{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:48:19Z","timestamp":1792183699002,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-025-01854-1","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T02:30:00Z","timestamp":1763433000000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["LDB2 is a novel diagnostic and prognostic biomarker and inhibits bladder cancer metastasis by activating p38 MAPK\/ERK1\/2\/JNK signaling pathway"],"prefix":"10.1007","volume":"26","author":[{"given":"Yue","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"issue":"3","key":"1854_CR1","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"1854_CR2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.eururo.2019.08.016","volume":"76","author":"M Babjuk","year":"2019","unstructured":"Babjuk M, Burger M, Comp\u00e9rat EM, et al. European association of urology guidelines on non-muscle-invasive bladder cancer (TaT1 and CIS). Eur Urol. 2019;76(5):639\u201357.","journal-title":"Eur Urol"},{"issue":"1","key":"1854_CR3","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.eururo.2016.06.010","volume":"71","author":"S Antoni","year":"2017","unstructured":"Antoni S, Ferlay J, Soerjomataram I, et al. Bladder cancer incidence and mortality: a global overview and recent trends. Eur Urol. 2017;71(1):96\u2013108.","journal-title":"Eur Urol"},{"issue":"1","key":"1854_CR4","first-page":"17","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel RL, Miller KD, Wagle NS, et al. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17\u201348.","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"1854_CR5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.eururo.2023.08.016","volume":"85","author":"JA Witjes","year":"2023","unstructured":"Witjes JA, Bruins HM, Cathomas R, et al. European association of urology guidelines on muscle-invasive and metastatic bladder cancer. Eur Urol. 2023;85(1):17\u201331.","journal-title":"Eur Urol"},{"issue":"3","key":"1854_CR6","first-page":"1143","volume":"10","author":"H Iwamura","year":"2021","unstructured":"Iwamura H, Hatakeyama S, Momota M, et al. Relationship of frailty with treatment modality selection in patients with muscle-invasive bladder cancer (FRART-BC study). Int J Clin Oncol. 2021;10(3):1143\u201351.","journal-title":"Int J Clin Oncol"},{"key":"1854_CR7","doi-asserted-by":"crossref","first-page":"1397738","DOI":"10.3389\/fonc.2024.1397738","volume":"14","author":"DMC Poon","year":"2024","unstructured":"Poon DMC, Ho LY, Kwong YM. Avelumab maintenance therapy for node-positive muscle invasive bladder cancer: a report of two cases. Front Oncol. 2024;14:1397738.","journal-title":"Front Oncol"},{"issue":"22","key":"1854_CR8","doi-asserted-by":"crossref","first-page":"8491","DOI":"10.1002\/cam4.3478","volume":"9","author":"ON Gofrit","year":"2020","unstructured":"Gofrit ON, Meirovitz A, Frank SJ, et al. Trimodal therapy in T2\u20134aN0M0 bladder cancer\u2014how to select the best candidate? Cancer Med. 2020;9(22):8491\u20137.","journal-title":"Cancer Med"},{"issue":"3","key":"1854_CR9","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1200\/JCO.2001.19.3.666","volume":"19","author":"JP Stein","year":"2001","unstructured":"Stein JP, Lieskovsky G, Cote R, et al. Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1054 patients. J Clin Oncol. 2001;19(3):666\u201375.","journal-title":"J Clin Oncol"},{"issue":"4","key":"1854_CR10","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.eururo.2007.09.008","volume":"53","author":"JA Nieuwenhuijzen","year":"2008","unstructured":"Nieuwenhuijzen JA, de Vries RR, Bex A, et al. Urinary diversions after cystectomy: the association of clinical factors, complications and functional results of four different diversions. Eur Urol. 2008;53(4):834\u201342.","journal-title":"Eur Urol"},{"issue":"16","key":"1854_CR11","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1200\/JCO.2010.32.3139","volume":"29","author":"G Griffiths","year":"2011","unstructured":"Griffiths G, Hall R, Sylvester R, et al. International phase III trial assessing neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer: long-term results of the BA06 30894 trial. J Clin Oncol. 2011;29(16):2171\u20137.","journal-title":"J Clin Oncol"},{"key":"1854_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400030","author":"JM Matthews","year":"2003","unstructured":"Matthews JM, Visvader JE. LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins. EMBO Rep. 2003. https:\/\/doi.org\/10.1038\/sj.embor.7400030.","journal-title":"EMBO Rep"},{"key":"1854_CR13","doi-asserted-by":"crossref","first-page":"100145","DOI":"10.1016\/j.clinsp.2022.100145","volume":"78","author":"X Chu","year":"2022","unstructured":"Chu X, Xu J, Zhang Y, et al. LIM-domain binding protein 2 was down-regulated by miRNA-96-5p inhibited the proliferation, invasion and metastasis of lung cancer H1299 cells. Clinics (Sao Paulo). 2022;78:100145.","journal-title":"Clinics (Sao Paulo)"},{"issue":"11","key":"1854_CR14","first-page":"920","volume":"15","author":"I Bach","year":"2014","unstructured":"Bach I, Rodriguez-Esteban C, Carriere C, et al. The LIM domain: from the cytoskeleton to the nucleus. Nat Rev Mol Cell Biol. 2014;15(11):920\u201331.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"55","key":"1854_CR15","doi-asserted-by":"crossref","first-page":"94440","DOI":"10.18632\/oncotarget.21772","volume":"8","author":"H Yu","year":"2017","unstructured":"Yu H, Jia R, Zhao L, et al. LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression. Oncotarget. 2017;8(55):94440\u20139.","journal-title":"Oncotarget"},{"issue":"4","key":"1854_CR16","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/03936155241287219","volume":"39","author":"L Zhang","year":"2024","unstructured":"Zhang L, Cai Y. CircLPHN3 correlates with prognosis in colorectal cancer and regulates cellular processes by targeting miR-142-5p. Int J Biol Mark. 2024;39(4):292\u2013300.","journal-title":"Int J Biol Mark"},{"key":"1854_CR17","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","volume":"38","author":"MJ Goldman","year":"2020","unstructured":"Goldman MJ, Craft B, Hastie M, Repe\u010dka K, McDade F, Kamath A, Banerjee A, Luo Y, Rogers D, Brooks AN, et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol. 2020;38:675\u20138.","journal-title":"Nat Biotechnol"},{"key":"1854_CR18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2147\/JHC.S500119","volume":"12","author":"L Lu","year":"2025","unstructured":"Lu L, Zhou X, Zheng J, et al. Coilin affects the prognosis of hepatocellular carcinoma through cell cycle and apoptosis. J Hepatocell Carcinoma. 2025;12:367\u201382.","journal-title":"J Hepatocell Carcinoma"},{"key":"1854_CR19","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","volume":"45","author":"Z Tang","year":"2017","unstructured":"Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45:W98\u2013102.","journal-title":"Nucleic Acids Res"},{"key":"1854_CR20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. Clusterprofiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16:284\u20137.","journal-title":"OMICS"},{"key":"1854_CR21","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","volume":"43","author":"D Szklarczyk","year":"2015","unstructured":"Szklarczyk D, Franceschini A, Wyder S, Forslund K, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015;43:D447\u201352.","journal-title":"Nucleic Acids Res"},{"key":"1854_CR22","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1093\/bioinformatics\/btm369","volume":"23","author":"A Subramanian","year":"2007","unstructured":"Subramanian A, Kuehn H, Gould J, Tamayo P, Mesirov JP. GSEA-P: a desktop application for gene set enrichment analysis. Bioinformatics. 2007;23:3251\u20133.","journal-title":"Bioinformatics"},{"key":"1854_CR23","doi-asserted-by":"crossref","first-page":"e78342","DOI":"10.7554\/eLife.78342","volume":"11","author":"X Li","year":"2022","unstructured":"Li X, Gordon PJ, Gaynes JA, et al. Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis. Elife. 2022;11:e78342.","journal-title":"Elife"},{"key":"1854_CR24","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.bbrc.2007.10.071","volume":"364","author":"A Hansson","year":"2007","unstructured":"Hansson A, Zetterblad J, van Duren C, et al. The Lim-only protein LMO2 acts as a positive regulator of erythroid differentiation. Biochem Biophys Res Commun. 2007;364:675\u201381.","journal-title":"Biochem Biophys Res Commun"},{"key":"1854_CR25","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1128\/MCB.25.4.1215-1227.2005","volume":"25","author":"R Ferreira","year":"2005","unstructured":"Ferreira R, Ohneda K, Yamamoto M, et al. GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol. 2005;25:1215\u201327.","journal-title":"Mol Cell Biol"},{"key":"1854_CR26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ccr.2012.06.007","volume":"22","author":"T Sanda","year":"2012","unstructured":"Sanda T, Lawton LN, Barrasa MI, et al. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 2012;22:209\u201321.","journal-title":"Cancer Cell"},{"issue":"1","key":"1854_CR27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13148-023-01570-1","volume":"15","author":"M Gallardo-G\u00f3mez","year":"2023","unstructured":"Gallardo-G\u00f3mez M, Rodr\u00edguez-Girondo M, S\u00e1nchez-Mu\u00f1oz A, et al. Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas. Clin Epigenetics. 2023;15(1):157.","journal-title":"Clin Epigenetics"},{"issue":"19","key":"1854_CR28","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.7150\/jca.61581","volume":"12","author":"C Yuan","year":"2021","unstructured":"Yuan C, Wu C, Xue R, et al. Suppression of human colon tumor by EERAC through regulating Notch\/DLL4\/Hes pathway inhibiting angiogenesis in vivo. J Cancer. 2021;12(19):5914\u201322.","journal-title":"J Cancer"},{"issue":"1","key":"1854_CR29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5483\/BMBRep.2018.51.1.140","volume":"51","author":"HJ Choi","year":"2018","unstructured":"Choi HJ, Rho SS, Choi DH, et al. LDB2 regulates the expression of DLL4 through the formation of oligomeric complexes in endothelial cells. BMB Rep. 2018;51(1):21\u20136.","journal-title":"BMB Rep"},{"issue":"9","key":"1854_CR30","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.3390\/biomedicines10092067","volume":"10","author":"M Sinitsky","year":"2022","unstructured":"Sinitsky M, Sinitskaya A, Shishkova D, et al. Identification of key genes and pathways in genotoxic stress induced endothelial dysfunction: results of whole transcriptome sequencing. Biomedicines. 2022;10(9):2067.","journal-title":"Biomedicines"},{"issue":"4","key":"1854_CR31","doi-asserted-by":"crossref","first-page":"e12574","DOI":"10.15252\/emmm.202012574","volume":"13","author":"T Ohnishi","year":"2021","unstructured":"Ohnishi T, Kiyama Y, Arima-Yoshida F, et al. Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia. EMBO Mol Med. 2021;13(4):e12574.","journal-title":"EMBO Mol Med"},{"key":"1854_CR32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41439-020-00117-7","volume":"7","author":"Y Horiuchi","year":"2020","unstructured":"Horiuchi Y, Ichikawa T, Ohnishi T, et al. LDB2 locus disruption on 4p16.1 as a risk factor for schizophrenia and bipolar disorder. Hum Genome Var. 2020;7:31.","journal-title":"Hum Genome Var"},{"issue":"3","key":"1854_CR33","first-page":"329","volume":"21","author":"D Zhai","year":"2021","unstructured":"Zhai D, Wang G, Li X, et al. LIM-domain binding protein 2 regulated by m6A modification inhibits lung adenocarcinoma cell proliferation in vitro. Oncol Lett. 2021;21(3):329\u201335.","journal-title":"Oncol Lett"},{"issue":"4","key":"1854_CR34","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1017\/S0016672312000419","volume":"94","author":"S Ma","year":"2012","unstructured":"Ma S, Huang Y, Huang J, et al. Gene network-based cancer prognosis analysis with sparse boosting. Genet Res Camb. 2012;94(4):205\u201321.","journal-title":"Genet Res Camb"},{"issue":"1","key":"1854_CR35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/12615","volume":"23","author":"D Cappellen","year":"1999","unstructured":"Cappellen D, de Oliveira C, Ricol D, et al. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nat Genet. 1999;23(1):18\u201320.","journal-title":"Nat Genet"},{"issue":"3","key":"1854_CR36","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/ijc.2910560309","volume":"56","author":"P Lianes","year":"1994","unstructured":"Lianes P, Orlow I, Zhang ZF, et al. TP53 mutations in human bladder cancer: genotypic versus phenotypic patterns. Int J Cancer. 1994;56(3):347\u201353.","journal-title":"Int J Cancer"},{"issue":"12","key":"1854_CR37","first-page":"1235","volume":"53","author":"E Wieczorek","year":"2015","unstructured":"Wieczorek E, Jablonowski Z, Tomaszewski J, et al. MMP, VEGF and TIMP as prognostic factors in recurring bladder cancer. Clin Chem Lab Med. 2015;53(12):1235\u201340.","journal-title":"Clin Chem Lab Med"},{"key":"1854_CR38","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ccell.2020.03.013","volume":"37","author":"M Drosten","year":"2020","unstructured":"Drosten M, Barbacid M. Targeting the MAPK pathway in KRAS-driven tumors. Cancer Cell. 2020;37:543\u201350.","journal-title":"Cancer Cell"},{"key":"1854_CR39","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.semcancer.2021.05.010","volume":"85","author":"R Ullah","year":"2022","unstructured":"Ullah R, Yin Q, Snell AH, Wan L. RAF-MEK-ERK pathway in cancer evolution and treatment. Semin Cancer Biol. 2022;85:123\u201354.","journal-title":"Semin Cancer Biol"},{"key":"1854_CR40","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3390\/ijms21031102","volume":"21","author":"S Lee","year":"2020","unstructured":"Lee S, Rauch J, Kolch W. Targeting MAPK signaling in cancer: mechanisms of drug resistance and sensitivity. Int J Mol Sci. 2020;21:1102.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1854_CR41","first-page":"119","volume":"28","author":"J Bellmunt","year":"2017","unstructured":"Bellmunt J, Orsola A, Leow JJ, et al. Bladder cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017;28(4):119\u201342.","journal-title":"Ann Oncol"},{"issue":"4","key":"1854_CR42","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2017.01.017","volume":"168","author":"P Sharma","year":"2017","unstructured":"Sharma P, Hu-Lieskovan S, Wargo JA, et al. Primary, adaptive, and acquired resistance to cancer immunotherapy. Cell. 2017;168(4):707\u201323.","journal-title":"Cell"},{"issue":"10031","key":"1854_CR43","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/S0140-6736(16)00561-4","volume":"387","author":"JE Rosenberg","year":"2016","unstructured":"Rosenberg JE, Hoffman-Censits J, Powles T, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet. 2016;387(10031):1909\u201320.","journal-title":"Lancet"},{"issue":"4","key":"1854_CR44","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri1806","volume":"6","author":"W Zou","year":"2006","unstructured":"Zou W. Regulatory t cells, tumour immunity and immunotherapy. Nat Rev Immunol. 2006;6(4):295\u2013307.","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"1854_CR45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41577-019-0127-6","volume":"19","author":"DG DeNardo","year":"2019","unstructured":"DeNardo DG, Ruffell B. Macrophages as regulators of tumour immunity and immunotherapy. Nat Rev Immunol. 2019;19(6):369\u201382.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"1854_CR46","doi-asserted-by":"crossref","first-page":"ltab007","DOI":"10.1093\/immadv\/ltab007","volume":"1","author":"AJ Petty","year":"2021","unstructured":"Petty AJ, Yang Y. Tumor-associated macrophages: implications in cancer immunotherapy. Immunother Adv. 2021;1(1):ltab007.","journal-title":"Immunother Adv"},{"issue":"6013","key":"1854_CR47","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1126\/science.1198687","volume":"331","author":"E Vivier","year":"2011","unstructured":"Vivier E, Raulet DH, Moretta A, et al. Innate or adaptive immunity? The example of natural killer cells. Science. 2011;331(6013):44\u20139.","journal-title":"Science"},{"issue":"1","key":"1854_CR48","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41577-019-0210-z","volume":"20","author":"SK Wculek","year":"2020","unstructured":"Wculek SK, Cueto FJ, Mujal AM, et al. Dendritic cells in cancer immunology and immunotherapy. Nat Rev Immunol. 2020;20(1):7\u201324.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"1854_CR49","first-page":"23","volume":"138","author":"JC Antvorskov","year":"2013","unstructured":"Antvorskov JC, Fundova P, Buschard K, et al. Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB\/c mice. Clin Exp Immunol. 2013;138(1):23\u201333.","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"1854_CR50","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/nm.3291","volume":"19","author":"AS Chung","year":"2013","unstructured":"Chung AS, Wu X, Zhuang G, et al. An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy. Nat Med. 2013;19(9):1114\u201323.","journal-title":"Nat Med"}],"updated-by":[{"DOI":"10.1007\/s10238-025-02009-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000}}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01854-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-025-01854-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01854-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T01:17:45Z","timestamp":1767489465000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-025-01854-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1854"],"URL":"https:\/\/doi.org\/10.1007\/s10238-025-01854-1","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"21 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10238-025-02009-y","URL":"https:\/\/doi.org\/10.1007\/s10238-025-02009-y","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors take full responsibility for the integrity and accuracy of the entire study and ensure that any concerns regarding the work are properly examined and addressed. The study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki (2013 revision) and received approval from the Ethics Committee of Peking University First Hospital \u2013 Miyun Branch (Approval No. 2023-029-001).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"We approve publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9"}}