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In systemic sclerosis (SSc), IL-33 and sST2 are involved in cardiac manifestations such as diastolic dysfunction (DD), autonomic dysfunction (AD) and right ventricular\u2013pulmonary arterial coupling assessed by tricuspid annular plane systolic excursion (TAPSE)\/systolic pulmonary artery pressure (sPAP). Serum levels of IL33 and sST2 were assessed in 50 SSc patients and 14 healthy controls (HC). Clinical assessment, echocardiography and heart rate variability (HRV) analysis were performed in SSc patients. Serum levels of IL-33 and sST2 were significantly higher in SSc patients than HC. A linear positive correlation between modified Rodnan skin score and IL33 was observed. Serum values of sST2 were higher in SSc patients with DD than in patients without DD [15403\u00a0pg\/ml (12,208\u201319,941) vs 8556\u00a0pg\/ml (6820\u201311,036), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001]. sST2 showed a negative correlation with standard deviation of normal-to-normal RR intervals (SDNN) (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u20090.281, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and positive correlation with low frequency\/high frequency (LF\/HF) (<jats:italic>r<\/jats:italic>\u2009=\u20090,349, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Negative linear correlation exists between sST2 and TAPSE\/sPAP (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u20090.398, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Serum levels of IL-33 and sST2 are higher in SSc patients than HC. Serum levels of sST2 are a potential marker of DD, AD and right ventricular\u2013pulmonary arterial coupling.<\/jats:p>","DOI":"10.1007\/s10238-022-00864-7","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T11:03:56Z","timestamp":1658747036000},"page":"897-903","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Interleukin-33 and soluble suppression of tumorigenicity 2 in scleroderma cardiac involvement"],"prefix":"10.1007","volume":"23","author":[{"given":"Francesco","family":"Iannazzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Pellicano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Colalillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesarina","family":"Ramaccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Romaniello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Gigante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-8093","authenticated-orcid":false,"given":"Edoardo","family":"Rosato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"864_CR1","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1191\/0961203305lu2204oa","volume":"14","author":"C Ferri","year":"2005","unstructured":"Ferri C, Giuggioli D, Sebastiani M, et al. 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Approval was granted by the Ethics Committee of Sapienza University of Rome (March 3, 2021 N. 6264).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}