{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:43:32Z","timestamp":1792190612729,"version":"4.4.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T00:00:00Z","timestamp":1658620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T00:00:00Z","timestamp":1658620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human papillary thyroid cancer (PTC) is often associated with Hashimoto\u2019s thyroiditis (HT), and their coexistence improves the prognosis of PTC.<jats:italic>Aim of the study<\/jats:italic>. The objective of our study is to investigate the expression of cadherins and TGF-\u03b2 which are regulators in the tumour aggressiveness with metastatic spread in PTC patients and its relationship with HT. The expression of E-cadherin and N-cadherin was measured in thyroid tissues of healthy volunteers and PTC patients with HT (PTC\/HT) or without. The E-cadherin expression was also determined in thyroid cancer cells (TPC1, SNU373, SNU790, 8505C, CAL62, and FTC133). Cell migration was measured by wound healing assay. The expression of N-cadherin, ICAM1, and TGF-\u03b2 was measured in thyroid tissues and plasma. The E-cadherin expression was significantly increased in PTC\/HT patients compared with PTC alone. Meanwhile, the N-cadherin expression was significantly decreased in PTC\/HT patients. The E-cadherin expression was only observed in FTC cells, and the overexpression of E-cadherin inhibited cancer cell migration. The TGF-\u03b2 expression was significantly increased in PTC\/HT patients, and the plasma levels were higher in PTC\/HT patients than in PTC alone. The expression of N-cadherin and ICAM-1 was significantly decreased in PTC\/HT patients. Our results indicate that the expression of E-cadherin and TGF-\u03b2 was higher in PTC\/HT patients than in PTC alone. This suggests that the presence of PTC with HT may attenuate the tumour aggressiveness and metastasis through the up-regulation of E-cadherin and TGF-\u03b2 expression.<\/jats:p>","DOI":"10.1007\/s10238-022-00857-6","type":"journal-article","created":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T15:02:27Z","timestamp":1658674947000},"page":"833-840","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Papillary thyroid cancer with Hashimoto\u2019s thyroiditis attenuates the tumour aggressiveness through the up-regulation of E-cadherin and TGF-\u03b2 expression"],"prefix":"10.1007","volume":"23","author":[{"given":"Su Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Sung","family":"Nam-Goong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3623-5528","authenticated-orcid":false,"given":"Hyo Won","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Sook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,24]]},"reference":[{"key":"857_CR1","doi-asserted-by":"publisher","first-page":"2638","DOI":"10.1002\/(SICI)1097-0142(19981215)83:12<2638::AID-CNCR31>3.0.CO;2-1","volume":"83","author":"SA Hundahl","year":"1998","unstructured":"Hundahl SA, Fleming ID, Fremgen AM, Menck HR. 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