{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T16:10:16Z","timestamp":1785687016152,"version":"3.56.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-025-01809-6","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T04:28:16Z","timestamp":1753331296000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-inflammatory mechanism of resveratrol\u2019s Triglyceride-lowering effect in hyperlipidemia: a meta-analysis integrated network pharmacology and molecular dynamics simulation"],"prefix":"10.1007","volume":"25","author":[{"given":"Yinyan","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"1809_CR1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2025.0530","author":"H Wu","year":"2025","unstructured":"Wu H, Wu JY, Gao SJ, et al. Resveratrol: Harnessing Nature\u2019s Potential for Chronic Pain Relief. Aging Dis. 2025. https:\/\/doi.org\/10.14336\/AD.2025.0530.","journal-title":"Aging Dis"},{"key":"1809_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-1198-x","author":"M Akbari","year":"2020","unstructured":"Akbari M, Tamtaji OR, Lankarani KB, et al. The effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. 2020. https:\/\/doi.org\/10.1186\/s12944-020-1198-x.","journal-title":"Lipids Health Dis"},{"key":"1809_CR3","doi-asserted-by":"publisher","first-page":"115541","DOI":"10.1016\/j.bcp.2023.115541","volume":"211","author":"Y Jing","year":"2023","unstructured":"Jing Y, Hu T, Yuan J, et al. Resveratrol protects against postmenopausal atherosclerosis progression through reducing PCSK9 expression via the regulation of the ER\u03b1-mediated signaling pathway. Biochem Pharmacol. 2023;211:115541.","journal-title":"Biochem Pharmacol"},{"key":"1809_CR4","doi-asserted-by":"publisher","first-page":"8414627","DOI":"10.1155\/jnme\/8414627","volume":"2025","author":"PH Huang","year":"2025","unstructured":"Huang PH, Chen YW, Shie CK, et al. Chinese sausage simulates high calorie-induced obesity in vivo, identifying the potential benefits of weight loss and metabolic syndrome of resveratrol butyrate monomer derivatives. J Nutr Metab. 2025;2025:8414627.","journal-title":"J Nutr Metab"},{"issue":"21","key":"1809_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217524","volume":"27","author":"D Fan","year":"2022","unstructured":"Fan D, Liu C, Zhang Z, et al. Progress in the preclinical and clinical study of resveratrol for vascular metabolic disease. Molecules. 2022;27(21): 7524.","journal-title":"Molecules"},{"issue":"3","key":"1809_CR6","doi-asserted-by":"publisher","first-page":"E39","DOI":"10.1161\/CIR.0000000000000743","volume":"141","author":"JAS Carson","year":"2020","unstructured":"Carson JAS, Lichtenstein AH, Anderson CAM, et al. Dietary cholesterol and cardiovascular risk: a science advisory from the American Heart Association. Circulation. 2020;141(3):E39\u201353.","journal-title":"Circulation"},{"issue":"2","key":"1809_CR7","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/cvr\/cvab032","volume":"118","author":"DB Yu","year":"2022","unstructured":"Yu DB, Liao JK. Emerging views of statin pleiotropy and cholesterol lowering [J]. Cardiovasc Res. 2022;118(2):413\u201323.","journal-title":"Cardiovasc Res"},{"key":"1809_CR8","doi-asserted-by":"publisher","first-page":"106903","DOI":"10.1016\/j.prostaglandins.2024.106903","volume":"175","author":"Z Li","year":"2024","unstructured":"Li Z, Liu S, Liu Q, et al. Efficacy of resveratrol supplementation on lipid profile parameters: an umbrella of meta-analysis. Prostaglandins Other Lipid Mediat. 2024;175:106903.","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"1809_CR9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030049","author":"N Ma","year":"2022","unstructured":"Ma N, Zhang YZ. Effects of resveratrol therapy on glucose metabolism, insulin resistance, inflammation, and renal function in the elderly patients with type 2 diabetes mellitus: a randomized controlled clinical trial protocol. Medicine (Baltimore). 2022. https:\/\/doi.org\/10.1097\/MD.0000000000030049.","journal-title":"Medicine (Baltimore)"},{"key":"1809_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.cbi.2014.12.033","volume":"227","author":"RC Macedo","year":"2015","unstructured":"Macedo RC, Vieira A, Marin DP, et al. Effects of chronic resveratrol supplementation in military firefighters undergo a physical fitness test\u2013a placebo-controlled, double blind study. Chem Biol Interact. 2015;227:89\u201395.","journal-title":"Chem Biol Interact"},{"key":"1809_CR11","first-page":"1","volume":"2025","author":"N Beheshtkhoo","year":"2025","unstructured":"Beheshtkhoo N, Jadidi Kouhbanani MA, Daghighi SM, et al. Effect of oral resveratrol-loaded nanoliposomes on hyperlipidemia via toll-like receptor 3 and TIR domain-containing adaptor inducing interferon-\u03b2 protein expression in an animal model. J Liposome Res. 2025;2025:1\u201327.","journal-title":"J Liposome Res"},{"issue":"18","key":"1809_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/nu14183755","volume":"14","author":"X Cao","year":"2022","unstructured":"Cao X, Liao W, Xia H, et al. The effect of resveratrol on blood lipid profile: a dose-response meta-analysis of randomized controlled trials. Nutrients. 2022;14(18): 3755.","journal-title":"Nutrients"},{"issue":"10","key":"1809_CR13","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/nbt1007-1110","volume":"25","author":"AL Hopkins","year":"2007","unstructured":"Hopkins AL. Network pharmacology [J]. Nat Biotechnol. 2007;25(10):1110\u20131.","journal-title":"Nat Biotechnol"},{"key":"1809_CR14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535","volume":"339","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339: b2535.","journal-title":"BMJ"},{"issue":"1002","key":"1809_CR15","first-page":"14651858","volume":"4","author":"JPTTJ Higgins","year":"2024","unstructured":"Higgins JPTTJ, Chandler J, Cumpston M, Li T, Page MJ, Welch VA. Cochrane handbook for systematic reviews of interventions version 65 (updated August 2024). Cochrane. 2024;4(1002):14651858.","journal-title":"Cochrane"},{"issue":"5","key":"1809_CR16","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1188\/15.ONF.552-554","volume":"42","author":"M Vrabel","year":"2015","unstructured":"Vrabel M. Preferred reporting items for systematic reviews and meta-analyses. Oncol Nurs Forum. 2015;42(5):552\u20134.","journal-title":"Oncol Nurs Forum"},{"issue":"2","key":"1809_CR17","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott O, Olson AJ. Autodock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading [J]. J Comput Chem. 2010;31(2):455\u201361.","journal-title":"J Comput Chem"},{"issue":"8","key":"1809_CR18","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","volume":"61","author":"J Eberhardt","year":"2021","unstructured":"Eberhardt J, Santos-Martins D, Tillack AF, et al. AutoDock vina 1.2.0: new docking methods, expanded force field, and python bindings. J Chem Inf Model. 2021;61(8):3891\u20138.","journal-title":"J Chem Inf Model"},{"issue":"16","key":"1809_CR19","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"GM Morris","year":"2009","unstructured":"Morris GM, Huey R, Lindstrom W, et al. Autodock4 and Autodocktools4: automated docking with selective receptor flexibility [J]. J Comput Chem. 2009;30(16):2785\u201391.","journal-title":"J Comput Chem"},{"key":"1809_CR20","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","volume":"1\u20132","author":"MJ Abraham","year":"2015","unstructured":"Abraham MJ, Murtola T, Schulz R, et al. GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX. 2015;1\u20132:19\u201325.","journal-title":"SoftwareX"},{"issue":"13","key":"1809_CR21","doi-asserted-by":"publisher","DOI":"10.1063\/5.0018516","volume":"153","author":"S P\u00e1ll","year":"2020","unstructured":"P\u00e1ll S, Zhmurov A, Bauer P, et al. Heterogeneous parallelization and acceleration of molecular dynamics simulations in GROMACS. J Chem Phys. 2020;153(13): 134110.","journal-title":"J Chem Phys"},{"issue":"7","key":"1809_CR22","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","volume":"29","author":"S Pronk","year":"2013","unstructured":"Pronk S, P\u00e1ll S, Schulz R, et al. GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit. Bioinformatics. 2013;29(7):845\u201354.","journal-title":"Bioinformatics"},{"issue":"21","key":"1809_CR23","doi-asserted-by":"publisher","first-page":"6469","DOI":"10.1021\/acs.jcim.3c01053","volume":"63","author":"M Bugnon","year":"2023","unstructured":"Bugnon M, Goullieux M, R\u00f6hrig UF, et al. SwissParam 2023: a modern web-based tool for efficient small molecule parametrization [J]. J Chem Inf Model. 2023;63(21):6469\u201375.","journal-title":"J Chem Inf Model"},{"issue":"11","key":"1809_CR24","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1002\/jcc.21816","volume":"32","author":"V Zoete","year":"2011","unstructured":"Zoete V, Cuendet MA, Grosdidier A, et al. Swissparam: a fast force field generation tool for small organic molecules [J]. J Comput Chem. 2011;32(11):2359\u201368.","journal-title":"J Comput Chem"},{"issue":"9","key":"1809_CR25","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1021\/ct300418h","volume":"8","author":"BR Miller 3rd","year":"2012","unstructured":"Miller BR 3rd, McGee TD Jr., Swails JM, et al. MMPBSA.py: an efficient program for end-state free energy calculations. J Chem Theory Comput. 2012;8(9):3314\u201321.","journal-title":"J Chem Theory Comput"},{"issue":"10","key":"1809_CR26","doi-asserted-by":"publisher","first-page":"6281","DOI":"10.1021\/acs.jctc.1c00645","volume":"17","author":"MS Vald\u00e9s-Tresanco","year":"2021","unstructured":"Vald\u00e9s-Tresanco MS, Vald\u00e9s-Tresanco ME, Valiente PA, et al. gmx_MMPBSA: a new tool to perform end-state free energy calculations with GROMACS [J]. J Chem Theory Comput. 2021;17(10):6281\u201391.","journal-title":"J Chem Theory Comput"},{"issue":"9","key":"1809_CR27","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1210\/jc.2010-0482","volume":"95","author":"H Ghanim","year":"2010","unstructured":"Ghanim H, Sia CL, Abuaysheh S, et al. An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol [J]. J Clin Endocrinol Metab. 2010;95(9):E1-8.","journal-title":"J Clin Endocrinol Metab"},{"issue":"20","key":"1809_CR28","doi-asserted-by":"publisher","first-page":"5047","DOI":"10.1113\/jphysiol.2013.258061","volume":"591","author":"L Gliemann","year":"2013","unstructured":"Gliemann L, Schmidt JF, Olesen J, et al. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men [J]. J Physiol. 2013;591(20):5047\u201359.","journal-title":"J Physiol"},{"issue":"4","key":"1809_CR29","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.2337\/db12-0975","volume":"62","author":"MM Poulsen","year":"2013","unstructured":"Poulsen MM, Vestergaard PF, Clasen BF, et al. High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition [J]. Diabetes. 2013;62(4):1186\u201395.","journal-title":"Diabetes"},{"key":"1809_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.03.023","volume":"174","author":"S Huhn","year":"2018","unstructured":"Huhn S, Beyer F, Zhang R, et al. Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults - a randomized controlled trial. Neuroimage. 2018;174: 177\u201390.","journal-title":"Neuroimage"},{"key":"1809_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030828","author":"JJ Thaung Zaw","year":"2020","unstructured":"Thaung Zaw JJ, Howe PRC, Wong RHX. Sustained cerebrovascular and cognitive benefits of resveratrol in postmenopausal women. Nutrients. 2020. https:\/\/doi.org\/10.3390\/nu12030828.","journal-title":"Nutrients"},{"issue":"5","key":"1809_CR32","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.cmet.2012.09.015","volume":"16","author":"J Yoshino","year":"2012","unstructured":"Yoshino J, Conte C, Fontana L, et al. Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance [J]. Cell Metab. 2012;16(5):658\u201364.","journal-title":"Cell Metab"},{"issue":"18","key":"1809_CR33","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.3390\/nu14183755","volume":"14","author":"X Cao","year":"2022","unstructured":"Cao X, Liao W, Xia H, et al. The effect of Resveratrol on blood lipid profile: a dose-response meta-analysis of randomized controlled trials [J]. Nutrients. 2022;14(18):3755.","journal-title":"Nutrients"},{"issue":"4","key":"1809_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2024.103827","volume":"35","author":"ML Rodrigues Uggioni","year":"2025","unstructured":"Rodrigues Uggioni ML, Ronsani L, Motta S, et al. Effects of resveratrol on the lipid profile of post-menopause women: systematic review and meta-analysis. Nutr Metab Cardiovasc Dis. 2025;35(4): 103827.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"1809_CR35","first-page":"5644171","volume":"2021","author":"T Zhang","year":"2021","unstructured":"Zhang T, He Q, Liu Y, et al. Efficacy and safety of resveratrol supplements on blood lipid and blood glucose control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med. 2021;2021:5644171.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"7","key":"1809_CR36","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1080\/1028415X.2024.2425649","volume":"28","author":"S Keramatzadeh","year":"2025","unstructured":"Keramatzadeh S, Hosseini SA, Majdinasab N, et al. Effects of resveratrol supplementation on inflammatory markers, fatigue scale, fasting blood sugar and lipid profile in relapsing-remitting multiple sclerosis patients: a double-blind, randomized placebo-controlled trial. Nutr Neurosci. 2025;28(7):854\u201362.","journal-title":"Nutr Neurosci"},{"issue":"3","key":"1809_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2025.104318","volume":"30","author":"Z Xie","year":"2025","unstructured":"Xie Z, Xin J, Huang C, et al. Drugs targeting peroxisome proliferator-activated receptors. Drug Discov Today. 2025;30(3): 104318.","journal-title":"Drug Discov Today"},{"issue":"4","key":"1809_CR38","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1194\/jlr.R600021-JLR200","volume":"48","author":"C Popa","year":"2007","unstructured":"Popa C, Netea MG, van Riel PLCM, et al. The role of TNF-\u03b1 in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res. 2007;48(4):751\u201362.","journal-title":"J Lipid Res"},{"issue":"1","key":"1809_CR39","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.smim.2013.11.002","volume":"26","author":"J Scheller","year":"2014","unstructured":"Scheller J, Garbers C, Rose-John S. Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities [J]. Semin Immunol. 2014;26(1):2\u201312.","journal-title":"Semin Immunol"},{"issue":"4","key":"1809_CR40","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1158\/2326-6066.CIR-14-0022","volume":"2","author":"T Tanaka","year":"2014","unstructured":"Tanaka T, Kishimoto T. The biology and medical implications of interleukin-6 [J]. Cancer Immunol Res. 2014;2(4):288\u201394.","journal-title":"Cancer Immunol Res"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01809-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-025-01809-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01809-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:46:53Z","timestamp":1764917213000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-025-01809-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1809"],"URL":"https:\/\/doi.org\/10.1007\/s10238-025-01809-6","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]},"assertion":[{"value":"15 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"262"}}