{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:44:26Z","timestamp":1789767866484,"version":"4.0.1"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021JDRC0045 and 2021YFS0164"],"award-info":[{"award-number":["2021JDRC0045 and 2021YFS0164"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021JDRC0045 and 2021YFS0164"],"award-info":[{"award-number":["2021JDRC0045 and 2021YFS0164"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021JDRC0045 and 2021YFS0164"],"award-info":[{"award-number":["2021JDRC0045 and 2021YFS0164"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021JDRC0045 and 2021YFS0164"],"award-info":[{"award-number":["2021JDRC0045 and 2021YFS0164"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021JDRC0045 and 2021YFS0164"],"award-info":[{"award-number":["2021JDRC0045 and 2021YFS0164"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021JDRC0045 and 2021YFS0164"],"award-info":[{"award-number":["2021JDRC0045 and 2021YFS0164"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of chronic autoimmune diseases characterized by muscle damage and extramuscular symptoms, including specific skin rash, arthritis, interstitial lung disease, and cardiac involvement. While the etiology and pathogenesis of IIM are not yet fully understood, emerging evidence suggests that neutrophils and neutrophil extracellular traps (NETs) have a role in the pathogenesis. Recent research has identified increased levels of circulating and tissue neutrophils as well as NETs in patients with IIM; these contribute to the activation of the type I and type II interferons pathway. During active IIM disease, myositis-specific antibodies are associated with the formation and incomplete degradation of NETs, leading to damage in the lungs, muscles, and blood vessels of patients. This review focuses on the pathogenic role and clinical significance of neutrophils and NETs in IIM, and it includes a discussion of potential targeted treatment strategies.<\/jats:p>","DOI":"10.1007\/s10238-024-01384-2","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T09:45:49Z","timestamp":1717062349000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pathogenic role and clinical significance of neutrophils and neutrophil extracellular traps in idiopathic inflammatory myopathies"],"prefix":"10.1007","volume":"24","author":[{"given":"Ruiting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changpei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"issue":"1","key":"1384_CR1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41572-021-00321-x","volume":"7","author":"IE Lundberg","year":"2021","unstructured":"Lundberg IE, et al. Idiopathic inflammatory myopathies. Nat Rev Dis Primers. 2021;7(1):86.","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"1384_CR2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrrheum.2018.41","volume":"14","author":"IE Lundberg","year":"2018","unstructured":"Lundberg IE, de Visser M, Werth VP. Classification of myositis. Nat Rev Rheumatol. 2018;14(5):269\u201378.","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"1384_CR3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/path.4359","volume":"233","author":"A Chrysanthopoulou","year":"2014","unstructured":"Chrysanthopoulou A, et al. Neutrophil extracellular traps promote differentiation and function of fibroblasts. J Pathol. 2014;233(3):294\u2013307.","journal-title":"J Pathol"},{"issue":"5","key":"1384_CR4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrrheum.2018.48","volume":"14","author":"FW Miller","year":"2018","unstructured":"Miller FW, et al. Risk factors and disease mechanisms in myositis. Nat Rev Rheumatol. 2018;14(5):255\u201368.","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"1384_CR5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4049\/jimmunol.1100450","volume":"187","author":"E Villanueva","year":"2011","unstructured":"Villanueva E, et al. Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J Immunol. 2011;187(1):538\u201352.","journal-title":"J Immunol"},{"issue":"178","key":"1384_CR6","doi-asserted-by":"crossref","first-page":"178ra40","DOI":"10.1126\/scitranslmed.3005580","volume":"5","author":"R Khandpur","year":"2013","unstructured":"Khandpur R, et al. NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis. Sci Transl Med. 2013;5(178):178ra40.","journal-title":"Sci Transl Med"},{"issue":"7","key":"1384_CR7","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1002\/art.39153","volume":"67","author":"PC Grayson","year":"2015","unstructured":"Grayson PC, et al. Neutrophil-related gene expression and low-density granulocytes associated with disease activity and response to treatment in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheumatol. 2015;67(7):1922\u201332.","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"1384_CR8","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/cei\/uxad059","volume":"213","author":"W Ma","year":"2023","unstructured":"Ma W, et al. The role of neutrophil extracellular traps and proinflammatory damage-associated molecular patterns in idiopathic inflammatory myopathies. Clin Exp Immunol. 2023;213(2):202\u20138.","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"1384_CR9","doi-asserted-by":"crossref","first-page":"e480","DOI":"10.1097\/RHU.0000000000001772","volume":"28","author":"J Torres-Ruiz","year":"2022","unstructured":"Torres-Ruiz J, et al. Low-density granulocytes and neutrophil extracellular traps as biomarkers of disease activity in adult inflammatory myopathies. J Clin Rheumatol. 2022;28(2):e480\u20137.","journal-title":"J Clin Rheumatol"},{"issue":"2","key":"1384_CR10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1189\/jlb.5BT0615-247R","volume":"99","author":"PC Grayson","year":"2016","unstructured":"Grayson PC, Kaplan MJ. At the bench: neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases. J Leukoc Biol. 2016;99(2):253\u201364.","journal-title":"J Leukoc Biol"},{"issue":"1","key":"1384_CR11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/cei.12319","volume":"177","author":"S Zhang","year":"2014","unstructured":"Zhang S, et al. Enhanced formation and impaired degradation of neutrophil extracellular traps in dermatomyositis and polymyositis: a potential contributor to interstitial lung disease complications. Clin Exp Immunol. 2014;177(1):134\u201341.","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"1384_CR12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00019052-199606000-00015","volume":"9","author":"MC Dalakas","year":"1996","unstructured":"Dalakas MC, Sivakumar K. The immunopathologic and inflammatory differences between dermatomyositis, polymyositis and sporadic inclusion body myositis. Curr Opin Neurol. 1996;9(3):235\u20139.","journal-title":"Curr Opin Neurol"},{"issue":"10","key":"1384_CR13","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.autrev.2017.07.021","volume":"16","author":"S Gao","year":"2017","unstructured":"Gao S, et al. Using multi-omics methods to understand dermatomyositis\/polymyositis. Autoimmun Rev. 2017;16(10):1044\u20138.","journal-title":"Autoimmun Rev"},{"issue":"6","key":"1384_CR14","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/BOR.0b013e3283317b31","volume":"21","author":"B De Paepe","year":"2009","unstructured":"De Paepe B, Creus KK, De Bleecker JL. Role of cytokines and chemokines in idiopathic inflammatory myopathies. Curr Opin Rheumatol. 2009;21(6):610\u20136.","journal-title":"Curr Opin Rheumatol"},{"issue":"3","key":"1384_CR15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/japplphysiol.00971.2016","volume":"122","author":"JM Peake","year":"2017","unstructured":"Peake JM, et al. Muscle damage and inflammation during recovery from exercise. J Appl Physiol. 2017;122(3):559\u201370.","journal-title":"J Appl Physiol"},{"key":"1384_CR16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/bs.ctdb.2017.08.002","volume":"126","author":"DCL Robinson","year":"2018","unstructured":"Robinson DCL, Dilworth FJ. Epigenetic regulation of adult myogenesis. Curr Top Dev Biol. 2018;126:235\u201384.","journal-title":"Curr Top Dev Biol"},{"key":"1384_CR17","doi-asserted-by":"crossref","first-page":"866747","DOI":"10.3389\/fimmu.2022.866747","volume":"13","author":"JG Filep","year":"2022","unstructured":"Filep JG. Targeting neutrophils for promoting the resolution of inflammation. Front Immunol. 2022;13:866747.","journal-title":"Front Immunol"},{"key":"1384_CR18","doi-asserted-by":"crossref","first-page":"103063","DOI":"10.1016\/j.jaut.2023.103063","volume":"138","author":"SJ Moon","year":"2023","unstructured":"Moon SJ, et al. Molecular signature of neutrophil extracellular trap mediating disease module in idiopathic inflammatory myopathy. J Autoimmun. 2023;138:103063.","journal-title":"J Autoimmun"},{"issue":"10","key":"1384_CR19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11926-020-00936-1","volume":"22","author":"A Tambralli","year":"2020","unstructured":"Tambralli A, Gockman K, Knight JS. NETs in APS: current knowledge and future perspectives. Curr Rheumatol Rep. 2020;22(10):67.","journal-title":"Curr Rheumatol Rep"},{"issue":"2","key":"1384_CR20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.smim.2016.03.004","volume":"28","author":"N Thieblemont","year":"2016","unstructured":"Thieblemont N, et al. Human neutrophils in auto-immunity. Semin Immunol. 2016;28(2):159\u201373.","journal-title":"Semin Immunol"},{"issue":"5663","key":"1384_CR21","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303(5663):1532\u20135.","journal-title":"Science"},{"issue":"5\u20136","key":"1384_CR22","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1159\/000489829","volume":"10","author":"V Brinkmann","year":"2018","unstructured":"Brinkmann V. Neutrophil extracellular traps in the second decade. J Innate Immun. 2018;10(5\u20136):414\u201321.","journal-title":"J Innate Immun"},{"issue":"3","key":"1384_CR23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41418-018-0261-x","volume":"26","author":"S Boeltz","year":"2019","unstructured":"Boeltz S, et al. To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death Differ. 2019;26(3):395\u2013408.","journal-title":"Cell Death Differ"},{"issue":"22","key":"1384_CR24","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1182\/blood-2011-12-401133","volume":"120","author":"K Chen","year":"2012","unstructured":"Chen K, et al. Endocytosis of soluble immune complexes leads to their clearance by Fc\u03b3RIIIB but induces neutrophil extracellular traps via Fc\u03b3RIIA in vivo. Blood. 2012;120(22):4421\u201331.","journal-title":"Blood"},{"key":"1384_CR25","doi-asserted-by":"publisher","unstructured":"Carmona-Rivera C, et al. Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis. Sci Immunol. 2017;2(10). https:\/\/doi.org\/10.1126\/sciimmunol.aag3358 .","DOI":"10.1126\/sciimmunol.aag3358"},{"issue":"6","key":"1384_CR26","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.4049\/jimmunol.0902199","volume":"184","author":"MF Denny","year":"2010","unstructured":"Denny MF, et al. A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. J Immunol. 2010;184(6):3284\u201397.","journal-title":"J Immunol"},{"issue":"2","key":"1384_CR27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm.4027","volume":"22","author":"C Lood","year":"2016","unstructured":"Lood C, et al. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med. 2016;22(2):146\u201353.","journal-title":"Nat Med"},{"issue":"1","key":"1384_CR28","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/14397595.2016.1179861","volume":"27","author":"S Zhang","year":"2017","unstructured":"Zhang S, et al. Abnormally increased low-density granulocytes in peripheral blood mononuclear cells are associated with interstitial lung disease in dermatomyositis. Mod Rheumatol. 2017;27(1):122\u20139.","journal-title":"Mod Rheumatol"},{"issue":"5","key":"1384_CR29","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1378\/chest.08-2740","volume":"136","author":"H Mukae","year":"2009","unstructured":"Mukae H, et al. Clinical differences between interstitial lung disease associated with clinically amyopathic dermatomyositis and classic dermatomyositis. Chest. 2009;136(5):1341\u20137.","journal-title":"Chest"},{"issue":"4","key":"1384_CR30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jaad.2005.10.041","volume":"54","author":"P Gerami","year":"2006","unstructured":"Gerami P, et al. A systematic review of adult-onset clinically amyopathic dermatomyositis (dermatomyositis sin\u00e9 myositis): a missing link within the spectrum of the idiopathic inflammatory myopathies. J Am Acad Dermatol. 2006;54(4):597\u2013613.","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"1384_CR31","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.chest.2020.06.001","volume":"158","author":"MC Baker","year":"2020","unstructured":"Baker MC, Chung L, Fiorentino DF. A mortality risk score model for clinically amyopathic dermatomyositis-associated interstitial lung disease: will it have the necessary \u201cFLAIR\u201d to improve clinical outcomes? Chest. 2020;158(4):1307\u20139.","journal-title":"Chest"},{"key":"1384_CR32","first-page":"1886083","volume":"2022","author":"L Liu","year":"2022","unstructured":"Liu L, et al. Promising neutrophil-associated biomarkers in lung diseases of patients with antisynthetase syndrome and dermatomyositis. J Immunol Res. 2022;2022:1886083.","journal-title":"J Immunol Res"},{"issue":"5","key":"1384_CR33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/sarh.2002.50012","volume":"32","author":"A Schnabel","year":"2003","unstructured":"Schnabel A, et al. Interstitial lung disease in polymyositis and dermatomyositis: clinical course and response to treatment. Semin Arthritis Rheum. 2003;32(5):273\u201384.","journal-title":"Semin Arthritis Rheum"},{"issue":"6","key":"1384_CR34","doi-asserted-by":"crossref","first-page":"e98824","DOI":"10.1371\/journal.pone.0098824","volume":"9","author":"T Fujisawa","year":"2014","unstructured":"Fujisawa T, et al. Prognostic factors for myositis-associated interstitial lung disease. PLoS ONE. 2014;9(6):e98824.","journal-title":"PLoS ONE"},{"issue":"16","key":"1384_CR35","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.2169\/internalmedicine.55.5774","volume":"55","author":"H Chino","year":"2016","unstructured":"Chino H, et al. Radiological and pathological correlation in Anti-MDA5 antibody-positive interstitial lung disease: rapidly progressive perilobular opacities and diffuse alveolar damage. Intern Med. 2016;55(16):2241\u20136.","journal-title":"Intern Med"},{"issue":"1","key":"1384_CR36","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12890-018-0609-5","volume":"18","author":"N Sakamoto","year":"2018","unstructured":"Sakamoto N, et al. Elevated alpha-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease. BMC Pulm Med. 2018;18(1):44.","journal-title":"BMC Pulm Med"},{"issue":"12","key":"1384_CR37","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1093\/rheumatology\/keu258","volume":"53","author":"T Gono","year":"2014","unstructured":"Gono T, et al. Cytokine profiles in polymyositis and dermatomyositis complicated by rapidly progressive or chronic interstitial lung disease. Rheumatology. 2014;53(12):2196\u2013203.","journal-title":"Rheumatology"},{"issue":"2","key":"1384_CR38","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/rheumatology\/kez301","volume":"59","author":"S Matsuda","year":"2020","unstructured":"Matsuda S, et al. Exploration of pathomechanism using comprehensive analysis of serum cytokines in polymyositis\/dermatomyositis-interstitial lung disease. Rheumatology (Oxford). 2020;59(2):310\u20138.","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"1384_CR39","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1080\/08820139.2020.1778720","volume":"50","author":"X Chen","year":"2021","unstructured":"Chen X, et al. Neutrophil extracellular trapping network promotes the pathogenesis of neutrophil-associated asthma through macrophages. Immunol Invest. 2021;50(5):544\u201361.","journal-title":"Immunol Invest"},{"issue":"1","key":"1384_CR40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10067-017-3799-y","volume":"37","author":"Y Peng","year":"2018","unstructured":"Peng Y, et al. Neutrophil extracellular traps may contribute to interstitial lung disease associated with anti-MDA5 autoantibody positive dermatomyositis. Clin Rheumatol. 2018;37(1):107\u201315.","journal-title":"Clin Rheumatol"},{"issue":"73","key":"1384_CR41","first-page":"73ra20","volume":"3","author":"GS Garcia-Romo","year":"2011","unstructured":"Garcia-Romo GS, et al. Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci Transl Med. 2011;3(73):73ra20.","journal-title":"Sci Transl Med"},{"issue":"73","key":"1384_CR42","doi-asserted-by":"crossref","first-page":"73ra19","DOI":"10.1126\/scitranslmed.3001180","volume":"3","author":"R Lande","year":"2011","unstructured":"Lande R, et al. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci Transl Med. 2011;3(73):73ra19.","journal-title":"Sci Transl Med"},{"issue":"7","key":"1384_CR43","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1172\/JCI61303","volume":"122","author":"A Caudrillier","year":"2012","unstructured":"Caudrillier A, et al. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012;122(7):2661\u201371.","journal-title":"J Clin Invest"},{"issue":"2","key":"1384_CR44","doi-asserted-by":"crossref","first-page":"e32366","DOI":"10.1371\/journal.pone.0032366","volume":"7","author":"M Saffarzadeh","year":"2012","unstructured":"Saffarzadeh M, et al. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. PLoS ONE. 2012;7(2):e32366.","journal-title":"PLoS ONE"},{"issue":"4","key":"1384_CR45","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/ar3347","volume":"13","author":"SK Danoff","year":"2011","unstructured":"Danoff SK, Casciola-Rosen L. The lung as a possible target for the immune reaction in myositis. Arthritis Res Ther. 2011;13(4):230.","journal-title":"Arthritis Res Ther"},{"key":"1384_CR46","first-page":"1","volume":"4","author":"OZ Cheng","year":"2013","unstructured":"Cheng OZ, Palaniyar N. NET balancing: a problem in inflammatory lung diseases. Front Immunol. 2013;4:1.","journal-title":"Front Immunol"},{"issue":"2","key":"1384_CR47","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1111\/jcmm.14858","volume":"24","author":"S Zhang","year":"2020","unstructured":"Zhang S, et al. Neutrophil extracellular traps activate lung fibroblast to induce polymyositis-related interstitial lung diseases via TLR9-miR-7-Smad2 pathway. J Cell Mol Med. 2020;24(2):1658\u201369.","journal-title":"J Cell Mol Med"},{"issue":"3","key":"1384_CR48","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1165\/rcmb.2016-0121TR","volume":"55","author":"S Kolahian","year":"2016","unstructured":"Kolahian S, et al. Immune mechanisms in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2016;55(3):309\u201322.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"1384_CR49","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.ajpath.2012.02.004","volume":"180","author":"B Hinz","year":"2012","unstructured":"Hinz B, et al. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol. 2012;180(4):1340\u201355.","journal-title":"Am J Pathol"},{"key":"1384_CR50","doi-asserted-by":"crossref","first-page":"1113214","DOI":"10.3389\/fimmu.2023.1113214","volume":"14","author":"J Torres-Ruiz","year":"2023","unstructured":"Torres-Ruiz J, et al. Inflammatory myopathies and beyond: the dual role of neutrophils in muscle damage and regeneration. Front Immunol. 2023;14:1113214.","journal-title":"Front Immunol"},{"issue":"1","key":"1384_CR51","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1038\/s41598-022-07916-8","volume":"12","author":"K Suzuki","year":"2022","unstructured":"Suzuki K, et al. Tissue accumulation of neutrophil extracellular traps mediates muscle hyperalgesia in a mouse model. Sci Rep. 2022;12(1):4136.","journal-title":"Sci Rep"},{"issue":"10","key":"1384_CR52","doi-asserted-by":"crossref","first-page":"e12775","DOI":"10.1111\/cpr.12775","volume":"53","author":"L Liu","year":"2020","unstructured":"Liu L, et al. Induction of neutrophil extracellular traps during tissue injury: involvement of STING and toll-like receptor 9 pathways. Cell Prolif. 2020;53(10):e12775.","journal-title":"Cell Prolif"},{"key":"1384_CR53","doi-asserted-by":"publisher","unstructured":"Seto N, et al. Neutrophil dysregulation is pathogenic in idiopathic inflammatory myopathies. JCI Insight. 2020;5(3). https:\/\/doi.org\/10.1172\/jci.insight.134189 .","DOI":"10.1172\/jci.insight.134189"},{"issue":"1","key":"1384_CR54","doi-asserted-by":"crossref","first-page":"e002864","DOI":"10.1136\/rmdopen-2022-002864","volume":"9","author":"J Rodr\u00edguez-Carrio","year":"2023","unstructured":"Rodr\u00edguez-Carrio J, et al. Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider. RMD Open. 2023;9(1):e002864.","journal-title":"RMD Open"},{"issue":"5","key":"1384_CR55","doi-asserted-by":"crossref","first-page":"R1173","DOI":"10.1152\/ajpregu.00735.2009","volume":"298","author":"JG Tidball","year":"2010","unstructured":"Tidball JG, Villalta SA. Regulatory interactions between muscle and the immune system during muscle regeneration. Am J Physiol Regul Integr Comp Physiol. 2010;298(5):R1173-87.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7755","key":"1384_CR56","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41586-019-1167-6","volume":"569","author":"C Silvestre-Roig","year":"2019","unstructured":"Silvestre-Roig C, et al. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature. 2019;569(7755):236\u201340.","journal-title":"Nature"},{"issue":"7","key":"1384_CR57","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1136\/annrheumdis-2013-204837","volume":"74","author":"C Carmona-Rivera","year":"2015","unstructured":"Carmona-Rivera C, et al. Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2. Ann Rheum Dis. 2015;74(7):1417\u201324.","journal-title":"Ann Rheum Dis"},{"key":"1384_CR58","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.99276","author":"PM Carlucci","year":"2018","unstructured":"Carlucci PM, et al. Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus. JCI Insight. 2018;3(8). https:\/\/doi.org\/10.1172\/jci.insight.99276 .","journal-title":"JCI Insight"},{"issue":"5","key":"1384_CR59","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jpeds.2011.05.015","volume":"159","author":"MJ Eimer","year":"2011","unstructured":"Eimer MJ, et al. Clinical status and cardiovascular risk profile of adults with a history of juvenile dermatomyositis. J Pediatr. 2011;159(5):795\u2013801.","journal-title":"J Pediatr"},{"issue":"6245","key":"1384_CR60","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.aaa8064","volume":"349","author":"A Warnatsch","year":"2015","unstructured":"Warnatsch A, et al. Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis. Science. 2015;349(6245):316\u201320.","journal-title":"Science"},{"issue":"5","key":"1384_CR61","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nm.3547","volume":"20","author":"C Schauer","year":"2014","unstructured":"Schauer C, et al. Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat Med. 2014;20(5):511\u20137.","journal-title":"Nat Med"},{"issue":"8","key":"1384_CR62","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1002\/art.39656","volume":"68","author":"C Lood","year":"2016","unstructured":"Lood C, et al. Platelet-derived S100A8\/A9 and cardiovascular disease in systemic lupus erythematosus. Arthritis Rheumatol. 2016;68(8):1970\u201380.","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"1384_CR63","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/art.21023","volume":"52","author":"S Sato","year":"2005","unstructured":"Sato S, et al. Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis. Arthritis Rheum. 2005;52(5):1571\u20136.","journal-title":"Arthritis Rheum"},{"issue":"7","key":"1384_CR64","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1093\/rheumatology\/ker518","volume":"51","author":"T Koga","year":"2012","unstructured":"Koga T, et al. The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM. Rheumatology (Oxford). 2012;51(7):1278\u201384.","journal-title":"Rheumatology (Oxford)"},{"issue":"8","key":"1384_CR65","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/acr.21985","volume":"65","author":"Z Chen","year":"2013","unstructured":"Chen Z, et al. Utility of anti-melanoma differentiation-associated gene 5 antibody measurement in identifying patients with dermatomyositis and a high risk for developing rapidly progressive interstitial lung disease: a review of the literature and a meta-analysis. Arthritis Care Res (Hoboken). 2013;65(8):1316\u201324.","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"7","key":"1384_CR66","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nrrheum.2013.26","volume":"9","author":"A Tournadre","year":"2013","unstructured":"Tournadre A, Miossec P. A critical role for immature muscle precursors in myositis. Nat Rev Rheumatol. 2013;9(7):438\u201342.","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"1384_CR67","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm.1959","volume":"15","author":"K Kessenbrock","year":"2009","unstructured":"Kessenbrock K, et al. Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009;15(6):623\u20135.","journal-title":"Nat Med"},{"key":"1384_CR68","doi-asserted-by":"crossref","first-page":"802499","DOI":"10.3389\/fimmu.2022.802499","volume":"13","author":"L Zhao","year":"2022","unstructured":"Zhao L, et al. Machine learning algorithms identify clinical subtypes and cancer in anti-TIF1\u03b3\u2009+\u2009myositis: a longitudinal study of 87 patients. Front Immunol. 2022;13:802499.","journal-title":"Front Immunol"},{"issue":"2","key":"1384_CR69","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/jlb.65.2.137","volume":"65","author":"CA Owen","year":"1999","unstructured":"Owen CA, Campbell EJ. The cell biology of leukocyte-mediated proteolysis. J Leukoc Biol. 1999;65(2):137\u201350.","journal-title":"J Leukoc Biol"},{"issue":"1","key":"1384_CR70","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1186\/s12967-019-02176-z","volume":"17","author":"S Wu","year":"2019","unstructured":"Wu S, et al. Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis. J Transl Med. 2019;17(1):420.","journal-title":"J Transl Med"},{"issue":"2","key":"1384_CR71","first-page":"H385","volume":"275","author":"D Carden","year":"1998","unstructured":"Carden D, et al. Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol. 1998;275(2):H385-92.","journal-title":"Am J Physiol"},{"issue":"2","key":"1384_CR72","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/sj.mn.7800185","volume":"10","author":"CV Ionescu","year":"2003","unstructured":"Ionescu CV, et al. Neutrophils induce sequential focal changes in endothelial adherens junction components: role of elastase. Microcirculation. 2003;10(2):205\u201320.","journal-title":"Microcirculation"},{"issue":"5","key":"1384_CR73","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1513\/pats.200603-078AW","volume":"3","author":"F Chua","year":"2006","unstructured":"Chua F, Laurent GJ. Neutrophil elastase: mediator of extracellular matrix destruction and accumulation. Proc Am Thorac Soc. 2006;3(5):424\u20137.","journal-title":"Proc Am Thorac Soc"},{"issue":"2\u20133","key":"1384_CR74","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-5793(96)01508-6","volume":"402","author":"G Ferry","year":"1997","unstructured":"Ferry G, et al. Activation of MMP-9 by neutrophil elastase in an in vivo model of acute lung injury. FEBS Lett. 1997;402(2\u20133):111\u20135.","journal-title":"FEBS Lett"},{"issue":"Pt 9","key":"1384_CR75","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1242\/jcs.02340","volume":"118","author":"S Wang","year":"2005","unstructured":"Wang S, et al. PECAM-1, alpha6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration. J Cell Sci. 2005;118(Pt 9):2067\u201376.","journal-title":"J Cell Sci"},{"issue":"3","key":"1384_CR76","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00441-017-2785-7","volume":"371","author":"J Wang","year":"2018","unstructured":"Wang J. Neutrophils in tissue injury and repair. Cell Tissue Res. 2018;371(3):531\u20139.","journal-title":"Cell Tissue Res"},{"issue":"3","key":"1384_CR77","first-page":"526","volume":"113","author":"M D'Alessandro","year":"2022","unstructured":"D\u2019Alessandro M, et al. Neutrophil-to-lymphocyte ratio in bronchoalveolar lavage from IPF patients: a novel prognostic biomarker? Minerva Med. 2022;113(3):526\u201331.","journal-title":"Minerva Med"},{"issue":"2","key":"1384_CR78","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1189\/jlb.3HI1014-493R","volume":"98","author":"AD Gregory","year":"2015","unstructured":"Gregory AD, et al. Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis. J Leukoc Biol. 2015;98(2):143\u201352.","journal-title":"J Leukoc Biol"},{"key":"1384_CR79","doi-asserted-by":"crossref","first-page":"24708","DOI":"10.1038\/srep24708","volume":"6","author":"N Arecco","year":"2016","unstructured":"Arecco N, et al. Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation. Sci Rep. 2016;6:24708.","journal-title":"Sci Rep"},{"issue":"1","key":"1384_CR80","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13075-018-1632-x","volume":"20","author":"S Gao","year":"2018","unstructured":"Gao S, et al. The roles of neutrophil serine proteinases in idiopathic inflammatory myopathies. Arthritis Res Ther. 2018;20(1):134.","journal-title":"Arthritis Res Ther"},{"issue":"10","key":"1384_CR81","doi-asserted-by":"crossref","first-page":"e1000639","DOI":"10.1371\/journal.ppat.1000639","volume":"5","author":"CF Urban","year":"2009","unstructured":"Urban CF, et al. Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans. PLoS Pathog. 2009;5(10):e1000639.","journal-title":"PLoS Pathog"},{"issue":"11","key":"1384_CR82","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/nm.2053","volume":"15","author":"J Xu","year":"2009","unstructured":"Xu J, et al. Extracellular histones are major mediators of death in sepsis. Nat Med. 2009;15(11):1318\u201321.","journal-title":"Nat Med"},{"issue":"5","key":"1384_CR83","doi-asserted-by":"crossref","first-page":"107602","DOI":"10.1016\/j.celrep.2020.107602","volume":"31","author":"TD Tsourouktsoglou","year":"2020","unstructured":"Tsourouktsoglou TD, et al. Histones, DNA, and citrullination promote neutrophil extracellular trap inflammation by regulating the localization and activation of TLR4. Cell Rep. 2020;31(5):107602.","journal-title":"Cell Rep"},{"key":"1384_CR84","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.3389\/fimmu.2019.02535","volume":"10","author":"B Shrestha","year":"2019","unstructured":"Shrestha B, et al. Recombinant thrombomodulin suppresses histone-induced neutrophil extracellular trap formation. Front Immunol. 2019;10:2535.","journal-title":"Front Immunol"},{"issue":"4","key":"1384_CR85","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/JLB.3A0620-342R","volume":"109","author":"IN Hsieh","year":"2021","unstructured":"Hsieh IN, et al. Histone H4 directly stimulates neutrophil activation through membrane permeabilization. J Leukoc Biol. 2021;109(4):763\u201375.","journal-title":"J Leukoc Biol"},{"key":"1384_CR86","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fimmu.2012.00360","volume":"3","author":"AS Rohrbach","year":"2012","unstructured":"Rohrbach AS, et al. Activation of PAD4 in NET formation. Front Immunol. 2012;3:360.","journal-title":"Front Immunol"},{"issue":"6","key":"1384_CR87","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1165\/rcmb.2019-0433OC","volume":"63","author":"M Suzuki","year":"2020","unstructured":"Suzuki M, et al. PAD4 deficiency improves bleomycin-induced neutrophil extracellular traps and fibrosis in mouse lung. Am J Respir Cell Mol Biol. 2020;63(6):806\u201318.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"8","key":"1384_CR88","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.4049\/jimmunol.174.8.5057","volume":"174","author":"S Chapuy-Regaud","year":"2005","unstructured":"Chapuy-Regaud S, et al. Fibrin deimination in synovial tissue is not specific for rheumatoid arthritis but commonly occurs during synovitides. J Immunol. 2005;174(8):5057\u201364.","journal-title":"J Immunol"},{"issue":"9","key":"1384_CR89","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1136\/ard.2005.049403","volume":"65","author":"D Makrygiannakis","year":"2006","unstructured":"Makrygiannakis D, et al. Citrullination is an inflammation-dependent process. Ann Rheum Dis. 2006;65(9):1219\u201322.","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"1384_CR90","doi-asserted-by":"crossref","first-page":"e24876","DOI":"10.1002\/jcla.24876","volume":"37","author":"W Wang","year":"2023","unstructured":"Wang W, Peng W, Wu S. Low serum level of citrullinated histone H3 in patients with dermatomyositis. J Clin Lab Anal. 2023;37(6):e24876.","journal-title":"J Clin Lab Anal"},{"issue":"1","key":"1384_CR91","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12931-017-0692-9","volume":"18","author":"KD Samara","year":"2017","unstructured":"Samara KD, et al. Upregulation of citrullination pathway: from autoimmune to idiopathic lung fibrosis. Respir Res. 2017;18(1):218.","journal-title":"Respir Res"},{"issue":"4","key":"1384_CR92","doi-asserted-by":"crossref","first-page":"102781","DOI":"10.1016\/j.autrev.2021.102781","volume":"20","author":"M Negreros","year":"2021","unstructured":"Negreros M, Flores-Suarez LF. A proposed role of neutrophil extracellular traps and their interplay with fibroblasts in ANCA-associated vasculitis lung fibrosis. Autoimmun Rev. 2021;20(4):102781.","journal-title":"Autoimmun Rev"},{"issue":"5","key":"1384_CR93","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.chom.2010.10.005","volume":"8","author":"OA Chow","year":"2010","unstructured":"Chow OA, et al. Statins enhance formation of phagocyte extracellular traps. Cell Host Microbe. 2010;8(5):445\u201354.","journal-title":"Cell Host Microbe"},{"issue":"10","key":"1384_CR94","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.4049\/jimmunol.1302005","volume":"191","author":"JM Kahlenberg","year":"2013","unstructured":"Kahlenberg JM, Kaplan MJ. Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J Immunol. 2013;191(10):4895\u2013901.","journal-title":"J Immunol"},{"issue":"5","key":"1384_CR95","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1007\/s00415-014-7313-z","volume":"261","author":"J van de Vlekkert","year":"2014","unstructured":"van de Vlekkert J, Hoogendijk JE, de Visser M. Long-term follow-up of 62 patients with myositis. J Neurol. 2014;261(5):992\u20138.","journal-title":"J Neurol"},{"issue":"4","key":"1384_CR96","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1093\/rheumatology\/keaa459","volume":"60","author":"J Lim","year":"2021","unstructured":"Lim J, et al. Intravenous immunoglobulins as first-line treatment in idiopathic inflammatory myopathies: a pilot study. Rheumatology (Oxford). 2021;60(4):1784\u201392.","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"1384_CR97","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3109\/14397595.2013.852847","volume":"24","author":"H Ichiyasu","year":"2014","unstructured":"Ichiyasu H, et al. Favorable outcome with hemoperfusion of polymyxin B-immobilized fiber column for rapidly progressive interstitial pneumonia associated with clinically amyopathic dermatomyositis: report of three cases. Mod Rheumatol. 2014;24(2):361\u20135.","journal-title":"Mod Rheumatol"},{"issue":"4","key":"1384_CR98","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3390\/cells9040915","volume":"9","author":"E Fousert","year":"2020","unstructured":"Fousert E, Toes R, Desai J. Neutrophil extracellular traps (NETs) take the central stage in driving autoimmune responses. Cells. 2020;9(4):915.","journal-title":"Cells"},{"issue":"11","key":"1384_CR99","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/intimm\/dxx039","volume":"29","author":"C Galeotti","year":"2017","unstructured":"Galeotti C, Kaveri SV, Bayry J. IVIG-mediated effector functions in autoimmune and inflammatory diseases. Int Immunol. 2017;29(11):491\u20138.","journal-title":"Int Immunol"},{"issue":"1","key":"1384_CR100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.semarthrit.2020.09.020","volume":"51","author":"AH Opinc","year":"2021","unstructured":"Opinc AH, Makowska JS. Antisynthetase syndrome - much more than just a myopathy. Semin Arthritis Rheum. 2021;51(1):72\u201383.","journal-title":"Semin Arthritis Rheum"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-024-01384-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-024-01384-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-024-01384-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T17:19:29Z","timestamp":1732987169000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-024-01384-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":100,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1384"],"URL":"https:\/\/doi.org\/10.1007\/s10238-024-01384-2","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,30]]},"assertion":[{"value":"8 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"115"}}