{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:14:41Z","timestamp":1790673281747,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"PRODEP- SEP Mexico","award":["(PTC-1433)"],"award-info":[{"award-number":["(PTC-1433)"]}]},{"name":"University of Guadalajara - Strengthening Research and Postgraduate 2018","award":["(244159)"],"award-info":[{"award-number":["(244159)"]}]},{"name":"The Universidad de Guadalajara through Fortalecimiento de la Investigaci\u00f3n y el Posgrado 2021","award":["(425)"],"award-info":[{"award-number":["(425)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-022-00841-0","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T14:02:21Z","timestamp":1653832941000},"page":"471-481","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Transforming growth factor beta isoforms and TGF-\u03b2R1 and TGF-\u03b2R2 expression in systemic sclerosis patients"],"prefix":"10.1007","volume":"23","author":[{"given":"Jos\u00e9 Alvaro","family":"Lomel\u00ed-Nieto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Francisco","family":"Mu\u00f1oz-Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Johana","family":"Ba\u00f1os-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Eduardo","family":"Navarro-Zarza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Marisol","family":"God\u00ednez-Rub\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Garc\u00eda-Arellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Guadalupe","family":"Ram\u00edrez-Due\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isela","family":"Parra-Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arisbeth","family":"Villanueva-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8004-1811","authenticated-orcid":false,"given":"Jorge","family":"Hern\u00e1ndez-Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"issue":"Suppl 106","key":"841_CR1","first-page":"3","volume":"35","author":"S Barsotti","year":"2017","unstructured":"Barsotti S, Bruni C, Orlandi M, Della Rossa A, Marasco E, Codullo V, et al. One year in review 2017: systemic sclerosis. Clin Exp Rheumatol. 2017;35(Suppl 106):3\u201320.","journal-title":"Clin Exp Rheumatol"},{"key":"841_CR2","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1007\/s10067-018-4182-3","volume":"37","author":"JG Royle","year":"2018","unstructured":"Royle JG, Lanyon PC, Grainge MJ, Abhishek A, Pearce FA. The incidence, prevalence, and survival of systemic sclerosis in the UK clinical practice research datalink. Clin Rheumatol. 2018;37:2103\u201311.","journal-title":"Clin Rheumatol"},{"key":"841_CR3","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1007\/s10067-019-04459-8","volume":"38","author":"CJ Ba\u00f1os-Hern\u00e1ndez","year":"2019","unstructured":"Ba\u00f1os-Hern\u00e1ndez CJ, Navarro-Zarza JE, Bucala R, Hern\u00e1ndez-Bello J, Parra-Rojas I, Ram\u00edrez-Due\u00f1as MG, et al. Macrophage migration inhibitory factor polymorphisms are a potential susceptibility marker in systemic sclerosis from southern Mexican population: association with MIF mRNA expression and cytokine profile. Clin Rheumatol. 2019;38:1643\u201354.","journal-title":"Clin Rheumatol"},{"key":"841_CR4","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/s10067-017-3936-7","volume":"37","author":"M Rubio-Rivas","year":"2018","unstructured":"Rubio-Rivas M, Corbella X, Pesta\u00f1a-Fern\u00e1ndez M, Tolosa-Vilella C, Guillen-Del Castillo A, Colunga-Arg\u00fcelles D, et al. First clinical symptom as a prognostic factor in systemic sclerosis: results of a retrospective nationwide cohort study. Clin Rheumatol. 2018;37:999\u20131009.","journal-title":"Clin Rheumatol"},{"key":"841_CR5","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s10238-019-00569-4","volume":"19","author":"JA Lomel\u00ed-Nieto","year":"2019","unstructured":"Lomel\u00ed-Nieto JA, Mu\u00f1oz-Valle JF, Ba\u00f1os-Hern\u00e1ndez CJ, Navarro-Zarza JE, Ram\u00edrez-Due\u00f1as MG, S\u00e1nchez-Hern\u00e1ndez PE, et al. TNFA -308G>A and -238G>A polymorphisms and risk to systemic sclerosis: impact on TNF-\u03b1 serum levels, TNFA mRNA expression, and autoantibodies. Clin Exp Med. 2019;19:439\u201347.","journal-title":"Clin Exp Med"},{"key":"841_CR6","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.3899\/jrheum.161369","volume":"44","author":"L Bossini-Castillo","year":"2017","unstructured":"Bossini-Castillo L, Campillo-Dav\u00f3 D, L\u00f3pez-Isac E, Carmona FD, Simeon CP, Carreira P, et al. An MIF promoter polymorphism is associated with susceptibility to pulmonary arterial hypertension in diffuse cutaneous systemic sclerosis. J Rheumatol. 2017;44:1453\u20137.","journal-title":"J Rheumatol"},{"key":"841_CR7","doi-asserted-by":"publisher","first-page":"6808061","DOI":"10.1155\/2019\/6808061","volume":"2019","author":"AC Machado-Sulbaran","year":"2019","unstructured":"Machado-Sulbaran AC, Ram\u00edrez-Due\u00f1as MG, Navarro-Zarza JE, Mu\u00f1oz-Valle JF, Mendoza-Carrera F, Ba\u00f1os-Hern\u00e1ndez CJ, et al. KIR\/HLA gene profile implication in systemic sclerosis patients from Mexico. J Immunol Res. 2019;2019:6808061.","journal-title":"J Immunol Res"},{"key":"841_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.587773","author":"C Yang","year":"2020","unstructured":"Yang C, Tang S, Zhu D, Ding Y, Qiao J. Classical disease-specific autoantibodies in systemic sclerosis: clinical features, gene susceptibility, and disease stratification. Front Med. 2020. https:\/\/doi.org\/10.3389\/fmed.2020.587773.","journal-title":"Front Med"},{"key":"841_CR9","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nrrheum.2011.149","volume":"8","author":"S Bhattacharyya","year":"2011","unstructured":"Bhattacharyya S, Wei J, Varga J. Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities. Nat Rev Rheumatol. 2011;8:42\u201354.","journal-title":"Nat Rev Rheumatol"},{"key":"841_CR10","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/path.2277","volume":"214","author":"TA Wynn","year":"2008","unstructured":"Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008;214:199\u2013210.","journal-title":"J Pathol"},{"key":"841_CR11","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1186\/s13075-015-0848-2","volume":"17","author":"D Hirigoyen","year":"2015","unstructured":"Hirigoyen D, Burgos PI, Mezzano V, Duran J, Barrientos M, Saez CG, et al. Inhibition of angiogenesis by platelets in systemic sclerosis patients. Arthritis Res Ther. 2015;17:332.","journal-title":"Arthritis Res Ther"},{"key":"841_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1346-8138.2009.00738.x","volume":"37","author":"M Jinnin","year":"2010","unstructured":"Jinnin M. Mechanisms of skin fibrosis in systemic sclerosis. J Dermatol. 2010;37:11\u201325.","journal-title":"J Dermatol"},{"key":"841_CR13","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/nrrheum.2014.137","volume":"10","author":"R Lafyatis","year":"2014","unstructured":"Lafyatis R. Transforming growth factor \u03b2\u2013at the centre of systemic sclerosis. Nat Rev Rheumatol. 2014;10:706\u201319.","journal-title":"Nat Rev Rheumatol"},{"key":"841_CR14","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/art.27220","volume":"62","author":"G Farina","year":"2010","unstructured":"Farina G, Lafyatis D, Lemaire R, Lafyatis R. A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum. 2010;62:580\u20138.","journal-title":"Arthritis Rheum"},{"key":"841_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.7555\/JBR.31.20170034","volume":"32","author":"NB Ayers","year":"2018","unstructured":"Ayers NB, Sun C-M, Chen S-Y. Transforming growth factor-\u03b2 signaling in systemic sclerosis. J Biomed Res. 2018;32:3\u201312.","journal-title":"J Biomed Res"},{"key":"841_CR16","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.cellsig.2018.09.002","volume":"52","author":"A Vander Ark","year":"2018","unstructured":"Vander Ark A, Cao J, Li X. TGF-\u03b2 receptors: In and beyond TGF-\u03b2 signaling. Cell Signal. 2018;52:112\u201320.","journal-title":"Cell Signal"},{"key":"841_CR17","first-page":"215","volume":"24","author":"MK Lichtman","year":"2016","unstructured":"Lichtman MK, Otero-Vinas M, Falanga V. Transforming growth factor beta (TGF-\u03b2) isoforms in wound healing and fibrosis. Wound Repair Regen Off Publ Wound Heal Soc Eur Tissue Repair Soc. 2016;24:215\u201322.","journal-title":"Wound Repair Regen Off Publ Wound Heal Soc Eur Tissue Repair Soc"},{"key":"841_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6064830","author":"AT Dantas","year":"2016","unstructured":"Dantas AT, Gon\u00e7alves SMC, de Almeida AR, Gon\u00e7alves RSG, Sampaio MCPD, de Vilar KM, et al. Reassessing the role of the active TGF-\u03b21 as a biomarker in systemic sclerosis: association of serum levels with clinical manifestations. Dis Markers. 2016. https:\/\/doi.org\/10.1155\/2016\/6064830.","journal-title":"Dis Markers"},{"key":"841_CR19","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1093\/rheumatology\/kei088","volume":"44","author":"M Dziadzio","year":"2005","unstructured":"Dziadzio M, Smith RE, Abraham DJ, Black CM, Denton CP. Circulating levels of active transforming growth factor beta1 are reduced in diffuse cutaneous systemic sclerosis and correlate inversely with the modified Rodnan skin score. Rheumatol Oxf Engl. 2005;44:1518\u201324.","journal-title":"Rheumatol Oxf Engl"},{"key":"841_CR20","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/5584_2019_341","volume":"1153","author":"D Majewski","year":"2019","unstructured":"Majewski D, Majewska KA, Kuznar-Kaminska B, Runowska M, Piorunek T, Batura-Gabryel H, et al. Systemic sclerosis and serum content of transforming growth factor. Adv Exp Med Biol. 2019;1153:63\u20137.","journal-title":"Adv Exp Med Biol"},{"key":"841_CR21","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/S0923-1811(01)00128-1","volume":"27","author":"S Sato","year":"2001","unstructured":"Sato S, Hasegawa M, Takehara K. Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis. J Dermatol Sci. 2001;27:140\u20136.","journal-title":"J Dermatol Sci"},{"key":"841_CR22","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/j.1365-2249.2004.02642.x","volume":"138","author":"E Scala","year":"2004","unstructured":"Scala E, Pallotta S, Frezzolini A, Abeni D, Barbieri C, Sampogna F, et al. Cytokine and chemokine levels in systemic sclerosis: relationship with cutaneous and internal organ involvement. Clin Exp Immunol. 2004;138:540\u20136.","journal-title":"Clin Exp Immunol"},{"key":"841_CR23","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/nrrheum.2009.26","volume":"5","author":"J Varga","year":"2009","unstructured":"Varga J, Pasche B. Transforming growth factor-\u00df as a therapeutic target in systemic sclerosis. Nat Rev Rheumatol. 2009;5:200\u20136.","journal-title":"Nat Rev Rheumatol"},{"key":"841_CR24","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/art.38098","volume":"65","author":"F van den Hoogen","year":"2013","unstructured":"van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative. Arthritis Rheum. 2013;65:2737\u201347.","journal-title":"Arthritis Rheum"},{"issue":"Suppl 5","key":"841_CR25","doi-asserted-by":"publisher","first-page":"v5","DOI":"10.1093\/rheumatology\/ken275","volume":"47","author":"R Sgonc","year":"2008","unstructured":"Sgonc R, Wick G. Pro- and anti-fibrotic effects of TGF-beta in scleroderma. Rheumatol Oxf Engl. 2008;47(Suppl 5):v5-7.","journal-title":"Rheumatol Oxf Engl"},{"key":"841_CR26","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","volume":"342","author":"GC Blobe","year":"2000","unstructured":"Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med. 2000;342:1350\u20138.","journal-title":"N Engl J Med"},{"key":"841_CR27","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/37284","volume":"390","author":"CH Heldin","year":"1997","unstructured":"Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature. 1997;390:465\u201371.","journal-title":"Nature"},{"key":"841_CR28","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5114\/pdia.2015.48044","volume":"33","author":"J Budzy\u0144ska-W\u0142odarczyk","year":"2016","unstructured":"Budzy\u0144ska-W\u0142odarczyk J, Michalska-Jakubus MM, Kowal M, Krasowska D. Evaluation of serum concentrations of the selected cytokines in patients with localized scleroderma. Postepy Dermatol Alergol. 2016;33:47\u201351.","journal-title":"Postepy Dermatol Alergol"},{"key":"841_CR29","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0923-1811(99)00008-0","volume":"21","author":"C Querfeld","year":"1999","unstructured":"Querfeld C, Eckes B, Huerkamp C, Krieg T, Sollberg S. Expression of TGF-beta 1, -beta 2 and -beta 3 in localized and systemic scleroderma. J Dermatol Sci. 1999;21:13\u201322.","journal-title":"J Dermatol Sci"},{"key":"841_CR30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1159\/000046507","volume":"104","author":"S-Y Yoon","year":"2000","unstructured":"Yoon S-Y, Tefferi A, Li C-Y. Cellular distribution of platelet-derived growth factor, transforming growth factor-\u03b2, basic fibroblast growth factor, and their receptors in normal bone marrow. Acta Haematol Karger Publishers. 2000;104:151\u20137.","journal-title":"Acta Haematol Karger Publishers"},{"key":"841_CR31","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1177\/154405910208101007","volume":"81","author":"K Kohama","year":"2002","unstructured":"Kohama K, Nonaka K, Hosokawa R, Shum L, Ohishi M. TGF-beta-3 promotes scarless repair of cleft lip in mouse fetuses. J Dent Res. 2002;81:688\u201394.","journal-title":"J Dent Res."},{"key":"841_CR32","doi-asserted-by":"publisher","first-page":"7155","DOI":"10.1016\/S0021-9258(18)32345-7","volume":"258","author":"RK Assoian","year":"1983","unstructured":"Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB. Transforming growth factor-beta in human platelets. Identification of a major storage site purification and characterization. J Biol Chem. 1983;258:7155\u201360.","journal-title":"J Biol Chem."},{"key":"841_CR33","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1182\/blood-2011-09-377648","volume":"119","author":"A Meyer","year":"2012","unstructured":"Meyer A, Wang W, Qu J, Croft L, Degen JL, Coller BS, et al. Platelet TGF-\u03b21 contributions to plasma TGF-\u03b21, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload. Blood. 2012;119:1064\u201374.","journal-title":"Blood"},{"key":"841_CR34","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/fimmu.2012.00160","volume":"3","author":"GA Ramirez","year":"2012","unstructured":"Ramirez GA, Franchini S, Rovere-Querini P, Sabbadini MG, Manfredi AA, Maugeri N. The role of platelets in the pathogenesis of systemic sclerosis. Front Immunol. 2012;3:160.","journal-title":"Front Immunol"},{"key":"841_CR35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11926-019-0815-z","volume":"21","author":"K Ntelis","year":"2019","unstructured":"Ntelis K, Bogdanos D, Dimitroulas T, Sakkas L, Daoussis D. Platelets in systemic sclerosis: The missing link connecting vasculopathy, autoimmunity, and fibrosis? Curr Rheumatol Rep. 2019;21:15.","journal-title":"Curr Rheumatol Rep"},{"issue":"145","key":"841_CR36","first-page":"2507","volume":"1990","author":"AW Taylor","year":"1950","unstructured":"Taylor AW, Ku NO, Mortensen RF. Regulation of cytokine-induced human C-reactive protein production by transforming growth factor-beta. J Immunol Baltim Md. 1950;1990(145):2507\u201313.","journal-title":"J Immunol Baltim Md"},{"key":"841_CR37","first-page":"125","volume":"12","author":"J Gao","year":"2020","unstructured":"Gao J. Changes and significance of serum C-reactive protein and transforming growth factor-\u03b2 1 levels in patients with primary Sj?gren\u2019s syndrome. Chin J Rheumatol. 2020;12:125\u20138.","journal-title":"Chin J Rheumatol"},{"key":"841_CR38","first-page":"953","volume":"55","author":"R Zhang","year":"2010","unstructured":"Zhang R, Zhang YY, Huang XR, Wu Y, Chung ACK, Wu EX, et al. C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II\u2013induced hypertensive cardiac disease. Hypertens Am Heart Assoc. 2010;55:953\u201360.","journal-title":"Hypertens Am Heart Assoc"},{"key":"841_CR39","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1111\/j.1582-4934.2008.00647.x","volume":"13","author":"DE Sullivan","year":"2009","unstructured":"Sullivan DE, Ferris M, Nguyen H, Abboud E, Brody AR. TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation. J Cell Mol Med. 2009;13:1866\u201376.","journal-title":"J Cell Mol Med"},{"key":"841_CR40","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1006\/bbrc.1994.2588","volume":"204","author":"TL Yue","year":"1994","unstructured":"Yue TL, Wang XK, Olson B, Feuerstein G. Interleukin-1 beta (IL-1 beta) induces transforming growth factor-beta, (TGF-beta 1) production by rat aortic smooth muscle cells. Biochem Biophys Res Commun. 1994;204:1186\u201392.","journal-title":"Biochem Biophys Res Commun"},{"key":"841_CR41","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190888","author":"W Sun","year":"2019","unstructured":"Sun W, Wu Y, Gao M, Tian Y, Qi P, Shen Y, et al. C-reactive protein promotes inflammation through TLR4\/NF-\u03baB\/TGF-\u03b2 pathway in HL-1 cells. 2019. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20190888."},{"key":"841_CR42","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1002\/acr.21968","volume":"65","author":"X Liu","year":"2013","unstructured":"Liu X, Mayes MD, Pedroza C, Draeger HT, Gonzalez EB, Harper BE, et al. Does C-reactive protein predict the long-term progression of interstitial lung disease and survival in patients with early systemic sclerosis? Arthritis Care Res. 2013;65:1375\u201380.","journal-title":"Arthritis Care Res"},{"key":"841_CR43","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1006\/clin.1993.1170","volume":"69","author":"PP Sfikakis","year":"1993","unstructured":"Sfikakis PP, McCune BK, Tsokos M, Aroni K, Vayiopoulos G, Tsokos GC. Immunohistological demonstration of transforming growth factor-beta isoforms in the skin of patients with systemic sclerosis. Clin Immunol Immunopathol. 1993;69:199\u2013204.","journal-title":"Clin Immunol Immunopathol"},{"key":"841_CR44","first-page":"2558","volume":"29","author":"M Kubo","year":"2002","unstructured":"Kubo M, Ihn H, Yamane K, Tamaki K. Upregulated expression of transforming growth factor-beta receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis. J Rheumatol. 2002;29:2558\u201364.","journal-title":"J Rheumatol"},{"key":"841_CR45","unstructured":"Cell atlas - TGFBR1 - The Human Protein Atlas [Internet]. [cited 2021 Aug 7]. Available from: https:\/\/www.proteinatlas.org\/ENSG00000106799-TGFBR1\/cell"},{"key":"841_CR46","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1083\/jcb.201411025","volume":"210","author":"I Yakymovych","year":"2015","unstructured":"Yakymovych I, Yakymovych M, Zang G, Mu Y, Bergh A, Landstr\u00f6m M, et al. CIN85 modulates TGF\u03b2 signaling by promoting the presentation of TGF\u03b2 receptors on the cell surface. J Cell Biol. 2015;210:319\u201332.","journal-title":"J Cell Biol"},{"key":"841_CR47","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/abbs\/gmx119","volume":"50","author":"I Yakymovych","year":"2018","unstructured":"Yakymovych I, Yakymovych M, Heldin C-H. Intracellular trafficking of transforming growth factor \u03b2 receptors. Acta Biochim Biophys Sin. 2018;50:3\u201311.","journal-title":"Acta Biochim Biophys Sin"},{"key":"841_CR48","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/ncomms1332","volume":"2","author":"Y Mu","year":"2011","unstructured":"Mu Y, Sundar R, Thakur N, Ekman M, Gudey SK, Yakymovych M, et al. TRAF6 ubiquitinates TGF\u03b2 type I receptor to promote its cleavage and nuclear translocation in cancer. Nat Commun. 2011;2:330.","journal-title":"Nat Commun"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-022-00841-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-022-00841-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-022-00841-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T16:08:56Z","timestamp":1685203736000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-022-00841-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,29]]},"references-count":48,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["841"],"URL":"https:\/\/doi.org\/10.1007\/s10238-022-00841-0","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,29]]},"assertion":[{"value":"22 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Local Bioethical Committee at the Hospital General de Chilpancingo \u2018\u2018Dr. Raymundo Abarca Alarc\u00f3n\u201d (CI\/317\/2016) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study. In this consent, the participants accepted to participate in the study and to publish their results.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}