{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:07:42Z","timestamp":1784945262060,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81870150"],"award-info":[{"award-number":["81870150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82000216"],"award-info":[{"award-number":["82000216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-026-02113-7","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T07:34:04Z","timestamp":1772955244000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Single-cell profiling reveals MIF-mediated immune evasion and CD8\u2009+\u2009T cell exhaustion in relapsed multiple myeloma"],"prefix":"10.1007","volume":"26","author":[{"given":"Jing","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"issue":"1","key":"2113_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31430-0","volume":"13","author":"JN Vo","year":"2022","unstructured":"Vo JN, Wu YM, Mishler J, Hall S, Mannan R, Wang L, et al. The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma. Nat Commun. 2022;13(1):3750.","journal-title":"Nat Commun"},{"issue":"10272","key":"2113_CR2","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/S0140-6736(21)00135-5","volume":"397","author":"N de Van Donk","year":"2021","unstructured":"de Van Donk N, Pawlyn C, Yong KL. Multiple myeloma. Lancet (London, England). 2021;397(10272):410\u201327.","journal-title":"Lancet (London, England)"},{"issue":"1","key":"2113_CR3","first-page":"12","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12\u201349.","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"2113_CR4","doi-asserted-by":"publisher","first-page":"e293","DOI":"10.1016\/S1470-2045(23)00223-1","volume":"24","author":"MA Dimopoulos","year":"2023","unstructured":"Dimopoulos MA, Merlini G, Bridoux F, Leung N, Mikhael J, Harrison SJ, et al. Management of multiple myeloma-related renal impairment: recommendations from the International Myeloma Working Group. Lancet Oncol. 2023;24(7):e293\u2013311.","journal-title":"Lancet Oncol"},{"key":"2113_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205154","author":"K Podar","year":"2021","unstructured":"Podar K, Leleu X. Relapsed\/refractory multiple myeloma in 2020\/2021 and beyond. Cancers (Basel). 2021. https:\/\/doi.org\/10.3390\/cancers13205154.","journal-title":"Cancers (Basel)"},{"key":"2113_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17040653","author":"S Li","year":"2025","unstructured":"Li S, Liu J, Peyton M, Lazaro O, McCabe SD, Huang X, et al. Multiple myeloma insights from single-cell analysis: clonal evolution, the microenvironment, therapy evasion, and clinical implications. Cancers (Basel). 2025. https:\/\/doi.org\/10.3390\/cancers17040653.","journal-title":"Cancers (Basel)"},{"key":"2113_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/cells14110776","author":"D De Novellis","year":"2025","unstructured":"De Novellis D, Scala P, Giudice V, Selleri C. High-risk genetic multiple myeloma: from molecular classification to innovative treatment with monoclonal antibodies and T-cell redirecting therapies. Cells. 2025. https:\/\/doi.org\/10.3390\/cells14110776.","journal-title":"Cells"},{"issue":"6","key":"2113_CR8","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1111\/cas.15773","volume":"114","author":"H Wu","year":"2023","unstructured":"Wu H, Guo C, Wang C, Xu J, Zheng S, Duan J, et al. Single-cell RNA sequencing reveals tumor heterogeneity, microenvironment, and drug-resistance mechanisms of recurrent glioblastoma. Cancer Sci. 2023;114(6):2609\u201321.","journal-title":"Cancer Sci"},{"issue":"1-2","key":"2113_CR9","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/s10495-024-02044-2","volume":"30","author":"Z Chen","year":"2025","unstructured":"Chen Z, Zhang T, Li W, Hu J, Ou Y, Ye F, et al. Single-cell RNA sequencing analysis reveals the dynamic changes in the tumor microenvironment during NMIBC recurrence. Apoptosis Intern J Program Cell Death. 2025;30(1\u20132):282\u201396.","journal-title":"Apoptosis Intern J Program Cell Death"},{"key":"2113_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1458638","volume":"15","author":"X Li","year":"2024","unstructured":"Li X, Lin Z, Zhao F, Huang T, Fan W, Cen L, et al. Unveiling the cellular landscape: insights from single-cell RNA sequencing in multiple myeloma. Front Immunol. 2024;15:1458638.","journal-title":"Front Immunol"},{"issue":"1","key":"2113_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01172-x","volume":"14","author":"Y Cheng","year":"2024","unstructured":"Cheng Y, Sun F, Alapat DV, Wanchai V, Mery D, Siegel ER, et al. Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages. Blood Cancer J. 2024;14(1):194.","journal-title":"Blood Cancer J"},{"issue":"9","key":"2113_CR12","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41419-024-07027-4","volume":"15","author":"Y Wang","year":"2024","unstructured":"Wang Y, Peng Y, Yang C, Xiong D, Wang Z, Peng H, et al. Single-cell sequencing analysis of multiple myeloma heterogeneity and identification of new theranostic targets. Cell Death Dis. 2024;15(9):672.","journal-title":"Cell Death Dis"},{"issue":"3","key":"2113_CR13","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/s41591-021-01232-w","volume":"27","author":"YC Cohen","year":"2021","unstructured":"Cohen YC, Zada M, Wang SY, Bornstein C, David E, Moshe A, et al. Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing. Nat Med. 2021;27(3):491\u2013503.","journal-title":"Nat Med"},{"key":"2113_CR14","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.2147\/JIR.S452062","volume":"17","author":"X Long","year":"2024","unstructured":"Long X, Li F, Tang S, Liu J, Fu Y, Feng Y. ScRNA-Seq and bulk-seq analysis identifies S100A9 plasma cells as a potentially effective immunotherapeutic agent for multiple myeloma. J Inflamm Res. 2024;17:1527\u201348.","journal-title":"J Inflamm Res"},{"issue":"1","key":"2113_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26951-z","volume":"12","author":"SM Tirier","year":"2021","unstructured":"Tirier SM, Mallm JP, Steiger S, Poos AM, Awwad MHS, Giesen N, et al. Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single-cell transcriptomics. Nat Commun. 2021;12(1):6960.","journal-title":"Nat Commun"},{"issue":"12","key":"2113_CR16","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","volume":"16","author":"I Korsunsky","year":"2019","unstructured":"Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K, et al. Fast, sensitive and accurate integration of single-cell data with Harmony. Nat Methods. 2019;16(12):1289\u201396.","journal-title":"Nat Methods"},{"issue":"5","key":"2113_CR17","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284\u20137.","journal-title":"OMICS"},{"issue":"10","key":"2113_CR18","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/nmeth.4402","volume":"14","author":"X Qiu","year":"2017","unstructured":"Qiu X, Mao Q, Tang Y, Wang L, Chawla R, Pliner HA, et al. Reversed graph embedding resolves complex single-cell trajectories. Nat Methods. 2017;14(10):979\u201382.","journal-title":"Nat Methods"},{"key":"2113_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01121","volume":"10","author":"BG Barwick","year":"2019","unstructured":"Barwick BG, Gupta VA, Vertino PM, Boise LH. Cell of origin and genetic alterations in the pathogenesis of multiple myeloma. Front Immunol. 2019;10:1121.","journal-title":"Front Immunol"},{"key":"2113_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01310-w","author":"H Mao","year":"2025","unstructured":"Mao H, Zhao X, Sun SC. NF-\u03baB in inflammation and cancer. Cell Mol Immunol. 2025. https:\/\/doi.org\/10.1038\/s41423-025-01310-w.","journal-title":"Cell Mol Immunol"},{"issue":"20","key":"2113_CR21","doi-asserted-by":"publisher","first-page":"6035","DOI":"10.1182\/bloodadvances.2023009890","volume":"7","author":"N Gudgeon","year":"2023","unstructured":"Gudgeon N, Giles H, Bishop EL, Fulton-Ward T, Escribano-Gonzalez C, Munford H, et al. Uptake of long-chain fatty acids from the bone marrow suppresses CD8+ T-cell metabolism and function in multiple myeloma. Blood Adv. 2023;7(20):6035\u201347.","journal-title":"Blood Adv"},{"issue":"1","key":"2113_CR22","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ccell.2023.12.010","volume":"42","author":"ME Hoekstra","year":"2024","unstructured":"Hoekstra ME, Slagter M, Urbanus J, Toebes M, Slingerland N, de Rink I, et al. Distinct spatiotemporal dynamics of CD8(+) T cell-derived cytokines in the tumor microenvironment. Cancer Cell. 2024;42(1):157-67.e9.","journal-title":"Cancer Cell"},{"key":"2113_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1101769","volume":"14","author":"K Zhao","year":"2023","unstructured":"Zhao K, Ren C, Tang D, Zhao L, Chen X, Wang Y, et al. The altering cellular components and function in tumor microenvironment during remissive and relapsed stages of anti-CD19 CAR T-cell treated lymphoma mice. Front Immunol. 2023;14:1101769.","journal-title":"Front Immunol"},{"issue":"6","key":"2113_CR24","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1172\/JCI88169","volume":"128","author":"Y Kawano","year":"2018","unstructured":"Kawano Y, Zavidij O, Park J, Moschetta M, Kokubun K, Mouhieddine TH, et al. Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression. J Clin Investig. 2018;128(6):2487\u201399.","journal-title":"J Clin Investig"},{"key":"2113_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194588","author":"C Hadjiaggelidou","year":"2021","unstructured":"Hadjiaggelidou C, Katodritou E. Regulatory T-cells and multiple myeloma: implications in tumor immune biology and treatment. J Clin Med. 2021. https:\/\/doi.org\/10.3390\/jcm10194588.","journal-title":"J Clin Med"},{"key":"2113_CR26","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003975","author":"J Sun","year":"2022","unstructured":"Sun J, Park C, Guenthner N, Gurley S, Zhang L, Lubben B, et al. Tumor-associated macrophages in multiple myeloma: advances in biology and therapy. J Immunother Cancer. 2022. https:\/\/doi.org\/10.1136\/jitc-2021-003975.","journal-title":"J Immunother Cancer"},{"key":"2113_CR27","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.canlet.2021.08.009","volume":"520","author":"H Yi","year":"2021","unstructured":"Yi H, Liang L, Wang H, Luo S, Hu L, Wang Y, et al. Albendazole inhibits NF-\u03baB signaling pathway to overcome tumor stemness and bortezomib resistance in multiple myeloma. Cancer Lett. 2021;520:307\u201320.","journal-title":"Cancer Lett"},{"issue":"1","key":"2113_CR28","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1186\/s12967-025-06516-0","volume":"23","author":"F Peng","year":"2025","unstructured":"Peng F, Liu Z, Jiang F, Li N, Wang H, Meng N, et al. T-lymphocytes suppression by CD14(+) monocytes with high expression of ULK2 in patients with multiple myeloma. J Transl Med. 2025;23(1):511.","journal-title":"J Transl Med"},{"key":"2113_CR29","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2147\/CCID.S350711","volume":"15","author":"J Li","year":"2022","unstructured":"Li J, Liu Y, Cao Y, Wang J, Zhao X, Jiao J, et al. Inhibition of miR-155 attenuates CD14(+) monocyte-mediated inflammatory response and oxidative stress in psoriasis through TLR4\/MyD88\/NF-\u03baB signaling pathway. Clin Cosmet Investig Dermatol. 2022;15:193\u2013201.","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2113_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082203","author":"AH Wong","year":"2020","unstructured":"Wong AH, Shin EM, Tergaonkar V, Chng WJ. Targeting NF-\u03baB signaling for multiple myeloma. Cancers (Basel). 2020. https:\/\/doi.org\/10.3390\/cancers12082203.","journal-title":"Cancers (Basel)"},{"key":"2113_CR31","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2025.5718","author":"N He","year":"2025","unstructured":"He N, Yang Q, Li Z, Guo J, Kuang C, Zhu Y, et al. LGR4 promotes proliferation and homing via activation of the NF\u2011\u03baB signaling pathway in multiple myeloma. Int J Oncol. 2025. https:\/\/doi.org\/10.3892\/ijo.2025.5718.","journal-title":"Int J Oncol"},{"issue":"16","key":"2113_CR32","doi-asserted-by":"publisher","first-page":"8220","DOI":"10.18632\/aging.204965","volume":"15","author":"R Wei","year":"2023","unstructured":"Wei R, Cao Y, Wu H, Liu X, Jiang M, Luo X, et al. Inhibition of VCP modulates NF-\u03baB signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation. Aging Albany NY. 2023;15(16):8220\u201336.","journal-title":"Aging Albany NY"},{"issue":"6","key":"2113_CR33","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1002\/JLB.2A1017-420RR","volume":"104","author":"Y Yao","year":"2018","unstructured":"Yao Y, Zhang Y, Shi M, Sun Y, Chen C, Niu M, et al. Blockade of deubiquitinase USP7 overcomes bortezomib resistance by suppressing NF-\u03baB signaling pathway in multiple myeloma. J Leukoc Biol. 2018;104(6):1105\u201315.","journal-title":"J Leukoc Biol"},{"issue":"9","key":"2113_CR34","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1007\/s13238-017-0500-9","volume":"9","author":"L Yang","year":"2018","unstructured":"Yang L, Chen J, Han X, Zhang E, Huang X, Guo X, et al. Pirh2 mediates the sensitivity of myeloma cells to bortezomib via canonical NF-\u03baB signaling pathway. Protein Cell. 2018;9(9):770\u201384.","journal-title":"Protein Cell"},{"key":"2113_CR35","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgaf033","author":"D Li","year":"2025","unstructured":"Li D, Qiao B, Cheng Q, Chen L, Zhao F, Zuo L, et al. Macrophage migration inhibitory factor as a prognostic biomarker in multiple myeloma: clinical significance and in vitro effects. Carcinog. 2025. https:\/\/doi.org\/10.1093\/carcin\/bgaf033.","journal-title":"Carcinog"},{"issue":"9","key":"2113_CR36","first-page":"1429","volume":"64","author":"M Sharaf-Eldein","year":"2018","unstructured":"Sharaf-Eldein M, Elghannam D, Elderiny W, Abdel-Malak C. Prognostic implication of MIF gene expression in childhood acute lymphoblastic leukemia. Clin Lab. 2018;64(9):1429\u201337.","journal-title":"Clin Lab"},{"issue":"3","key":"2113_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00440-4","volume":"11","author":"A Visram","year":"2021","unstructured":"Visram A, Dasari S, Anderson E, Kumar S, Kourelis TV. Relapsed multiple myeloma demonstrates distinct patterns of immune microenvironment and malignant cell-mediated immunosuppression. Blood Cancer J. 2021;11(3):45.","journal-title":"Blood Cancer J"},{"issue":"1","key":"2113_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0614-4","volume":"11","author":"RE Piddock","year":"2018","unstructured":"Piddock RE, Marlein CR, Abdul-Aziz A, Shafat MS, Auger MJ, Bowles KM, et al. Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC. J Hematol Oncol. 2018;11(1):66.","journal-title":"J Hematol Oncol"},{"issue":"1-2","key":"2113_CR39","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s11010-015-2631-8","volume":"412","author":"GB Park","year":"2016","unstructured":"Park GB, Kim YS, Lee HK, Yang JW, Kim D, Hur DY. ASK1\/JNK-mediated TAp63 activation controls the cell survival signal of baicalein-treated EBV-transformed B cells. Mol Cell Biochem. 2016;412(1\u20132):247\u201358.","journal-title":"Mol Cell Biochem"},{"issue":"11","key":"2113_CR40","doi-asserted-by":"publisher","first-page":"4497","DOI":"10.1096\/fj.15-273904","volume":"29","author":"S Alampour-Rajabi","year":"2015","unstructured":"Alampour-Rajabi S, El Bounkari O, Rot A, M\u00fcller-Newen G, Bachelerie F, Gawaz M, et al. MIF interacts with CXCR7 to promote receptor internalization, ERK1\/2 and ZAP-70 signaling, and lymphocyte chemotaxis. FASEB J. 2015;29(11):4497\u2013511.","journal-title":"FASEB J"},{"issue":"7","key":"2113_CR41","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.it.2020.05.001","volume":"41","author":"SL Cook","year":"2020","unstructured":"Cook SL, Franke MC, Sievert EP, Sciammas R. A synchronous IRF4-dependent gene regulatory network in B and helper T cells orchestrating the antibody response. Trends Immunol. 2020;41(7):614\u201328.","journal-title":"Trends Immunol"},{"issue":"1","key":"2113_CR42","doi-asserted-by":"publisher","first-page":"7165","DOI":"10.1038\/s41467-024-51496-2","volume":"15","author":"J Holzgruber","year":"2024","unstructured":"Holzgruber J, Martins C, Kulcsar Z, Duplaine A, Rasbach E, Migayron L, et al. Type I interferon signaling induces melanoma cell-intrinsic PD-1 and its inhibition antagonizes immune checkpoint blockade. Nat Commun. 2024;15(1):7165.","journal-title":"Nat Commun"},{"issue":"1","key":"2113_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01234-2","volume":"15","author":"M Swamydas","year":"2022","unstructured":"Swamydas M, Murphy EV, Ignatz-Hoover JJ, Malek E, Driscoll JJ. Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma. J Hematol Oncol. 2022;15(1):17.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"2113_CR44","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1084\/jem.20130901","volume":"211","author":"GR Starbeck-Miller","year":"2014","unstructured":"Starbeck-Miller GR, Xue HH, Harty JT. IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo. J Exp Med. 2014;211(1):105\u201320.","journal-title":"J Exp Med"},{"key":"2113_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.107126","volume":"160","author":"SH Pracha","year":"2025","unstructured":"Pracha SH, Shrestha S, Ryan N, Upadhaya P, Lamenza FF, Jagadeesha S, et al. Targeting macrophage migration inhibitory factor to inhibit T cell immunosuppression in the tumor microenvironment and improve cancer outcomes in head and neck squamous cell carcinoma. Oral Oncol. 2025;160:107126.","journal-title":"Oral Oncol"},{"key":"2113_CR46","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-006944","author":"M Westhrin","year":"2023","unstructured":"Westhrin M, Blazevski J, Textor A, Abdollahi P, Gopalakrishnan RP, Ngo LT, et al. Id-neoantigen vaccine induces therapeutic CD8(+) T cells against multiple myeloma: H chain-loss escapees cause FLC MM. J Immunother Cancer. 2023. https:\/\/doi.org\/10.1136\/jitc-2023-006944.","journal-title":"J Immunother Cancer"},{"issue":"1","key":"2113_CR47","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1146\/annurev-immunol-090222-110914","volume":"42","author":"A Baessler","year":"2024","unstructured":"Baessler A, Vignali DAA. T cell exhaustion. Annu Rev Immunol. 2024;42(1):179\u2013206.","journal-title":"Annu Rev Immunol"},{"issue":"3","key":"2113_CR48","first-page":"1877","volume":"181","author":"Q Zhou","year":"2008","unstructured":"Zhou Q, Yan X, Gershan J, Orentas RJ, Johnson BD. Expression of macrophage migration inhibitory factor by neuroblastoma leads to the inhibition of antitumor T cell reactivity in vivo. J Invest Med. 2008;181(3):1877\u201386.","journal-title":"J Invest Med"},{"issue":"1","key":"2113_CR49","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03528-y","volume":"20","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Zhou X, Guo J, Zhang F, Qian Y, Wang G, et al. TA-MSCs, TA-MSCs-EVs, MIF: their crosstalk in immunosuppressive tumor microenvironment. J Transl Med. 2022;20(1):320.","journal-title":"J Transl Med"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-026-02113-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-026-02113-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-026-02113-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:50:13Z","timestamp":1773888613000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-026-02113-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,8]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2113"],"URL":"https:\/\/doi.org\/10.1007\/s10238-026-02113-7","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,8]]},"assertion":[{"value":"12 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted according to the principles expressed in the Declaration of Helsinki and was approved by the Ethics Committee of This study has garnered approval from Medical Ethics Committee of Tianjin Cancer Hospital Airport Hospital (IREC number: LWK-2025\u20130012). Written informed consent was obtained from all patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"188"}}