{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:12:49Z","timestamp":1794107569697,"version":"4.8.0"},"reference-count":126,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-022-00829-w","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T06:03:32Z","timestamp":1650953012000},"page":"645-654","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":152,"title":["Pathophysiology of deep vein thrombosis"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-1215","authenticated-orcid":false,"given":"Sim\u00f3n","family":"Navarrete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Solar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Palomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"issue":"3","key":"829_CR1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.acmx.2015.04.001","volume":"85","author":"C Jerjes-Sanchez","year":"2015","unstructured":"Jerjes-Sanchez C, Martinez-Sanchez C, Borrayo-Sanchez G, Carrillo-Calvillo J, Juarez-Herrera U, Quintanilla-Gutierrez J. Third national registry of acute coronary syndromes (RENASICA III). Archivos de Cardiologia de Mexico. 2015;85(3):207\u201314.","journal-title":"Archivos de Cardiologia de Mexico"},{"key":"829_CR2","doi-asserted-by":"crossref","first-page":"15006","DOI":"10.1038\/nrdp.2015.6","volume":"1","author":"AS Wolberg","year":"2015","unstructured":"Wolberg AS, Rosendaal FR, Weitz JI, et al. Venous thrombosis. Nat Rev Disease Primers. 2015;1:15006.","journal-title":"Nat Rev Disease Primers"},{"issue":"3","key":"829_CR3","first-page":"95","volume":"33","author":"KR Bruni-Fitzgerald","year":"2015","unstructured":"Bruni-Fitzgerald KR. Venous thromboembolism: an overview. J Vascular Nurs Official Publ Soc Peripheral Vascular Nurs. 2015;33(3):95\u20139.","journal-title":"J Vascular Nurs Official Publ Soc Peripheral Vascular Nurs"},{"issue":"525","key":"829_CR4","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1259\/0007-1285-44-525-653","volume":"44","author":"AN Nicolaides","year":"1971","unstructured":"Nicolaides AN, Kakkar VV, Field ES, Renney JT. The origin of deep vein thrombosis: a venographic study. Br J Radiol. 1971;44(525):653\u201363.","journal-title":"Br J Radiol"},{"issue":"Suppl 1","key":"829_CR5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1538-7836.2007.02515.x","volume":"5","author":"WC Aird","year":"2007","unstructured":"Aird WC. Vascular bed-specific thrombosis. J Thrombosis Haemostasis: JTH. 2007;5(Suppl 1):283\u201391.","journal-title":"J Thrombosis Haemostasis: JTH"},{"issue":"4","key":"829_CR6","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1542\/peds.2009-0768","volume":"124","author":"L Raffini","year":"2009","unstructured":"Raffini L, Huang YS, Witmer C, Feudtner C. Dramatic increase in venous thromboembolism in children\u2019s hospitals in the United States from 2001 to 2007. Pediatrics. 2009;124(4):1001\u20138.","journal-title":"Pediatrics"},{"key":"829_CR7","volume-title":"Venous Thromboembolism: Reducing the Risk of Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism) in Patients Admitted to Hospital","author":"N Centre-Acute","year":"2010","unstructured":"Centre-Acute N. Venous Thromboembolism: Reducing the Risk of Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism) in Patients Admitted to Hospital. London: Royal College of Physicians; 2010."},{"issue":"2","key":"829_CR8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/j.seminhematol.2007.02.004","volume":"44","author":"M Cushman","year":"2007","unstructured":"Cushman M. Epidemiology and risk factors for venous thrombosis. Semin Hematol. 2007;44(2):62\u20139.","journal-title":"Semin Hematol"},{"issue":"4","key":"829_CR9","first-page":"595","volume":"94","author":"P Lindqvist","year":"1999","unstructured":"Lindqvist P, Dahlback B, Marsal K. Thrombotic risk during pregnancy: a population study. Obstet Gynecol. 1999;94(4):595\u20139.","journal-title":"Obstet Gynecol"},{"key":"829_CR10","doi-asserted-by":"crossref","unstructured":"Jaffray J, Young G. Deep vein thrombosis in pediatric patients. Pediatric Blood Cancer. 2018; 65(3).","DOI":"10.1002\/pbc.26881"},{"issue":"11","key":"829_CR11","first-page":"785","volume":"38","author":"M Koupenova","year":"2017","unstructured":"Koupenova M, Kehrel BE, Corkrey HA, Freedman JE. Thrombosis and platelets: an update. Eur Heart J. 2017;38(11):785\u201391.","journal-title":"Eur Heart J"},{"issue":"6","key":"829_CR12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/archinte.158.6.585","volume":"158","author":"MD Silverstein","year":"1998","unstructured":"Silverstein MD, Heit JA, Mohr DN, Petterson TM, O\u2019Fallon WM, Melton LJ 3rd. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998;158(6):585\u201393.","journal-title":"Arch Intern Med"},{"issue":"23 Suppl 1","key":"829_CR13","first-page":"I9","volume":"107","author":"FA Anderson Jr","year":"2003","unstructured":"Anderson FA Jr, Spencer FA. Risk factors for venous thromboembolism. Circulation. 2003;107(23 Suppl 1):I9-16.","journal-title":"Circulation"},{"issue":"4","key":"829_CR14","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1538-7836.2008.02921.x","volume":"6","author":"ER Pomp","year":"2008","unstructured":"Pomp ER, Lenselink AM, Rosendaal FR, Doggen CJ. Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study. J Thrombosis Haemostasis JTH. 2008;6(4):632\u20137.","journal-title":"J Thrombosis Haemostasis JTH"},{"issue":"Suppl 1","key":"829_CR15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1538-7836.2009.03394.x","volume":"7","author":"FR Rosendaal","year":"2009","unstructured":"Rosendaal FR, Reitsma PH. Genetics of venous thrombosis. J Thrombosis Haemostasis: JTH. 2009;7(Suppl 1):301\u20134.","journal-title":"J Thrombosis Haemostasis: JTH"},{"issue":"1","key":"829_CR16","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1160\/TH08-08-0502","volume":"101","author":"ER Pomp","year":"2009","unstructured":"Pomp ER, Doggen CJ, Vos HL, Reitsma PH, Rosendaal FR. Polymorphisms in the protein C gene as risk factor for venous thrombosis. Thromb Haemost. 2009;101(1):62\u20137.","journal-title":"Thromb Haemost"},{"issue":"19","key":"829_CR17","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1182\/blood.2019000435","volume":"134","author":"S Lindstrom","year":"2019","unstructured":"Lindstrom S, Wang L, Smith EN, et al. Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism. Blood. 2019;134(19):1645\u201357.","journal-title":"Blood"},{"key":"829_CR18","unstructured":"Kushner A, West DW, Pillarisetty LS. Virchow Triad. StatPearls. Treasure Island (FL) 2020."},{"key":"829_CR19","doi-asserted-by":"crossref","unstructured":"Panova-Noeva M, Wagner B, Nagler M, et al. Comprehensive platelet phenotyping supports the role of platelets in the pathogenesis of acute venous thromboembolism\u2014results from clinical observation studies. EBioMedicine. 2020;60:102978.","DOI":"10.1016\/j.ebiom.2020.102978"},{"issue":"7","key":"829_CR20","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1172\/JCI60229","volume":"122","author":"N Mackman","year":"2012","unstructured":"Mackman N. New insights into the mechanisms of venous thrombosis. J Clin Investig. 2012;122(7):2331\u20136.","journal-title":"J Clin Investig"},{"issue":"4","key":"829_CR21","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1182\/blood-2010-05-287623","volume":"117","author":"A Brill","year":"2011","unstructured":"Brill A, Fuchs TA, Chauhan AK, et al. von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models. Blood. 2011;117(4):1400\u20137.","journal-title":"Blood"},{"issue":"4","key":"829_CR22","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","volume":"209","author":"ML von Bruhl","year":"2012","unstructured":"von Bruhl ML, Stark K, Steinhart A, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012;209(4):819\u201335.","journal-title":"J Exp Med"},{"key":"829_CR23","doi-asserted-by":"crossref","unstructured":"Pinsky DJ, Naka Y, Liao H, et al. Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. J Clin Investig. 1996;97(2):493\u2013500.","DOI":"10.1172\/JCI118440"},{"issue":"3","key":"829_CR24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3324\/haematol.2014.114728","volume":"100","author":"EM Sparkenbaugh","year":"2015","unstructured":"Sparkenbaugh EM, Chantrathammachart P, Wang S, et al. Excess of heme induces tissue factor-dependent activation of coagulation in mice. Haematologica. 2015;100(3):308\u201314.","journal-title":"Haematologica"},{"issue":"5","key":"829_CR25","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJMra055289","volume":"355","author":"JJ Bergan","year":"2006","unstructured":"Bergan JJ, Schmid-Schonbein GW, Smith PD, Nicolaides AN, Boisseau MR, Eklof B. Chronic venous disease. N Engl J Med. 2006;355(5):488\u201398.","journal-title":"N Engl J Med"},{"issue":"1","key":"829_CR26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1152\/physrev.00047.2009","volume":"91","author":"JJ Chiu","year":"2011","unstructured":"Chiu JJ, Chien S. Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev. 2011;91(1):327\u201387.","journal-title":"Physiol Rev"},{"issue":"5","key":"829_CR27","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0741-5214(03)00711-0","volume":"38","author":"F Lurie","year":"2003","unstructured":"Lurie F, Kistner RL, Eklof B, Kessler D. Mechanism of venous valve closure and role of the valve in circulation: a new concept. J Vasc Surg. 2003;38(5):955\u201361.","journal-title":"J Vasc Surg"},{"issue":"5","key":"829_CR28","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.ATV.18.5.677","volume":"18","author":"O Traub","year":"1998","unstructured":"Traub O, Berk BC. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol. 1998;18(5):677\u201385.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"829_CR29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1254\/jphs.91.172","volume":"91","author":"M Yoshizumi","year":"2003","unstructured":"Yoshizumi M, Abe J, Tsuchiya K, Berk BC, Tamaki T. Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases. J Pharmacol Sci. 2003;91(3):172\u20136.","journal-title":"J Pharmacol Sci"},{"issue":"5","key":"829_CR30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1161\/01.RES.82.5.532","volume":"82","author":"DC Chappell","year":"1998","unstructured":"Chappell DC, Varner SE, Nerem RM, Medford RM, Alexander RW. Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium. Circ Res. 1998;82(5):532\u20139.","journal-title":"Circ Res"},{"key":"829_CR31","doi-asserted-by":"crossref","unstructured":"Methe H, Balcells M, Alegret MdelC, et al. Vascular bed origin dictates flow pattern regulation of endothelial adhesion molecule expression. Am J Physiol Heart Circulatory Physiol. 2007;292(5):H2167\u201375.","DOI":"10.1152\/ajpheart.00403.2006"},{"issue":"1","key":"829_CR32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0741-5214(98)70303-9","volume":"27","author":"T Ono","year":"1998","unstructured":"Ono T, Bergan JJ, Schmid-Schonbein GW, Takase S. Monocyte infiltration into venous valves. J Vasc Surg. 1998;27(1):158\u201366.","journal-title":"J Vasc Surg"},{"issue":"5","key":"829_CR33","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ejvs.2004.05.012","volume":"28","author":"S Takase","year":"2004","unstructured":"Takase S, Pascarella L, Lerond L, Bergan JJ, Schmid-Schonbein GW. Venous hypertension, inflammation and valve remodeling. Eur J Vascular Endovascular Surg Official J Eur Soc Vascular Surg. 2004;28(5):484\u201393.","journal-title":"Eur J Vascular Endovascular Surg Official J Eur Soc Vascular Surg"},{"issue":"Suppl 1","key":"829_CR34","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1177\/00033197050560i104","volume":"56","author":"JJ Bergan","year":"2005","unstructured":"Bergan JJ. Chronic venous insufficiency and the therapeutic effects of Daflon 500 mg. Angiology. 2005;56(Suppl 1):S21\u20134.","journal-title":"Angiology"},{"issue":"3","key":"829_CR35","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/bjs.1800680308","volume":"68","author":"JD Hamer","year":"1981","unstructured":"Hamer JD, Malone PC, Silver IA. The PO2 in venous valve pockets: its possible bearing on thrombogenesis. Br J Surg. 1981;68(3):166\u201370.","journal-title":"Br J Surg"},{"issue":"2","key":"829_CR36","doi-asserted-by":"crossref","first-page":"L159","DOI":"10.1152\/ajplung.00060.2005","volume":"289","author":"MS Wolin","year":"2005","unstructured":"Wolin MS, Ahmad M, Gupte SA. Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH. Am J Physiol Lung Cell Mol Physiol. 2005;289(2):L159\u201373.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"829_CR37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/978-1-60761-500-2_22","volume":"661","author":"NS Chandel","year":"2010","unstructured":"Chandel NS. Mitochondrial regulation of oxygen sensing. Adv Exp Med Biol. 2010;661:339\u201354.","journal-title":"Adv Exp Med Biol"},{"issue":"21","key":"829_CR38","doi-asserted-by":"crossref","first-page":"15030","DOI":"10.1074\/jbc.274.21.15030","volume":"274","author":"SF Yan","year":"1999","unstructured":"Yan SF, Lu J, Zou YS, et al. Hypoxia-associated induction of early growth response-1 gene expression. J Biol Chem. 1999;274(21):15030\u201340.","journal-title":"J Biol Chem"},{"issue":"2","key":"829_CR39","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/01.RES.0000200177.53882.c3","volume":"98","author":"LM Khachigian","year":"2006","unstructured":"Khachigian LM. Early growth response-1 in cardiovascular pathobiology. Circ Res. 2006;98(2):186\u201391.","journal-title":"Circ Res"},{"key":"829_CR40","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1146\/annurev-physiol-012110-142305","volume":"73","author":"EG Bovill","year":"2011","unstructured":"Bovill EG, van der Vliet A. Venous valvular stasis-associated hypoxia and thrombosis: What is the link? Annu Rev Physiol. 2011;73:527\u201345.","journal-title":"Annu Rev Physiol"},{"issue":"9","key":"829_CR41","first-page":"5820","volume":"14","author":"U Schindler","year":"1994","unstructured":"Schindler U, Baichwal VR. Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression. Mol Cell Biol. 1994;14(9):5820\u201331.","journal-title":"Mol Cell Biol"},{"issue":"12","key":"829_CR42","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/82168","volume":"6","author":"SF Yan","year":"2000","unstructured":"Yan SF, Fujita T, Lu J, et al. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med. 2000;6(12):1355\u201361.","journal-title":"Nat Med"},{"issue":"12","key":"829_CR43","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1134\/S000629791612018X","volume":"81","author":"MA Chelombitko","year":"2016","unstructured":"Chelombitko MA, Fedorov AV, Ilyinskaya OP, Zinovkin RA, Chernyak BV. Role of Reactive Oxygen Species in Mast Cell Degranulation. Biochemistry Biokhimiia. 2016;81(12):1564\u201377.","journal-title":"Biochemistry Biokhimiia"},{"issue":"8","key":"829_CR44","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1161\/CIRCRESAHA.117.311185","volume":"121","author":"T Ponomaryov","year":"2017","unstructured":"Ponomaryov T, Payne H, Fabritz L, Wagner DD, Brill A. Mast cells granular contents are crucial for deep vein thrombosis in mice. Circ Res. 2017;121(8):941\u201350.","journal-title":"Circ Res"},{"issue":"2","key":"829_CR45","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/cimm.1996.0205","volume":"171","author":"I Miki","year":"1996","unstructured":"Miki I, Kusano A, Ohta S, et al. Histamine enhanced the TNF-alpha-induced expression of E-selectin and ICAM-1 on vascular endothelial cells. Cell Immunol. 1996;171(2):285\u20138.","journal-title":"Cell Immunol"},{"issue":"Pt 1","key":"829_CR46","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1113\/jphysiol.2007.132993","volume":"583","author":"M Erent","year":"2007","unstructured":"Erent M, Meli A, Moisoi N, et al. Rate, extent and concentration dependence of histamine-evoked Weibel-Palade body exocytosis determined from individual fusion events in human endothelial cells. J Physiol. 2007;583(Pt 1):195\u2013212.","journal-title":"J Physiol"},{"issue":"3","key":"829_CR47","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/CIRCULATIONAHA.105.553735","volume":"112","author":"J Steffel","year":"2005","unstructured":"Steffel J, Akhmedov A, Greutert H, Luscher TF, Tanner FC. Histamine induces tissue factor expression: implications for acute coronary syndromes. Circulation. 2005;112(3):341\u20139.","journal-title":"Circulation"},{"issue":"5","key":"829_CR48","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1055\/s-2000-13202","volume":"26","author":"PL Gross","year":"2000","unstructured":"Gross PL, Aird WC. The endothelium and thrombosis. Semin Thromb Hemost. 2000;26(5):463\u201378.","journal-title":"Semin Thromb Hemost"},{"issue":"2","key":"829_CR49","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1055\/s-0038-1675614","volume":"39","author":"ML Bochenek","year":"2019","unstructured":"Bochenek ML, Schafer K. Role of endothelial cells in acute and chronic thrombosis. Hamostaseologie. 2019;39(2):128\u201339.","journal-title":"Hamostaseologie"},{"issue":"10","key":"829_CR50","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.7150\/ijbs.7502","volume":"9","author":"P Rajendran","year":"2013","unstructured":"Rajendran P, Rengarajan T, Thangavel J, et al. The vascular endothelium and human diseases. Int J Biol Sci. 2013;9(10):1057\u201369.","journal-title":"Int J Biol Sci"},{"issue":"7","key":"829_CR51","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1177\/0003319717732238","volume":"69","author":"P Poredos","year":"2018","unstructured":"Poredos P, Jezovnik MK. Endothelial dysfunction and venous thrombosis. Angiology. 2018;69(7):564\u20137.","journal-title":"Angiology"},{"issue":"4","key":"829_CR52","doi-asserted-by":"crossref","first-page":"e138","DOI":"10.1016\/j.thromres.2009.10.022","volume":"125","author":"E Ramacciotti","year":"2010","unstructured":"Ramacciotti E, Myers DD Jr, Wrobleski SK, et al. P-selectin\/ PSGL-1 inhibitors versus enoxaparin in the resolution of venous thrombosis: a meta-analysis. Thromb Res. 2010;125(4):e138\u201342.","journal-title":"Thromb Res"},{"issue":"2","key":"829_CR53","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/1076029616670259","volume":"23","author":"MK Jezovnik","year":"2017","unstructured":"Jezovnik MK, Fareed J, Poredos P. Patients With a History of Idiopathic Deep Venous Thrombosis Have Long-Term Increased Levels of Inflammatory Markers and Markers of Endothelial Damage. Clin Appl Thrombosis\/Hemostasis Official J Int Acad Clin Appl Thrombosis\/Hemostasis. 2017;23(2):124\u201331.","journal-title":"Clin Appl Thrombosis\/Hemostasis Official J Int Acad Clin Appl Thrombosis\/Hemostasis"},{"issue":"6","key":"829_CR54","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00380-010-0111-3","volume":"26","author":"P Poredos","year":"2011","unstructured":"Poredos P, Jezovnik MK. In patients with idiopathic venous thrombosis, interleukin-10 is decreased and related to endothelial dysfunction. Heart Vessels. 2011;26(6):596\u2013602.","journal-title":"Heart Vessels"},{"issue":"1 Suppl","key":"829_CR55","first-page":"7","volume":"30","author":"DD Myers Jr","year":"2015","unstructured":"Myers DD Jr. Pathophysiology of venous thrombosis. Phlebology. 2015;30(1 Suppl):7\u201313.","journal-title":"Phlebology"},{"key":"829_CR56","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.thromres.2016.09.019","volume":"147","author":"ML Bochenek","year":"2016","unstructured":"Bochenek ML, Schutz E, Schafer K. Endothelial cell senescence and thrombosis: ageing clots. Thromb Res. 2016;147:36\u201345.","journal-title":"Thromb Res"},{"issue":"1","key":"829_CR57","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1006\/excr.1995.1232","volume":"219","author":"P Comi","year":"1995","unstructured":"Comi P, Chiaramonte R, Maier JA. Senescence-dependent regulation of type 1 plasminogen activator inhibitor in human vascular endothelial cells. Exp Cell Res. 1995;219(1):304\u20138.","journal-title":"Exp Cell Res"},{"issue":"1\u20132","key":"829_CR58","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0047-6374(93)90036-Q","volume":"71","author":"I Sato","year":"1993","unstructured":"Sato I, Kaji K, Morita I, Nagao M, Murota S. Augmentation of endothelin-1, prostacyclin and thromboxane A2 secretion associated with in vitro ageing in cultured human umbilical vein endothelial cells. Mech Ageing Dev. 1993;71(1\u20132):73\u201384.","journal-title":"Mech Ageing Dev"},{"issue":"6","key":"829_CR59","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1271\/bbb.100909","volume":"75","author":"M Yanaka","year":"2011","unstructured":"Yanaka M, Honma T, Sato K, et al. Increased monocytic adhesion by senescence in human umbilical vein endothelial cells. Biosci Biotechnol Biochem. 2011;75(6):1098\u2013103.","journal-title":"Biosci Biotechnol Biochem"},{"issue":"4","key":"829_CR60","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00418-012-0913-8","volume":"137","author":"B Hemmeryckx","year":"2012","unstructured":"Hemmeryckx B, Emmerechts J, Bovill EG, Hoylaerts MF, Lijnen HR. Effect of ageing on the murine venous circulation. Histochem Cell Biol. 2012;137(4):537\u201346.","journal-title":"Histochem Cell Biol"},{"issue":"8","key":"829_CR61","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.it.2018.04.010","volume":"39","author":"I Budnik","year":"2018","unstructured":"Budnik I, Brill A. Immune factors in deep vein thrombosis initiation. Trends Immunol. 2018;39(8):610\u201323.","journal-title":"Trends Immunol"},{"key":"829_CR62","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.vph.2015.07.007","volume":"83","author":"WD Li","year":"2016","unstructured":"Li WD, Li XQ. Endothelial progenitor cells accelerate the resolution of deep vein thrombosis. Vascul Pharmacol. 2016;83:10\u20136.","journal-title":"Vascul Pharmacol"},{"issue":"5","key":"829_CR63","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/MBC.0000000000000629","volume":"28","author":"B Dai","year":"2017","unstructured":"Dai B, Li L, Li Q, et al. Novel microspheres reduce the formation of deep venous thrombosis and repair the vascular wall in a rat model. Blood Coagulation Fibrinolysis Int J Haemostasis Thrombosis. 2017;28(5):398\u2013406.","journal-title":"Blood Coagulation Fibrinolysis Int J Haemostasis Thrombosis"},{"issue":"Suppl 4","key":"829_CR64","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0049-3848(09)70141-0","volume":"123","author":"TW Wakefield","year":"2009","unstructured":"Wakefield TW, Myers DD, Henke PK. Role of selectins and fibrinolysis in VTE. Thromb Res. 2009;123(Suppl 4):S35-40.","journal-title":"Thromb Res"},{"issue":"Suppl 1","key":"829_CR65","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/jth.12261","volume":"11","author":"C Schulz","year":"2013","unstructured":"Schulz C, Engelmann B, Massberg S. Crossroads of coagulation and innate immunity: the case of deep vein thrombosis. J Thrombosis Haemostasis: JTH. 2013;11(Suppl 1):233\u201341.","journal-title":"J Thrombosis Haemostasis: JTH"},{"key":"829_CR66","unstructured":"Palomo I, Pereira J, Palma J. HEMATOLOG\u00cdA. Fisiopatolog\u00eda y Diagn\u00f3stico. 1st ed. Talca: Editorial Universidad de Talca; 2005."},{"issue":"3","key":"829_CR67","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0035-1564835","volume":"42","author":"T Gremmel","year":"2016","unstructured":"Gremmel T, Frelinger AL 3rd, Michelson AD. Platelet Physiology. Semin Thromb Hemost. 2016;42(3):191\u2013204.","journal-title":"Semin Thromb Hemost"},{"issue":"5","key":"829_CR68","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/19336918.2016.1173803","volume":"10","author":"S Sorrentino","year":"2016","unstructured":"Sorrentino S, Studt JD, Horev MB, Medalia O, Sapra KT. Toward correlating structure and mechanics of platelets. Cell Adh Migr. 2016;10(5):568\u201375.","journal-title":"Cell Adh Migr"},{"issue":"Suppl 3","key":"829_CR69","doi-asserted-by":"crossref","first-page":"S276","DOI":"10.21037\/cdt.2017.09.01","volume":"7","author":"J Stone","year":"2017","unstructured":"Stone J, Hangge P, Albadawi H, et al. Deep vein thrombosis: pathogenesis, diagnosis, and medical management. Cardiovascular Diagnosis Therapy. 2017;7(Suppl 3):S276\u201384.","journal-title":"Cardiovascular Diagnosis Therapy"},{"issue":"11","key":"829_CR70","first-page":"1391","volume":"24","author":"M Takahashi","year":"2009","unstructured":"Takahashi M, Yamashita A, Moriguchi-Goto S, et al. Critical role of von Willebrand factor and platelet interaction in venous thromboembolism. Histol Histopathol. 2009;24(11):1391\u20138.","journal-title":"Histol Histopathol"},{"key":"829_CR71","doi-asserted-by":"crossref","unstructured":"Kang C, Bonneau M, Brouland JP, Bal dit Sollier C, Drouet L. In vivo pig models of venous thrombosis mimicking human disease. Thrombosis and haemostasis. 2003;89(2):256\u201363.","DOI":"10.1055\/s-0037-1613440"},{"issue":"5","key":"829_CR72","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1161\/ATVBAHA.118.310731","volume":"38","author":"M Lehmann","year":"2018","unstructured":"Lehmann M, Schoeman RM, Krohl PJ, et al. Platelets Drive Thrombus Propagation in a Hematocrit and Glycoprotein VI-Dependent Manner in an In Vitro Venous Thrombosis Model. Arterioscler Thromb Vasc Biol. 2018;38(5):1052\u201362.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"19","key":"829_CR73","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1182\/blood-2018-06-853762","volume":"133","author":"M Heestermans","year":"2019","unstructured":"Heestermans M, Salloum-Asfar S, Streef T, et al. Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils. Blood. 2019;133(19):2090\u20139.","journal-title":"Blood"},{"issue":"14","key":"829_CR74","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1182\/blood-2016-09-742999","volume":"129","author":"H Payne","year":"2017","unstructured":"Payne H, Ponomaryov T, Watson SP, Brill A. Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis. Blood. 2017;129(14):2013\u201320.","journal-title":"Blood"},{"issue":"13","key":"829_CR75","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1182\/blood-2016-06-720714","volume":"129","author":"J Riedl","year":"2017","unstructured":"Riedl J, Preusser M, Nazari PM, et al. Podoplanin expression in primary brain tumors induces platelet aggregation and increases risk of venous thromboembolism. Blood. 2017;129(13):1831\u20139.","journal-title":"Blood"},{"key":"829_CR76","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.intimp.2018.02.006","volume":"57","author":"P Ding","year":"2018","unstructured":"Ding P, Zhang S, Yu M, et al. IL-17A promotes the formation of deep vein thrombosis in a mouse model. Int Immunopharmacol. 2018;57:132\u20138.","journal-title":"Int Immunopharmacol"},{"issue":"16","key":"829_CR77","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1182\/blood-2016-11-749879","volume":"129","author":"S Subramaniam","year":"2017","unstructured":"Subramaniam S, Jurk K, Hobohm L, et al. Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. Blood. 2017;129(16):2291\u2013302.","journal-title":"Blood"},{"issue":"6","key":"829_CR78","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.V64.6.1200.1200","volume":"64","author":"RC Reimers","year":"1984","unstructured":"Reimers RC, Sutera SP, Joist JH. Potentiation by red blood cells of shear-induced platelet aggregation: relative importance of chemical and physical mechanisms. Blood. 1984;64(6):1200\u20136.","journal-title":"Blood"},{"issue":"10","key":"829_CR79","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1182\/blood-2002-03-0712","volume":"100","author":"MS Goel","year":"2002","unstructured":"Goel MS, Diamond SL. Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma. Blood. 2002;100(10):3797\u2013803.","journal-title":"Blood"},{"issue":"6","key":"829_CR80","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.cell.2009.11.001","volume":"139","author":"F Muller","year":"2009","unstructured":"Muller F, Mutch NJ, Schenk WA, et al. Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell. 2009;139(6):1143\u201356.","journal-title":"Cell"},{"issue":"3","key":"829_CR81","first-page":"1110","volume":"118","author":"C Reinhardt","year":"2008","unstructured":"Reinhardt C, von Bruhl ML, Manukyan D, et al. Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation. J Clin Investig. 2008;118(3):1110\u201322.","journal-title":"J Clin Investig"},{"issue":"1","key":"829_CR82","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","volume":"13","author":"B Engelmann","year":"2013","unstructured":"Engelmann B, Massberg S. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol. 2013;13(1):34\u201345.","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"829_CR83","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1182\/bloodadvances.2018026294","volume":"3","author":"H Setiadi","year":"2019","unstructured":"Setiadi H, Yago T, Liu Z, McEver RP. Endothelial signaling by neutrophil-released oncostatin M enhances P-selectin-dependent inflammation and thrombosis. Blood Adv. 2019;3(2):168\u201383.","journal-title":"Blood Adv"},{"issue":"5663","key":"829_CR84","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303(5663):1532\u20135.","journal-title":"Science"},{"issue":"11","key":"829_CR85","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.it.2009.07.011","volume":"30","author":"V Papayannopoulos","year":"2009","unstructured":"Papayannopoulos V, Zychlinsky A. NETs: a new strategy for using old weapons. Trends Immunol. 2009;30(11):513\u201321.","journal-title":"Trends Immunol"},{"key":"829_CR86","doi-asserted-by":"crossref","first-page":"15559","DOI":"10.1038\/ncomms15559","volume":"8","author":"Y Wang","year":"2017","unstructured":"Wang Y, Gao H, Shi C, et al. Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbalpha. Nat Commun. 2017;8:15559.","journal-title":"Nat Commun"},{"issue":"1","key":"829_CR87","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/s41598-018-20479-x","volume":"8","author":"MR Dyer","year":"2018","unstructured":"Dyer MR, Chen Q, Haldeman S, et al. Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA. Sci Rep. 2018;8(1):2068.","journal-title":"Sci Rep"},{"issue":"36","key":"829_CR88","doi-asserted-by":"crossref","first-page":"15880","DOI":"10.1073\/pnas.1005743107","volume":"107","author":"TA Fuchs","year":"2010","unstructured":"Fuchs TA, Brill A, Duerschmied D, et al. Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci USA. 2010;107(36):15880\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"18","key":"829_CR89","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1182\/blood-2013-10-463646","volume":"123","author":"K Martinod","year":"2014","unstructured":"Martinod K, Wagner DD. Thrombosis: tangled up in NETs. Blood. 2014;123(18):2768\u201376.","journal-title":"Blood"},{"issue":"1","key":"829_CR90","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1538-7836.2011.04544.x","volume":"10","author":"A Brill","year":"2012","unstructured":"Brill A, Fuchs TA, Savchenko AS, et al. Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thrombosis Haemostasis: JTH. 2012;10(1):136\u201344.","journal-title":"J Thrombosis Haemostasis: JTH"},{"issue":"7","key":"829_CR91","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1182\/blood-2011-03-343061","volume":"118","author":"F Semeraro","year":"2011","unstructured":"Semeraro F, Ammollo CT, Morrissey JH, et al. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood. 2011;118(7):1952\u201361.","journal-title":"Blood"},{"issue":"8","key":"829_CR92","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.2184","volume":"16","author":"S Massberg","year":"2010","unstructured":"Massberg S, Grahl L, von Bruehl ML, et al. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med. 2010;16(8):887\u201396.","journal-title":"Nat Med"},{"issue":"4","key":"829_CR93","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1160\/TH08-09-0620","volume":"101","author":"E Ramacciotti","year":"2009","unstructured":"Ramacciotti E, Hawley AE, Farris DM, et al. Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis. Thromb Haemost. 2009;101(4):748\u201354.","journal-title":"Thromb Haemost"},{"issue":"2","key":"829_CR94","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3324\/haematol.2016.142471","volume":"102","author":"S Pfeiler","year":"2017","unstructured":"Pfeiler S, Stark K, Massberg S, Engelmann B. Propagation of thrombosis by neutrophils and extracellular nucleosome networks. Haematologica. 2017;102(2):206\u201313.","journal-title":"Haematologica"},{"issue":"Suppl 2","key":"829_CR95","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/S0049-3848(16)30363-2","volume":"141","author":"JI Weitz","year":"2016","unstructured":"Weitz JI. Factor XI and factor XII as targets for new anticoagulants. Thromb Res. 2016;141(Suppl 2):S40\u20135.","journal-title":"Thromb Res"},{"issue":"2","key":"829_CR96","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1160\/TH10-05-0307","volume":"105","author":"O Salomon","year":"2011","unstructured":"Salomon O, Steinberg DM, Zucker M, Varon D, Zivelin A, Seligsohn U. Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis. Thromb Haemost. 2011;105(2):269\u201373.","journal-title":"Thromb Haemost"},{"issue":"3","key":"829_CR97","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1056\/NEJMoa1405760","volume":"372","author":"HR Buller","year":"2015","unstructured":"Buller HR, Bethune C, Bhanot S, et al. Factor XI antisense oligonucleotide for prevention of venous thrombosis. N Engl J Med. 2015;372(3):232\u201340.","journal-title":"N Engl J Med"},{"issue":"7","key":"829_CR98","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1056\/NEJMoa2105872","volume":"385","author":"P Verhamme","year":"2021","unstructured":"Verhamme P, Yi BA, Segers A, et al. Abelacimab for Prevention of Venous Thromboembolism. N Engl J Med. 2021;385(7):609\u201317.","journal-title":"N Engl J Med"},{"key":"829_CR99","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.thromres.2017.10.009","volume":"159","author":"RO Kool","year":"2017","unstructured":"Kool RO, Kohler HP, Coutinho JM, et al. Coagulation factor XIII-A subunit and activation peptide levels in individuals with established symptomatic acute deep vein thrombosis. Thromb Res. 2017;159:96\u20139.","journal-title":"Thromb Res"},{"issue":"Suppl 1","key":"829_CR100","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1111\/jth.12918","volume":"13","author":"BL Walton","year":"2015","unstructured":"Walton BL, Byrnes JR, Wolberg AS. Fibrinogen, red blood cells, and factor XIII in venous thrombosis. J Thrombosis Haemostasis: JTH. 2015;13(Suppl 1):S208\u201315.","journal-title":"J Thrombosis Haemostasis: JTH"},{"issue":"Suppl 1","key":"829_CR101","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.thromres.2014.03.017","volume":"133","author":"MM Aleman","year":"2014","unstructured":"Aleman MM, Walton BL, Byrnes JR, Wolberg AS. Fibrinogen and red blood cells in venous thrombosis. Thromb Res. 2014;133(Suppl 1):S38-40.","journal-title":"Thromb Res"},{"issue":"10","key":"829_CR102","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1111\/jth.13416","volume":"14","author":"MF Whelihan","year":"2016","unstructured":"Whelihan MF, Lim MY, Mooberry MJ, et al. Thrombin generation and cell-dependent hypercoagulability in sickle cell disease. J Thrombosis Haemostasis: JTH. 2016;14(10):1941\u201352.","journal-title":"J Thrombosis Haemostasis: JTH"},{"issue":"1","key":"829_CR103","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.intimp.2015.07.044","volume":"28","author":"A Saghazadeh","year":"2015","unstructured":"Saghazadeh A, Hafizi S, Rezaei N. Inflammation in venous thromboembolism: Cause or consequence? Int Immunopharmacol. 2015;28(1):655\u201365.","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"829_CR104","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/jth.14339","volume":"17","author":"FR Bertin","year":"2019","unstructured":"Bertin FR, Rys RN, Mathieu C, Laurance S, Lemarie CA, Blostein MD. Natural killer cells induce neutrophil extracellular trap formation in venous thrombosis. J Thrombosis Haemostasis JTH. 2019;17(2):403\u201314.","journal-title":"J Thrombosis Haemostasis JTH"},{"issue":"7","key":"829_CR105","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1172\/JCI40782","volume":"121","author":"M Nosaka","year":"2011","unstructured":"Nosaka M, Ishida Y, Kimura A, et al. Absence of IFN-gamma accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice. J Clin Investig. 2011;121(7):2911\u201320.","journal-title":"J Clin Investig"},{"issue":"2","key":"829_CR106","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1161\/ATVBAHA.119.313137","volume":"40","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Zhang Z, Wei R, et al. IL (Interleukin)-6 Contributes to Deep Vein Thrombosis and Is Negatively Regulated by miR-338-5p. Arterioscler Thromb Vasc Biol. 2020;40(2):323\u201334.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"829_CR107","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.4238\/2015.March.27.26","volume":"14","author":"JW Mo","year":"2015","unstructured":"Mo JW, Zhang DF, Ji GL, Liu XZ, Fan B. Detection of targets and their mechanisms for early diagnosis of traumatic deep vein thrombosis. Genetics Moler Research GMR. 2015;14(1):2413\u201321.","journal-title":"Genetics Moler Research GMR"},{"issue":"18","key":"829_CR108","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1073\/pnas.1620458114","volume":"114","author":"N Gupta","year":"2017","unstructured":"Gupta N, Sahu A, Prabhakar A, et al. Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia. Proc Natl Acad Sci USA. 2017;114(18):4763\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"829_CR109","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1161\/ATVBAHA.118.311194","volume":"38","author":"M Nosaka","year":"2018","unstructured":"Nosaka M, Ishida Y, Kimura A, et al. Contribution of the TNF-alpha (Tumor Necrosis Factor-alpha)-TNF-Rp55 (Tumor Necrosis Factor Receptor p55) Axis in the Resolution of Venous Thrombus. Arterioscler Thromb Vasc Biol. 2018;38(11):2638\u201350.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"829_CR110","doi-asserted-by":"crossref","first-page":"13835","DOI":"10.4238\/2015.October.29.3","volume":"14","author":"JW Mo","year":"2015","unstructured":"Mo JW, Zhang DF, Ji GL, Liu XZ, Fan B. TGF-beta1 and Serpine 1 expression changes in traumatic deep vein thrombosis. Genetics Mole Res GMR. 2015;14(4):13835\u201342.","journal-title":"Genetics Mole Res GMR"},{"issue":"1","key":"829_CR111","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/jsre.2001.6122","volume":"99","author":"PK Henke","year":"2001","unstructured":"Henke PK, Wakefield TW, Kadell AM, et al. Interleukin-8 administration enhances venous thrombosis resolution in a rat model. J Surg Res. 2001;99(1):84\u201391.","journal-title":"J Surg Res"},{"issue":"13","key":"829_CR112","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1182\/blood-2018-05-850859","volume":"132","author":"T Yago","year":"2018","unstructured":"Yago T, Liu Z, Ahamed J, McEver RP. Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice. Blood. 2018;132(13):1426\u201337.","journal-title":"Blood"},{"issue":"7","key":"829_CR113","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1161\/ATVBAHA.116.308925","volume":"37","author":"S Laurance","year":"2017","unstructured":"Laurance S, Bertin FR, Ebrahimian T, et al. Gas6 Promotes Inflammatory (CCR2(hi)CX3CR1(lo)) Monocyte Recruitment in Venous Thrombosis. Arterioscler Thromb Vasc Biol. 2017;37(7):1315\u201322.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"829_CR114","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11239-014-1131-0","volume":"39","author":"J Qin","year":"2015","unstructured":"Qin J, Liang H, Shi D, et al. A panel of microRNAs as a new biomarkers for the detection of deep vein thrombosis. J Thromb Thrombolysis. 2015;39(2):215\u201321.","journal-title":"J Thromb Thrombolysis"},{"issue":"2","key":"829_CR115","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281\u201397.","journal-title":"Cell"},{"issue":"12","key":"829_CR116","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/sj.mt.6300311","volume":"15","author":"HS Soifer","year":"2007","unstructured":"Soifer HS, Rossi JJ, Saetrom P. MicroRNAs in disease and potential therapeutic applications. Mole Therapy J Am Soc Gene Therapy. 2007;15(12):2070\u20139.","journal-title":"Mole Therapy J Am Soc Gene Therapy"},{"issue":"12","key":"829_CR117","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/CIRCRESAHA.107.163147","volume":"101","author":"MV Latronico","year":"2007","unstructured":"Latronico MV, Catalucci D, Condorelli G. Emerging role of microRNAs in cardiovascular biology. Circ Res. 2007;101(12):1225\u201336.","journal-title":"Circ Res"},{"issue":"6","key":"829_CR118","first-page":"4617","volume":"18","author":"J Jin","year":"2019","unstructured":"Jin J, Wang C, Ouyang Y, Zhang D. Elevated miR-195-5p expression in deep vein thrombosis and mechanism of action in the regulation of vascular endothelial cell physiology. Exp Ther Med. 2019;18(6):4617\u201324.","journal-title":"Exp Ther Med"},{"key":"829_CR119","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12967-016-0775-2","volume":"14","author":"L Kong","year":"2016","unstructured":"Kong L, Hu N, Du X, et al. Upregulation of miR-483-3p contributes to endothelial progenitor cells dysfunction in deep vein thrombosis patients via SRF. J Transl Med. 2016;14:23.","journal-title":"J Transl Med"},{"key":"829_CR120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.yjmcc.2020.05.011","volume":"144","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Miao X, Zhang Z, et al. miR-374b-5p is increased in deep vein thrombosis and negatively targets IL-10. J Mol Cell Cardiol. 2020;144:97\u2013108.","journal-title":"J Mol Cell Cardiol"},{"key":"829_CR121","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.thromres.2015.12.020","volume":"138","author":"L Kong","year":"2016","unstructured":"Kong L, Du X, Hu N, et al. Downregulation of let-7e-5p contributes to endothelial progenitor cell dysfunction in deep vein thrombosis via targeting FASLG. Thromb Res. 2016;138:30\u20136.","journal-title":"Thromb Res"},{"issue":"5","key":"829_CR122","first-page":"5069","volume":"14","author":"Z Li","year":"2017","unstructured":"Li Z, Ni J. Role of microRNA-26a in the diagnosis of lower extremity deep vein thrombosis in patients with bone trauma. Exp Ther Med. 2017;14(5):5069\u201374.","journal-title":"Exp Ther Med"},{"issue":"3","key":"829_CR123","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/iub.2168","volume":"72","author":"S Sun","year":"2020","unstructured":"Sun S, Chai S, Zhang F, Lu L. Overexpressed microRNA-103a-3p inhibits acute lower-extremity deep venous thrombosis via inhibition of CXCL12. IUBMB Life. 2020;72(3):492\u2013504.","journal-title":"IUBMB Life"},{"key":"829_CR124","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.avsg.2019.10.048","volume":"64","author":"P Zhang","year":"2020","unstructured":"Zhang P, Zhao Q, Gong K, et al. Downregulation of miR-103a-3p contributes to endothelial progenitor cell dysfunction in deep vein thrombosis through PTEN targeting. Ann Vasc Surg. 2020;64:339\u201346.","journal-title":"Ann Vasc Surg"},{"key":"829_CR125","doi-asserted-by":"crossref","unstructured":"Morelli VM, Braekkan SK, Hansen JB. Role of microRNAs in Venous Thromboembolism. Int J Mole Sci. 2020;21(7).","DOI":"10.3390\/ijms21072602"},{"key":"829_CR126","doi-asserted-by":"crossref","unstructured":"Hembrom AA, Srivastava S, Garg I, Kumar B. MicroRNAs in venous thrombo-embolism. Clinica chimica acta; Int J Clin Chem. 2020;504:66\u201372.","DOI":"10.1016\/j.cca.2020.01.034"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-022-00829-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-022-00829-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-022-00829-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T10:06:20Z","timestamp":1687341980000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-022-00829-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":126,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["829"],"URL":"https:\/\/doi.org\/10.1007\/s10238-022-00829-w","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"assertion":[{"value":"3 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}