{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:48:08Z","timestamp":1757540888681,"version":"3.37.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"a faculty research grant of Yonsei University College of Medicine","award":["6-2019-0184"],"award-info":[{"award-number":["6-2019-0184"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously reported that fibrosis-4 (FIB-4) was associated with poor outcomes of microscopic polyangiitis (MPA) and granuloma with polyangiitis (GPA). We also investigated the potential of FIB-5, a novel index, in predicting all-cause mortality and end-stage renal disease (ESRD) during follow-up in patients with MPA and GPA without substantial liver diseases. Clinical and laboratory data at diagnosis were collected by reviewing the medical records of 180 patients with MPA and GPA. FIB-5 was obtained by a following equation: FIB-5\u2009=\u2009(serum albumin (g\/L)\u2009\u00d7\u20090.3\u2009+\u2009platelet count (10<jats:sup>9<\/jats:sup>\/L)\u2009\u00d7\u20090.05) \u2212 (alkaline phosphatase (IU\/L)\u2009\u00d7\u20090.014\u2009+\u2009aspartate aminotransferase\/alanine aminotransferase ratio\u2009\u00d7\u20096\u2009+\u200914). The median age of the patients at diagnosis was 61.0\u00a0years. FIB-5 at diagnosis could not reflect the cross-sectional vasculitis activity. The cutoffs of FIB-5 for poor outcomes was set as 0.82 (the lowest tertile) and -0.42 (the lowest quartile) at diagnosis. In Kaplan\u2013Meier survival analysis, patients with FIB-5\u2009&lt;\u20090.82 and those with FIB-5\u2009&lt;\u2009-0.42 exhibited lower ESRD-free survival rates than those without. However, it could not predict all-cause mortality. In multivariable Cox hazards analysis, both FFS (Hazard ratio (HR) 1.554) and FIB-5\u2009&lt;\u20090.82 (HR 2.096) as well as both FFS (HR 1.534) and FIB-5\u2009&lt;\u2009-0.42 (HR 2.073) at diagnosis independently predicted ESRD during follow-up. In conclusion, FIB-5\u2009&lt;\u20090.82 and FIB-5\u2009&lt;\u2009-0.42 at diagnosis could predict the occurrence of ESRD, but not all-cause mortality, during follow-up in patients with MPA and GPA without substantial liver diseases.<\/jats:p>","DOI":"10.1007\/s10238-021-00691-2","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T17:51:49Z","timestamp":1613843509000},"page":"399-406","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fibrosis-5 predicts end-stage renal disease in patients with microscopic polyangiitis and granulomatosis with polyangiitis without substantial liver diseases"],"prefix":"10.1007","volume":"21","author":[{"given":"Hyeok Chan","family":"Kwon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason Jungsik","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Beom","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-3341","authenticated-orcid":false,"given":"Sang-Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,20]]},"reference":[{"issue":"1","key":"691_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/art.37715","volume":"65","author":"JC Jennette","year":"2013","unstructured":"Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International chapel hill consensus conference nomenclature of vasculitides. 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