{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:29:31Z","timestamp":1786980571007,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["YCJJ20230244"],"award-info":[{"award-number":["YCJJ20230244"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Research Fund","award":["2023D24"],"award-info":[{"award-number":["2023D24"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-025-01707-x","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:27:40Z","timestamp":1749515260000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development and validation of a nomogram risk prediction model for PICC-related thrombosis in children with hematological malignancies"],"prefix":"10.1007","volume":"25","author":[{"given":"Maoling","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lexue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genzhen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"1707_CR1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41408-023-00853-3","volume":"13","author":"N Zhang","year":"2023","unstructured":"Zhang N, Wu J, Wang Q, Liang Y, Li X, Chen G, Ma L, Liu X, Zhou F. Global burden of hematologic malignancies and evolution patterns over the past 30\u00a0years. Blood Cancer J. 2023;13:82. https:\/\/doi.org\/10.1038\/s41408-023-00853-3.","journal-title":"Blood Cancer J"},{"key":"1707_CR2","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/s0140-6736(22)01541-0","volume":"400","author":"X Ni","year":"2022","unstructured":"Ni X, Li Z, Li X, Zhang X, Bai G, Liu Y, Zheng R, Zhang Y, Xu X, Liu Y, Jia C, Wang H, Ma X, Zheng H, Su Y, Ge M, Zeng Q, Wang S, Zhao J, Zeng Y, Feng G, Xi Y, Deng Z, Guo Y, Yang Z, Zhang J. Socioeconomic inequalities in cancer incidence and access to health services among children and adolescents in China: a cross-sectional study. Lancet. 2022;400:1020\u201332. https:\/\/doi.org\/10.1016\/s0140-6736(22)01541-0.","journal-title":"Lancet"},{"key":"1707_CR3","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1126\/science.aaw4892","volume":"363","author":"CG Lam","year":"2019","unstructured":"Lam CG, Howard SC, Bouffet E, Pritchard-Jones K. Science and health for all children with cancer. Science. 2019;363:1182\u20136. https:\/\/doi.org\/10.1126\/science.aaw4892.","journal-title":"Science"},{"key":"1707_CR4","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1038\/s41409-021-01246-5","volume":"56","author":"RM Shah","year":"2021","unstructured":"Shah RM. Contemporary haploidentical stem cell transplant strategies in children with hematological malignancies. Bone Marrow Transpl. 2021;56:1518\u201334. https:\/\/doi.org\/10.1038\/s41409-021-01246-5.","journal-title":"Bone Marrow Transpl"},{"key":"1707_CR5","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/s41375-023-01852-w","volume":"37","author":"K Hemminki","year":"2023","unstructured":"Hemminki K, Hemminki J, F\u00f6rsti A, Sud A. Survival in hematological malignancies in the Nordic countries through a half century with correlation to treatment. Leukemia. 2023;37:854\u201363. https:\/\/doi.org\/10.1038\/s41375-023-01852-w.","journal-title":"Leukemia"},{"issue":"1S","key":"1707_CR6","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1097\/NAN.0000000000000396","volume":"44","author":"LA Gorski","year":"2021","unstructured":"Gorski LA, Hadaway L, Hagle ME, Broadhurst D, Clare S, Kleidon T, Meyer BM, Nickel B, Rowley S, Sharpe E, Alexander M. Infusion therapy standards of practice, 8th edition. J Inf Nurs. 2021;44(1S):S1\u2013224. https:\/\/doi.org\/10.1097\/NAN.0000000000000396.","journal-title":"J Inf Nurs"},{"key":"1707_CR7","doi-asserted-by":"publisher","first-page":"4753","DOI":"10.1007\/s00520-019-05276-0","volume":"28","author":"D Mielke","year":"2020","unstructured":"Mielke D, Wittig A, Teichgr\u00e4ber U. Peripherally inserted central venous catheter (PICC) in outpatient and inpatient oncological treatment. Support Care Cancer. 2020;28:4753\u201360. https:\/\/doi.org\/10.1007\/s00520-019-05276-0.","journal-title":"Support Care Cancer"},{"key":"1707_CR8","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s00134-017-4852-7","volume":"43","author":"RS Yamaguchi","year":"2017","unstructured":"Yamaguchi RS, Noritomi DT, Degaspare NV, Mu\u00f1oz GOC, Porto APM, Costa SF, Ranzani OT. Peripherally inserted central catheters are associated with lower risk of bloodstream infection compared with central venous catheters in paediatric intensive care patients: a propensity-adjusted analysis. Intensive Care Med. 2017;43:1097\u2013104. https:\/\/doi.org\/10.1007\/s00134-017-4852-7.","journal-title":"Intensive Care Med"},{"key":"1707_CR9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s13756-022-01180-1","volume":"11","author":"V Pitiriga","year":"2022","unstructured":"Pitiriga V, Bakalis J, Theodoridou K, Kanellopoulos P, Saroglou G, Tsakris A. Lower risk of bloodstream infections for peripherally inserted central catheters compared to central venous catheters in critically ill patients. Antimicrob Resist Infect Control. 2022;11:137. https:\/\/doi.org\/10.1186\/s13756-022-01180-1.","journal-title":"Antimicrob Resist Infect Control"},{"key":"1707_CR10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.thromres.2022.02.024","volume":"213","author":"P Wang","year":"2022","unstructured":"Wang P, Soh KL, Ying Y, Liu Y, Huang X, Huang J. Risk of VTE associated with PORTs and PICCs in cancer patients: a systematic review and meta-analysis. Thromb Res. 2022;213:34\u201342. https:\/\/doi.org\/10.1016\/j.thromres.2022.02.024.","journal-title":"Thromb Res"},{"key":"1707_CR11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13756-023-01285-1","volume":"12","author":"V Pitiriga","year":"2023","unstructured":"Pitiriga V, Bakalis J, Theodoridou K, Dimitroulia E, Saroglou G, Tsakris A. Comparison of microbial colonization rates between central venous catheters and peripherally inserted central catheters. Antimicrob Resist Infect Control. 2023;12:74. https:\/\/doi.org\/10.1186\/s13756-023-01285-1.","journal-title":"Antimicrob Resist Infect Control"},{"key":"1707_CR12","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1055\/s-2007-976177","volume":"33","author":"UH Athale","year":"2007","unstructured":"Athale UH, Chan AK. Thromboembolic complications in pediatric hematologic malignancies. Semin Thromb Hemost. 2007;33:416\u201326. https:\/\/doi.org\/10.1055\/s-2007-976177.","journal-title":"Semin Thromb Hemost"},{"key":"1707_CR13","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00247-018-4096-x","volume":"48","author":"R Gnannt","year":"2018","unstructured":"Gnannt R, Waespe N, Temple M, Amirabadi A, Liu K, Brand\u00e3o LR, Connolly BL. Increased risk of symptomatic upper-extremity venous thrombosis with multiple peripherally inserted central catheter insertions in pediatric patients. Pediatr Radiol. 2018;48:1013\u201320. https:\/\/doi.org\/10.1007\/s00247-018-4096-x.","journal-title":"Pediatr Radiol"},{"key":"1707_CR14","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1111\/jth.13478","volume":"14","author":"JJ Men\u00e9ndez","year":"2016","unstructured":"Men\u00e9ndez JJ, Verd\u00fa C, Calder\u00f3n B, G\u00f3mez-Zamora A, Sch\u00fcffelmann C, de la Cruz JJ, de la Oliva P. Incidence and risk factors of superficial and deep vein thrombosis associated with peripherally inserted central catheters in children. J Thromb Haemost. 2016;14:2158\u201368. https:\/\/doi.org\/10.1111\/jth.13478.","journal-title":"J Thromb Haemost"},{"key":"1707_CR15","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1503\/cmaj.070316","volume":"177","author":"J Dubois","year":"2007","unstructured":"Dubois J, Rypens F, Garel L, David M, Lacroix J, Gauvin F. Incidence of deep vein thrombosis related to peripherally inserted central catheters in children and adolescents. CMAJ. 2007;177:1185\u201390. https:\/\/doi.org\/10.1503\/cmaj.070316.","journal-title":"CMAJ"},{"key":"1707_CR16","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1007\/s00247-017-3915-9","volume":"47","author":"HS Shin","year":"2017","unstructured":"Shin HS, Towbin AJ, Zhang B, Johnson ND, Goldstein SL. Venous thrombosis and stenosis after peripherally inserted central catheter placement in children. Pediatr Radiol. 2017;47:1670\u20135. https:\/\/doi.org\/10.1007\/s00247-017-3915-9.","journal-title":"Pediatr Radiol"},{"key":"1707_CR17","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1097\/ccm.0000000000004461","volume":"48","author":"N Patel","year":"2020","unstructured":"Patel N, Petersen TL, Simpson PM, Feng M, Hanson SJ. Rates of venous thromboembolism and central line-associated bloodstream infections among types of central venous access devices in critically ill children. Crit Care Med. 2020;48:1340\u20138. https:\/\/doi.org\/10.1097\/ccm.0000000000004461.","journal-title":"Crit Care Med"},{"key":"1707_CR18","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1038\/s41390-022-01977-1","volume":"92","author":"AJ Ullman","year":"2022","unstructured":"Ullman AJ, Gibson V, Takashima MD, Kleidon TM, Schults J, Saiyed M, Cattanach P, Paterson R, Cooke M, Rickard CM, Byrnes J, Chopra V. Pediatric central venous access devices: practice, performance, and costs. Pediatr Res. 2022;92:1381\u201390. https:\/\/doi.org\/10.1038\/s41390-022-01977-1.","journal-title":"Pediatr Res"},{"key":"1707_CR19","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1007\/s00431-023-05078-x","volume":"182","author":"L Tian","year":"2023","unstructured":"Tian L, Su Y, Gao H, Wang L, Zeng J, Yang Q, Li W, Lin P, Gao Y, Tan X, Yang H, Feng X, Luo H, Li W, Zhang X, Wu X, Li Y. Development and validation of a nomogram model for central venous access device-related thrombosis in hospitalized children. Eur J Pediatr. 2023;182:4909\u201319. https:\/\/doi.org\/10.1007\/s00431-023-05078-x.","journal-title":"Eur J Pediatr"},{"key":"1707_CR20","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.21037\/tp-22-529","volume":"11","author":"S Li","year":"2022","unstructured":"Li S, Luo Y, Deng J, Zeng J, Fan M, Wang T, Xia Q. Risk factors for central venous catheter-related thrombosis in hospitalized children: a single-center a retrospective cohort study. Transl Pediatr. 2022;11:1840\u201351. https:\/\/doi.org\/10.21037\/tp-22-529.","journal-title":"Transl Pediatr"},{"key":"1707_CR21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.asjsur.2023.05.043","volume":"47","author":"L Chen","year":"2024","unstructured":"Chen L, Lu Y, Wang L, Pan Y, Zhou X. Construction of a nomogram risk prediction model for PICC-related venous thrombosis and its application. Asian J Surg. 2024;47:107\u201311. https:\/\/doi.org\/10.1016\/j.asjsur.2023.05.043.","journal-title":"Asian J Surg"},{"key":"1707_CR22","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.jvsv.2020.12.075","volume":"9","author":"Y Lin","year":"2021","unstructured":"Lin Y, Zeng Z, Lin R, Zheng J, Liu S, Gao X. The Caprini thrombosis risk model predicts the risk of peripherally inserted central catheter-related upper extremity venous thrombosis in patients with cancer. J Vasc Surg Venous Lymphat Disord. 2021;9:1151\u20138. https:\/\/doi.org\/10.1016\/j.jvsv.2020.12.075.","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"1707_CR23","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.semcancer.2020.10.013","volume":"84","author":"TH Tran","year":"2022","unstructured":"Tran TH, Hunger SP. The genomic landscape of pediatric acute lymphoblastic leukemia and precision medicine opportunities. Semin Cancer Biol. 2022;84:144\u201352. https:\/\/doi.org\/10.1016\/j.semcancer.2020.10.013.","journal-title":"Semin Cancer Biol"},{"key":"1707_CR24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.thromres.2017.09.002","volume":"158","author":"IL Gade","year":"2017","unstructured":"Gade IL, Br\u00e6kkan S, N\u00e6ss IA, Hansen JB, Rosendaal F, Cannegieter S, Overvad K, Jensvoll H, Hammerstr\u00f8m J, Gran OV, Tj\u00f8nneland A, Kristensen SR, Severinsen MT. Epidemiology of venous thromboembolism in hematological cancers: the scandinavian thrombosis and cancer (STAC) cohort. Thromb Res. 2017;158:157\u201360. https:\/\/doi.org\/10.1016\/j.thromres.2017.09.002.","journal-title":"Thromb Res"},{"key":"1707_CR25","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nrc3066","volume":"11","author":"H Schwarzenbach","year":"2011","unstructured":"Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer. 2011;11:426\u201337. https:\/\/doi.org\/10.1038\/nrc3066.","journal-title":"Nat Rev Cancer"},{"key":"1707_CR26","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1160\/th17-08-0596","volume":"118","author":"E Campello","year":"2018","unstructured":"Campello E, Henderson MW, Noubouossie DF, Simioni P, Key NS. Contact system activation and cancer: new insights in the pathophysiology of cancer-associated thrombosis. Thromb Haemost. 2018;118:251\u201365. https:\/\/doi.org\/10.1160\/th17-08-0596.","journal-title":"Thromb Haemost"},{"key":"1707_CR27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fped.2017.00012","volume":"5","author":"RH Ko","year":"2017","unstructured":"Ko RH, Thornburg CD. Venous thromboembolism in children with cancer and blood disorders. Front Pediatr. 2017;5:12. https:\/\/doi.org\/10.3389\/fped.2017.00012.","journal-title":"Front Pediatr"},{"key":"1707_CR28","first-page":"120","volume":"16","author":"LG Mitchell","year":"1994","unstructured":"Mitchell LG, Halton JM, Vegh PA, Barr RD, Venneri T, Pai KM, Andrew ME. Effect of disease and chemotherapy on hemostasis in children with acute lymphoid leukemia. Am J Pediatr Hematol Oncol. 1994;16:120\u20136.","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"1707_CR29","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1177\/1076029612450771","volume":"19","author":"M Albayrak","year":"2013","unstructured":"Albayrak M, G\u00fcrsel T, Kaya Z, Ko\u00e7ak U. Alterations in procoagulant, anticoagulant, and fibrinolytic systems before and after start of induction chemotherapy in children with acute lymphoblastic leukemia. Clin Appl Thromb Hemost. 2013;19:644\u201351. https:\/\/doi.org\/10.1177\/1076029612450771.","journal-title":"Clin Appl Thromb Hemost"},{"key":"1707_CR30","doi-asserted-by":"publisher","first-page":"e14468","DOI":"10.1111\/iwj.14468","volume":"21","author":"N Ding","year":"2023","unstructured":"Ding N, Peng H, Zhao W, Yi Y, Ma Y, Guo Y, Li H, Wu X. Effects of peripherally inserted central catheter (PICC) materials and designs on reduction of PICC-related complications: a systematic review and meta-analysis. Int Wound J. 2023;21:e14468. https:\/\/doi.org\/10.1111\/iwj.14468.","journal-title":"Int Wound J"},{"key":"1707_CR31","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.addr.2011.06.012","volume":"63","author":"KN Ekdahl","year":"2011","unstructured":"Ekdahl KN, Lambris JD, Elwing H, Ricklin D, Nilsson PH, Teramura Y, Nicholls IA, Nilsson B. Innate immunity activation on biomaterial surfaces: a mechanistic model and coping strategies. Adv Drug Deliv Rev. 2011;63:1042\u201350. https:\/\/doi.org\/10.1016\/j.addr.2011.06.012.","journal-title":"Adv Drug Deliv Rev"},{"key":"1707_CR32","doi-asserted-by":"publisher","first-page":"10090","DOI":"10.1038\/s41598-020-67038-x","volume":"10","author":"X Song","year":"2020","unstructured":"Song X, Lu H, Chen F, Bao Z, Li S, Li S, Peng Y, Liu Q, Chen X, Li J, Zhang W. A longitudinal observational retrospective study on risk factors and predictive model of PICC associated thrombosis in cancer patients. Sci Rep. 2020;10:10090. https:\/\/doi.org\/10.1038\/s41598-020-67038-x.","journal-title":"Sci Rep"},{"key":"1707_CR33","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1515\/biol-2018-0012","volume":"13","author":"C Wang","year":"2018","unstructured":"Wang C, Cui F, Li J, Yuan X, Wang J, Liu L, Wang M. Risk factors for venous thromboembolism in hospitalized patients in the Chinese population. Open Life Sci. 2018;13:82\u20139. https:\/\/doi.org\/10.1515\/biol-2018-0012.","journal-title":"Open Life Sci"},{"key":"1707_CR34","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.thromres.2021.01.009","volume":"200","author":"AV Badheka","year":"2021","unstructured":"Badheka AV, Hodge D, Ramesh S, Bloxham J, Espinoza E, Allareddy V, Karhade DS, Chegondi M, Allareddy V. Catheter related thrombosis in hospitalized infants: a neural network approach to predict risk factors. Thromb Res. 2021;200:34\u201340. https:\/\/doi.org\/10.1016\/j.thromres.2021.01.009.","journal-title":"Thromb Res"},{"key":"1707_CR35","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1016\/j.ekir.2021.09.009","volume":"6","author":"MA Sohail","year":"2021","unstructured":"Sohail MA, Vachharajani TJ, Anvari E. Central venous catheters for hemodialysis-the myth and the evidence. Kidney Int Rep. 2021;6:2958\u201368. https:\/\/doi.org\/10.1016\/j.ekir.2021.09.009.","journal-title":"Kidney Int Rep"},{"key":"1707_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004084.pub3","author":"X Ge","year":"2012","unstructured":"Ge X, Cavallazzi R, Li C, Pan SM, Wang Y-W, Wang F-L. Central venous access sites for the prevention of venous thrombosis, stenosis and infection. Cochrane Database Syst Rev. 2012. https:\/\/doi.org\/10.1002\/14651858.CD004084.pub3.","journal-title":"Cochrane Database Syst Rev"},{"key":"1707_CR37","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s00109-006-0101-1","volume":"84","author":"WS Nesbitt","year":"2006","unstructured":"Nesbitt WS, Mangin P, Salem HH, Jackson SP. The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis. J Mol Med (Berl). 2006;84:989\u201395. https:\/\/doi.org\/10.1007\/s00109-006-0101-1.","journal-title":"J Mol Med (Berl)"},{"key":"1707_CR38","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1542\/hpeds.2014-0041","volume":"5","author":"AB Smitherman","year":"2015","unstructured":"Smitherman AB, Alexander T, Connelly M, Snavely AC, Weston BW, Liles EA, Steiner MJ. The incidence of catheter-associated venous thrombosis in noncritically ill children. Hosp Pediatr. 2015;5:59\u201366. https:\/\/doi.org\/10.1542\/hpeds.2014-0041.","journal-title":"Hosp Pediatr"},{"key":"1707_CR39","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1055\/s-0040-1720976","volume":"121","author":"L Tian","year":"2021","unstructured":"Tian L, Li W, Su Y, Gao H, Yang Q, Lin P, Wang L, Zeng J, Li Y. Risk factors for central venous access device-related thrombosis in hospitalized children: a systematic review and meta-analysis. Thromb Haemost. 2021;121:625\u201340. https:\/\/doi.org\/10.1055\/s-0040-1720976.","journal-title":"Thromb Haemost"},{"key":"1707_CR40","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1177\/014860710803200188","volume":"32","author":"V Kakzanov","year":"2008","unstructured":"Kakzanov V, Monagle P, Chan AK. Thromboembolism in infants and children with gastrointestinal failure receiving long-term parenteral nutrition. JPEN J Parenter Enteral Nutr. 2008;32:88\u201393. https:\/\/doi.org\/10.1177\/014860710803200188.","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"1707_CR41","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1055\/s-0030-1248720","volume":"36","author":"P de Moerloose","year":"2010","unstructured":"de Moerloose P, Boehlen F, Neerman-Arbez M. Fibrinogen and the risk of thrombosis. Semin Thromb Hemost. 2010;36:7\u201317. https:\/\/doi.org\/10.1055\/s-0030-1248720.","journal-title":"Semin Thromb Hemost"},{"key":"1707_CR42","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/ajh.25482","volume":"94","author":"ED Johnson","year":"2019","unstructured":"Johnson ED, Schell JC, Rodgers GM. The D-dimer assay. Am J Hematol. 2019;94:833\u20139. https:\/\/doi.org\/10.1002\/ajh.25482.","journal-title":"Am J Hematol"},{"key":"1707_CR43","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.thromres.2015.02.007","volume":"135","author":"M Sartori","year":"2015","unstructured":"Sartori M, Migliaccio L, Favaretto E, Cini M, Legnani C, Palareti G, Cosmi B. D-dimer for the diagnosis of upper extremity deep and superficial venous thrombosis. Thromb Res. 2015;135:673\u20138. https:\/\/doi.org\/10.1016\/j.thromres.2015.02.007.","journal-title":"Thromb Res"},{"key":"1707_CR44","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.thromres.2022.03.019","volume":"213","author":"B Cosmi","year":"2022","unstructured":"Cosmi B, Legnani C, Cini M, Tomba S, Migliaccio L, Borgese L, Sartori M, Palareti G. Thrombotic burden, D-dimer levels and complete compression ultrasound for diagnosis of acute symptomatic deep vein thrombosis of the lower limbs. Thromb Res. 2022;213:163\u20139. https:\/\/doi.org\/10.1016\/j.thromres.2022.03.019.","journal-title":"Thromb Res"},{"key":"1707_CR45","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.ejvs.2017.12.002","volume":"55","author":"A Chandrashekar","year":"2018","unstructured":"Chandrashekar A, Singh G, Jonah G, Sikalas N, Labropoulos N. Mechanical and biochemical role of fibrin within a venous thrombus. Eur J Vasc Endovasc Surg. 2018;55:417\u201324. https:\/\/doi.org\/10.1016\/j.ejvs.2017.12.002.","journal-title":"Eur J Vasc Endovasc Surg"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01707-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-025-01707-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01707-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:51:31Z","timestamp":1764917491000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-025-01707-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1707"],"URL":"https:\/\/doi.org\/10.1007\/s10238-025-01707-x","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"assertion":[{"value":"30 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The institutional review board of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology approved this study (TJ-IRB20230851). As this study was a retrospective cohort study, informed consent was not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"195"}}