{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:14:13Z","timestamp":1784542453416,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-025-01876-9","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T05:01:33Z","timestamp":1761368493000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential prognostic biomarker MIER2 in colon adenocarcinoma: from data mining to validation"],"prefix":"10.1007","volume":"25","author":[{"given":"Chen","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"1876_CR1","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1200\/JCO.22.01690","volume":"41","author":"VK Morris","year":"2023","unstructured":"Morris VK, Kennedy EB, Baxter NN, et al. Treatment of metastatic colorectal cancer: ASCO guideline [J]. J Clin Oncol. 2023;41:678\u2013700.","journal-title":"J Clin Oncol"},{"key":"1876_CR2","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1053\/j.gastro.2008.07.076","volume":"135","author":"WM Grady","year":"2008","unstructured":"Grady WM, Carethers JM. Genomic and epigenetic instability in colorectal cancer pathogenesis [J]. Gastroenterology. 2008;135:1079\u201399.","journal-title":"Gastroenterology"},{"key":"1876_CR3","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2174\/0109298665256238231120093150","volume":"31","author":"M Wu","year":"2024","unstructured":"Wu M, Wu X, Han J. KIF20A promotes CRC progression and the Warburg effect through the C-Myc\/HIF-1alpha axis [J]. Protein Pept Lett. 2024;31:107\u201315.","journal-title":"Protein Pept Lett"},{"key":"1876_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.2174\/0929866530666230516143823","volume":"30","author":"Y Jin","year":"2023","unstructured":"Jin Y, Yu L, Wu Q, et al. CircPSMC3 inhibits colorectal cancer cell growth and migration by controlling miR-31-5p\/YAP\/beta-catenin [J]. Protein Pept Lett. 2023;30:469\u201376.","journal-title":"Protein Pept Lett"},{"key":"1876_CR5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1146\/annurev-physiol-042022-025619","volume":"86","author":"G El Tekle","year":"2024","unstructured":"El Tekle G, Andreeva N, Garrett WS. The role of the microbiome in the etiopathogenesis of colon cancer [J]. Annu Rev Physiol. 2024;86:453\u201378.","journal-title":"Annu Rev Physiol"},{"key":"1876_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.101002","volume":"71","author":"P Xing","year":"2023","unstructured":"Xing P, Wang S, Cao Y, et al. Treatment strategies and drug resistance mechanisms in adenocarcinoma of different organs. Drug Resist Updat. 2023;71:101002.","journal-title":"Drug Resist Updat"},{"key":"1876_CR7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3590","volume":"354","author":"SG Thrumurthy","year":"2016","unstructured":"Thrumurthy SG, Thrumurthy SS, Gilbert CE, Ross P, Haji A. Colorectal adenocarcinoma: risks, prevention and diagnosis. BMJ. 2016;354:i3590.","journal-title":"BMJ"},{"key":"1876_CR8","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2174\/1389202924666230503122134","volume":"24","author":"F Pang","year":"2023","unstructured":"Pang F, Yang P, Wang T, et al. Comprehensive analysis of alternative polyadenylation events associated with the tumor immune microenvironment in colon adenocarcinoma [J]. Curr Genomics. 2023;24:48\u201361.","journal-title":"Curr Genomics"},{"key":"1876_CR9","doi-asserted-by":"publisher","first-page":"95","DOI":"10.2174\/0113892029312303240821080358","volume":"26","author":"J Liu","year":"2025","unstructured":"Liu J, Qiu S, Fu X, et al. Transcriptomic landscape of colorectal mucinous adenocarcinoma has similarity with intestinal goblet cell differentiation. Curr Genomics. 2025;26:95\u2013117.","journal-title":"Curr Genomics"},{"key":"1876_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169338","volume":"12","author":"R Derwish","year":"2017","unstructured":"Derwish R, Paterno GD, Gillespie LL. Differential HDAC1 and 2 recruitment by members of the MIER family. PLoS ONE. 2017;12:e0169338.","journal-title":"PLoS ONE"},{"key":"1876_CR11","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1038\/s41467-023-37247-9","volume":"14","author":"Y Chen","year":"2023","unstructured":"Chen Y, Chen L, Wu X, et al. Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice. Nat Commun. 2023;14:1521.","journal-title":"Nat Commun"},{"key":"1876_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2022.102179","volume":"70","author":"K Lee","year":"2022","unstructured":"Lee K, Whedon SD, Wang ZA, Cole PA. Distinct biochemical properties of the class I histone deacetylase complexes. Curr Opin Chem Biol. 2022;70:102179.","journal-title":"Curr Opin Chem Biol"},{"key":"1876_CR13","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jare.2024.04.032","volume":"70","author":"Z Wei","year":"2025","unstructured":"Wei Z, Ye Y, Liu C, et al. MIER2\/PGC1A elicits sunitinib resistance via lipid metabolism in renal cell carcinoma. J Adv Res. 2025;70:287\u2013305.","journal-title":"J Adv Res"},{"key":"1876_CR14","doi-asserted-by":"publisher","first-page":"D956","DOI":"10.1093\/nar\/gkx1090","volume":"46","author":"SV Vasaikar","year":"2018","unstructured":"Vasaikar SV, Straub P, Wang J, Zhang B. Linkedomics: analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res. 2018;46:D956\u201363.","journal-title":"Nucleic Acids Res"},{"key":"1876_CR15","volume":"17","author":"X Niu","year":"2024","unstructured":"Niu X, Wang B. A network medical framework based on inflammatory genes to identify drug candidates for abdominal aortic aneurysms. Curr Mol Pharmacol. 2024;17:e170523216998.","journal-title":"Curr Mol Pharmacol"},{"key":"1876_CR16","doi-asserted-by":"publisher","first-page":"966","DOI":"10.2174\/0115734129331758241022113026","volume":"20","author":"S Wang","year":"2025","unstructured":"Wang S, Xie C, Hu H, et al. iTRAQ-based proteomic analysis unveils NCAM1 as a novel regulator in doxorubicin-induced cardiotoxicity and DT-010-exerted cardioprotection. Curr Pharm Anal. 2025;20:966\u201377.","journal-title":"Curr Pharm Anal"},{"key":"1876_CR17","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1200\/JCO.2007.12.9791","volume":"26","author":"A Iasonos","year":"2008","unstructured":"Iasonos A, Schrag D, Raj GV, Panageas KS. How to build and interpret a nomogram for cancer prognosis. J Clin Oncol. 2008;26:1364\u201370.","journal-title":"J Clin Oncol"},{"key":"1876_CR18","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1038\/ncomms3612","volume":"4","author":"K Yoshihara","year":"2013","unstructured":"Yoshihara K, Shahmoradgoli M, Martinez E, et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013;4:2612.","journal-title":"Nat Commun"},{"key":"1876_CR19","volume":"17","author":"S Yan","year":"2024","unstructured":"Yan S, Han Z, Wang T, et al. Exploring the immune-related molecular mechanisms underlying the comorbidity of temporal lobe epilepsy and major depressive disorder through integrated data set analysis. Curr Mol Pharmacol. 2024;17:e18761429380394.","journal-title":"Curr Mol Pharmacol"},{"key":"1876_CR20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s10142-023-01055-7","volume":"23","author":"F Xie","year":"2023","unstructured":"Xie F, Wang J, Zhang B. RefFinder: a web-based tool for comprehensively analyzing and identifying reference genes. Funct Integr Genomics. 2023;23:125.","journal-title":"Funct Integr Genomics"},{"key":"1876_CR21","doi-asserted-by":"publisher","first-page":"116","DOI":"10.2174\/1874467215666220308122716","volume":"16","author":"X Peng","year":"2023","unstructured":"Peng X, Wu X, Wu G, et al. Mir-129-2-3p inhibits esophageal carcinoma cell proliferation, migration, and invasion via targeting DNMT3B. Curr Mol Pharmacol. 2023;16:116\u201323.","journal-title":"Curr Mol Pharmacol"},{"key":"1876_CR22","doi-asserted-by":"publisher","first-page":"544","DOI":"10.2174\/0109298665305114240718072029","volume":"31","author":"S Tian","year":"2024","unstructured":"Tian S, Chen M, Jing W, Meng Q, Wu J. Mir-1204 positioning in 8q24.21 involved in the tumorigenesis of colorectal cancer by targeting MASPIN. Protein Peptide Lett. 2024;31:544\u201358.","journal-title":"Protein Peptide Lett"},{"key":"1876_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.156075","volume":"161","author":"B Modl","year":"2023","unstructured":"Modl B, Moritsch S, Zwolanek D, Eferl R. Type I and II interferon signaling in colorectal cancer liver metastasis. Cytokine. 2023;161:156075.","journal-title":"Cytokine"},{"key":"1876_CR24","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s13046-021-01962-2","volume":"40","author":"RSA Goedegebuure","year":"2021","unstructured":"Goedegebuure RSA, Kleibeuker EA, Buffa FM, et al. Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation. J Exp Clin Cancer Res. 2021;40:161.","journal-title":"J Exp Clin Cancer Res"},{"key":"1876_CR25","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.trecan.2019.10.007","volume":"5","author":"K Mehla","year":"2019","unstructured":"Mehla K, Singh PK. Metabolic regulation of macrophage polarization in cancer. Trends Cancer. 2019;5:822\u201334.","journal-title":"Trends Cancer"},{"key":"1876_CR26","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/B978-0-12-394387-3.00005-7","volume":"116","author":"GM Matthews","year":"2012","unstructured":"Matthews GM, Newbold A, Johnstone RW. Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity. Adv Cancer Res. 2012;116:165\u201397.","journal-title":"Adv Cancer Res"},{"key":"1876_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020448","author":"CM Pfeffer","year":"2018","unstructured":"Pfeffer CM, Singh ATK. Apoptosis: a target for anticancer therapy. Int J Mol Sci. 2018. https:\/\/doi.org\/10.3390\/ijms19020448.","journal-title":"Int J Mol Sci"},{"key":"1876_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16050984","author":"R Kim","year":"2024","unstructured":"Kim R, Kin T, Beck WT. Impact of complex apoptotic signaling pathways on cancer cell sensitivity to therapy. Cancers (Basel). 2024. https:\/\/doi.org\/10.3390\/cancers16050984.","journal-title":"Cancers (Basel)"},{"key":"1876_CR29","doi-asserted-by":"publisher","first-page":"0217","DOI":"10.34133\/bmr.0217","volume":"29","author":"S Helmueller","year":"2025","unstructured":"Helmueller S, Lee S, Song X, Kim DH, Lee YJ. Tumoricidal efficacy of Artesunate-eluting microsphere: differential role of Bax\/Bak in orchestration of cell death pathways. Biomater Res. 2025;29:0217.","journal-title":"Biomater Res"},{"key":"1876_CR30","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1007\/s10495-023-01835-3","volume":"28","author":"V Shoshan-Barmatz","year":"2023","unstructured":"Shoshan-Barmatz V, Arif T, Shteinfer-Kuzmine A. Apoptotic proteins with non-apoptotic activity: expression and function in cancer. Apoptosis. 2023;28:730\u201353.","journal-title":"Apoptosis"},{"key":"1876_CR31","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41420-025-02375-2","volume":"11","author":"K Saxena","year":"2025","unstructured":"Saxena K, Hung SH, Ryu E, et al. BH3 mimetics augment cytotoxic T cell killing of acute myeloid leukemia via mitochondrial apoptotic mechanism. Cell Death Discov. 2025;11:120.","journal-title":"Cell Death Discov"},{"key":"1876_CR32","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1111\/jdv.19050","volume":"37","author":"G Evangelou","year":"2023","unstructured":"Evangelou G, Koumaki D, Fragiadaki I, et al. Intralesional photodynamic therapy induces apoptosis in basal cell carcinoma and Bowen\u2019s disease through caspase 3 and granzyme B. J Eur Acad Dermatol Venereol. 2023;37:1311\u20137.","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01876-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-025-01876-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01876-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:53:21Z","timestamp":1764917601000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-025-01876-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,25]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1876"],"URL":"https:\/\/doi.org\/10.1007\/s10238-025-01876-9","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,25]]},"assertion":[{"value":"20 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"323"}}