{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:05:11Z","timestamp":1783386311059,"version":"3.54.6"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020J01120297"],"award-info":[{"award-number":["2020J01120297"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-022-00825-0","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T03:02:54Z","timestamp":1649300574000},"page":"347-355","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The latest research trends in primary biliary cholangitis: a bibliometric analysis"],"prefix":"10.1007","volume":"23","author":[{"given":"Yu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjie","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fajing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8956-6814","authenticated-orcid":false,"given":"Hongbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"issue":"12","key":"825_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2152\/jmi.64.7","volume":"64","author":"K Tsuneyama","year":"2017","unstructured":"Tsuneyama K, Baba H, Morimoto Y, Tsunematsu T, Ogawa H. Primary biliary cholangitis: its pathological characteristics and immunopathological mechanisms. J Med Investig. 2017;64(12):7\u201313. https:\/\/doi.org\/10.2152\/jmi.64.7.","journal-title":"J Med Investig"},{"issue":"6","key":"825_CR2","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1053\/j.gastro.2015.08.031","volume":"149","author":"U Beuers","year":"2015","unstructured":"Beuers U, Gershwin ME, Gish RG, et al. Changing nomenclature for PBC: from \u201ccirrhosis\u201d to \u201ccholangitis.\u201d Gastroenterology. 2015;149(6):1627\u20139. https:\/\/doi.org\/10.1053\/j.gastro.2015.08.031.","journal-title":"Gastroenterology"},{"issue":"10003","key":"825_CR3","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/s0140-6736(15)00154-3","volume":"386","author":"EJ Carey","year":"2015","unstructured":"Carey EJ, Ali AH, Lindor KD. Primary biliary cirrhosis. Lancet. 2015;386(10003):1565\u201375. https:\/\/doi.org\/10.1016\/s0140-6736(15)00154-3.","journal-title":"Lancet"},{"issue":"9","key":"825_CR4","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1136\/gutjnl-2017-315259","volume":"67","author":"GM Hirschfield","year":"2018","unstructured":"Hirschfield GM, Dyson JK, Alexander GJM, et al. The British Society of Gastroenterology\/UK-PBC primary biliary cholangitis treatment and management guidelines. Gut. 2018;67(9):1568\u201394. https:\/\/doi.org\/10.1136\/gutjnl-2017-315259.","journal-title":"Gut"},{"key":"825_CR5","unstructured":"Pandit S, Samant H (2021) Primary biliary cholangitis. In StatPearls. Copyright\u00a9 2021, StatPearls Publishing LLC"},{"issue":"9","key":"825_CR6","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/s2468-1253(18)30163-8","volume":"3","author":"M Carbone","year":"2018","unstructured":"Carbone M, Nardi A, Flack S, et al. Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA response score. Lancet Gastroenterol Hepatol. 2018;3(9):626\u201334. https:\/\/doi.org\/10.1016\/s2468-1253(18)30163-8.","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"12","key":"825_CR7","doi-asserted-by":"publisher","first-page":"3660","DOI":"10.7150\/jca.52842","volume":"12","author":"B Jin","year":"2021","unstructured":"Jin B, Wu X, Xu G, et al. Evolutions of the management of colorectal cancer liver metastasis: a bibliometric analysis. J Cancer. 2021;12(12):3660\u201370. https:\/\/doi.org\/10.7150\/jca.52842.","journal-title":"J Cancer"},{"key":"825_CR8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ijsu.2016.02.028","volume":"28","author":"AG Powell","year":"2016","unstructured":"Powell AG, Hughes DL, Wheat JR, Lewis WG. The 100 most influential manuscripts in gastric cancer: a bibliometric analysis. Int J Surg. 2016;28:83\u201390. https:\/\/doi.org\/10.1016\/j.ijsu.2016.02.028.","journal-title":"Int J Surg"},{"issue":"10","key":"825_CR9","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1007\/s00586-012-2303-2","volume":"21","author":"MR Murray","year":"2012","unstructured":"Murray MR, Wang T, Schroeder GD, Hsu WK. The 100 most cited spine articles. Eur Spine J. 2012;21(10):2059\u201369. https:\/\/doi.org\/10.1007\/s00586-012-2303-2.","journal-title":"Eur Spine J"},{"issue":"4","key":"825_CR10","doi-asserted-by":"publisher","first-page":"e35366","DOI":"10.1371\/journal.pone.0035366","volume":"7","author":"B Qin","year":"2012","unstructured":"Qin B, Liang Y, Yang Z, Zhong R. Scientific publications on primary biliary cirrhosis from 2000 through 2010: an 11-year survey of the literature. PLoS ONE. 2012;7(4):e35366. https:\/\/doi.org\/10.1371\/journal.pone.0035366.","journal-title":"PLoS ONE"},{"issue":"13","key":"825_CR11","doi-asserted-by":"publisher","first-page":"816","DOI":"10.21037\/atm-20-4235","volume":"8","author":"Y Yu","year":"2020","unstructured":"Yu Y, Li Y, Zhang Z, et al. A bibliometric analysis using VOSviewer of publications on COVID-19. Ann Transl Med. 2020;8(13):816. https:\/\/doi.org\/10.21037\/atm-20-4235.","journal-title":"Ann Transl Med"},{"issue":"2","key":"825_CR12","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","volume":"84","author":"NJ van Eck","year":"2010","unstructured":"van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84(2):523\u201338. https:\/\/doi.org\/10.1007\/s11192-009-0146-3.","journal-title":"Scientometrics"},{"issue":"1","key":"825_CR13","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/hep.22906","volume":"50","author":"KD Lindor","year":"2009","unstructured":"Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ. Primary biliary cirrhosis. Hepatology. 2009;50(1):291\u2013308. https:\/\/doi.org\/10.1002\/hep.22906.","journal-title":"Hepatology"},{"issue":"3","key":"825_CR14","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1053\/j.gastro.2008.11.035","volume":"136","author":"Y Moritoki","year":"2009","unstructured":"Moritoki Y, Zhang W, Tsuneyama K, et al. B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology. 2009;136(3):1037\u201347. https:\/\/doi.org\/10.1053\/j.gastro.2008.11.035.","journal-title":"Gastroenterology"},{"issue":"10","key":"825_CR15","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1136\/gut.24.10.940","volume":"24","author":"AN Hamlyn","year":"1983","unstructured":"Hamlyn AN, Macklon AF, James O. Primary biliary cirrhosis: geographical clustering and symptomatic onset seasonality. Gut. 1983;24(10):940\u20135. https:\/\/doi.org\/10.1136\/gut.24.10.940.","journal-title":"Gut"},{"issue":"4","key":"825_CR16","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1177\/0300060519835974","volume":"47","author":"JW Hwang","year":"2019","unstructured":"Hwang JW, Kim H, Lee DJ. The 100 most influential manuscripts on hepatocellular carcinoma: a bibliometric analysis. J Int Med Res. 2019;47(4):1467\u201382. https:\/\/doi.org\/10.1177\/0300060519835974.","journal-title":"J Int Med Res"},{"issue":"7","key":"825_CR17","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1056\/NEJMoa1509840","volume":"375","author":"F Nevens","year":"2016","unstructured":"Nevens F, Andreone P, Mazzella G, et al. A placebo-controlled trial of obeticholic acid in primary biliary cholangitis. N Engl J Med. 2016;375(7):631\u201343. https:\/\/doi.org\/10.1056\/NEJMoa1509840.","journal-title":"N Engl J Med"},{"issue":"23","key":"825_CR18","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1056\/NEJMoa1714519","volume":"378","author":"C Corpechot","year":"2018","unstructured":"Corpechot C, Chazouill\u00e8res O, Rousseau A, et al. A placebo-controlled trial of bezafibrate in primary biliary cholangitis. N Engl J Med. 2018;378(23):2171\u201381. https:\/\/doi.org\/10.1056\/NEJMoa1714519.","journal-title":"N Engl J Med"},{"issue":"8","key":"825_CR19","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.ajem.2015.04.047","volume":"33","author":"W Shuaib","year":"2015","unstructured":"Shuaib W, Acevedo JN, Khan MS, Santiago LJ, Gaeta TJ. The top 100 cited articles published in emergency medicine journals. Am J Emerg Med. 2015;33(8):1066\u201371. https:\/\/doi.org\/10.1016\/j.ajem.2015.04.047.","journal-title":"Am J Emerg Med"},{"issue":"37","key":"825_CR20","doi-asserted-by":"publisher","first-page":"e7338","DOI":"10.1097\/md.0000000000007338","volume":"96","author":"J Tian","year":"2017","unstructured":"Tian J, Li M, Lian F, Tong X. The hundred most-cited publications in microbiota of diabetes research: a bibliometric analysis. Medicine (Baltimore). 2017;96(37):e7338. https:\/\/doi.org\/10.1097\/md.0000000000007338.","journal-title":"Medicine (Baltimore)"},{"issue":"10266","key":"825_CR21","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1016\/s0140-6736(20)31607-x","volume":"396","author":"A Lleo","year":"2020","unstructured":"Lleo A, Wang GQ, Gershwin ME, Hirschfield GM. Primary biliary cholangitis. Lancet. 2020;396(10266):1915\u201326. https:\/\/doi.org\/10.1016\/s0140-6736(20)31607-x.","journal-title":"Lancet"},{"key":"825_CR22","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1172\/jci4213","volume":"102","author":"S Shimoda","year":"1998","unstructured":"Shimoda S, van de Water J, Ansari A, et al. Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis. J Clin Investig. 1998;102:1831\u201340. https:\/\/doi.org\/10.1172\/jci4213.","journal-title":"J Clin Investig"},{"key":"825_CR23","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/978-981-15-3449-2_10","volume":"1253","author":"Y Li","year":"2020","unstructured":"Li Y, Tang R, Ma X. Epigenetics of primary biliary cholangitis. Adv Exp Med Biol. 2020;1253:259\u201383. https:\/\/doi.org\/10.1007\/978-981-15-3449-2_10.","journal-title":"Adv Exp Med Biol"},{"issue":"23","key":"825_CR24","doi-asserted-by":"publisher","first-page":"5209","DOI":"10.1093\/hmg\/dds359","volume":"21","author":"BD Juran","year":"2012","unstructured":"Juran BD, Hirschfield GM, Invernizzi P, et al. Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants. Hum Mol Genet. 2012;21(23):5209\u201321. https:\/\/doi.org\/10.1093\/hmg\/dds359.","journal-title":"Hum Mol Genet"},{"issue":"1","key":"825_CR25","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jaut.2008.11.001","volume":"32","author":"RY Lan","year":"2009","unstructured":"Lan RY, Salunga TL, Tsuneyama K, et al. Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun. 2009;32(1):43\u201351. https:\/\/doi.org\/10.1016\/j.jaut.2008.11.001.","journal-title":"J Autoimmun"},{"issue":"5","key":"825_CR26","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1002\/hep.26979","volume":"59","author":"CY Yang","year":"2014","unstructured":"Yang CY, Ma X, Tsuneyama K, et al. IL-12\/Th1 and IL-23\/Th17 biliary microenvironment in primary biliary cirrhosis: implications for therapy. Hepatology. 2014;59(5):1944\u201353. https:\/\/doi.org\/10.1002\/hep.26979.","journal-title":"Hepatology"},{"key":"825_CR27","doi-asserted-by":"publisher","first-page":"14828","DOI":"10.1038\/ncomms14828","volume":"8","author":"F Qiu","year":"2017","unstructured":"Qiu F, Tang R, Zuo X, et al. A genome-wide association study identifies six novel risk loci for primary biliary cholangitis. Nat Commun. 2017;8:14828. https:\/\/doi.org\/10.1038\/ncomms14828.","journal-title":"Nat Commun"},{"issue":"8","key":"825_CR28","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/ng.631","volume":"42","author":"GM Hirschfield","year":"2015","unstructured":"Hirschfield GM, Liu X, Han Y, et al. Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. Nat Genet. 2015;42(8):655\u20137. https:\/\/doi.org\/10.1038\/ng.631.","journal-title":"Nat Genet"},{"issue":"1","key":"825_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/cmi.2009.104","volume":"7","author":"C Selmi","year":"2010","unstructured":"Selmi C, Meda F, Kasangian A, et al. Experimental evidence on the immunopathogenesis of primary biliary cirrhosis. Cell Mol Immunol. 2010;7(1):1\u201310. https:\/\/doi.org\/10.1038\/cmi.2009.104.","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"825_CR30","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1136\/gut.2009.184218","volume":"59","author":"MI Prince","year":"2010","unstructured":"Prince MI, Ducker SJ, James OF. Case-control studies of risk factors for primary biliary cirrhosis in two United Kingdom populations. Gut. 2010;59(4):508\u201312. https:\/\/doi.org\/10.1136\/gut.2009.184218.","journal-title":"Gut"},{"issue":"5","key":"825_CR31","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.jhep.2011.10.025","volume":"56","author":"K Boonstra","year":"2012","unstructured":"Boonstra K, Beuers U, Ponsioen CY. Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: a systematic review. J Hepatol. 2012;56(5):1181\u20138. https:\/\/doi.org\/10.1016\/j.jhep.2011.10.025.","journal-title":"J Hepatol"},{"issue":"6\u20137","key":"825_CR32","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.gcb.2010.04.014","volume":"34","author":"AL Mason","year":"2010","unstructured":"Mason AL, Zhang G. Linking human beta retrovirus infection with primary biliary cirrhosis. Gastroenterol Clin Biol. 2010;34(6\u20137):359\u201366. https:\/\/doi.org\/10.1016\/j.gcb.2010.04.014.","journal-title":"Gastroenterol Clin Biol"},{"issue":"5","key":"825_CR33","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1002\/hep.20907","volume":"42","author":"ME Gershwin","year":"2005","unstructured":"Gershwin ME, Selmi C, Worman HJ, et al. Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients. Hepatology. 2005;42(5):1194\u2013202. https:\/\/doi.org\/10.1002\/hep.20907.","journal-title":"Hepatology"},{"issue":"7390","key":"825_CR34","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/s0140-6736(65)91372-3","volume":"1","author":"JG Walker","year":"1965","unstructured":"Walker JG, Doniach D, Roitt IM, Sherlock S. Serological tests in diagnosis of primary biliary cirrhosis. Lancet. 1965;1(7390):827\u201331. https:\/\/doi.org\/10.1016\/s0140-6736(65)91372-3.","journal-title":"Lancet"},{"issue":"6","key":"825_CR35","first-page":"334","volume":"59","author":"CP Li","year":"1997","unstructured":"Li CP, Hwang SJ, Chan CY, et al. Clinical evaluation of primary biliary cirrhosis in Chinese patients without serum anti-mitochondrial antibody. Zhonghua Yi Xue Za Zhi (Taipei). 1997;59(6):334\u201340.","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"issue":"5","key":"825_CR36","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1002\/hep.510250507","volume":"25","author":"P Invernizzi","year":"1997","unstructured":"Invernizzi P, Crosignani A, Battezzati PM, et al. Comparison of the clinical features and clinical course of antimitochondrial antibody-positive and -negative primary biliary cirrhosis. Hepatology. 1997;25(5):1090\u20135. https:\/\/doi.org\/10.1002\/hep.510250507.","journal-title":"Hepatology"},{"issue":"1","key":"825_CR37","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/hep.1840120116","volume":"12","author":"H Witt-Sullivan","year":"1990","unstructured":"Witt-Sullivan H, Heathcote J, Cauch K, et al. The demography of primary biliary cirrhosis in Ontario, Canada. Hepatology. 1990;12(1):98\u2013105. https:\/\/doi.org\/10.1002\/hep.1840120116.","journal-title":"Hepatology"},{"key":"825_CR38","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8959103","author":"Q Zhang","year":"2019","unstructured":"Zhang Q, Liu Z, Wu S, et al. Meta-analysis of antinuclear antibodies in the diagnosis of antimitochondrial antibody-negative primary biliary cholangitis. Gastroenterol Res Pract. 2019. https:\/\/doi.org\/10.1155\/2019\/8959103.","journal-title":"Gastroenterol Res Pract"},{"issue":"11","key":"825_CR39","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/s1590-8658(03)00466-3","volume":"35","author":"DP Bogdanos","year":"2003","unstructured":"Bogdanos DP, Baum H, Butler P, et al. Association between the primary biliary cirrhosis specific anti-sp100 antibodies and recurrent urinary tract infection. Dig Liver Dis. 2003;35(11):801\u20135. https:\/\/doi.org\/10.1016\/s1590-8658(03)00466-3.","journal-title":"Dig Liver Dis"},{"issue":"29","key":"825_CR40","doi-asserted-by":"publisher","first-page":"3616","DOI":"10.3748\/wjg.v16.i29.3616","volume":"16","author":"CJ Hu","year":"2010","unstructured":"Hu CJ, Zhang FC, Li YZ, Zhang X. Primary biliary cirrhosis: what do autoantibodies tell us? World J Gastroenterol. 2010;16(29):3616\u201329. https:\/\/doi.org\/10.3748\/wjg.v16.i29.3616.","journal-title":"World J Gastroenterol"},{"issue":"6","key":"825_CR41","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1177\/2050640620919585","volume":"8","author":"A Laschtowitz","year":"2020","unstructured":"Laschtowitz A, de Veer RC, Van der Meer AJ, Schramm C. Diagnosis and treatment of primary biliary cholangitis. United Eur Gastroenterol J. 2020;8(6):667\u201374. https:\/\/doi.org\/10.1177\/2050640620919585.","journal-title":"United Eur Gastroenterol J"},{"issue":"33","key":"825_CR42","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.4254\/wjh.v8.i33.1419","volume":"8","author":"YQ Huang","year":"2016","unstructured":"Huang YQ. Recent advances in the diagnosis and treatment of primary biliary cholangitis. World J Hepatol. 2016;8(33):1419\u201341. https:\/\/doi.org\/10.4254\/wjh.v8.i33.1419.","journal-title":"World J Hepatol"},{"issue":"2","key":"825_CR43","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1111\/liv.12560","volume":"35","author":"C Quarneti","year":"2015","unstructured":"Quarneti C, Muratori P, Lalanne C, et al. Fatigue and pruritus at onset identify a more aggressive subset of primary biliary cirrhosis. Liver Int. 2015;35(2):636\u201341. https:\/\/doi.org\/10.1111\/liv.12560.","journal-title":"Liver Int"},{"issue":"2","key":"825_CR44","doi-asserted-by":"publisher","first-page":"S785","DOI":"10.1016\/S0168-8278(15)31349-0","volume":"62","author":"VS Hegade","year":"2015","unstructured":"Hegade VS, Mells GF, Lammert C, Juran B, Jones DE. P1152: a comparative study of pruritus in PBC cohorts from UK, USA and Italy. J Hepatol. 2015;62(2):S785\u2013S785.","journal-title":"J Hepatol"},{"issue":"6","key":"825_CR45","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1002\/hep.21609","volume":"45","author":"JL Newton","year":"2007","unstructured":"Newton JL, Hudson M, Tachtatzis P, et al. Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis. Hepatology. 2007;45(6):1496\u2013505. https:\/\/doi.org\/10.1002\/hep.21609.","journal-title":"Hepatology"},{"issue":"11","key":"825_CR46","first-page":"861","volume":"17","author":"EL Gu","year":"2009","unstructured":"Gu EL, Yao GB. The clinical characteristics of primary biliary cirrhosis in China: a systematic review. Zhonghua Gan Zang Bing Za Zhi. 2009;17(11):861\u20136.","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"2","key":"825_CR47","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1002\/hep.23683","volume":"52","author":"N Al-Harthy","year":"2010","unstructured":"Al-Harthy N, Kumagi T, Coltescu C, Hirschfield GM. The specificity of fatigue in primary biliary cirrhosis: evaluation of a large clinic practice. Hepatology. 2010;52(2):562\u201370. https:\/\/doi.org\/10.1002\/hep.23683.","journal-title":"Hepatology"},{"issue":"7","key":"825_CR48","doi-asserted-by":"publisher","first-page":"926","DOI":"10.4254\/wjh.v7.i7.926","volume":"7","author":"T Purohit","year":"2015","unstructured":"Purohit T, Cappell MS. Primary biliary cirrhosis: pathophysiology, clinical presentation and therapy. World J Hepatol. 2015;7(7):926\u201341. https:\/\/doi.org\/10.4254\/wjh.v7.i7.926.","journal-title":"World J Hepatol"},{"issue":"3","key":"825_CR49","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00281-009-0164-5","volume":"31","author":"S Hohenester","year":"2009","unstructured":"Hohenester S, Oude-Elferink RP, Beuers U. Primary biliary cirrhosis. Semin Immunopathol. 2009;31(3):283\u2013307. https:\/\/doi.org\/10.1007\/s00281-009-0164-5.","journal-title":"Semin Immunopathol"},{"issue":"3","key":"825_CR50","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1002\/hep.22428","volume":"48","author":"C Corpechot","year":"2008","unstructured":"Corpechot C, Abenavoli L, Rabahi N, et al. Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology. 2008;48(3):871\u20137. https:\/\/doi.org\/10.1002\/hep.22428.","journal-title":"Hepatology"},{"issue":"6","key":"825_CR51","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/ajg.2013.51","volume":"108","author":"RP Myers","year":"2013","unstructured":"Myers RP, Swain MG, Lee SS, Shaheen AA, Burak KW. B-cell depletion with rituximab in patients with primary biliary cirrhosis refractory to ursodeoxycholic acid. Am J Gastroenterol. 2013;108(6):933\u201341. https:\/\/doi.org\/10.1038\/ajg.2013.51.","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"825_CR52","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1002\/hep.23238","volume":"50","author":"Y Moritoki","year":"2009","unstructured":"Moritoki Y, Lian ZX, Lindor K, et al. B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice. Hepatology. 2009;50(6):1893\u2013903. https:\/\/doi.org\/10.1002\/hep.23238.","journal-title":"Hepatology"},{"issue":"7","key":"825_CR53","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1053\/j.gastro.2015.07.061","volume":"149","author":"WJ Lammers","year":"2015","unstructured":"Lammers WJ, Hirschfield GM, Corpechot C, et al. Development and validation of a scoring system to predict outcomes of patients with primary biliary cirrhosis receiving ursodeoxycholic acid therapy. Gastroenterology. 2015;149(7):1804-1812.e4. https:\/\/doi.org\/10.1053\/j.gastro.2015.07.061.","journal-title":"Gastroenterology"},{"issue":"3","key":"825_CR54","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1002\/hep.28017","volume":"63","author":"M Carbone","year":"2016","unstructured":"Carbone M, Sharp SJ, Flack S, et al. The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis. Hepatology (Baltimore, MD). 2016;63(3):930\u201350. https:\/\/doi.org\/10.1002\/hep.28017.","journal-title":"Hepatology (Baltimore, MD)"},{"issue":"4","key":"825_CR55","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1053\/j.gastro.2009.01.003","volume":"136","author":"EMM Kuiper","year":"2009","unstructured":"Kuiper EMM, Hansen BE, de Vries RA, et al. Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid. Gastroenterology. 2009;136(4):1281\u20137. https:\/\/doi.org\/10.1053\/j.gastro.2009.01.003.","journal-title":"Gastroenterology"},{"issue":"6","key":"825_CR56","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.jhep.2011.02.031","volume":"55","author":"C Corpechot","year":"2011","unstructured":"Corpechot C, Chazouill\u00e8res O, Poupon R. Early primary biliary cirrhosis: biochemical response to treatment and prediction of long-term outcome. J Hepatol. 2011;55(6):1361\u20137. https:\/\/doi.org\/10.1016\/j.jhep.2011.02.031.","journal-title":"J Hepatol"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-022-00825-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-022-00825-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-022-00825-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T11:39:18Z","timestamp":1685187558000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-022-00825-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,7]]},"references-count":56,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["825"],"URL":"https:\/\/doi.org\/10.1007\/s10238-022-00825-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-974714\/v1","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-974714\/v2","asserted-by":"object"}]},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,7]]},"assertion":[{"value":"28 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}