{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:17:10Z","timestamp":1793297830507,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Changzhou Science and Technology Bureau","award":["CJ20243007"],"award-info":[{"award-number":["CJ20243007"]}]},{"name":"Changzhou Science and Technology Bureau","award":["CJ20243007"],"award-info":[{"award-number":["CJ20243007"]}]},{"name":"Changzhou Science and Technology Bureau","award":["CJ20243007"],"award-info":[{"award-number":["CJ20243007"]}]},{"name":"Changzhou Science and Technology Bureau","award":["CJ20243007"],"award-info":[{"award-number":["CJ20243007"]}]},{"name":"Changzhou Municipal Health Commission","award":["QY202301"],"award-info":[{"award-number":["QY202301"]}]},{"name":"Changzhou Municipal Health Commission","award":["QY202301"],"award-info":[{"award-number":["QY202301"]}]},{"name":"Changzhou Municipal Health Commission","award":["QY202301"],"award-info":[{"award-number":["QY202301"]}]},{"name":"Changzhou Municipal Health Commission","award":["QY202301"],"award-info":[{"award-number":["QY202301"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-025-01722-y","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:38:20Z","timestamp":1748479100000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mechanism and role of ferroptosis in the development of gastric cancer"],"prefix":"10.1007","volume":"25","author":[{"given":"Fang","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Xia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"issue":"10251","key":"1722_CR1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","volume":"396","author":"EC Smyth","year":"2020","unstructured":"Smyth EC, et al. Gastric cancer. Lancet. 2020;396(10251):635\u201348. https:\/\/doi.org\/10.1016\/S0140-6736(20)31288-5.","journal-title":"Lancet"},{"issue":"1","key":"1722_CR2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13045-023-01451-3","volume":"16","author":"WL Guan","year":"2023","unstructured":"Guan WL, He Y, Xu RH. Gastric cancer treatment: recent progress and future perspectives. J Hematol Oncol. 2023;16(1):57. https:\/\/doi.org\/10.1186\/s13045-023-01451-3.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"1722_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","volume":"6","author":"HF Yan","year":"2021","unstructured":"Yan HF, et al. Ferroptosis: mechanisms and links with diseases. Signal Transduct Target Ther. 2021;6(1):49. https:\/\/doi.org\/10.1038\/s41392-020-00428-9.","journal-title":"Signal Transduct Target Ther"},{"issue":"10","key":"1722_CR4","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1038\/s41418-021-00859-z","volume":"28","author":"X Chen","year":"2021","unstructured":"Chen X, et al. Organelle-specific regulation of ferroptosis. Cell Death Differ. 2021;28(10):2843\u201356. https:\/\/doi.org\/10.1038\/s41418-021-00859-z.","journal-title":"Cell Death Differ"},{"issue":"7","key":"1722_CR5","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1016\/j.ymthe.2021.03.022","volume":"29","author":"H Wang","year":"2021","unstructured":"Wang H, et al. Emerging mechanisms and targeted therapy of ferroptosis in cancer. Mol Ther. 2021;29(7):2185\u2013208. https:\/\/doi.org\/10.1016\/j.ymthe.2021.03.022.","journal-title":"Mol Ther"},{"issue":"20","key":"1722_CR6","doi-asserted-by":"publisher","first-page":"e38193","DOI":"10.1097\/MD.0000000000038193","volume":"103","author":"J Yu","year":"2024","unstructured":"Yu J, et al. Identification and characterization of ferroptosis-related genes in therapy-resistant gastric cancer. Medicine (Baltimore). 2024;103(20):e38193. https:\/\/doi.org\/10.1097\/MD.0000000000038193.","journal-title":"Medicine (Baltimore)"},{"key":"1722_CR7","doi-asserted-by":"publisher","first-page":"104919","DOI":"10.1016\/j.phrs.2020.104919","volume":"159","author":"Y Qiu","year":"2020","unstructured":"Qiu Y, et al. The application of ferroptosis in diseases. Pharmacol Res. 2020;159:104919. https:\/\/doi.org\/10.1016\/j.phrs.2020.104919.","journal-title":"Pharmacol Res"},{"issue":"1","key":"1722_CR8","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12864-022-08296-z","volume":"23","author":"Y Xu","year":"2022","unstructured":"Xu Y, et al. Ferroptosis-associated DNA methylation signature predicts overall survival in patients with head and neck squamous cell carcinoma. BMC Genomics. 2022;23(1):63. https:\/\/doi.org\/10.1186\/s12864-022-08296-z.","journal-title":"BMC Genomics"},{"issue":"2","key":"1722_CR9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.21037\/atm-21-6265","volume":"10","author":"X Yang","year":"2022","unstructured":"Yang X, et al. Ferroptosis-related genes identify tumor immune microenvironment characterization for the prediction of prognosis in cervical cancer. Ann Transl Med. 2022;10(2):123. https:\/\/doi.org\/10.21037\/atm-21-6265.","journal-title":"Ann Transl Med"},{"issue":"6","key":"1722_CR10","doi-asserted-by":"publisher","first-page":"151919","DOI":"10.1016\/j.acthis.2022.151919","volume":"124","author":"ZH Bao","year":"2022","unstructured":"Bao ZH, et al. The mechanism and progress of ferroptosis in pancreatic cancer. Acta Histochem. 2022;124(6):151919. https:\/\/doi.org\/10.1016\/j.acthis.2022.151919.","journal-title":"Acta Histochem"},{"issue":"4","key":"1722_CR11","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1038\/s41418-020-00728-1","volume":"28","author":"X Chen","year":"2021","unstructured":"Chen X, et al. Cellular degradation systems in ferroptosis. Cell Death Differ. 2021;28(4):1135\u201348. https:\/\/doi.org\/10.1038\/s41418-020-00728-1.","journal-title":"Cell Death Differ"},{"issue":"1","key":"1722_CR12","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/s41392-023-01720-0","volume":"8","author":"Y Wang","year":"2023","unstructured":"Wang Y, et al. Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases. Signal Transduct Target Ther. 2023;8(1):449. https:\/\/doi.org\/10.1038\/s41392-023-01720-0.","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"1722_CR13","doi-asserted-by":"publisher","first-page":"e2006203","DOI":"10.1371\/journal.pbio.2006203","volume":"16","author":"H Feng","year":"2018","unstructured":"Feng H, Stockwell BR. Unsolved mysteries: How does lipid peroxidation cause ferroptosis? PLoS Biol. 2018;16(5):e2006203. https:\/\/doi.org\/10.1371\/journal.pbio.2006203.","journal-title":"PLoS Biol"},{"issue":"1\u20133","key":"1722_CR14","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1089\/ars.2022.0179","volume":"40","author":"V Consoli","year":"2024","unstructured":"Consoli V, et al. Novel insights on ferroptosis modulation as potential strategy for cancer treatment: when nature kills. Antioxid Redox Signal. 2024;40(1\u20133):40\u201385. https:\/\/doi.org\/10.1089\/ars.2022.0179.","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"1722_CR15","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.chembiol.2018.11.016","volume":"26","author":"L Magtanong","year":"2019","unstructured":"Magtanong L, et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state. Cell Chem Biol. 2019;26(3):420\u201332. https:\/\/doi.org\/10.1016\/j.chembiol.2018.11.016.","journal-title":"Cell Chem Biol"},{"issue":"1","key":"1722_CR16","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12964-022-01025-9","volume":"21","author":"A Amos","year":"2023","unstructured":"Amos A, et al. The Warburg effect modulates DHODH role in ferroptosis: a review. Cell Commun Signal. 2023;21(1):100. https:\/\/doi.org\/10.1186\/s12964-022-01025-9.","journal-title":"Cell Commun Signal"},{"issue":"10","key":"1722_CR17","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1016\/j.celrep.2020.02.049","volume":"30","author":"H Feng","year":"2020","unstructured":"Feng H, et al. Transferrin receptor is a specific ferroptosis marker. Cell Rep. 2020;30(10):3411-3423.e7. https:\/\/doi.org\/10.1016\/j.celrep.2020.02.049.","journal-title":"Cell Rep"},{"issue":"20","key":"1722_CR18","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.21037\/atm-21-4863","volume":"9","author":"M Jiang","year":"2021","unstructured":"Jiang M, et al. A narrative review of mechanisms of ferroptosis in cancer: new challenges and opportunities. Ann Transl Med. 2021;9(20):1599. https:\/\/doi.org\/10.21037\/atm-21-4863.","journal-title":"Ann Transl Med"},{"key":"1722_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081504","author":"H Chen","year":"2022","unstructured":"Chen H, et al. Ferroptosis and its multifaceted role in cancer: mechanisms and therapeutic approach. Antioxidants (Basel). 2022. https:\/\/doi.org\/10.3390\/antiox11081504.","journal-title":"Antioxidants (Basel)."},{"issue":"8","key":"1722_CR20","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1089\/ars.2018.7502","volume":"30","author":"R Mittler","year":"2019","unstructured":"Mittler R, et al. NEET proteins: a new link between iron metabolism, reactive oxygen species, and cancer. Antioxid Redox Signal. 2019;30(8):1083\u201395. https:\/\/doi.org\/10.1089\/ars.2018.7502.","journal-title":"Antioxid Redox Signal"},{"key":"1722_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210037","author":"X Cheng","year":"2023","unstructured":"Cheng X, et al. Mitochondrial regulation of ferroptosis in cancer therapy. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms241210037.","journal-title":"Int J Mol Sci"},{"key":"1722_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175451","author":"C Abe","year":"2022","unstructured":"Abe C, Miyazawa T, Miyazawa T. Current use of Fenton reaction in drugs and food. Molecules. 2022. https:\/\/doi.org\/10.3390\/molecules27175451.","journal-title":"Molecules"},{"key":"1722_CR23","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","volume":"152","author":"F Ursini","year":"2020","unstructured":"Ursini F, Maiorino M. Lipid peroxidation and ferroptosis: the role of GSH and GPx4. Free Radic Biol Med. 2020;152:175\u201385. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2020.02.027.","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"1722_CR24","first-page":"3106","volume":"10","author":"W Lin","year":"2020","unstructured":"Lin W, et al. SLC7A11\/xCT in cancer: biological functions and therapeutic implications. Am J Cancer Res. 2020;10(10):3106\u201326.","journal-title":"Am J Cancer Res"},{"issue":"1","key":"1722_CR25","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12964-023-01369-w","volume":"22","author":"L Liu","year":"2024","unstructured":"Liu L, et al. Ferroptosis: a promising candidate for exosome-mediated regulation in different diseases. Cell Commun Signal. 2024;22(1):6. https:\/\/doi.org\/10.1186\/s12964-023-01369-w.","journal-title":"Cell Commun Signal"},{"issue":"1","key":"1722_CR26","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.cmet.2020.12.007","volume":"33","author":"YP Kang","year":"2021","unstructured":"Kang YP, et al. Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. Cell Metab. 2021;33(1):174-189.e7. https:\/\/doi.org\/10.1016\/j.cmet.2020.12.007.","journal-title":"Cell Metab"},{"issue":"3","key":"1722_CR27","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","volume":"172","author":"I Ingold","year":"2018","unstructured":"Ingold I, et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell. 2018;172(3):409-422.e21. https:\/\/doi.org\/10.1016\/j.cell.2017.11.048.","journal-title":"Cell"},{"issue":"9","key":"1722_CR28","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.molmed.2023.05.013","volume":"29","author":"W Li","year":"2023","unstructured":"Li W, et al. FSP1: a key regulator of ferroptosis. Trends Mol Med. 2023;29(9):753\u201364. https:\/\/doi.org\/10.1016\/j.molmed.2023.05.013.","journal-title":"Trends Mol Med"},{"issue":"7784","key":"1722_CR29","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker K, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575(7784):688\u201392. https:\/\/doi.org\/10.1038\/s41586-019-1705-2.","journal-title":"Nature"},{"issue":"6632","key":"1722_CR30","doi-asserted-by":"publisher","first-page":"eaaw3835","DOI":"10.1126\/science.aaw3835","volume":"379","author":"AP Feinberg","year":"2023","unstructured":"Feinberg AP, Levchenko A. Epigenetics as a mediator of plasticity in cancer. Science. 2023;379(6632):eaaw3835. https:\/\/doi.org\/10.1126\/science.aaw3835.","journal-title":"Science"},{"issue":"1","key":"1722_CR31","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41419-025-07510-6","volume":"16","author":"R Deng","year":"2025","unstructured":"Deng R, et al. Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer. Cell Death Dis. 2025;16(1):254. https:\/\/doi.org\/10.1038\/s41419-025-07510-6.","journal-title":"Cell Death Dis"},{"issue":"7860","key":"1722_CR32","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","volume":"593","author":"C Mao","year":"2021","unstructured":"Mao C, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593(7860):586\u201390. https:\/\/doi.org\/10.1038\/s41586-021-03539-7.","journal-title":"Nature"},{"key":"1722_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.810327","volume":"10","author":"Q Hu","year":"2022","unstructured":"Hu Q, et al. Blockade of GCH1\/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis. Front Cell Dev Biol. 2022;10: 810327. https:\/\/doi.org\/10.3389\/fcell.2022.810327.","journal-title":"Front Cell Dev Biol"},{"issue":"12","key":"1722_CR34","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/s41589-020-0613-y","volume":"16","author":"M Soula","year":"2020","unstructured":"Soula M, et al. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers. Nat Chem Biol. 2020;16(12):1351\u201360. https:\/\/doi.org\/10.1038\/s41589-020-0613-y.","journal-title":"Nat Chem Biol"},{"key":"1722_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061505","author":"AM Battaglia","year":"2020","unstructured":"Battaglia AM, et al. Ferroptosis and cancer: mitochondria meet the \u201ciron maiden\u201d cell death. Cells. 2020. https:\/\/doi.org\/10.3390\/cells9061505.","journal-title":"Cells"},{"key":"1722_CR36","doi-asserted-by":"publisher","first-page":"116893","DOI":"10.1016\/j.lfs.2019.116893","volume":"237","author":"Y Niu","year":"2019","unstructured":"Niu Y, et al. RETRACTED: physcion 8-O-\u03b2-glucopyranoside induced ferroptosis via regulating miR-103a-3p\/GLS2 axis in gastric cancer. Life Sci. 2019;237:116893. https:\/\/doi.org\/10.1016\/j.lfs.2019.116893.","journal-title":"Life Sci"},{"issue":"1","key":"1722_CR37","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12943-020-01168-8","volume":"19","author":"H Zhang","year":"2020","unstructured":"Zhang H, et al. CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer. Mol Cancer. 2020;19(1):43. https:\/\/doi.org\/10.1186\/s12943-020-01168-8.","journal-title":"Mol Cancer"},{"key":"1722_CR38","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2022.12634","author":"G Wang","year":"2022","unstructured":"Wang G, et al. Ferroptosis-related long non-coding RNAs and the roles of LASTR in stomach adenocarcinoma. Mol Med Rep. 2022. https:\/\/doi.org\/10.3892\/mmr.2022.12634.","journal-title":"Mol Med Rep"},{"issue":"1","key":"1722_CR39","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12935-021-02122-4","volume":"20","author":"C Li","year":"2020","unstructured":"Li C, et al. Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599\/EIF4A1 axis. Cancer Cell Int. 2020;20(1):84. https:\/\/doi.org\/10.1186\/s12935-021-02122-4.","journal-title":"Cancer Cell Int"},{"key":"1722_CR40","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvac062","author":"M Jiang","year":"2022","unstructured":"Jiang M, et al. Circ_0000190 sponges miR-382-5p to suppress cell proliferation and motility and promote cell death by targeting ZNRF3 in gastric cancer. J Biochem. 2022. https:\/\/doi.org\/10.1093\/jb\/mvac062.","journal-title":"J Biochem"},{"issue":"9","key":"1722_CR41","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1136\/gutjnl-2019-319696","volume":"69","author":"Y Guo","year":"2020","unstructured":"Guo Y, et al. Effect of Helicobacter pylori on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer. Gut. 2020;69(9):1598\u2013607. https:\/\/doi.org\/10.1136\/gutjnl-2019-319696.","journal-title":"Gut"},{"issue":"12","key":"1722_CR42","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1056\/NEJMcp1710945","volume":"380","author":"SE Crowe","year":"2019","unstructured":"Crowe SE. Helicobacter pylori Infection. N Engl J Med. 2019;380(12):1158\u201365.","journal-title":"N Engl J Med"},{"issue":"2","key":"1722_CR43","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/s12276-024-01167-5","volume":"56","author":"Y Peng","year":"2024","unstructured":"Peng Y, et al. Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer. Exp Mol Med. 2024;56(2):441\u201352. https:\/\/doi.org\/10.1038\/s12276-024-01167-5.","journal-title":"Exp Mol Med"},{"issue":"18","key":"1722_CR44","doi-asserted-by":"publisher","first-page":"e37263","DOI":"10.1016\/j.heliyon.2024.e37263","volume":"10","author":"M Chen","year":"2024","unstructured":"Chen M, et al. Induction, growth, drug resistance, and metastasis: a comprehensive summary of the relationship between STAT3 and gastric cancer. Heliyon. 2024;10(18):e37263. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e37263.","journal-title":"Heliyon"},{"issue":"1","key":"1722_CR45","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1186\/s13287-021-02394-7","volume":"12","author":"H Ni","year":"2021","unstructured":"Ni H, et al. MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis. Stem Cell Res Ther. 2021;12(1):325. https:\/\/doi.org\/10.1186\/s13287-021-02394-7.","journal-title":"Stem Cell Res Ther"},{"key":"1722_CR46","doi-asserted-by":"publisher","first-page":"1458716","DOI":"10.3389\/fcell.2024.1458716","volume":"12","author":"J Sun","year":"2024","unstructured":"Sun J, et al. CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers. Front Cell Dev Biol. 2024;12:1458716. https:\/\/doi.org\/10.3389\/fcell.2024.1458716.","journal-title":"Front Cell Dev Biol"},{"key":"1722_CR47","doi-asserted-by":"publisher","first-page":"694003","DOI":"10.3389\/fcell.2021.694003","volume":"9","author":"S Xiao","year":"2021","unstructured":"Xiao S, et al. Expression of ferroptosis-related genes shapes tumor microenvironment and pharmacological profile in gastric cancer. Front Cell Dev Biol. 2021;9:694003. https:\/\/doi.org\/10.3389\/fcell.2021.694003.","journal-title":"Front Cell Dev Biol"},{"key":"1722_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122591","author":"MY Hsu","year":"2020","unstructured":"Hsu MY, et al. Iron: an essential element of cancer metabolism. Cells. 2020. https:\/\/doi.org\/10.3390\/cells9122591.","journal-title":"Cells"},{"key":"1722_CR49","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3389\/fonc.2018.00549","volume":"8","author":"C Pfeifhofer-Obermair","year":"2018","unstructured":"Pfeifhofer-Obermair C, et al. Iron in the tumor microenvironment-connecting the dots. Front Oncol. 2018;8:549. https:\/\/doi.org\/10.3389\/fonc.2018.00549.","journal-title":"Front Oncol"},{"issue":"8","key":"1722_CR50","doi-asserted-by":"publisher","first-page":"e1386","DOI":"10.1002\/ctm2.1386","volume":"13","author":"J Li","year":"2023","unstructured":"Li J, et al. Tumour-associated macrophages in gastric cancer: from function and mechanism to application. Clin Transl Med. 2023;13(8):e1386. https:\/\/doi.org\/10.1002\/ctm2.1386.","journal-title":"Clin Transl Med"},{"issue":"2","key":"1722_CR51","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.bbrc.2019.01.090","volume":"510","author":"Q Wen","year":"2019","unstructured":"Wen Q, et al. The release and activity of HMGB1 in ferroptosis. Biochem Biophys Res Commun. 2019;510(2):278\u201383. https:\/\/doi.org\/10.1016\/j.bbrc.2019.01.090.","journal-title":"Biochem Biophys Res Commun"},{"issue":"7755","key":"1722_CR52","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","volume":"569","author":"W Wang","year":"2019","unstructured":"Wang W, et al. CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569(7755):270\u20134. https:\/\/doi.org\/10.1038\/s41586-019-1170-y.","journal-title":"Nature"},{"issue":"7939","key":"1722_CR53","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41586-022-05443-0","volume":"612","author":"R Kim","year":"2022","unstructured":"Kim R, et al. Ferroptosis of tumour neutrophils causes immune suppression in cancer. Nature. 2022;612(7939):338\u201346. https:\/\/doi.org\/10.1038\/s41586-022-05443-0.","journal-title":"Nature"},{"issue":"2","key":"1722_CR54","doi-asserted-by":"publisher","first-page":"117","DOI":"10.2174\/1566523219666190628152137","volume":"19","author":"X Xia","year":"2019","unstructured":"Xia X, et al. The relationship between ferroptosis and tumors: a novel landscape for therapeutic approach. Curr Gene Ther. 2019;19(2):117\u201324. https:\/\/doi.org\/10.2174\/1566523219666190628152137.","journal-title":"Curr Gene Ther"},{"issue":"3","key":"1722_CR55","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.gendis.2021.12.023","volume":"10","author":"M Chen","year":"2023","unstructured":"Chen M, et al. Cysteine dioxygenase type 1 (CDO1): its functional role in physiological and pathophysiological processes. Genes Dis. 2023;10(3):877\u201390. https:\/\/doi.org\/10.1016\/j.gendis.2021.12.023.","journal-title":"Genes Dis"},{"issue":"4","key":"1722_CR56","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.chembiol.2020.03.013","volume":"27","author":"BR Stockwell","year":"2020","unstructured":"Stockwell BR, Jiang X. The chemistry and biology of ferroptosis. Cell Chem Biol. 2020;27(4):365\u201375. https:\/\/doi.org\/10.1016\/j.chembiol.2020.03.013.","journal-title":"Cell Chem Biol"},{"issue":"7","key":"1722_CR57","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","volume":"21","author":"H Sies","year":"2020","unstructured":"Sies H, Jones DP. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol. 2020;21(7):363\u201383. https:\/\/doi.org\/10.1038\/s41580-020-0230-3.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"8","key":"1722_CR58","doi-asserted-by":"publisher","first-page":"6321","DOI":"10.1007\/s11033-020-05669-z","volume":"47","author":"BH Kiani","year":"2020","unstructured":"Kiani BH, et al. Artemisinin and its derivatives: a promising cancer therapy. Mol Biol Rep. 2020;47(8):6321\u201336. https:\/\/doi.org\/10.1007\/s11033-020-05669-z.","journal-title":"Mol Biol Rep"},{"issue":"2","key":"1722_CR59","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41401-020-0478-3","volume":"42","author":"ZJ Li","year":"2021","unstructured":"Li ZJ, et al. Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma. Acta Pharmacol Sin. 2021;42(2):301\u201310. https:\/\/doi.org\/10.1038\/s41401-020-0478-3.","journal-title":"Acta Pharmacol Sin"},{"issue":"10","key":"1722_CR60","first-page":"1933","volume":"8","author":"S Wang","year":"2018","unstructured":"Wang S, et al. Iron and magnetic: new research direction of the ferroptosis-based cancer therapy. Am J Cancer Res. 2018;8(10):1933\u201346.","journal-title":"Am J Cancer Res"},{"key":"1722_CR61","doi-asserted-by":"publisher","first-page":"9598783","DOI":"10.1155\/2023\/9598783","volume":"2023","author":"Y Zheng","year":"2023","unstructured":"Zheng Y, et al. Ferroptosis-related lncRNAs act as novel prognostic biomarkers in the gastric adenocarcinoma microenvironment, immunotherapy, and chemotherapy. Oxid Med Cell Longev. 2023;2023:9598783. https:\/\/doi.org\/10.1155\/2023\/9598783.","journal-title":"Oxid Med Cell Longev"},{"issue":"7755","key":"1722_CR62","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","volume":"569","author":"W Wang","year":"2019","unstructured":"Wang W, et al. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569(7755):270\u20134. https:\/\/doi.org\/10.1038\/s41586-019-1170-y.","journal-title":"Nature"},{"issue":"6","key":"1722_CR63","doi-asserted-by":"publisher","first-page":"e227","DOI":"10.1016\/S1470-2045(21)00246-1","volume":"22","author":"M Kosaka","year":"2021","unstructured":"Kosaka M, Honma Y, Ishiki H. Unresolved questions regarding the promise of the TPEx regimen. Lancet Oncol. 2021;22(6):e227. https:\/\/doi.org\/10.1016\/S1470-2045(21)00246-1.","journal-title":"Lancet Oncol"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01722-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-025-01722-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01722-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:52:48Z","timestamp":1764917568000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-025-01722-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1722"],"URL":"https:\/\/doi.org\/10.1007\/s10238-025-01722-y","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]},"assertion":[{"value":"13 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"182"}}