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We analyzed changes over time in CD4\n                    <jats:sup>+<\/jats:sup>\n                    subsets in AC-patients. We included patients with alcohol use disorder admitted at least twice for treatment. Patients without evidence of liver disease were the control group (CG). We analyzed na\u00efve, memory, TEMRA, Th1, Th2, Th17, early activated, and late activated subsets. During the follow-up, TEMRA T cells\u00a0were increased (1.2\u2009\u00b1\u20091.1% vs. 2.1\u2009\u00b1\u20091.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) in AC-patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095) and Th17 cells\u00a0were decreased (14.1\u2009\u00b1\u20094.3% vs. 12.3\u2009\u00b1\u20096.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) in the CG (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200922). Late activated cells were associated with a decrease in memory cells in both the groups. This association was stronger in AC-patients (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u2009\u2212\u20090.90,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). The proportion of memory cells was correlated with an increased of Th1\/Th2\/Th17\u00a0cells\u00a0 in the CG (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.70,\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.68,\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.63;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01, respectively), whereas in AC-patients was correlated with a decrease in Th17\u00a0cells (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u2009\u2212\u20090.90,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). AC-patients showed an increase in the proportion of TEMRA\u00a0T cells, loss of heterogeneity and decreased CD4\n                    <jats:sup>+<\/jats:sup>\n                    differentiation.\n                  <\/jats:p>","DOI":"10.1007\/s10238-024-01548-0","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T01:43:28Z","timestamp":1736041408000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in CD4+ T cells subsets in patients with alcohol-related cirrhosis"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0247-0351","authenticated-orcid":false,"given":"Paola","family":"Zuluaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Zurera-Egea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Fuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hernandez-Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aina","family":"Teniente-Serra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Mart\u00ednez-C\u00e1ceres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Muga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,5]]},"reference":[{"issue":"8","key":"1548_CR1","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1002\/eji.200939722","volume":"39","author":"F Sallusto","year":"2009","unstructured":"Sallusto F, Lanzavecchia A. 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The methods used in this study met the ethical standards and principles of good clinical practice as established in the 1975 Declaration of Helsinki. All patients provided informed consent for the data transfer and sample extraction.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"31"}}