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Resistin has been implied in microvascular dysfunction. Objective of this study is to evaluate the association between baseline resistin and development of new digital ulcers (DUs) in SSc patients. At baseline, serum resistin has been assessed in 70 female SSc patients and 26 healthy controls (HC). In SSc patients, clinical assessment was performed at baseline and after a 52-weeks follow-up. Serum resistin level was increased in SSc patients compared to HC [5.89\u00a0ng\/ml (2.5\u00a0ng\/ml\u20138.1\u00a0ng\/ml) vs 2.3\u00a0ng\/ml (0.4\u00a0ng\/ml\u20132.4\u00a0ng\/ml), <jats:italic>p<\/jats:italic>\u2009=\u20090.0004)]. Resistin was lower (<jats:italic>p<\/jats:italic>\u2009=\u20090.005) in SSc patients with early capillaroscopic pattern than patients with active or late capillaroscopic pattern [2.49\u00a0ng\/ml (0.89\u00a0ng\/ml\u20135.81\u00a0ng\/ml) vs 7.11\u00a0ng\/ml (3.48\u00a0ng\/ml\u201311.35\u00a0ng\/ml) and 6.49\u00a0ng\/ml (3.35\u00a0ng\/ml\u20138.87\u00a0ng\/ml), respectively]. After a 52-weeks follow-up, 34 (48.6%) patients developed new DUs. Median serum resistin was significantly higher in patients with new DUs than in patients without new DUs [6.54\u00a0ng\/ml (3.35\u00a0ng\/ml\u201311.02\u00a0ng\/ml) vs 4.78\u00a0ng\/ml (1.06\u00a0ng\/ml\u20137.6\u00a0ng\/ml), <jats:italic>p<\/jats:italic>\u2009=\u20090.019]. Kaplan\u2013Meier curves show a significantly reduced free survival from DUs in patients with increased resistin (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). In multivariate analysis, resistin is associated with the development of new DUs. Increased serum resistin level is a predictive marker of new DUs in SSc.<\/jats:p>","DOI":"10.1007\/s10238-021-00756-2","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T19:02:35Z","timestamp":1630350155000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serum resistin is predictive marker of development of new digital ulcers in systemic sclerosis"],"prefix":"10.1007","volume":"22","author":[{"given":"Chiara","family":"Pellicano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Leodori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Colalillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Navarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Gigante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-8093","authenticated-orcid":false,"given":"Edoardo","family":"Rosato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"756_CR1","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1056\/NEJMra0806188","volume":"360","author":"A Gabrielli","year":"2009","unstructured":"Gabrielli A, Avvedimento EV, Krieg T. 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The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Patients signed informed consent regarding publishing their data and photographs.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}