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Our study aimed to investigate the clinical characteristics and prognosis of LC through analyzing patients from the literature and our own center, so as to improve early diagnosis and treatment. PubMed, Web of Science and our hospital databases were reviewed, and information on demographic, clinical, pathological, cerebrospinal fluid (CSF), neuroimaging and treatment options was extracted. Univariate survival analysis was conducted by generating survival curves and comparing them using the log-rank test. Multivariate analysis was performed using the Cox proportional hazards regression model to identify the prognostic predictors. A total of 81 patients (median age: 58\u00a0years; interquartile range, IQR: 50\u201366.5\u00a0years), 45 males and 36 females, were included. The most common symptoms were cognitive impairment (65.4%) and gait impairment (50.6%). Imaging studies indicated that all 81 patients had supratentorial structure involvement, and 93.8% (76\/81) had bilateral hemisphere involvement. There were 53.3% (32\/60) patients with CSF pleocytosis and 65% (39\/60) patients with increased CSF protein levels. The median time of diagnosis was 4.8\u00a0months (IQR: 2.3\u20136.9\u00a0months). Compared with 4 (95% CI: 1.78\u20136.22) months for all 81 patients, the median OS was 20 (95% CI: 8.24\u201331.76) months for those who had chemotherapy plus radiotherapy. Multivariate Cox analysis revealed that chemoradiotherapy (HR: 0.12; 95% CI: 0.02\u20130.68) and higher CSF glucose level (HR: 0.01; 95% CI: 0.00\u20130.26) were inversely associated with death. The diagnosis of LC should be alerted when neuroimaging with bilateral hemispheric involvement and CSF abnormality with pleocytosis and increased protein. Once the diagnosis is confirmed, the combination of chemotherapy and radiotherapy can be considered if the patient\u2019s physical condition permits.Journal standard instruction requires an unstructured abstract. Kindly check and confirm.We have checked and confirmed that there is no problem.<\/jats:p>","DOI":"10.1007\/s10238-023-01224-9","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T11:03:12Z","timestamp":1700305392000},"page":"4673-4680","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical and imaging features of lymphomatosis cerebri: analysis of 8 cases and systematic review of the literature"],"prefix":"10.1007","volume":"23","author":[{"given":"Mengke","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,18]]},"reference":[{"issue":"2","key":"1224_CR1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/jnnp-2013-307327","volume":"86","author":"A Samani","year":"2015","unstructured":"Samani A, Davagnanam I, Cockerell OC, et al. 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