{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:29:10Z","timestamp":1793971750631,"version":"4.8.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Key R&D Program in Xinjiang Uygur Autonomous Region","award":["2022B03019-4"],"award-info":[{"award-number":["2022B03019-4"]}]},{"name":"Scientific Research and Innovation Team Project of Xinjiang Medical University","award":["XYD-2024C09"],"award-info":[{"award-number":["XYD-2024C09"]}],"id":[{"id":"https:\/\/ror.org\/01p455v08","id-type":"ROR","asserted-by":"crossref"}]},{"name":"2022 Tianchi Young Talent Doctoral Program","award":["2022TCYCGWJ"],"award-info":[{"award-number":["2022TCYCGWJ"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"DOI":"10.1007\/s10238-026-02125-3","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T06:44:39Z","timestamp":1774334679000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["TMEM132A is associated with metabolic reprogramming, macrophage-oriented immune remodeling, and breast cancer progression"],"prefix":"10.1007","volume":"26","author":[{"given":"Yi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruonan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy Yue","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Aldridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Whitmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehao","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"2125_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229\u201363.","journal-title":"CA Cancer J Clin"},{"key":"2125_CR2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41572-019-0111-2","volume":"5","author":"N Harbeck","year":"2019","unstructured":"Harbeck N, Penault-Llorca F, Cortes J, Gnant M, Houssami N, Poortmans P, Ruddy K, Tsang J, Cardoso F. Breast cancer. Nat Rev Dis Primers. 2019;5:66.","journal-title":"Nat Rev Dis Primers"},{"key":"2125_CR3","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1016\/S0140-6736(16)32419-9","volume":"389","author":"NC Turner","year":"2017","unstructured":"Turner NC, Neven P, Loibl S, Andre F. Advances in the treatment of advanced oestrogen-receptor-positive breast cancer. Lancet. 2017;389:2403\u201314.","journal-title":"Lancet"},{"key":"2125_CR4","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/35021093","volume":"406","author":"CM Perou","year":"2000","unstructured":"Perou CM, S\u00f8rlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature. 2000;406:747\u201352.","journal-title":"Nature"},{"key":"2125_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04334-1","volume":"9","author":"QH Nguyen","year":"2018","unstructured":"Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, et al. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018;9:2028.","journal-title":"Nat Commun"},{"key":"2125_CR6","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/pro6.1245","volume":"8","author":"J Qin","year":"2024","unstructured":"Qin J, Zhao J, Yu J, Wei Y. [(18)F]-NOTA-FAPI-04 PET\/CT downgraded the staging of a breast cancer patient and changed their treatment management. Precis Radiat Oncol. 2024;8:227\u201331.","journal-title":"Precis Radiat Oncol"},{"key":"2125_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05237-0","volume":"22","author":"M Zhang","year":"2024","unstructured":"Zhang M, Zhang F, Wang J, Liang Q, Zhou W, Liu J. Comprehensive characterization of stemness-related lncRNAs in triple-negative breast cancer identified a novel prognostic signature related to treatment outcomes, immune landscape analysis and therapeutic guidance: a silico analysis with in vivo experiments. J Transl Med. 2024;22:423.","journal-title":"J Transl Med"},{"key":"2125_CR8","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1038\/s12276-024-01206-1","volume":"56","author":"H Kang","year":"2024","unstructured":"Kang H, Lee CJ. Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles. Exp Mol Med. 2024;56:850\u201360.","journal-title":"Exp Mol Med"},{"key":"2125_CR9","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.semcancer.2019.08.018","volume":"60","author":"S Marx","year":"2020","unstructured":"Marx S, Dal Maso T, Chen JW, Bury M, Wouters J, Michiels C, et al. Transmembrane (TMEM) protein family members: poorly characterized even if essential for the metastatic process. Semin Cancer Biol. 2020;60:96\u2013106.","journal-title":"Semin Cancer Biol"},{"key":"2125_CR10","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.3389\/fphar.2018.01345","volume":"9","author":"K Schmit","year":"2018","unstructured":"Schmit K, Michiels C. TMEM proteins in cancer: a review. Front Pharmacol. 2018;9:1345.","journal-title":"Front Pharmacol"},{"key":"2125_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1244740","volume":"13","author":"GA Herrera-Quiterio","year":"2023","unstructured":"Herrera-Quiterio GA, Encarnaci\u00f3n-Guevara S. The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer. Front Oncol. 2023;13:1244740.","journal-title":"Front Oncol"},{"key":"2125_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-03068-z","volume":"16","author":"B Li","year":"2025","unstructured":"Li B, Lin R, Hua Y, Ma B, Chen Y. Single\u2011cell RNA sequencing reveals TMEM71 as an immunomodulatory biomarker predicting immune checkpoint blockade response in breast cancer. Discov Oncol. 2025;16:1256.","journal-title":"Discov Oncol"},{"key":"2125_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-08752-2","volume":"15","author":"HQ Xu","year":"2025","unstructured":"Xu HQ, Zhao D, Xu SH, Mao R, Yang WQ, Han Q. TMEM150A overexpression was associated with poor prognosis and cancer progression in glioma verified by comprehensive analysis and cell experiments. Sci Rep. 2025;15:25017.","journal-title":"Sci Rep"},{"key":"2125_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02336-9","volume":"11","author":"C Chen","year":"2025","unstructured":"Chen C, Chen Z, Zhao J, Wen X, Yao H, Weng Z, et al. TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT\/mTOR signaling pathway in HR+ breast cancer. Cell Death Discov. 2025;11:47.","journal-title":"Cell Death Discov"},{"key":"2125_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-021-00767-w","volume":"14","author":"X Wang","year":"2021","unstructured":"Wang X, Jiang W, Luo S, Yang X, Wang C, Wang B, et al. The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex. Mol Brain. 2021;14:54.","journal-title":"Mol Brain"},{"key":"2125_CR16","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1080\/15257770.2022.2148692","volume":"42","author":"Q Gao","year":"2023","unstructured":"Gao Q, Chen Y, Yue L, Li Z, Wang M. Knockdown of TMEM132A restrains the malignant phenotype of gastric cancer cells via inhibiting Wnt signaling. Nucleosides Nucleotides Nucleic Acids. 2023;42:343\u201357.","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"2125_CR17","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2910360","volume":"29","author":"Y Wang","year":"2024","unstructured":"Wang Y, Hu H, Liu H, Zhou D, Zhang Y, Li L, et al. Study of the role of E2F1 and TMEM132A in prostate cancer development. Front Biosci (Landmark Ed). 2024;29:360.","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2125_CR18","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.1016\/j.asjsur.2023.03.116","volume":"46","author":"R Wu","year":"2023","unstructured":"Wu R, Li D, Feng D, Han P. Transmembrane protein 132A (TMEM132A) predicts overall survival for bladder cancer patients. Asian J Surg. 2023;46:3804\u20136.","journal-title":"Asian J Surg"},{"key":"2125_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-68111-5","volume":"14","author":"D Wu","year":"2024","unstructured":"Wu D, Liu Y, Liu J, Ma L, Tong X. Myeloid cell differentiation-related gene signature for predicting clinical outcome, immune microenvironment, and treatment response in lung adenocarcinoma. Sci Rep. 2024;14:17460.","journal-title":"Sci Rep"},{"key":"2125_CR20","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","volume":"141","author":"BZ Qian","year":"2010","unstructured":"Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010;141:39\u201351.","journal-title":"Cell"},{"key":"2125_CR21","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1158\/2159-8274.CD-10-0028","volume":"1","author":"DG DeNardo","year":"2011","unstructured":"DeNardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL, Madden SF, Gallagher WM, Wadhwani N, Keil SD, Junaid SA, Rugo HS, Hwang ES, Jirstr\u00f6m K, West BL, Coussens LM. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 2011;1:54\u201367.","journal-title":"Cancer Discov"},{"key":"2125_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-03074-1","volume":"16","author":"H Ma","year":"2025","unstructured":"Ma H, Liu J, Jin H, Zhang M, Liang Q, Guo Z. Comprehensive characterization of NK cell-related genes in cutaneous melanoma identified a novel prognostic signature for predicting the prognosis, immunotherapy, and chemotherapy efficacy. Discover Oncol. 2025;16:1243.","journal-title":"Discover Oncol"},{"key":"2125_CR23","first-page":"558","volume":"5","author":"X Wang","year":"2025","unstructured":"Wang X, Tao Y, Zhou J, Zhang J, Ding G. Breaking the noninflamed barrier: tumor-secreted erythropoietin as a master regulator of immunosuppressive macrophages. J Natl Cancer Cent. 2025;5:558\u201360.","journal-title":"J Natl Cancer Cent"},{"key":"2125_CR24","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/pro6.1221","volume":"8","author":"K Takeda","year":"2024","unstructured":"Takeda K, Umezawa R, Yamamoto T, Takahashi N, Suzuki Y, Kishida K, Omata S, Jingu K. Lymphocytopenia following adjuvant radiotherapy for breast cancer. Precis Radiat Oncol. 2024;8:22\u20139.","journal-title":"Precis Radiat Oncol"},{"key":"2125_CR25","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/pro6.1241","volume":"8","author":"X Xu","year":"2024","unstructured":"Xu X, Yin Y, Zhang L, Wang D, Zhou Y, Li Q. Research progress of cardiotoxicity caused by radiotherapy in breast cancer. Precis Radiat Oncol. 2024;8:153\u20138.","journal-title":"Precis Radiat Oncol"},{"key":"2125_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43458-x","volume":"14","author":"A Janesick","year":"2023","unstructured":"Janesick A, Shelansky R, Gottscho AD, Wagner F, Williams SR, Rouault M, et al. High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis. Nat Commun. 2023;14:8353.","journal-title":"Nat Commun"},{"key":"2125_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1649468","volume":"16","author":"W Shi","year":"2025","unstructured":"Shi W, Zhang Z, Xu X, Tian Y, Feng L, Huang X, et al. Single-cell and spatial transcriptomics integration: new frontiers in tumor microenvironment and cellular communication. Front Immunol. 2025;16:1649468.","journal-title":"Front Immunol"},{"key":"2125_CR28","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.immuni.2018.03.023","volume":"48","author":"V Thorsson","year":"2018","unstructured":"Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, et al. The Immune Landscape of Cancer. Immunity. 2018;48:812-830.e14.","journal-title":"Immunity"},{"key":"2125_CR29","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1158\/0008-5472.CAN-23-2650","volume":"84","author":"J Shi","year":"2024","unstructured":"Shi J, Wei X, Xun Z, Ding X, Liu Y, Liu L, et al. The web-based portal SpatialTME integrates histological images with single-cell and spatial transcriptomics to explore the tumor microenvironment. Cancer Res. 2024;84:1210\u201320.","journal-title":"Cancer Res"},{"key":"2125_CR30","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/s41467-023-36560-7","volume":"14","author":"Z Xun","year":"2023","unstructured":"Xun Z, Ding X, Zhang Y, Zhang B, Lai S, Zou D, Zheng J, Chen G, Su B, Han L, Ye Y. Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis. Nat Commun. 2023;14:933.","journal-title":"Nat Commun"},{"key":"2125_CR31","doi-asserted-by":"publisher","first-page":"D1425","DOI":"10.1093\/nar\/gkac959","volume":"51","author":"Y Han","year":"2023","unstructured":"Han Y, Wang Y, Dong X, Sun D, Liu Z, Yue J, Wang H, Li T, Wang C. TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment. Nucleic Acids Res. 2023;51:D1425\u201331.","journal-title":"Nucleic Acids Res"},{"key":"2125_CR32","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1093\/bioinformatics\/btab003","volume":"37","author":"J Alquicira-Hernandez","year":"2021","unstructured":"Alquicira-Hernandez J, Powell JE. Nebulosa recovers single-cell gene expression signals by kernel density estimation. Bioinformatics. 2021;37:2485\u20137.","journal-title":"Bioinformatics"},{"key":"2125_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH, et al. Inference and analysis of cell-cell communication using CellChat. Nat Commun. 2021;12:1088.","journal-title":"Nat Commun"},{"key":"2125_CR34","doi-asserted-by":"publisher","first-page":"e107468","DOI":"10.1371\/journal.pone.0107468","volume":"9","author":"P Geeleher","year":"2014","unstructured":"Geeleher P, Cox N, Huang RS. pRRophetic: an R package for prediction of clinical chemotherapeutic response from tumor gene expression levels. PLoS One. 2014;9:e107468.","journal-title":"PLoS One"},{"key":"2125_CR35","doi-asserted-by":"publisher","first-page":"R47","DOI":"10.1186\/gb-2014-15-3-r47","volume":"15","author":"P Geeleher","year":"2014","unstructured":"Geeleher P, Cox NJ, Huang RS. Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines. Genome Biol. 2014;15:R47.","journal-title":"Genome Biol"},{"key":"2125_CR36","doi-asserted-by":"crossref","unstructured":"Maeser D, Gruener RF, Huang RS. oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data. Brief Bioinform. 2021;22:bbab260","DOI":"10.1093\/bib\/bbab260"},{"key":"2125_CR37","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.cell.2018.03.034","volume":"173","author":"TM Malta","year":"2018","unstructured":"Malta TM, Sokolov A, Gentles AJ, Burzykowski T, Poisson L, Weinstein JN, et al. Machine learning identifies stemness features associated with oncogenic dedifferentiation. Cell. 2018;173:338-354.e315.","journal-title":"Cell"},{"key":"2125_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1137025","volume":"14","author":"H Chi","year":"2023","unstructured":"Chi H, Zhao S, Yang J, Gao X, Peng G, Zhang J, et al. T-cell exhaustion signatures characterize the immune landscape and predict HCC prognosis via integrating single-cell RNA-seq and bulk RNA-sequencing. Front Immunol. 2023;14:1137025.","journal-title":"Front Immunol"},{"key":"2125_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1564114","volume":"15","author":"P Xie","year":"2025","unstructured":"Xie P, Liu Y, Bai P, Ming Y, Zheng Q, Zhu L, et al. TMEM132A: a novel susceptibility gene for lung adenocarcinoma combined with venous thromboembolism identified through comprehensive bioinformatic analysis. Front Oncol. 2025;15:1564114.","journal-title":"Front Oncol"},{"key":"2125_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.599890","volume":"8","author":"B Li","year":"2020","unstructured":"Li B, Niswander LA. TMEM132A, a novel Wnt signaling pathway regulator through Wntless (WLS) interaction. Front Cell Dev Biol. 2020;8:599890.","journal-title":"Front Cell Dev Biol"},{"key":"2125_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01855-9","volume":"22","author":"SA Oh","year":"2024","unstructured":"Oh SA, Jeon J, Je SY, Kim S, Jung J, Ko HW. TMEM132A regulates Wnt\/\u03b2-catenin signaling through stabilizing LRP6 during mouse embryonic development. Cell Commun Signal. 2024;22:482.","journal-title":"Cell Commun Signal"},{"key":"2125_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1421905","volume":"15","author":"Y Yan","year":"2024","unstructured":"Yan Y, Li S, Su L, Tang X, Chen X, Gu X, et al. Mitochondrial inhibitors: a new horizon in breast cancer therapy. Front Pharmacol. 2024;15:1421905.","journal-title":"Front Pharmacol"},{"key":"2125_CR43","first-page":"426","volume":"5","author":"W Xu","year":"2025","unstructured":"Xu W, Lu J, Zhang H, Ye D. Decoding the tumor microenvironment: insights into immunotherapy and beyond. J Natl Cancer Cent. 2025;5:426\u20138.","journal-title":"J Natl Cancer Cent"},{"key":"2125_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-07010-3","volume":"23","author":"X Cheng","year":"2025","unstructured":"Cheng X, Zeng W, Yin B, Gui J, Zhang H, Lv Z, et al. Spatiotemporal microenvironment landscape and malignant epithelial pattern transition in breast ductal carcinoma progression. J Transl Med. 2025;23:996.","journal-title":"J Transl Med"},{"key":"2125_CR45","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-07557-1","volume":"24","author":"B Li","year":"2026","unstructured":"Li B, Lau LY, Chen Y. Linking FAM111B to metabolic-immune remodeling in breast ductal carcinoma. J Transl Med. 2026;24:177.","journal-title":"J Transl Med"},{"key":"2125_CR46","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1016\/j.immuni.2024.08.015","volume":"57","author":"Z Nian","year":"2024","unstructured":"Nian Z, Dou Y, Shen Y, Liu J, Du X, Jiang Y, et al. Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation. Immunity. 2024;57:2344-2361.e2347.","journal-title":"Immunity"},{"key":"2125_CR47","doi-asserted-by":"publisher","first-page":"4309","DOI":"10.1038\/s41388-025-03578-8","volume":"44","author":"M Sun","year":"2025","unstructured":"Sun M, Tan Z, Lin K, Chang Z, Yang Z, Yang X, Tang G, Liu Y, Li C, Zhu J, Kan C, Peng C, Zheng H. FPR3 sustains the immunosuppression of tumor-associated macrophages and accelerates the progression of gastric adenocarcinoma. Oncogene. 2025;44:4309\u201323.","journal-title":"Oncogene"},{"key":"2125_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2022.100112","volume":"2","author":"S Horiba","year":"2022","unstructured":"Horiba S, Kami R, Tsutsui T, Hosoi J. IL-34 downregulation\u2012associated M1\/M2 macrophage imbalance is related to inflammaging in sun-exposed human skin. JID Innov. 2022;2:100112.","journal-title":"JID Innov"},{"key":"2125_CR49","first-page":"453","volume":"5","author":"H Zhang","year":"2025","unstructured":"Zhang H, Wang S, Wu P, Hu Z, Chen Y, Guan Y, Pang J. Revealing the landscape of targeting mitochondrial functions and behaviors to overcome cancer chemoresistance. J Natl Cancer Cent. 2025;5:453\u201373.","journal-title":"J Natl Cancer Cent"},{"key":"2125_CR50","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.cmet.2022.01.007","volume":"34","author":"NN Pavlova","year":"2022","unstructured":"Pavlova NN, Zhu J, Thompson CB. The hallmarks of cancer metabolism: still emerging. Cell Metab. 2022;34:355\u201377.","journal-title":"Cell Metab"},{"key":"2125_CR51","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0257-y","volume":"5","author":"MA Cannarile","year":"2017","unstructured":"Cannarile MA, Weisser M, Jacob W, Jegg AM, Ries CH, R\u00fcttinger D. Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy. J Immunother Cancer. 2017;5:53.","journal-title":"J Immunother Cancer"},{"key":"2125_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107126","volume":"202","author":"Q Lv","year":"2024","unstructured":"Lv Q, Zhang Y, Gao W, Wang J, Hu Y, Yang H, et al. CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer. Pharmacol Res. 2024;202:107126.","journal-title":"Pharmacol Res"},{"key":"2125_CR53","doi-asserted-by":"publisher","first-page":"3448","DOI":"10.1002\/tox.24205","volume":"39","author":"C Jiang","year":"2024","unstructured":"Jiang C, Zhang S, Jiang L, Chen Z, Chen H, Huang J, et al. Precision unveiled: synergistic genomic landscapes in breast cancer-integrating single-cell analysis and decoding drug toxicity for elite prognostication and tailored therapeutics. Environ Toxicol. 2024;39:3448\u201372.","journal-title":"Environ Toxicol"},{"key":"2125_CR54","doi-asserted-by":"crossref","unstructured":"Pinzi L, Rastelli G. Molecular docking: shifting paradigms in drug discovery. Int J Mol Sci. 2019;20:4331","DOI":"10.3390\/ijms20184331"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-026-02125-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-026-02125-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-026-02125-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T10:02:20Z","timestamp":1775124140000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10238-026-02125-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2125"],"URL":"https:\/\/doi.org\/10.1007\/s10238-026-02125-3","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"5 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All authors read the guidelines of the journal and agreed with consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declaration"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"206"}}