{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T07:20:33Z","timestamp":1764919233444,"version":"3.46.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Fund Program for the Scientific Activitific Activities of Selected Returned Overseas Professionals in Shanxi Province","award":["20210027","20210027","20210027"],"award-info":[{"award-number":["20210027","20210027","20210027"]}]},{"name":"Research Project Plan of Shanxi Provincial Health Commission","award":["2021056","2021056","2021056"],"award-info":[{"award-number":["2021056","2021056","2021056"]}]},{"name":"Basic Research Progam of Shanxi","award":["202103021224425","202103021224425","202103021224425"],"award-info":[{"award-number":["202103021224425","202103021224425","202103021224425"]}]},{"name":"Science and Technology Innovation Plan Project of Shanxi Provincial Colleges and Universities","award":["2022129","2022129","2022129"],"award-info":[{"award-number":["2022129","2022129","2022129"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-025-01823-8","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T04:27:58Z","timestamp":1755145678000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The expression of CD109 in B-cell acute lymphoblastic leukemia and its potential as a promising marker for minimal residual disease (MRD) detection"],"prefix":"10.1007","volume":"25","author":[{"given":"Zhifang","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaotong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanggang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianbian","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxia","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaofang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"issue":"6","key":"1823_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.53","volume":"7","author":"T Terwilliger","year":"2017","unstructured":"Terwilliger T, Abdul-Hay M. Acute lymphoblastic leukemia: a comprehensive review and 2017 update. Blood Cancer J. 2017;7(6): e577. https:\/\/doi.org\/10.1038\/bcj.2017.53.","journal-title":"Blood Cancer J"},{"issue":"1","key":"1823_CR2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41416-023-02294-y","volume":"129","author":"DG Gupta","year":"2023","unstructured":"Gupta DG, Varma N, Sreedharanunni S, Abdulkadir SA, Naseem S, Sachdeva MUS, Binota J, Bose P, Malhotra P, Khadwal A, Varma S. Evaluation of adverse prognostic gene alterations & MRD positivity in BCR::ABL1-like B-lineage acute lymphoblastic leukaemia patients, in a resource-constrained setting. Br J Cancer. 2023;129(1):143\u201352. https:\/\/doi.org\/10.1038\/s41416-023-02294-y.","journal-title":"Br J Cancer"},{"issue":"21","key":"1823_CR3","doi-asserted-by":"publisher","first-page":"3390","DOI":"10.1002\/cncr.34957","volume":"129","author":"DG Gupta","year":"2023","unstructured":"Gupta DG, Varma N, Sharma P, Truica MI, Abdulkadir SA, Singh P, Singh Sachdeva MU, Naseem S, Siddiqui MR, Bose P, Binota J, Malhotra P, Khadwal A, Trehan A, Varma S. Hematological, clinical, immunophenotypic characterization, and treatment outcomes of prognostically significant genetic subtypes of B-lineage acute lymphoblastic leukemia: a report of 1021 patients from India. Cancer. 2023;129(21):3390\u2013404. https:\/\/doi.org\/10.1002\/cncr.34957.","journal-title":"Cancer"},{"issue":"8","key":"1823_CR4","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/s0301-472x(99)00071-5","volume":"27","author":"LJ Murray","year":"1999","unstructured":"Murray LJ, Bruno E, Uchida N, Hoffman R, Nayar R, Yeo EL, Schuh AC, Sutherland DR. CD109 is expressed on a subpopulation of CD34+ cells enriched in hematopoietic stem and progenitor cells. Exp Hematol. 1999;27(8):1282\u201394. https:\/\/doi.org\/10.1016\/s0301-472x(99)00071-5.","journal-title":"Exp Hematol"},{"issue":"3","key":"1823_CR5","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/s41375-021-01463-3","volume":"36","author":"M Tanabe","year":"2022","unstructured":"Tanabe M, Hosokawa K, Nguyen MAT, Nakagawa N, Maruyama K, Tsuji N, Urushihara R, Espinoza L, Elbadry MI, Mohiuddin M, Katagiri T, Ono M, Fujiwara H, Chonabayashi K, Yoshida Y, Yamazaki H, Hirao A, Nakao S. The GPI-anchored protein CD109 protects hematopoietic progenitor cells from undergoing erythroid differentiation induced by TGF-\u03b2. Leukemia. 2022;36(3):847\u201355. https:\/\/doi.org\/10.1038\/s41375-021-01463-3.","journal-title":"Leukemia"},{"issue":"5","key":"1823_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1440-1827.2007.02097.x","volume":"57","author":"M Hasegawa","year":"2007","unstructured":"Hasegawa M, Hagiwara S, Sato T, Jijiwa M, Murakumo Y, Maeda M, Moritani S, Ichihara S, Takahashi M. CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells. Pathol Int. 2007;57(5):245\u201350. https:\/\/doi.org\/10.1111\/j.1440-1827.2007.02097.x.","journal-title":"Pathol Int"},{"issue":"5","key":"1823_CR7","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/s41416-020-0922-7","volume":"123","author":"XT Mo","year":"2020","unstructured":"Mo XT, Leung TH, Tang HW, Siu MK, Wan PK, Chan KK, Cheung AN, Ngan HY. CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma. Br J Cancer. 2020;123(5):833\u201343. https:\/\/doi.org\/10.1038\/s41416-020-0922-7.","journal-title":"Br J Cancer"},{"issue":"15","key":"1823_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14153672","volume":"14","author":"S Zhou","year":"2022","unstructured":"Zhou S, Hassan A, Kungyal T, Tabari\u00e8s S, Luna JLRG, Siegel PM, Philip A. CD109 is a critical determinant of EGFR expression and signaling, and tumorigenicity in squamous cell carcinoma cells. Cancers (Basel). 2022;14(15): 3672. https:\/\/doi.org\/10.3390\/cancers14153672.","journal-title":"Cancers (Basel)"},{"key":"1823_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154443","volume":"245","author":"N Mori","year":"2023","unstructured":"Mori N, Esaki N, Shimoyama Y, Shiraki Y, Asai N, Sakai T, Nishida Y, Takahashi M, Enomoto A, Mii S. Significance of expression of CD109 in osteosarcoma and its involvement in tumor progression via BMP signaling. Pathol Res Pract. 2023;245: 154443. https:\/\/doi.org\/10.1016\/j.prp.2023.154443.","journal-title":"Pathol Res Pract"},{"issue":"9","key":"1823_CR10","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.141486","volume":"6","author":"P Filppu","year":"2021","unstructured":"Filppu P, Tanjore Ramanathan J, Granberg KJ, Gucciardo E, Haapasalo H, Lehti K, Nykter M, Le Joncour V, Laakkonen P. CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity. JCI Insight. 2021;6(9): e141486. https:\/\/doi.org\/10.1172\/jci.insight.141486.","journal-title":"JCI Insight"},{"issue":"1","key":"1823_CR11","doi-asserted-by":"publisher","first-page":"5328","DOI":"10.1038\/s41598-022-09358-8","volume":"12","author":"O Benchama","year":"2022","unstructured":"Benchama O, Tyukhtenko S, Malamas MS, Williams MK, Makriyannis A, Avraham HK. Inhibition of triple negative breast cancer-associated inflammation, tumor growth and brain colonization by targeting monoacylglycerol lipase. Sci Rep. 2022;12(1):5328. https:\/\/doi.org\/10.1038\/s41598-022-09358-8.","journal-title":"Sci Rep"},{"issue":"1","key":"1823_CR12","doi-asserted-by":"publisher","first-page":"65","DOI":"10.7150\/ijms.7426","volume":"11","author":"J Li","year":"2013","unstructured":"Li J, Xin J, Zhang L, Wu J, Jiang L, Zhou Q, Li J, Guo J, Cao H, Li L. Human hepatic progenitor cells express hematopoietic cell markers CD45 and CD109. Int J Med Sci. 2013;11(1):65\u201379. https:\/\/doi.org\/10.7150\/ijms.7426.","journal-title":"Int J Med Sci"},{"issue":"25","key":"1823_CR13","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.1200\/JCO.2011.40.6652","volume":"30","author":"JH Mendler","year":"2012","unstructured":"Mendler JH, Maharry K, Radmacher MD, et al. RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and microRNA expression signatures. J Clin Oncol. 2012;30(25):3109\u201318. https:\/\/doi.org\/10.1200\/JCO.2011.40.6652.","journal-title":"J Clin Oncol"},{"issue":"1","key":"1823_CR14","doi-asserted-by":"publisher","first-page":"11293","DOI":"10.1038\/s41598-018-29593-2","volume":"8","author":"R Hornung","year":"2018","unstructured":"Hornung R, Jurinovic V, Batcha AMN, Bamopoulos SA, Rothenberg-Thurley M, Amler S, Sauerland MC, Berdel WE, W\u00f6rmann BJ, Bohlander SK, Braess J, Hiddemann W, Lehmann S, Mareschal S, Spiekermann K, Metzeler KH, Herold T, Boulesteix AL. Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1\/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia. Sci Rep. 2018;8(1):11293. https:\/\/doi.org\/10.1038\/s41598-018-29593-2.","journal-title":"Sci Rep"},{"key":"1823_CR15","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/946403","volume":"2013","author":"SM Hwang","year":"2013","unstructured":"Hwang SM, Kim MJ, Chang HE, Hong YJ, Kim TS, Song EY, Park KU, Song J, Han KS. Human platelet antigen genotyping and expression of CD109 (human platelet antigen 15) mRNA in various human cell types. Biomed Res Int. 2013;2013: 946403. https:\/\/doi.org\/10.1155\/2013\/946403.","journal-title":"Biomed Res Int"},{"issue":"5","key":"1823_CR16","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1007\/s12185-016-2173-1","volume":"105","author":"M Yokoyama","year":"2017","unstructured":"Yokoyama M, Ichinoe M, Okina S, Sakurai Y, Nakada N, Yanagisawa N, Jiang SX, Numata Y, Umezawa A, Miyazaki K, Higashihara M, Murakumo Y. CD109, a negative regulator of TGF-\u03b2 signaling, is a putative risk marker in diffuse large B-cell lymphoma. Int J Hematol. 2017;105(5):614\u201322. https:\/\/doi.org\/10.1007\/s12185-016-2173-1.","journal-title":"Int J Hematol"},{"issue":"10","key":"1823_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e11123","volume":"8","author":"ES Deepak Shyl","year":"2022","unstructured":"Deepak Shyl ES, Malgija B, Iniyan AM, Mahendran R, Prakash Vincent SG. Mining of transcriptome identifies CD109 and LRP12 as possible biomarkers and deregulation mechanism of T cell receptor pathway in Acute Myeloid Leukemia. Heliyon. 2022;8(10): e11123. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e11123.","journal-title":"Heliyon"},{"issue":"7","key":"1823_CR18","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","volume":"36","author":"R Alaggio","year":"2022","unstructured":"Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IB, Berti E, Bhagat G, Borges AM, Boyer D, Calaminici M, Chadburn A. The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia. 2022;36(7):1720\u201348.","journal-title":"Leukemia"},{"issue":"8","key":"1823_CR19","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.1007\/s10238-023-01131-z","volume":"23","author":"DG Gupta","year":"2023","unstructured":"Gupta DG, Varma N, Abdulkadir SA, Singh P, Sachdeva MUS, Naseem S, Siddiqui MR, Bose P, Binota J, Malhotra P, Khadwal A, Varma S. Identification and validation of the optimal reference genes for standardizing the gene expression profiling diagnostic panel of Ph-like B-lineage acute lymphoblastic leukemia. Clin Exp Med. 2023;23(8):4539\u201351. https:\/\/doi.org\/10.1007\/s10238-023-01131-z.","journal-title":"Clin Exp Med"},{"issue":"Suppl 1","key":"1823_CR20","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1002\/cyto.b.20365","volume":"72","author":"BH Davis","year":"2007","unstructured":"Davis BH, Holden JT, Bene MC, Borowitz MJ, Braylan RC, Cornfield D, Gorczyca W, Lee R, Maiese R, Orfao A, Wells D, Wood BL, Stetler-Stevenson M. 2006 Bethesda international consensus recommendations on the flow cytometric immunophenotypic analysis of hematolymphoid neoplasia: medical indications. Cytometry B Clin Cytom. 2007;72(Suppl 1):S5\u201313. https:\/\/doi.org\/10.1002\/cyto.b.20365.","journal-title":"Cytometry B Clin Cytom"},{"issue":"8","key":"1823_CR21","doi-asserted-by":"publisher","first-page":"3941","DOI":"10.1182\/blood-2007-11-120535","volume":"111","author":"FE Craig","year":"2008","unstructured":"Craig FE, Foon KA. Flow cytometric immunophenotyping for hematologic neoplasms. Blood. 2008;111(8):3941\u201367. https:\/\/doi.org\/10.1182\/blood-2007-11-120535.","journal-title":"Blood"},{"issue":"15","key":"1823_CR22","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1200\/JCO.2009.23.4732","volume":"28","author":"T Haferlach","year":"2010","unstructured":"Haferlach T, Kohlmann A, Wieczorek L, Basso G, Kronnie GT, B\u00e9n\u00e9 MC, De Vos J, Hern\u00e1ndez JM, Hofmann WK, Mills KI, Gilkes A, Chiaretti S, Shurtleff SA, Kipps TJ, Rassenti LZ, Yeoh AE, Papenhausen PR, Liu WM, Williams PM, Fo\u00e0 R. Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J Clin Oncol. 2010;28(15):2529\u201337. https:\/\/doi.org\/10.1200\/JCO.2009.23.4732.","journal-title":"J Clin Oncol"},{"issue":"12","key":"1823_CR23","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1002\/cncr.20668","volume":"101","author":"H Kantarjian","year":"2004","unstructured":"Kantarjian H, Thomas D, O\u2019Brien S, Cortes J, Giles F, Jeha S, Bueso-Ramos CE, Pierce S, Shan J, Koller C, Beran M, Keating M, Freireich EJ. Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. Cancer. 2004;101(12):2788\u2013801. https:\/\/doi.org\/10.1002\/cncr.20668.","journal-title":"Cancer"},{"issue":"10","key":"1823_CR24","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1001\/jamaoncol.2018.1915","volume":"4","author":"E Jabbour","year":"2018","unstructured":"Jabbour E, Pui CH, Kantarjian H. Progress and innovations in the management of adult acute lymphoblastic leukemia. JAMA Oncol. 2018;4(10):1413\u201320. https:\/\/doi.org\/10.1001\/jamaoncol.2018.1915.","journal-title":"JAMA Oncol"},{"issue":"17","key":"1823_CR25","doi-asserted-by":"publisher","first-page":"4290","DOI":"10.3390\/cancers14174290","volume":"14","author":"T K\u00fcnz","year":"2022","unstructured":"K\u00fcnz T, Hauswirth AW, Hetzenauer G, Rudzki J, Nachbaur D, Steiner N. Changing landscape in the treatment of adult acute lymphoblastic leukemia (ALL). Cancers. 2022;14(17):4290. https:\/\/doi.org\/10.3390\/cancers14174290.","journal-title":"Cancers"},{"issue":"1","key":"1823_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/diagnostics13010021","volume":"13","author":"Y Davydova","year":"2022","unstructured":"Davydova Y, Galtseva I, Kapranov N, Nikiforova K, Aleshina O, Chabaeva Y, Isinova G, Kotova E, Sokolov A, Troitskaya V, Kulikov S, Parovichnikova E. Immunophenotype of measurable residual blast cells as an additional prognostic factor in adults with B-cell acute lymphoblastic leukemia. Diagnostics (Basel, Switzerland). 2022;13(1):21. https:\/\/doi.org\/10.3390\/diagnostics13010021.","journal-title":"Diagnostics (Basel, Switzerland)"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01823-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-025-01823-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01823-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:50:16Z","timestamp":1764917416000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-025-01823-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1823"],"URL":"https:\/\/doi.org\/10.1007\/s10238-025-01823-8","relation":{},"ISSN":["1591-9528"],"issn-type":[{"type":"electronic","value":"1591-9528"}],"subject":[],"published":{"date-parts":[[2025,8,14]]},"assertion":[{"value":"12 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study received approval from the ethics committee of our hospital, and informed consent was obtained from patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"292"}}