatology"},{"key":"463_CR32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1440-1746.2010.06510.x","volume":"26","author":"GL Wong","year":"2011","unstructured":"Wong GL, Wong VW, Chim AM, et al. Factors associated with unreliable liver stiffness measurement and its failure with transient elastography in the Chinese population. J Gastroenterol Hepatol. 2011;26:300\u20135.","journal-title":"J Gastroenterol Hepatol"},{"key":"463_CR33","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.eimc.2011.11.004","volume":"30","author":"L Garc\u00eda-Jurado","year":"2012","unstructured":"Garc\u00eda-Jurado L, Oyag\u00fcez I, Casado M\u00c1, et al. Evaluation of the costs of transient elastography (FibroScan(\u00ae)) in the diagnosis of liver fibrosis in HIV patients with hepatitis C virus. Enferm Infecc Microbiol Clin. 2012;30:294\u20139.","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"463_CR34","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1007\/s10620-013-2705-y","volume":"58","author":"C Canavan","year":"2013","unstructured":"Canavan C, Eisenburg J, Meng L, Corey K, Hur C. Ultrasound elastography for fibrosis surveillance is cost effective in patients with chronic hepatitis C virus in the UK. Dig Dis Sci. 2013;58:2691\u2013704.","journal-title":"Dig Dis Sci"},{"key":"463_CR35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3111\/13696998.2013.867271","volume":"17","author":"JA Whitty","year":"2014","unstructured":"Whitty JA, Tallis C, Nguyen KH, et al. Cost and time savings from a rapid access model of care using transient elastography to screen and triage patients with chronic Hepatitis C infection. J Med Econ. 2014;17:159\u201365.","journal-title":"J Med Econ."},{"key":"463_CR36","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1053\/j.gastro.2008.01.034","volume":"134","author":"M Friedrich-Rust","year":"2008","unstructured":"Friedrich-Rust M, Ong MF, Martens S, et al. Performance of transient elastography for the staging of liver fibrosis: a metaanalysis. Gastroenterology. 2008;134:960\u201374.","journal-title":"Gastroenterology"},{"issue":"4","key":"463_CR37","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1515\/cclm-2011-0858","volume":"50","author":"J Gu\u00e9chot","year":"2012","unstructured":"Gu\u00e9chot J, Trocm\u00e9 C, Renversez JC, Sturm N, Zarski JP. ANRS HC EP 23 Fibrostar Study Group. Independent validation of the Enhanced Liver Fibrosis (ELF) score in the ANRS HC EP 23 Fibrostar cohort of patients with chronic hepatitis C. Clin Chem Lab Med. 2012;50(4):693\u20139.","journal-title":"Clin Chem Lab Med"},{"issue":"3","key":"463_CR38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/MCG.0000000000000128","volume":"49","author":"FF Fernandes","year":"2015","unstructured":"Fernandes FF, Ferraz ML, Andrade LE, et al. Enhanced liver fibrosis panel as a predictor of liver fibrosis in chronic hepatitis C patients. J Clin Gastroenterol. 2015;49(3):235\u201341.","journal-title":"J Clin Gastroenterol"},{"issue":"12","key":"463_CR39","doi-asserted-by":"crossref","first-page":"e51906","DOI":"10.1371\/journal.pone.0051906","volume":"7","author":"K Wahl","year":"2012","unstructured":"Wahl K, Rosenberg W, Vaske B, et al. Biopsy-controlled liver fibrosis staging using the enhanced liver fibrosis (ELF) score compared to transient elastography. PLoS ONE. 2012;7(12):e51906.","journal-title":"PLoS ONE"},{"issue":"4","key":"463_CR40","first-page":"145","volume":"3","author":"AM Gaballah","year":"2015","unstructured":"Gaballah AM, Elsaid HH, Shaheen NE. Enhanced Liver Fibrosis test can replace liver biopsy in detection of liver fibrosis in chronic hepatitis C patients\u00a0Int. J Adv Res. 2015;3(4):145\u201350.","journal-title":"J Adv Res"},{"issue":"1","key":"463_CR41","first-page":"A245","volume":"63","author":"GE Dolman","year":"2014","unstructured":"Dolman GE, Zaitoun A, IrvingWL Guha NI. PTH-081 enhanced liver fibrosis (ELF) test performs better than histological parameters in predicting clinical outcomes in patients with advanced fibrosis due to chronic hepatitis C infection. Gut. 2014;63(1):A245.","journal-title":"Gut"},{"issue":"5","key":"463_CR42","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/hep.22517","volume":"48","author":"MJ Mayo","year":"2008","unstructured":"Mayo MJ, Parkes J, Adams-Huet B, et al. Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay. Hepatology. 2008;48(5):1549\u201357.","journal-title":"Hepatology"},{"issue":"12","key":"463_CR43","doi-asserted-by":"crossref","first-page":"e0164883","DOI":"10.1371\/journal.pone.0164883","volume":"11","author":"M Puigveh\u00ed","year":"2016","unstructured":"Puigveh\u00ed M, Hern\u00e1ndez J, Broquetas T, et al. Diagnostic accuracy of the Enhanced Liver Fibrosis (ELF\u00ae) score using HCV-infected serum samples cryopreserved for up to 25 years. PLoS ONE. 2016;11(12):e0164883.","journal-title":"PLoS ONE"},{"key":"463_CR44","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","volume":"371","author":"D Schuppan","year":"2008","unstructured":"Schuppan D, Afdhal NH. Liver cirrhosis. Lancet. 2008;371:838\u201351.","journal-title":"Lancet"},{"key":"463_CR45","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/hep.23123","volume":"50","author":"Y Popov","year":"2009","unstructured":"Popov Y, Schuppan D. Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies. Hepatology. 2009;50:1294\u2013306.","journal-title":"Hepatology"},{"key":"463_CR46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/hep.22576","volume":"49","author":"S Naveau","year":"2009","unstructured":"Naveau S, Gaud\u00e9 G, Asnacios A, et al. Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease. Hepatology. 2009;49:97\u2013105.","journal-title":"Hepatology"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10238-017-0463-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-017-0463-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-017-0463-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T21:40:26Z","timestamp":1750282826000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10238-017-0463-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,31]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["463"],"URL":"https:\/\/doi.org\/10.1007\/s10238-017-0463-4","relation":{},"ISSN":["1591-8890","1591-9528"],"issn-type":[{"value":"1591-8890","type":"print"},{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,31]]}}}