{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:13:33Z","timestamp":1780758813682,"version":"3.54.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s10238-020-00622-7","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T12:03:05Z","timestamp":1585224185000},"page":"409-416","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cross-sectional associations between angiotensin-converting enzyme inhibitor use and cancer diagnosis in US adults"],"prefix":"10.1007","volume":"20","author":[{"given":"Lee","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Parris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Veronese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo F.","family":"L\u00f3pez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Nottegar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Raupach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Grabovac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Crichton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,26]]},"reference":[{"issue":"9215","key":"622_CR1","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1016\/S0140-6736(00)02212-1","volume":"355","author":"MD Flather","year":"2000","unstructured":"Flather MD, Yusuf S, K\u00f8ber L, et al. Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients. Lancet. 2000;355(9215):1575\u201381.","journal-title":"Lancet"},{"key":"622_CR2","first-page":"CD003823","volume":"4","author":"BS Heran","year":"2008","unstructured":"Heran BS, Wong MM, Heran IK, Wright JM. Blood pressure lowering efficacy of angiotensin converting enzyme (ACE) inhibitors for primary hypertension. Cochrane Database Syst Rev. 2008;4:CD003823.","journal-title":"Cochrane Database Syst Rev"},{"issue":"14","key":"622_CR3","doi-asserted-by":"publisher","first-page":"E1073","DOI":"10.1503\/cmaj.101497","volume":"183","author":"C Yoon","year":"2011","unstructured":"Yoon C, Yang H-S, Jeon I, Chang Y, Park SM. Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: a meta-analysis of observational studies. CMAJ Can Med Assoc J J Assoc Med Can. 2011;183(14):E1073\u201384.","journal-title":"CMAJ Can Med Assoc J J Assoc Med Can"},{"issue":"3","key":"622_CR4","first-page":"1","volume":"17","author":"J Shen","year":"2016","unstructured":"Shen J, Huang Y-M, Wang M, et al. Renin-angiotensin system blockade for the risk of cancer and death. JRAAS. 2016;17(3):1\u201314.","journal-title":"JRAAS"},{"key":"622_CR5","doi-asserted-by":"publisher","first-page":"k4209","DOI":"10.1136\/bmj.k4209","volume":"363","author":"BM Hicks","year":"2018","unstructured":"Hicks BM, Filion KB, Yin H, Sakr L, Udell JA, Azoulay L. Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study. BMJ. 2018;363:k4209.","journal-title":"BMJ"},{"issue":"15","key":"622_CR6","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1001\/jama.2015.13480","volume":"314","author":"JS Haukoos","year":"2015","unstructured":"Haukoos JS, Lewis RJ. The propensity score. JAMA. 2015;314(15):1637\u20138.","journal-title":"JAMA"},{"key":"622_CR7","unstructured":"American Cancer Society. How Common Is Breast Cancer? Breast Cancer Statistics. 2020. https:\/\/www.cancer.org\/cancer\/breast-cancer\/about\/how-common-is-breast-cancer.html. Accessed 10 Jan 2020."},{"key":"622_CR8","unstructured":"American Cancer Society. Prostate Cancer. 2020. https:\/\/www.cancer.org\/cancer\/prostate-cancer.html. Accessed 10 Jan 2020."},{"key":"622_CR9","unstructured":"American Cancer Society. Key Statistics for Colorectal Cancer. 2020. https:\/\/www.cancer.org\/cancer\/colon-rectal-cancer\/about\/key-statistics.html Accessed 10 Jan 2020."},{"key":"622_CR10","unstructured":"Centers for Disease Control and Prevention. NHANES-National Health and Nutrition Examination Survey Homepage. 2019. https:\/\/www.cdc.gov\/nchs\/nhanes\/index.htm Accessed 10 Jan 2020."},{"issue":"3","key":"622_CR11","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s10238-018-0498-1","volume":"18","author":"A Romaszko-Wojtowicz","year":"2018","unstructured":"Romaszko-Wojtowicz A, Buci\u0144ski A, Doboszy\u0144ska A. Impact of smoking on multiple primary cancers survival: a retrospective analysis. Clin Exp Med. 2018;18(3):391\u20137.","journal-title":"Clin Exp Med"},{"issue":"8","key":"622_CR12","doi-asserted-by":"publisher","first-page":"e494","DOI":"10.1016\/S1470-2045(17)30373-X","volume":"18","author":"J Beane","year":"2017","unstructured":"Beane J, Campbell JD, Lel J, Vick J, Spira A. Genomic approaches to accelerate cancer interception. Lancet Oncol. 2017;18(8):e494\u2013502.","journal-title":"Lancet Oncol"},{"key":"622_CR13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bcp.2019.01.020","volume":"162","author":"ALA Wong","year":"2019","unstructured":"Wong ALA, Bellot GL, Hirpara JL, Pervaiz S. Understanding the cancer stem cell phenotype: a step forward in the therapeutic management of cancer. Biochem Pharmacol. 2019;162:79\u201388.","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"622_CR14","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1080\/10409238.2018.1556578","volume":"53","author":"S Ganapathy-Kanniappan","year":"2018","unstructured":"Ganapathy-Kanniappan S. Molecular intricacies of aerobic glycolysis in cancer: current insights into the classic metabolic phenotype. Crit Rev Biochem Mol Biol. 2018;53(6):667\u201382.","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"622_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cancergen.2018.04.003","volume":"224\u2013225","author":"C Luchini","year":"2018","unstructured":"Luchini C, Nottegar A, Vaona A, et al. Female-specific association among I, J and K mitochondrial genetic haplogroups and cancer: A longitudinal cohort study. Cancer Genet. 2018;224\u2013225:29\u201336.","journal-title":"Cancer Genet"},{"key":"622_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2019.00348","volume":"10","author":"M Segovia-Mendoza","year":"2019","unstructured":"Segovia-Mendoza M, Morales-Montor J. Immune tumor microenvironment in breast cancer and the participation of estrogens and its receptors into cancer physiopathology. Front Immunol. 2019;10:1\u201316.","journal-title":"Front Immunol"},{"issue":"2","key":"622_CR17","doi-asserted-by":"publisher","first-page":"150","DOI":"10.2174\/1389200216666151015112356","volume":"17","author":"C Ciccarese","year":"2016","unstructured":"Ciccarese C, Santoni M, Massari F, et al. Metabolic alterations in renal and prostate cancer. Curr Drug Metab. 2016;17(2):150\u20135.","journal-title":"Curr Drug Metab"},{"key":"622_CR18","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0137","author":"BC \u00d6zdemir","year":"2019","unstructured":"\u00d6zdemir BC, Dotto G-P. Sex hormones and anticancer immunity. Clin Cancer Res. 2019. https:\/\/doi.org\/10.1158\/1078-0432.CCR-19-0137.","journal-title":"Clin Cancer Res"},{"key":"622_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2019.03.006","author":"YS Yoon","year":"2019","unstructured":"Yoon YS, Kwon AR, Lee YK, Oh SW. Circulating adipokines and risk of obesity related cancers: a systematic review and meta-analysis. Obes Res Clin Pract. 2019. https:\/\/doi.org\/10.1016\/j.orcp.2019.03.006.","journal-title":"Obes Res Clin Pract"},{"issue":"1","key":"622_CR20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.26444\/aaem\/100664","volume":"26","author":"A Budny","year":"2019","unstructured":"Budny A, Grochowski C, Koz\u0142owski P, et al. Obesity as a tumour development triggering factor. Ann Agric Environ Med AAEM. 2019;26(1):13\u201323.","journal-title":"Ann Agric Environ Med AAEM"},{"issue":"2","key":"622_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jcm8020201","volume":"8","author":"K Fujita","year":"2019","unstructured":"Fujita K, Hayashi T, Matsushita M, Uemura M, Nonomura N. Obesity, inflammation, and prostate cancer. J Clin Med. 2019;8(2):1\u201315.","journal-title":"J Clin Med"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-020-00622-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10238-020-00622-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-020-00622-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:49:36Z","timestamp":1616719776000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10238-020-00622-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,26]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["622"],"URL":"https:\/\/doi.org\/10.1007\/s10238-020-00622-7","relation":{},"ISSN":["1591-8890","1591-9528"],"issn-type":[{"value":"1591-8890","type":"print"},{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,26]]},"assertion":[{"value":"17 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The NHANES obtained approval from the National Centre for Health Statistics Research Ethics Review Board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Participants provided written consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}