{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:04:43Z","timestamp":1793851483421,"version":"4.6.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070127"],"award-info":[{"award-number":["82070127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-023-01043-y","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T06:02:35Z","timestamp":1679983355000},"page":"4483-4491","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Expression and prognostic value of C-reactive protein in adult immune thrombocytopenia (ITP) patients"],"prefix":"10.1007","volume":"23","author":[{"given":"YaNan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FengAn","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiuLi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JingJing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XueDong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhenYu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KaiLin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"issue":"10","key":"1043_CR1","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1056\/NEJMcp1810479","volume":"381","author":"N Cooper","year":"2019","unstructured":"Cooper N, Ghanima W. Immune thrombocytopenia. N Engl J Med. 2019;381(10):945\u201355.","journal-title":"N Engl J Med"},{"issue":"15","key":"1043_CR2","doi-asserted-by":"publisher","first-page":"4645","DOI":"10.1182\/bloodadvances.2022007195","volume":"6","author":"DR Lynch","year":"2022","unstructured":"Lynch DR, Stringham EN, Zhang B, et al. Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies. Blood Adv. 2022;6(15):4645\u201356.","journal-title":"Blood Adv"},{"issue":"1","key":"1043_CR3","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1600-065X.2012.01162.x","volume":"250","author":"J Lu","year":"2012","unstructured":"Lu J, Marjon KD, Mold C, Du Clos TW, Sun PD. Pentraxins and Fc receptors. Immunol Rev. 2012;250(1):230\u20138.","journal-title":"Immunol Rev"},{"issue":"8","key":"1043_CR4","first-page":"617","volume":"41","author":"Thrombosis and Hemostasis Group CSoHCMA","year":"2020","unstructured":"Thrombosis and Hemostasis Group CSoHCMA. Chinese guideline on the diagnosis and management of adult primary immune thrombocytopenia (version 2020). Zhonghua Xue Ye Xue Za Zhi. 2020;41(8):617\u201323.","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"1043_CR5","unstructured":"Nehring SM, Goyal A and Patel BC, C Reactive Protein, in StatPearls. 2022, StatPearls Publishing Copyright\u00a9 2022, StatPearls Publishing LLC: Treasure Island (FL)."},{"key":"1043_CR6","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","volume":"9","author":"NR Sproston","year":"2018","unstructured":"Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front Immunol. 2018;9:754.","journal-title":"Front Immunol"},{"issue":"7","key":"1043_CR7","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1007\/s11695-019-03832-5","volume":"29","author":"Y Lee","year":"2019","unstructured":"Lee Y, McKechnie T, Doumouras AG, et al. Diagnostic value of C-reactive protein levels in postoperative infectious complications after bariatric surgery: a systematic review and meta-analysis. Obes Surg. 2019;29(7):2022\u20139.","journal-title":"Obes Surg"},{"issue":"2","key":"1043_CR8","doi-asserted-by":"publisher","first-page":"e000849","DOI":"10.1136\/openhrt-2018-000849","volume":"5","author":"I Johns","year":"2018","unstructured":"Johns I, Moschonas KE, Medina J, et al. Risk classification in primary prevention of CVD according to QRISK2 and JBS3 \u2018heart age\u2019, and prevalence of elevated high-sensitivity C reactive protein in the UK cohort of the EURIKA study. Open Heart. 2018;5(2):e000849.","journal-title":"Open Heart"},{"issue":"4","key":"1043_CR9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1046\/j.1365-2796.2002.01019.x","volume":"252","author":"GJ Blake","year":"2002","unstructured":"Blake GJ, Ridker PM. Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med. 2002;252(4):283\u201394.","journal-title":"J Intern Med"},{"issue":"11","key":"1043_CR10","first-page":"2118","volume":"11","author":"L V\u00edtek","year":"2022","unstructured":"V\u00edtek L, Jir\u00e1skov\u00e1 A, Mal\u00edkov\u00e1 I, et al. serum bilirubin and markers of oxidative stress and inflammation in a healthy population and in patients with various forms of atherosclerosis. Antioxidants (Basel, Switzerland). 2022;11(11):2118.","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"11","key":"1043_CR11","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1182\/blood-2015-01-621219","volume":"125","author":"JW Semple","year":"2015","unstructured":"Semple JW. C-reactive protein boosts antibody-mediated platelet destruction. Blood. 2015;125(11):1690\u20131.","journal-title":"Blood"},{"issue":"11","key":"1043_CR12","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1182\/blood-2014-05-579110","volume":"125","author":"R Kapur","year":"2015","unstructured":"Kapur R, Heitink-Poll\u00e9 KMJ, Porcelijn L, et al. C-reactive protein enhances IgG-mediated phagocyte responses and thrombocytopenia. Blood. 2015;125(11):1793\u2013802.","journal-title":"Blood"},{"issue":"2","key":"1043_CR13","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s11239-010-0513-1","volume":"31","author":"CL Campbell","year":"2011","unstructured":"Campbell CL, Steinhubl SR, Hooper WC, et al. Bleeding events are associated with an increase in markers of inflammation in acute coronary syndromes: an ACUITY trial substudy. J Thromb Thrombolysis. 2011;31(2):139\u201345.","journal-title":"J Thromb Thrombolysis"},{"issue":"7","key":"1043_CR14","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1212\/WNL.0b013e318264e3be","volume":"79","author":"M Di Napoli","year":"2012","unstructured":"Di Napoli M, Godoy DA, Campi V, et al. C-reactive protein in intracerebral hemorrhage: time course, tissue localization, and prognosis. Neurology. 2012;79(7):690\u20139.","journal-title":"Neurology"},{"issue":"1","key":"1043_CR15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1161\/STROKEAHA.113.001721","volume":"45","author":"M Di Napoli","year":"2014","unstructured":"Di Napoli M, Parry-Jones AR, Smith CJ, et al. C-reactive protein predicts hematoma growth in intracerebral hemorrhage. Stroke. 2014;45(1):59\u201365.","journal-title":"Stroke"},{"issue":"3","key":"1043_CR16","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1111\/bjh.15668","volume":"184","author":"F Palandri","year":"2019","unstructured":"Palandri F, Catani L, Auteri G, et al. Understanding how older age drives decision-making and outcome in Immune Thrombocytopenia. A single centre study on 465 adult patients. Br J Haematol. 2019;184(3):424\u201330.","journal-title":"Br J Haematol"},{"key":"1043_CR17","doi-asserted-by":"publisher","first-page":"106231","DOI":"10.1016\/j.biocel.2022.106231","volume":"147","author":"V Kr\u00e9mer","year":"2022","unstructured":"Kr\u00e9mer V, de Chaisemartin L, J\u00f6nsson F. The role of neutrophils in antibody-driven autoimmune cytopenias. Int J Biochem Cell Biol. 2022;147:106231.","journal-title":"Int J Biochem Cell Biol"},{"issue":"5","key":"1043_CR18","first-page":"910","volume":"110","author":"A Verschoor","year":"2013","unstructured":"Verschoor A, Langer HF. Crosstalk between platelets and the complement system in immune protection and disease. Thromb Haemost. 2013;110(5):910\u20139.","journal-title":"Thromb Haemost"},{"issue":"2","key":"1043_CR19","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1111\/j.1365-2141.1986.tb05552.x","volume":"63","author":"T Tsubakio","year":"1986","unstructured":"Tsubakio T, Tani P, Curd JG, McMillan R. Complement activation in vitro by antiplatelet antibodies in chronic immune thrombocytopenic purpura. Br J Haematol. 1986;63(2):293\u2013300.","journal-title":"Br J Haematol"},{"issue":"2","key":"1043_CR20","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0168-8278(96)80021-3","volume":"24","author":"T Nagamine","year":"1996","unstructured":"Nagamine T, Ohtuka T, Takehara K, et al. Thrombocytopenia associated with hepatitis C viral infection. J Hepatol. 1996;24(2):135\u201340.","journal-title":"J Hepatol"},{"issue":"8882","key":"1043_CR21","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/0140-6736(93)92363-X","volume":"342","author":"AW Hohmann","year":"1993","unstructured":"Hohmann AW, Booth K, Peters V, Gordon DL, Comacchio RM. Common epitope on HIV p24 and human platelets. Lancet (London, England). 1993;342(8882):1274\u20135.","journal-title":"Lancet (London, England)"},{"issue":"8","key":"1043_CR22","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1080\/09537104.2020.1820975","volume":"32","author":"C-E Huang","year":"2021","unstructured":"Huang C-E, Chen W-M, Wu Y-Y, et al. Comparison of antiplatelet antibody profiles between hepatitis C virus-associated immune thrombocytopenia and primary immune thrombocytopenia. Platelets. 2021;32(8):1043\u201350.","journal-title":"Platelets"},{"issue":"17","key":"1043_CR23","doi-asserted-by":"publisher","first-page":"4086","DOI":"10.1182\/blood-2008-09-181073","volume":"113","author":"W Zhang","year":"2009","unstructured":"Zhang W, Nardi MA, Borkowsky W, Li Z, Karpatkin S. Role of molecular mimicry of hepatitis C virus protein with platelet GPIIIa in hepatitis C-related immunologic thrombocytopenia. Blood. 2009;113(17):4086\u201393.","journal-title":"Blood"},{"issue":"1","key":"1043_CR24","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1046\/j.1365-2141.1996.d01-1872.x","volume":"95","author":"JF Wright","year":"1996","unstructured":"Wright JF, Blanchette VS, Wang H, et al. Characterization of platelet-reactive antibodies in children with varicella-associated acute immune thrombocytopenic purpura (ITP). Br J Haematol. 1996;95(1):145\u201352.","journal-title":"Br J Haematol"},{"issue":"2","key":"1043_CR25","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1182\/blood-2005-01-0243","volume":"106","author":"Z Li","year":"2005","unstructured":"Li Z, Nardi MA, Karpatkin S. Role of molecular mimicry to HIV-1 peptides in HIV-1-related immunologic thrombocytopenia. Blood. 2005;106(2):572\u20136.","journal-title":"Blood"},{"issue":"16","key":"1043_CR26","doi-asserted-by":"publisher","first-page":"4822","DOI":"10.3390\/jcm11164822","volume":"11","author":"H Takeuchi","year":"2022","unstructured":"Takeuchi H, Okamoto A. Infection and chronic immune thrombocytopenia. J Clin Med. 2022;11(16):4822.","journal-title":"J Clin Med"},{"issue":"7","key":"1043_CR27","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1007\/s00277-022-04782-2","volume":"101","author":"B Han","year":"2022","unstructured":"Han B, Kim HJ, Yhim H-Y, et al. Sequential eradication of Helicobacter pylori as a treatment for immune thrombocytopenia in patients with moderate thrombocytopenia: a multicenter prospective randomized phase 3 study. Ann Hematol. 2022;101(7):1435\u201345.","journal-title":"Ann Hematol"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-023-01043-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-023-01043-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-023-01043-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T16:04:43Z","timestamp":1702742683000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-023-01043-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,28]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1043"],"URL":"https:\/\/doi.org\/10.1007\/s10238-023-01043-y","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,28]]},"assertion":[{"value":"30 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No relevant conflicts of interest are related to this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}