{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:14:25Z","timestamp":1788401665088,"version":"build-2803163510"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":73,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    and\n                    <jats:italic>Prevotella intermedia<\/jats:italic>\n                    are key oral pathogens implicated in periodontal disease and have been associated with rheumatoid arthritis and specific categories of juvenile idiopathic arthritis. Whether oral dysbiosis involving\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    or\n                    <jats:italic>Prevotella intermedia<\/jats:italic>\n                    contributes to axial spondyloarthritis pathogenesis remains unclear. We evaluated\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    - and\n                    <jats:italic>Prevotella intermedia<\/jats:italic>\n                    -specific IgG titres across early axial spondyloarthritis phenotypes within the DESIR cohort and assessed the potential influence of smoking status. Serum samples from 554 participants in the DESIR cohort were analyzed. Anti-\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    and anti-\n                    <jats:italic>Prevotella intermedia<\/jats:italic>\n                    IgG titres were measured using a validated in-house enzyme-linked immunosorbent assay. Patients were classified into axial spondyloarthritis, axial spondyloarthritis with psoriasis, axial spondyloarthritis with inflammatory bowel disease, undifferentiated axial spondyloarthritis, or chronic low back pain controls. Antibody titres were compared using non-parametric tests. In addition, multivariable logistic and linear regression analyses were performed adjusting for age, sex, BMI and smoking status. Anti-\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    and anti-\n                    <jats:italic>Prevotella intermedia<\/jats:italic>\n                    IgG titres did not differ significantly across axial spondyloarthritis phenotypes or between axial spondyloarthritis subgroups and chronic low back pain controls (\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    :\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.622;\n                    <jats:italic>Prevotella intermedia<\/jats:italic>\n                    :\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.491). These findings remained unchanged after multivariable adjustment for age, sex, BMI, and smoking status (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.1). Smoking status did not influence serological patterns in any group. Distributional analyses confirmed strong overlap in antibody titres across all phenotypes, with no subgroup showing a distinct P. gingivalis or P. intermedia serological signature. In this large early axial spondyloarthritis cohort, antibody responses to\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    and\n                    <jats:italic>Prevotella intermedia<\/jats:italic>\n                    did not differ across phenotypes and showed no detectable serological association with axSpA. These findings did not support a major role of\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    - or\n                    <jats:italic>Prevotella intermedia<\/jats:italic>\n                    \u2013related systemic humoral responses in early axial spondyloarthritis, although they did not exclude a broader role of mucosal dysbiosis in disease pathogenesis.\n                  <\/jats:p>","DOI":"10.1007\/s10238-026-02204-5","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:48:19Z","timestamp":1782139699000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No serological association between Porphyromonas gingivalis or Prevotella intermedia and early spondyloarthritis: analysis from the DESIR cohort"],"prefix":"10.1007","volume":"26","author":[{"given":"Franck","family":"Zekre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiphany","family":"Neel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Normand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tournadre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Marotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"issue":"Suppl 1","key":"2204_CR1","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1111\/j.1834-7819.2009.01140.x","volume":"54","author":"J Highfield","year":"2009","unstructured":"Highfield J. Diagnosis and classification of periodontal disease. Aust Dent J. 2009;54(Suppl 1):S11\u201326. https:\/\/doi.org\/10.1111\/j.1834-7819.2009.01140.x.","journal-title":"Aust Dent J"},{"key":"2204_CR2","doi-asserted-by":"publisher","unstructured":"Dalix E, Marotte H. From a better knowledge of periodontal disease to Porphyromonas gingivalis target for rheumatoid arthritis disease activity. Joint Bone Spine. 2024;105822. https:\/\/doi.org\/10.1016\/j.jbspin.2024.105822.","DOI":"10.1016\/j.jbspin.2024.105822"},{"key":"2204_CR3","doi-asserted-by":"publisher","first-page":"e1000316","DOI":"10.1371\/journal.ppat.1000316","volume":"5","author":"M Potempa","year":"2009","unstructured":"Potempa M, Potempa J, Kantyka T, Nguyen K-A, Wawrzonek K, Manandhar SP, et al. Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3. PLoS Pathog. 2009;5:e1000316. https:\/\/doi.org\/10.1371\/journal.ppat.1000316.","journal-title":"PLoS Pathog"},{"key":"2204_CR4","doi-asserted-by":"publisher","unstructured":"Seror R, Le Gall-David S, Bonnaure-Mallet M, Schaeverbeke T, Cantagrel A, Minet J, et al. Association of Anti-Porphyromonas gingivalis Antibody Titers With Nonsmoking Status in Early Rheumatoid Arthritis: Results From the Prospective French Cohort of Patients With Early Rheumatoid Arthritis. Volume 67. Arthritis & Rheumatology; 2015. pp. 1729\u201337. (Hoboken, NJ). https:\/\/doi.org\/10.1002\/art.39118.","DOI":"10.1002\/art.39118"},{"key":"2204_CR5","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1093\/rheumatology\/kez368","volume":"59","author":"X Mariette","year":"2020","unstructured":"Mariette X, Perrodeau E, Verner C, Struillou X, Picard N, Schaeverbeke T, et al. Role of good oral hygiene on clinical evolution of rheumatoid arthritis: a randomized study nested in the ESPOIR cohort. 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Increased Immunity against the Oral Germs Porphyromonas gingivalis and Prevotella intermedia in Different Categories of Juvenile Idiopathic Arthritis. Biomedicines. 2022;10:2613. https:\/\/doi.org\/10.3390\/biomedicines10102613.","journal-title":"Biomedicines"},{"key":"2204_CR8","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.jbspin.2018.01.006","volume":"85","author":"D Wendling","year":"2018","unstructured":"Wendling D, Lukas C, Prati C, Claudepierre P, Gossec L, Goupille P, et al. 2018 update of French Society for Rheumatology (SFR) recommendations about the everyday management of patients with spondyloarthritis. Joint Bone Spine. 2018;85:275\u201384. https:\/\/doi.org\/10.1016\/j.jbspin.2018.01.006.","journal-title":"Joint Bone Spine"},{"key":"2204_CR9","doi-asserted-by":"publisher","first-page":"168","DOI":"10.5152\/eurjrheum.2020.20177","volume":"8","author":"A Pandey","year":"2021","unstructured":"Pandey A, Rajak R, Pandey M. 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All patients gave their written informed consent. A website containing the detailed description of the centres, the organization of the cohort and the full detailed protocol and Case Record Form is at http:\/\/www.lacohortedesir.fr. The biological resources centre (Paris, Bichat Hospital Claude Bernard \u2013 CRB BCB, Certificate number 34457, S. Tubiana) was in charge of centralizing and managing biological data collection.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No individual person\u2019s data","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"317"}}