{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:14:41Z","timestamp":1773198881359,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-022-00856-7","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T10:02:46Z","timestamp":1659434566000},"page":"787-801","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Immunophenotypic changes of monocytes in myelodysplastic syndrome and clinical significance"],"prefix":"10.1007","volume":"23","author":[{"given":"Lijuan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunjie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"issue":"14","key":"856_CR1","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1056\/NEJMra1904794","volume":"383","author":"M Cazzola","year":"2020","unstructured":"Cazzola M. Myelodysplastic syndromes. N Engl J Med. 2020;383(14):1358\u201374. https:\/\/doi.org\/10.1056\/NEJMra1904794.","journal-title":"N Engl J Med"},{"issue":"1","key":"856_CR2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/ajh.24930","volume":"93","author":"G Montalban-Bravo","year":"2018","unstructured":"Montalban-Bravo G, Garcia-Manero G. Myelodysplastic syndromes: 2018 update on diagnosis, risk-stratification and management. Am J Hematol. 2018;93(1):129\u201347. https:\/\/doi.org\/10.1002\/ajh.24930.","journal-title":"Am J Hematol"},{"issue":"10","key":"856_CR3","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1182\/blood-2018-10-844670","volume":"133","author":"TN Tanaka","year":"2019","unstructured":"Tanaka TN, Bejar R. MDS overlap disorders and diagnostic boundaries. Blood. 2019;133(10):1086\u201395. https:\/\/doi.org\/10.1182\/blood-2018-10-844670.","journal-title":"Blood"},{"issue":"25","key":"856_CR4","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.1182\/blood-2017-01-763425","volume":"129","author":"L Malcovati","year":"2017","unstructured":"Malcovati L, Gall\u00ec A, Travaglino E, et al. Clinical significance of somatic mutation in unexplained blood cytopenia. Blood. 2017;129(25):3371\u20138. https:\/\/doi.org\/10.1182\/blood-2017-01-763425.","journal-title":"Blood"},{"issue":"3","key":"856_CR5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1751-553X.2009.01192.x","volume":"32","author":"M Huang","year":"2010","unstructured":"Huang M, Li J, Zhao G, Sui X, Zhao X, Xu H. Immunophenotype of myeloid granulocytes: a pilot study for distinguishing myelodysplastic syndrome and aplastic anemia by flow cytometry. Int J Lab Hematol. 2010;32(3):275\u201381. https:\/\/doi.org\/10.1111\/j.1751-553X.2009.01192.x.","journal-title":"Int J Lab Hematol"},{"key":"856_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.leukres.2017.11.010","volume":"67","author":"P Liu","year":"2018","unstructured":"Liu P, Jiang H, Che M, et al. Abnormal CD25 expression on hematopoietic cells in myelodysplastic syndromes. Leuk Res. 2018;67:12\u20136. https:\/\/doi.org\/10.1016\/j.leukres.2017.11.010.","journal-title":"Leuk Res"},{"key":"856_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.leukres.2017.01.021","volume":"56","author":"JX Chen","year":"2017","unstructured":"Chen JX, Mei LP, Chen BG, et al. Over-expression of CD200 predicts poor prognosis in MDS. Leuk Res. 2017;56:1\u20136. https:\/\/doi.org\/10.1016\/j.leukres.2017.01.021.","journal-title":"Leuk Res"},{"issue":"4","key":"856_CR8","doi-asserted-by":"publisher","first-page":"961","DOI":"10.3324\/haematol.2019.219303","volume":"105","author":"N van Leeuwen-Kerkhoff","year":"2020","unstructured":"van Leeuwen-Kerkhoff N, Westers TM, Poddighe PJ, de Gruijl TD, Kordasti S, van de Loosdrecht AA. Thrombomodulin-expressing monocytes are associated with low-risk features in myelodysplastic syndromes and dampen excessive immune activation. Haematologica. 2020;105(4):961\u201371. https:\/\/doi.org\/10.3324\/haematol.2019.219303.","journal-title":"Haematologica"},{"issue":"11","key":"856_CR9","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1182\/blood-2012-09-435057","volume":"121","author":"F Borrego","year":"2013","unstructured":"Borrego F. The CD300 molecules: an emerging family of regulators of the immune system. Blood. 2013;121(11):1951\u201360. https:\/\/doi.org\/10.1182\/blood-2012-09-435057.","journal-title":"Blood"},{"key":"856_CR10","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3389\/fonc.2016.00161","volume":"6","author":"CM Aanei","year":"2016","unstructured":"Aanei CM, Picot T, Tavernier E, Guyotat D, Campos CL. Diagnostic utility of flow cytometry in myelodysplastic syndromes. Front Oncol. 2016;6:161. https:\/\/doi.org\/10.3389\/fonc.2016.00161.","journal-title":"Front Oncol"},{"issue":"3","key":"856_CR11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1097\/01.cji.0000211342.65964.9e","volume":"30","author":"GJ Clark","year":"2007","unstructured":"Clark GJ, Jamriska L, Rao M, Hart DN. Monocytes immunoselected via the novel monocyte specific molecule, CD300e, differentiate into active migratory dendritic cells. J Immunother. 2007;30(3):303\u201311. https:\/\/doi.org\/10.1097\/01.cji.0000211342.65964.9e.","journal-title":"J Immunother"},{"issue":"3","key":"856_CR12","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1002\/eji.200939468","volume":"40","author":"T Brckalo","year":"2010","unstructured":"Brckalo T, Calzetti F, P\u00e9rez-Cabezas B, Borr\u00e0s FE, Cassatella MA, L\u00f3pez-Botet M. Functional analysis of the CD300e receptor in human monocytes and myeloid dendritic cells. Eur J Immunol. 2010;40(3):722\u201332. https:\/\/doi.org\/10.1002\/eji.200939468.","journal-title":"Eur J Immunol"},{"issue":"8","key":"856_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160576","volume":"11","author":"F Haseda","year":"2016","unstructured":"Haseda F, Imagawa A, Nishikawa H, et al. Antibody to CMRF35-like molecule 2, CD300e a novel biomarker detected in patients with fulminant type 1 diabetes. PLoS ONE. 2016;11(8): e0160576. https:\/\/doi.org\/10.1371\/journal.pone.0160576.","journal-title":"PLoS ONE"},{"key":"856_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.655934","volume":"12","author":"O Zenarruzabeitia","year":"2021","unstructured":"Zenarruzabeitia O, Astarloa-Pando G, Terr\u00e9n I, et al. T cell activation, highly armed cytotoxic cells and a shift in monocytes CD300 receptors expression is characteristic of patients with severe COVID-19. Front Immunol. 2021;12: 655934. https:\/\/doi.org\/10.3389\/fimmu.2021.655934.","journal-title":"Front Immunol"},{"issue":"20","key":"856_CR15","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","volume":"127","author":"DA Arber","year":"2016","unstructured":"Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the world health organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391\u2013405. https:\/\/doi.org\/10.1182\/blood-2016-03-643544.","journal-title":"Blood"},{"issue":"12","key":"856_CR16","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1182\/blood-2012-03-420489","volume":"120","author":"PL Greenberg","year":"2012","unstructured":"Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012;120(12):2454\u201365. https:\/\/doi.org\/10.1182\/blood-2012-03-420489.","journal-title":"Blood"},{"issue":"8","key":"856_CR17","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.3324\/haematol.2009.005801","volume":"94","author":"AA van de Loosdrecht","year":"2009","unstructured":"van de Loosdrecht AA, Alhan C, B\u00e9n\u00e9 MC, et al. Standardization of flow cytometry in myelodysplastic syndromes: report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic syndromes. Haematologica. 2009;94(8):1124\u201334. https:\/\/doi.org\/10.3324\/haematol.2009.005801.","journal-title":"Haematologica"},{"issue":"1","key":"856_CR18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000490727","volume":"86","author":"C Duetz","year":"2019","unstructured":"Duetz C, Westers TM, van de Loosdrecht AA. Clinical implication of multi-parameter flow cytometry in myelodysplastic syndromes. Pathobiology. 2019;86(1):14\u201323. https:\/\/doi.org\/10.1159\/000490727.","journal-title":"Pathobiology"},{"issue":"6","key":"856_CR19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3343\/alm.2019.39.6.509","volume":"39","author":"K Karner","year":"2019","unstructured":"Karner K, George TI, Patel JL. Current aspects of clonal hematopoiesis: implications for clinical diagnosis. Ann Lab Med. 2019;39(6):509\u201314. https:\/\/doi.org\/10.3343\/alm.2019.39.6.509.","journal-title":"Ann Lab Med"},{"key":"856_CR20","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13742.10.1111\/ejh.13742","author":"L Chee","year":"2021","unstructured":"Chee L, Ritchie D, Ludford-Menting M, et al. Dysregulation of immune cell and cytokine signaling correlates with clinical outcomes in myelodysplastic syndrome (MDS). Eur J Haematol. 2021. https:\/\/doi.org\/10.1111\/ejh.13742.10.1111\/ejh.13742.","journal-title":"Eur J Haematol"},{"issue":"1","key":"856_CR21","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/cyto.b.21744","volume":"96","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Moon A, Hoyle E, et al. Pattern associated leukemia immunophenotypes and measurable disease detection in acute myeloid leukemia or myelodysplastic syndrome with mutated NPM1. Cytometry B Clin Cytom. 2019;96(1):67\u201372. https:\/\/doi.org\/10.1002\/cyto.b.21744.","journal-title":"Cytometry B Clin Cytom"},{"issue":"2","key":"856_CR22","doi-asserted-by":"publisher","DOI":"10.1111\/sji.13028","volume":"94","author":"M Majcherek","year":"2021","unstructured":"Majcherek M, Kiernicka-Parulska J, Mierzwa A, et al. The diagnostic and prognostic significance of flow cytometric bone marrow assessment in myelodysplastic syndromes according to the European LeukemiaNet recommendations in single-centre real-life experience. Scand J Immunol. 2021;94(2): e13028. https:\/\/doi.org\/10.1111\/sji.13028.","journal-title":"Scand J Immunol"},{"issue":"10","key":"856_CR23","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1074\/jbc.RA117.000696","volume":"293","author":"M Isobe","year":"2018","unstructured":"Isobe M, Izawa K, Sugiuchi M, et al. The CD300e molecule in mice is an immune-activating receptor. J Biol Chem. 2018;293(10):3793\u2013805. https:\/\/doi.org\/10.1074\/jbc.RA117.000696.","journal-title":"J Biol Chem"},{"key":"856_CR24","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.3389\/fimmu.2017.01288","volume":"8","author":"M Pagliari","year":"2017","unstructured":"Pagliari M, Munari F, Toffoletto M, et al. Helicobacter pylori affects the antigen presentation activity of macrophages modulating the expression of the immune receptor CD300E through miR-4270. Front Immunol. 2017;8:1288. https:\/\/doi.org\/10.3389\/fimmu.2017.01288.","journal-title":"Front Immunol"},{"issue":"1","key":"856_CR25","doi-asserted-by":"publisher","first-page":"16501","DOI":"10.1038\/s41598-020-73552-9","volume":"10","author":"S Coletta","year":"2020","unstructured":"Coletta S, Salvi V, Della Bella C, et al. The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation. Sci Rep. 2020;10(1):16501. https:\/\/doi.org\/10.1038\/s41598-020-73552-9.","journal-title":"Sci Rep"},{"issue":"12","key":"856_CR26","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1007\/s00262-019-02420-x","volume":"68","author":"P Montes","year":"2019","unstructured":"Montes P, Bernal M, Campo LN, et al. Tumor genetic alterations and features of the immune microenvironment drive myelodysplastic syndrome escape and progression. Cancer Immunol Immunother. 2019;68(12):2015\u201327. https:\/\/doi.org\/10.1007\/s00262-019-02420-x.","journal-title":"Cancer Immunol Immunother"},{"issue":"5","key":"856_CR27","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.130155","volume":"5","author":"D Sarhan","year":"2020","unstructured":"Sarhan D, Wang J, Sunil Arvindam U, et al. Mesenchymal stromal cells shape the MDS microenvironment by inducing suppressive monocytes that dampen NK cell function. JCI Insight. 2020;5(5): e130155. https:\/\/doi.org\/10.1172\/jci.insight.130155.","journal-title":"JCI Insight"},{"key":"856_CR28","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.critrevonc.2016.08.016","volume":"107","author":"C Fozza","year":"2016","unstructured":"Fozza C, Crobu V, Isoni MA, Dore F. The immune landscape of myelodysplastic syndromes. Crit Rev Oncol Hematol. 2016;107:90\u20139. https:\/\/doi.org\/10.1016\/j.critrevonc.2016.08.016.","journal-title":"Crit Rev Oncol Hematol"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-022-00856-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-022-00856-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-022-00856-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T12:27:59Z","timestamp":1744201679000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-022-00856-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["856"],"URL":"https:\/\/doi.org\/10.1007\/s10238-022-00856-7","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,2]]},"assertion":[{"value":"26 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was done following the Declaration of Helsinki, confirmed by the Ethics Committee of Tianjin Medical University General Hospital and provided written informed consent to participate.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}