{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:55:31Z","timestamp":1782842131057,"version":"3.54.5"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30856"],"award-info":[{"award-number":["2023JJ30856"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ5524"],"award-info":[{"award-number":["2024JJ5524"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University","award":["YX202108"],"award-info":[{"award-number":["YX202108"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No.82172832"],"award-info":[{"award-number":["Grant No.82172832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-025-01880-z","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:54:20Z","timestamp":1761893660000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The ferroptosis-related gene MAFG screened by machine learning is associated with the diagnosis and prognosis of sepsis"],"prefix":"10.1007","volume":"25","author":[{"given":"Lin","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daosheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangren","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenrong","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"issue":"10219","key":"1880_CR1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"KE Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the global burden of disease study. Lancet. 2020;395(10219):200\u201311.","journal-title":"Lancet"},{"issue":"2","key":"1880_CR2","doi-asserted-by":"crossref","first-page":"e187571","DOI":"10.1001\/jamanetworkopen.2018.7571","volume":"2","author":"C Rhee","year":"2019","unstructured":"Rhee C, Jones TM, Hamad Y, et al. Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals. JAMA Netw Open. 2019;2(2):e187571.","journal-title":"JAMA Netw Open"},{"key":"1880_CR3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","volume":"149","author":"M Levi","year":"2017","unstructured":"Levi M, van der Poll T. Coagulation and sepsis. Thromb Res. 2017;149:38\u201344.","journal-title":"Thromb Res"},{"issue":"1","key":"1880_CR4","first-page":"56","volume":"9","author":"D Liu","year":"2022","unstructured":"Liu D, Huang SY, Sun JH, et al. Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options. Mil Med Res. 2022;9(1):56.","journal-title":"Mil Med Res"},{"issue":"3","key":"1880_CR5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","volume":"193","author":"C Fleischmann","year":"2016","unstructured":"Fleischmann C, Scherag A, Adhikari NK, et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259\u201372.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"1880_CR6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.critrevonc.2014.11.002","volume":"93","author":"RM Thushara","year":"2015","unstructured":"Thushara RM, Hemshekhar M, Basappa, et al. Biologicals, platelet apoptosis and human diseases: An outlook. Crit Rev Oncol Hematol. 2015;93(3):149\u201358.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"3","key":"1880_CR7","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1080\/1061186X.2021.1971237","volume":"30","author":"Z Chen","year":"2022","unstructured":"Chen Z, Jiang J, Fu N, et al. Targetting ferroptosis for blood cell-related diseases. J Drug Target. 2022;30(3):244\u201358.","journal-title":"J Drug Target"},{"key":"1880_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-025-01078-7","author":"T Direksunthorn","year":"2025","unstructured":"Direksunthorn T, TA A, Pluetrattanabha N, et al. Ferroptosis in immune chaos: Unraveling its impact on disease and therapeutic potential. J Physiol Biochem. 2025. https:\/\/doi.org\/10.1007\/s13105-025-01078-7.","journal-title":"J Physiol Biochem"},{"issue":"4","key":"1880_CR9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266\u201382.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"1880_CR10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","volume":"29","author":"D Tang","year":"2019","unstructured":"Tang D, Kang R, Berghe TV, et al. The molecular machinery of regulated cell death. Cell Res. 2019;29(5):347\u201364.","journal-title":"Cell Res"},{"key":"1880_CR11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.freeradbiomed.2020.08.009","volume":"160","author":"N Li","year":"2020","unstructured":"Li N, Wang W, Zhou H, et al. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. Free Radic Biol Med. 2020;160:303\u201318.","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"1880_CR12","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.7150\/ijbs.69141","volume":"18","author":"H Zhang","year":"2022","unstructured":"Zhang H, Liu J, Zhou Y, et al. Neutrophil extracellular traps mediate m(6)a modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells. Int J Biol Sci. 2022;18(8):3337\u201357.","journal-title":"Int J Biol Sci"},{"issue":"5","key":"1880_CR13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00018-022-04248-8","volume":"79","author":"Y Wang","year":"2022","unstructured":"Wang Y, Chen D, Xie H, et al. AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3. Cell Mol Life Sci. 2022;79(5):228.","journal-title":"Cell Mol Life Sci"},{"key":"1880_CR14","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002541","author":"JK Sun","year":"2025","unstructured":"Sun JK, Huangfu XT, Yin X, et al. Ferroptosis is involved in the IL-9-induced intestinal barrier injury in sepsis: an experimental animal and translational study. Int J Surg. 2025. https:\/\/doi.org\/10.1097\/JS9.0000000000002541.","journal-title":"Int J Surg"},{"issue":"1","key":"1880_CR15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13045-024-01564-3","volume":"17","author":"F Chen","year":"2024","unstructured":"Chen F, Kang R, Tang D, et al. Ferroptosis: principles and significance in health and disease. J Hematol Oncol. 2024;17(1):41.","journal-title":"J Hematol Oncol"},{"key":"1880_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2025.101550","author":"MJ Trites","year":"2025","unstructured":"Trites MJ, Li L, Njoku U, et al. Hepatic nuclear factor erythroid 2 related factor 1 activity promotes host defense in endotoxemia and bacterial sepsis. Cell Mol Gastroenterol Hepatol. 2025. https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101550.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"1880_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/biom10121688","author":"S Gunne","year":"2020","unstructured":"Gunne S, Heinicke U, Parnham MJ, et al. Nrf2-a molecular target for sepsis patients in critical care. Biomolecules. 2020. https:\/\/doi.org\/10.3390\/biom10121688.","journal-title":"Biomolecules"},{"key":"1880_CR18","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210518","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G, et al. Ferroptosis in infection, inflammation, and immunity. J Exp Med. 2021. https:\/\/doi.org\/10.1084\/jem.20210518.","journal-title":"J Exp Med"},{"issue":"18","key":"1880_CR19","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1111\/bph.15518","volume":"178","author":"S Wu","year":"2021","unstructured":"Wu S, Yang J, Sun G, et al. Macrophage extracellular traps aggravate iron overload-related liver ischaemia\/reperfusion injury. Br J Pharmacol. 2021;178(18):3783\u201396.","journal-title":"Br J Pharmacol"},{"key":"1880_CR20","volume":"185","author":"XS Chen","year":"2022","unstructured":"Chen XS, Wang SH, Liu CY, et al. Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-\u03baB and MAPK signaling. Pharmacol Res. 2022;185:106473.","journal-title":"Pharmacol Res"},{"issue":"13","key":"1880_CR21","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1001\/jama.2017.18391","volume":"319","author":"AL Beam","year":"2018","unstructured":"Beam AL, Kohane IS. Big data and machine learning in health care. JAMA. 2018;319(13):1317\u20138.","journal-title":"JAMA"},{"key":"1880_CR22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.103081","volume":"62","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Pan Q, Ge H, et al. Deep learning-based clustering robustly identified two classes of sepsis with both prognostic and predictive values. EBioMedicine. 2020;62:103081.","journal-title":"EBioMedicine"},{"key":"1880_CR23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103776","volume":"75","author":"A Baghela","year":"2022","unstructured":"Baghela A, Pena OM, Lee AH, et al. Predicting sepsis severity at first clinical presentation: the role of endotypes and mechanistic signatures. EBioMedicine. 2022;75:103776.","journal-title":"EBioMedicine"},{"issue":"D1","key":"1880_CR24","doi-asserted-by":"crossref","first-page":"D571","DOI":"10.1093\/nar\/gkac935","volume":"51","author":"N Zhou","year":"2023","unstructured":"Zhou N, Yuan X, Du Q, et al. FerrDb V2: update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations. Nucleic Acids Res. 2023;51(D1):D571\u201382.","journal-title":"Nucleic Acids Res"},{"key":"1880_CR25","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab108","author":"A Jia","year":"2021","unstructured":"Jia A, Xu L, Wang Y. Venn diagrams in bioinformatics. Brief Bioinform. 2021. https:\/\/doi.org\/10.1093\/bib\/bbab108.","journal-title":"Brief Bioinform"},{"key":"1880_CR26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.freeradbiomed.2022.06.242","volume":"188","author":"F Huang","year":"2022","unstructured":"Huang F, Zhang S, Li X, et al. STAT3-mediated ferroptosis is involved in ulcerative colitis. Free Radic Biol Med. 2022;188:375\u201385.","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"1880_CR27","doi-asserted-by":"crossref","DOI":"10.1016\/j.patter.2022.100434","volume":"3","author":"D Osorio","year":"2022","unstructured":"Osorio D, Zhong Y, Li G, et al. scTenifoldKnk: an efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation. Patterns. 2022;3(3):100434.","journal-title":"Patterns"},{"issue":"5","key":"1880_CR28","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/CCM.0000000000004842","volume":"49","author":"KM DeMerle","year":"2021","unstructured":"DeMerle KM, Angus DC, Baillie JK, et al. Sepsis subclasses: a framework for development and interpretation. Crit Care Med. 2021;49(5):748\u201359.","journal-title":"Crit Care Med"},{"key":"1880_CR29","volume":"257","author":"L Huo","year":"2023","unstructured":"Huo L, Liu C, Yuan Y, et al. Pharmacological inhibition of ferroptosis as a therapeutic target for sepsis-associated organ damage. Eur J Med Chem. 2023;257:115438.","journal-title":"Eur J Med Chem"},{"key":"1880_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215376","author":"M Huang","year":"2019","unstructured":"Huang M, Cai S, Su J. The pathogenesis of sepsis and potential therapeutic targets. Int J Mol Sci. 2019. https:\/\/doi.org\/10.3390\/ijms20215376.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1880_CR31","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.mcna.2020.02.011","volume":"104","author":"MD Font","year":"2020","unstructured":"Font MD, Thyagarajan B, Khanna AK. Sepsis and septic shock - basics of diagnosis, pathophysiology and clinical decision making. Med Clin North Am. 2020;104(4):573\u201385.","journal-title":"Med Clin North Am"},{"key":"1880_CR32","volume":"86","author":"JL Vincent","year":"2022","unstructured":"Vincent JL. Current sepsis therapeutics. EBioMedicine. 2022;86:104318.","journal-title":"EBioMedicine"},{"issue":"6","key":"1880_CR33","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/infdis\/jiaa191","volume":"222","author":"JS Lou","year":"2020","unstructured":"Lou JS, Wang JF, Fei MM, et al. Targeting lymphocyte activation gene 3 to reverse T-lymphocyte dysfunction and improve survival in murine polymicrobial sepsis. J Infect Dis. 2020;222(6):1051\u201361.","journal-title":"J Infect Dis"},{"key":"1880_CR34","volume":"254","author":"H Wu","year":"2023","unstructured":"Wu H, Tang T, Deng H, et al. Immune checkpoint molecule Tim-3 promotes NKT cell apoptosis and predicts poorer prognosis in sepsis. Clin Immunol. 2023;254:109249.","journal-title":"Clin Immunol"},{"issue":"1","key":"1880_CR35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41590-023-01660-5","volume":"25","author":"EJ Giamarellos-Bourboulis","year":"2024","unstructured":"Giamarellos-Bourboulis EJ, Aschenbrenner AC, Bauer M, et al. The pathophysiology of sepsis and precision-medicine-based immunotherapy. Nat Immunol. 2024;25(1):19\u201328.","journal-title":"Nat Immunol"},{"issue":"3","key":"1880_CR36","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.ymthe.2021.12.013","volume":"30","author":"S Huang","year":"2022","unstructured":"Huang S, Liu D, Sun J, et al. Tim-3 regulates sepsis-induced immunosuppression by inhibiting the NF-\u03baB signaling pathway in CD4 T cells. Mol Ther. 2022;30(3):1227\u201338.","journal-title":"Mol Ther"},{"issue":"7","key":"1880_CR37","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41419-022-05115-x","volume":"13","author":"J Wu","year":"2022","unstructured":"Wu J, Liu Q, Zhang X, et al. The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. Cell Death Dis. 2022;13(7):653.","journal-title":"Cell Death Dis"},{"issue":"7","key":"1880_CR38","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41590-020-0699-0","volume":"21","author":"M Jia","year":"2020","unstructured":"Jia M, Qin D, Zhao C, et al. Redox homeostasis maintained by GPX4 facilitates STING activation. Nat Immunol. 2020;21(7):727\u201335.","journal-title":"Nat Immunol"},{"key":"1880_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163567","author":"H Karami","year":"2021","unstructured":"Karami H, Derakhshani A, Ghasemigol M, et al. Weighted gene co-expression network analysis combined with machine learning validation to identify key modules and hub genes associated with SARS-CoV-2 infection. J Clin Med. 2021. https:\/\/doi.org\/10.3390\/jcm10163567.","journal-title":"J Clin Med"},{"issue":"2","key":"1880_CR40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","volume":"31","author":"D Tang","year":"2021","unstructured":"Tang D, Chen X, Kang R, et al. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021;31(2):107\u201325.","journal-title":"Cell Res"},{"issue":"5","key":"1880_CR41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","volume":"18","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G, et al. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021;18(5):280\u201396.","journal-title":"Nat Rev Clin Oncol"},{"key":"1880_CR42","volume":"159","author":"Y Qiu","year":"2020","unstructured":"Qiu Y, Cao Y, Cao W, et al. The application of ferroptosis in diseases. Pharmacol Res. 2020;159:104919.","journal-title":"Pharmacol Res"},{"key":"1880_CR43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2020.02.015","volume":"483","author":"Y Su","year":"2020","unstructured":"Su Y, Zhao B, Zhou L, et al. Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs. Cancer Lett. 2020;483:127\u201336.","journal-title":"Cancer Lett"},{"issue":"1","key":"1880_CR44","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.28251","volume":"63","author":"X Sun","year":"2016","unstructured":"Sun X, Ou Z, Chen R, et al. Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology. 2016;63(1):173\u201384.","journal-title":"Hepatology"},{"key":"1880_CR45","volume":"55","author":"H Zhou","year":"2022","unstructured":"Zhou H, Zhou YL, Mao JA, et al. NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells. Redox Biol. 2022;55:102413.","journal-title":"Redox Biol"},{"key":"1880_CR46","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.freeradbiomed.2024.06.007","volume":"222","author":"H Wang","year":"2024","unstructured":"Wang H, Mao W, Zhang Y, et al. NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson\u2019s disease. Free Radic Biol Med. 2024;222:331\u201343.","journal-title":"Free Radic Biol Med"},{"key":"1880_CR47","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2021.05.009","volume":"171","author":"Y Zhou","year":"2021","unstructured":"Zhou Y, Zhou H, Hua L, et al. Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis. Free Radic Biol Med. 2021;171:55\u201368.","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"1880_CR48","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41388-022-02537-x","volume":"42","author":"D Li","year":"2023","unstructured":"Li D, Wang Y, Dong C, et al. CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1. Oncogene. 2023;42(2):83\u201398.","journal-title":"Oncogene"},{"issue":"753","key":"1880_CR49","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adk0330","volume":"16","author":"HL Zhang","year":"2024","unstructured":"Zhang HL, Hu BX, Ye ZP, et al. TRPML1 triggers ferroptosis defense and is a potential therapeutic target in AKT-hyperactivated cancer. Sci Transl Med. 2024;16(753):eadk0330.","journal-title":"Sci Transl Med"},{"issue":"23","key":"1880_CR50","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1016\/j.molcel.2023.10.042","volume":"83","author":"W Zhang","year":"2023","unstructured":"Zhang W, Dai J, Hou G, et al. SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation. Mol Cell. 2023;83(23):4352-4369.e8.","journal-title":"Mol Cell"},{"issue":"5","key":"1880_CR51","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.ajpath.2013.01.029","volume":"182","author":"L Nayak","year":"2013","unstructured":"Nayak L, Goduni L, Takami Y, et al. Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation. Am J Pathol. 2013;182(5):1696\u2013704.","journal-title":"Am J Pathol"},{"issue":"6","key":"1880_CR52","first-page":"1701","volume":"1865","author":"R Tian","year":"2019","unstructured":"Tian R, Li R, Liu Y, et al. Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2. Biochem Biophys Acta. 2019;1865(6):1701\u201312.","journal-title":"Biochem Biophys Acta"},{"key":"1880_CR53","doi-asserted-by":"crossref","first-page":"1183769","DOI":"10.3389\/fimmu.2023.1183769","volume":"14","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Chen Y, Li J, et al. The development of endoplasmic reticulum-related gene signatures and the immune infiltration analysis of sepsis. Front Immunol. 2023;14:1183769.","journal-title":"Front Immunol"},{"issue":"5","key":"1880_CR54","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1080\/13813455.2020.1773860","volume":"128","author":"H Chen","year":"2022","unstructured":"Chen H, Peng Y, Wang L, et al. Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1\/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model. Arch Physiol Biochem. 2022;128(5):1413\u201320.","journal-title":"Arch Physiol Biochem"},{"key":"1880_CR55","doi-asserted-by":"publisher","DOI":"10.1080\/02648725.2023.2196475","author":"Q Mo","year":"2023","unstructured":"Mo Q, Mo Q, Mo F. Single-cell RNA sequencing and transcriptomic analysis reveal key genes and regulatory mechanisms in sepsis. Biotechnol Genet Eng Rev. 2023. https:\/\/doi.org\/10.1080\/02648725.2023.2196475.","journal-title":"Biotechnol Genet Eng Rev"},{"issue":"1","key":"1880_CR56","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12944-024-02116-x","volume":"23","author":"H Wang","year":"2024","unstructured":"Wang H, Xu L, Tang X, et al. Lipid peroxidation-induced ferroptosis as a therapeutic target for mitigating neuronal injury and inflammation in sepsis-associated encephalopathy: insights into the hippocampal PEBP-1\/15-LOX\/GPX4 pathway. Lipids Health Dis. 2024;23(1):128.","journal-title":"Lipids Health Dis"},{"issue":"10","key":"1880_CR57","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/j.bbamcr.2012.06.012","volume":"1823","author":"MB Kannan","year":"2012","unstructured":"Kannan MB, Solovieva V, Blank V. The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives. Biochim Biophys Acta. 2012;1823(10):1841\u20136.","journal-title":"Biochim Biophys Acta"},{"issue":"7796","key":"1880_CR58","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41586-020-1999-0","volume":"578","author":"MA Wheeler","year":"2020","unstructured":"Wheeler MA, Clark IC, Tjon EC, et al. MAFG-driven astrocytes promote CNS inflammation. Nature. 2020;578(7796):593\u20139.","journal-title":"Nature"},{"issue":"2","key":"1880_CR59","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1053\/j.gastro.2018.04.032","volume":"155","author":"T Liu","year":"2018","unstructured":"Liu T, Yang H, Fan W, et al. Mechanisms of MAFG dysregulation in cholestatic liver injury and development of liver cancer. Gastroenterology. 2018;155(2):557-571.e14.","journal-title":"Gastroenterology"},{"key":"1880_CR60","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.omtn.2021.03.006","volume":"24","author":"HJ Shan","year":"2021","unstructured":"Shan HJ, Zhu LQ, Yao C, et al. MAFG-driven osteosarcoma cell progression is inhibited by a novel miRNA miR-4660. Mol Ther Nucleic Acids. 2021;24:385\u2013402.","journal-title":"Mol Ther Nucleic Acids"},{"key":"1880_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061408","author":"O Vera","year":"2021","unstructured":"Vera O, Bok I, Jasani N, et al. A MAPK\/miR-29 axis suppresses melanoma by targeting MAFG and MYBL2. Cancers. 2021. https:\/\/doi.org\/10.3390\/cancers13061408.","journal-title":"Cancers"},{"key":"1880_CR62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2018.06.005","volume":"200","author":"O Vera-Puente","year":"2018","unstructured":"Vera-Puente O, Rodriguez-Antolin C, Salgado-Figueroa A, et al. MAFG is a potential therapeutic target to restore chemosensitivity in cisplatin-resistant cancer cells by increasing reactive oxygen species. Transl Res. 2018;200:1\u201317.","journal-title":"Transl Res"},{"key":"1880_CR63","doi-asserted-by":"crossref","first-page":"1226159","DOI":"10.3389\/fcimb.2023.1226159","volume":"13","author":"R Tong","year":"2023","unstructured":"Tong R, Ding X, Liu F, et al. Classification of subtypes and identification of dysregulated genes in sepsis. Front Cell Infect Microbiol. 2023;13:1226159.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"1880_CR64","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1038\/s41598-022-23062-7","volume":"13","author":"Y Tian","year":"2023","unstructured":"Tian Y, Wang C, Lu Q, et al. Screening of potential immune-related genes expressed during sepsis using gene sequencing technology. Sci Rep. 2023;13(1):4258.","journal-title":"Sci Rep"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01880-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-025-01880-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-025-01880-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:52:16Z","timestamp":1764917536000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-025-01880-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1880"],"URL":"https:\/\/doi.org\/10.1007\/s10238-025-01880-z","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]},"assertion":[{"value":"13 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The procedure was reviewed by the Ethics Committee of the Third Xiangya Hospital of Central South University (No. 25034) on January 13, 2025. The whole process was operated according to the principles of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants or their relatives included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"347"}}