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This study establishes patient-derived tissue slice cultures from routine endoscopic biopsies (ePDTC), as a potential translational platform for individualized drug response assessment. ePDTC were generated from routine colonic biopsies of ulcerative colitis (UC,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200911), Crohn\u2019s disease (CD,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20097), and non-IBD control patients (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20093). Tissue slices (350\u00a0\u03bcm high) were cultured at an air-liquid interface for 24 and 48\u00a0h, assessed for viability, immune cell composition, transcription factor activation, and mediator release profiles. Pharmacological responsiveness was evaluated using budesonide (1 \u00b5M) and myrrh extracts (50-100\u00a0\u00b5g\/mL). Structural integrity was preserved in 88.4% of ePDTC at 24\u00a0h after start of cultivation with low apoptosis rates (median: 1.21%), but declined to 56.0% of tissues at 48\u00a0h. ePDTC preserved disease-specific inflammatory signatures, including distinct neutrophil patterns between UC and CD subtypes. Budesonide significantly reduced 17 of 24 inflammatory mediators after 24\u00a0h (adjusted\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001) with indication of disease subtype-specific response patterns in principal component analysis. Myrrh extracts demonstrated concentration-dependent responses. Biopsy-derived ePDTC provide a clinically accessible ex vivo platform that preserves native tissue complexity and demonstrates the capacity to capture inter-individual pharmacodynamic heterogeneity within a 24-hour experimental window. This provides a biological basis for future patient-stratified pharmacological evaluation.\n                  <\/jats:p>","DOI":"10.1007\/s10238-026-02209-0","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:05:17Z","timestamp":1782137117000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient-derived tissue slice cultures from endoscopic biopsies as a translational ex vivo model for inflammatory bowel diseases"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0958-3118","authenticated-orcid":false,"given":"Julia","family":"Werner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2446-4278","authenticated-orcid":false,"given":"Laura","family":"Schiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3662-1023","authenticated-orcid":false,"given":"Jens","family":"Przybilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6018-0304","authenticated-orcid":false,"given":"Tobias","family":"Schlosser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Hoffmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-8307","authenticated-orcid":false,"given":"Sonja","family":"Kallendrusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4563-1493","authenticated-orcid":false,"given":"Cica","family":"Vissiennon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"2209_CR1","doi-asserted-by":"publisher","unstructured":"Puca P, Capobianco I, Coppola G, et al. 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All other authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the Medical Faculty, Leipzig University (reference numbers: 120\/20-ek and AZ 370\/13-ff).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Parts of this work were presented as an oral presentation at the Annual Congress of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS) - Viszeralmedizin 2025, Leipzig, Germany, September 2025.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conference presentation"}},{"value":"Patients meeting inclusion criteria were informed about the study at least 24\u00a0h before their scheduled endoscopy and provided written informed consent prior to study participation at the Clinic of Gastroenterology, University Hospital Leipzig.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"239"}}