{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:45:42Z","timestamp":1792079142375,"version":"4.4.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>El-Sehrawy and colleagues recently proposed a model of clonal thrombo-inflammation in myeloproliferative neoplasms organised around the inflammasome, clonal stability and a multi-compartmental thrombotic niche. Each of these elements was addressed in two reviews published by our group in 2021, neither of which is cited. The first set out the pathogenetic role of the NLRP3 and AIM2 inflammasomes and their link to hypercoagulable states; the second formalised the vascular consequence as the Circulating Wound, a self-sustaining lesion in which tissue-factor-rich clonal platelets, thrombin generation, protease-activated receptor signalling and TGF-\u03b2 crosstalk reinforce one another. This coagulative arm is absent from the more recent model. We summarise experimental findings from 53 therapy-naive patients that support the earlier formulation, and set out where the two accounts diverge and why the difference bears on the therapeutic reading.<\/jats:p>","DOI":"10.1007\/s10238-026-02343-9","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:04:17Z","timestamp":1792076657000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammasome, clonal stability and the thrombotic circuit in myeloproliferative neoplasms: an antecedent framework"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-5311","authenticated-orcid":false,"given":"Alessandro","family":"Lucchesi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariasanta","family":"Napolitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"1","key":"2343_CR1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s10238-026-02247-8","volume":"26","author":"AAMA El-Sehrawy","year":"2026","unstructured":"El-Sehrawy AAMA, Al-khreisat MJ, Kibriyeva M, et al. Beyond the JAK2 mutation: the inflammasome, clonal stability, and the thrombotic niche in myeloproliferative neoplasms. Clin Exp Med. 2026;26(1):241. https:\/\/doi.org\/10.1007\/s10238-026-02247-8.","journal-title":"Clin Exp Med"},{"issue":"2","key":"2343_CR2","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3390\/ijms22020561","volume":"22","author":"V Di Battista","year":"2021","unstructured":"Di Battista V, Bochicchio MT, Giordano G, Napolitano M, Lucchesi A. Genetics and pathogenetic role of inflammasomes in Philadelphia negative chronic myeloproliferative neoplasms: a narrative review. Int J Mol Sci. 2021;22(2):561. https:\/\/doi.org\/10.3390\/ijms22020561.","journal-title":"Int J Mol Sci"},{"key":"2343_CR3","doi-asserted-by":"publisher","first-page":"102476","DOI":"10.1155\/2015\/102476","volume":"2015","author":"HC Hasselbalch","year":"2015","unstructured":"Hasselbalch HC, Bj\u00f8rn ME. MPNs as inflammatory diseases: the evidence, consequences, and perspectives. Mediators Inflamm. 2015;2015:102476. https:\/\/doi.org\/10.1155\/2015\/102476.","journal-title":"Mediators Inflamm"},{"issue":"21","key":"2343_CR4","doi-asserted-by":"publisher","first-page":"11343","DOI":"10.3390\/ijms222111343","volume":"22","author":"A Lucchesi","year":"2021","unstructured":"Lucchesi A, Napolitano R, Bochicchio MT, Giordano G, Napolitano M. Platelets contribution to thrombin generation in Philadelphia-negative myeloproliferative neoplasms: the circulating wound model. Int J Mol Sci. 2021;22(21):11343. https:\/\/doi.org\/10.3390\/ijms222111343.","journal-title":"Int J Mol Sci"},{"issue":"Suppl 1","key":"2343_CR5","doi-asserted-by":"publisher","first-page":"12160","DOI":"10.1182\/blood-2022-171095","volume":"140","author":"A Lucchesi","year":"2022","unstructured":"Lucchesi A, Napolitano R, Bochicchio MT, et al. Preferential use of coagulation pathways differs between classical myeloproliferative neoplasms: results of global coagulation assays with respect to clinical and genetic features. Blood. 2022;140(Suppl 1):12160\u20131. https:\/\/doi.org\/10.1182\/blood-2022-171095.","journal-title":"Blood"},{"issue":"1","key":"2343_CR6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nri3345","volume":"13","author":"B Engelmann","year":"2013","unstructured":"Engelmann B, Massberg S. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol. 2013;13(1):34\u201345. https:\/\/doi.org\/10.1038\/nri3345.","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"2343_CR7","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.tcb.2022.12.001","volume":"33","author":"S Avagyan","year":"2023","unstructured":"Avagyan S, Zon LI. Clonal hematopoiesis and inflammation: the perpetual cycle. Trends Cell Biol. 2023;33(8):695\u2013707. https:\/\/doi.org\/10.1016\/j.tcb.2022.12.001.","journal-title":"Trends Cell Biol"}],"container-title":["Clinical and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-026-02343-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-026-02343-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10238-026-02343-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:04:17Z","timestamp":1792076657000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10238-026-02343-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2343"],"URL":"https:\/\/doi.org\/10.1007\/s10238-026-02343-9","relation":{},"ISSN":["1591-9528"],"issn-type":[{"value":"1591-9528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"assertion":[{"value":"20 September 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation of this work, the authors used Claude (Anthropic) to assist with text editing, structural reorganization, and language refinement. The authors thoroughly reviewed, verified, and edited all outputs for accuracy and consistency. The authors assume full accountability for the content and integrity of the final publication.","order":2,"name":"Ethics","label":"Statement on the use of AI tools","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"356"}}