{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:32:39Z","timestamp":1761561159914},"publisher-location":"Berlin, Heidelberg","reference-count":81,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"type":"print","value":"9783540311232"},{"type":"electronic","value":"9783540331469"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006]]},"DOI":"10.1007\/s10254-005-0003-0","type":"book-chapter","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T15:15:46Z","timestamp":1179933346000},"page":"45-60","source":"Crossref","is-referenced-by-count":9,"title":["An update on acid secretion"],"prefix":"10.1007","author":[{"given":"J. P.","family":"Geibel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,1,20]]},"reference":[{"key":"503_CR1","first-page":"183","volume":"71","author":"K Andersson","year":"1998","unstructured":"Andersson K, Chen D, Mattsson H, Sundler F, Hakanson R (1998) Physiological significance of ECL-cell histamine. Yale J Biol Med 71:183\u2013193","journal-title":"Yale J Biol Med"},{"key":"503_CR2","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1074\/jbc.271.29.16987","volume":"271","author":"S Asano","year":"1996","unstructured":"Asano S, Tega Y, Konishi K, Fujioka M, Takeguchi N (1996) Functional expression of gastric H+,K(+)-ATPase and site-directed mutagenesis of the putative cation binding site and catalytic center. J Biol Chem 271:2740\u20132745","journal-title":"J Biol Chem"},{"key":"503_CR3","doi-asserted-by":"publisher","first-page":"13968","DOI":"10.1074\/jbc.M308934200","volume":"279","author":"S Asano","year":"2004","unstructured":"Asano S, Yoshida A, Yashiro H, Kobayashi Y, Morisato A, Ogawa H, Takeguchi N, Morii M (2004) The cavity structure for docking the K(+)-competitive inhibitors in the gastric proton pump. J Biol Chem 279:13968\u201313975","journal-title":"J Biol Chem"},{"key":"503_CR4","doi-asserted-by":"publisher","first-page":"19537","DOI":"10.1074\/jbc.271.32.19537","volume":"271","author":"M Bai","year":"1996","unstructured":"Bai M, Quinn S, Trivedi S, Kifor O, Pearce SH, Pollak MR, Krapcho K, Hebert SC, Brown EM (1996) Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor. J Biol Chem 271:19537\u201319545","journal-title":"J Biol Chem"},{"key":"503_CR5","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S8756-3282(97)00002-1","volume":"20","author":"EM Brown","year":"1997","unstructured":"Brown EM, Hebert SC (1997) Calcium-receptor-regulated parathyroid and renal function. Bone 20:303\u2013309","journal-title":"Bone"},{"key":"503_CR6","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/366575a0","volume":"366","author":"EM Brown","year":"1993","unstructured":"Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hediger MA, Lytton J, Hebert SC (1993) Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature 366:575\u2013580","journal-title":"Nature"},{"key":"503_CR7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/S0014-5793(01)02301-8","volume":"494","author":"JT Bukrinsky","year":"2001","unstructured":"Bukrinsky JT, Buch-Pedersen MJ, Larsen S, Palmgren MG (2001) A putative proton binding site of plasma membrane H(+)-ATPase identified through homology modelling. FEBS Lett 494:6\u201310","journal-title":"FEBS Lett"},{"key":"503_CR8","doi-asserted-by":"crossref","unstructured":"Busque SM, Kerstetter JE, Geibel JP, Insogna K (2005) L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. Am J Physiol Gastrointest Liver Physiol (in press)","DOI":"10.1152\/ajpgi.00096.2005"},{"key":"503_CR9","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/S0016-5085(99)70235-0","volume":"116","author":"I Cheng","year":"1999","unstructured":"Cheng I, Qureshi I, Chattopadhyay N, Qureshi A, Butters RR, Hall AE, Cima RR, Rogers KV, Hebert SC, Geibel JP, Brown EM, Soybel DI (1999) Expression of an extracellular calcium-sensing receptor in rat stomach. Gastroenterology 116:118\u2013126","journal-title":"Gastroenterology"},{"key":"503_CR10","first-page":"G883","volume":"269","author":"JM Crothers Jr","year":"1995","unstructured":"Crothers JM Jr, Chow DC, Scalley ML, Forte JG (1995) In vivo trafficking of nascent H(+)-K(+)-ATPase in rabbit parietal cells. Am J Physiol 269:G883\u2013G891","journal-title":"Am J Physiol"},{"key":"503_CR11","doi-asserted-by":"crossref","first-page":"13740","DOI":"10.1016\/S0021-9258(18)42276-4","volume":"267","author":"MS Crowson","year":"1992","unstructured":"Crowson MS, Shull GE (1992) Isolation and characterization of a cDNA encoding the putative distal colon H+,K(+)-ATPase. Similarity of deduced amino acid sequence to gastric H+,K(+)-ATPase and Na+,K(+)-ATPase and mRNA expression in distal colon, kidney, and uterus. J Biol Chem 267:13740\u201313748","journal-title":"J Biol Chem"},{"key":"503_CR12","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1007\/s004240100609","volume":"442","author":"K Dedek","year":"2001","unstructured":"Dedek K, Waldegger S (2001) Colocalization of KCNQ1\/KCNE channel subunits in the mouse gastrointestinal tract. Pflugers Arch 442:896\u2013902","journal-title":"Pflugers Arch"},{"key":"503_CR13","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/j.1749-6632.2003.tb07157.x","volume":"986","author":"JJ Pont De","year":"2003","unstructured":"De Pont JJ, Swarts HG, Willems PH, Koenderink JB (2003) The E1\/E2-preference of gastric H,K-ATPase mutants. Ann NY Acad Sci 986:175\u2013182","journal-title":"Ann NY Acad Sci"},{"key":"503_CR14","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s00424-004-1347-5","volume":"449","author":"G Dockray","year":"2005","unstructured":"Dockray G, Dimaline R, Varro A (2005) Gastrin: old hormone, new functions. Pflugers Arch 449:344\u2013355","journal-title":"Pflugers Arch"},{"key":"503_CR15","doi-asserted-by":"crossref","unstructured":"Dufner MM, Kirchhoff P, Remy C, Hafner P, Muller MK, Cheng SX, Tang LQ, Hebert SC, Geibel JP, Wagner CA (2005) The Calcium-Sensing Receptor (CaSR) acts as a modulator of gastric acid secretion in freshly isolated human gastric glands. Am J Physiol Gastrointest Liver Physiol (in press)","DOI":"10.1152\/ajpgi.00571.2004"},{"key":"503_CR16","doi-asserted-by":"crossref","first-page":"C237","DOI":"10.1152\/ajpcell.00091.2003","volume":"285","author":"JG Duman","year":"2003","unstructured":"Duman JG, Forte JG (2003) What is the role of SNARE proteins in membrane fusion? Am J Physiol Cell Physiol 285:C237\u2013C249","journal-title":"Am J Physiol Cell Physiol"},{"key":"503_CR17","doi-asserted-by":"publisher","first-page":"7924","DOI":"10.1021\/bi036304q","volume":"43","author":"JG Duman","year":"2004","unstructured":"Duman JG, Lee E, Lee GY, Singh G, Forte JG (2004) Membrane fusion correlates with surface charge in exocytic vesicles. Biochemistry 43:7924\u20137939","journal-title":"Biochemistry"},{"key":"503_CR18","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1476-5381.1982.tb09232.x","volume":"76","author":"MD Ene","year":"1982","unstructured":"Ene MD, Khan-Daneshmend T, Roberts CJ (1982) A study of the inhibitory effects of SCH 28080 on gastric secretion in man. Br J Pharmacol 76:389\u2013391","journal-title":"Br J Pharmacol"},{"key":"503_CR20","first-page":"G183","volume":"242","author":"G Flemstrom","year":"1982","unstructured":"Flemstrom G, Garner A (1982) Gastroduodenal HCO3(-) transport: characteristics and proposed role in acidity regulation and mucosal protection. Am J Physiol 242:G183\u2013G193","journal-title":"Am J Physiol"},{"key":"503_CR19","doi-asserted-by":"publisher","first-page":"C478","DOI":"10.1152\/ajpcell.00531.2003","volume":"286","author":"JG Forte","year":"2004","unstructured":"Forte JG (2004) K+ channels in the secretory membrane of the parietal cell. focus on \"Gastric parietal cell secretory membrane contains PKA- and acid-activated Kir2.1 K+ channels\". Am J Physiol Cell Physiol 286:C478\u2013C479","journal-title":"Am J Physiol Cell Physiol"},{"key":"503_CR21","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1152\/ajplegacy.1963.205.4.631","volume":"205","author":"JG Forte","year":"1963","unstructured":"Forte JG, Nauss AH (1963) Effects of calcium removal on bullfrog gastric mucosa. Am J Physiol 205:631\u2013637","journal-title":"Am J Physiol"},{"key":"503_CR22","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0016-5085(19)31740-8","volume":"73","author":"TM Forte","year":"1977","unstructured":"Forte TM, Machen TE, Forte JG (1977) Ultrastructural changes in oxyntic cells associated with secretory function: a membrane-recycling hypothesis. Gastroenterology 73:941\u2013955","journal-title":"Gastroenterology"},{"key":"503_CR23","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1146\/annurev.ph.42.030180.000551","volume":"42","author":"JG Forte","year":"1980","unstructured":"Forte JG, Machen TE, Obrink KJ (1980) Mechanisms of gastric H+ and Cl- transport. Annu Rev Physiol 42:111\u2013126","journal-title":"Annu Rev Physiol"},{"key":"503_CR24","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1034\/j.1600-0773.2002.910614.x","volume":"91","author":"L Friis-Hansen","year":"2002","unstructured":"Friis-Hansen L (2002) Gastric functions in gastrin gene knock-out mice. Pharmacol Toxicol 91:363\u2013367","journal-title":"Pharmacol Toxicol"},{"key":"503_CR25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1113\/jphysiol.2001.013439","volume":"540","author":"A Fujita","year":"2002","unstructured":"Fujita A, Horio Y, Higashi K, Mouri T, Hata F, Takeguchi N, Kurachi Y (2002) Specific localization of an inwardly rectifying K(+) channel, Kir4.1, at the apical membrane of rat gastric parietal cells; its possible involvement in K(+) recycling for the H(+)-K(+)-pump. J Physiol 540:85\u201392","journal-title":"J Physiol"},{"key":"503_CR26","doi-asserted-by":"publisher","first-page":"13737","DOI":"10.1074\/jbc.274.20.13737","volume":"274","author":"C Gatto","year":"1999","unstructured":"Gatto C, Lutsenko S, Shin JM, Sachs G, Kaplan JH (1999) Stabilization of the H,K-ATPase M5M6 membrane hairpin by K+ ions. Mechanistic significance for p2-type atpases. J Biol Chem 274:13737\u201313740","journal-title":"J Biol Chem"},{"key":"503_CR27","doi-asserted-by":"publisher","first-page":"39549","DOI":"10.1074\/jbc.M107315200","volume":"276","author":"JP Geibel","year":"2001","unstructured":"Geibel JP, Wagner CA, Caroppo R, Qureshi I, Gloeckner J, Manuelidis L, Kirchhoff P, Radebold K (2001) The stomach divalent ion-sensing receptor scar is a modulator of gastric acid secretion. J Biol Chem 276:39549\u201339552","journal-title":"J Biol Chem"},{"key":"503_CR28","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1053\/gast.2001.24053","volume":"120","author":"F Grahammer","year":"2001","unstructured":"Grahammer F, Herling AW, Lang HJ, Schmitt-Graff A, Wittekindt OH, Nitschke R, Bleich M, Barhanin J, Warth R (2001) The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. Gastroenterology 120:1363\u20131371","journal-title":"Gastroenterology"},{"key":"503_CR29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1242\/jeb.200.2.295","volume":"200","author":"SC Hebert","year":"1997","unstructured":"Hebert SC, Brown EM, Harris HW (1997) Role of the Ca(2+)-sensing receptor in divalent mineral ion homeostasis. J Exp Biol 200:295\u2013302","journal-title":"J Exp Biol"},{"key":"503_CR30","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ceca.2003.10.015","volume":"35","author":"SC Hebert","year":"2004","unstructured":"Hebert SC, Cheng S, Geibel J (2004) Functions and roles of the extracellular Ca2+-sensing receptor in the gastrointestinal tract. Cell Calcium 35:239\u2013247","journal-title":"Cell Calcium"},{"key":"503_CR31","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/S0167-4838(00)00091-1","volume":"1480","author":"HP Hermsen","year":"2000","unstructured":"Hermsen HP, Swarts HG, Wassink L, Dijk FJ, Raijmakers MT, Klaassen CH, Koenderink JB, Maeda M, De Pont JJ (2000) The K(+) affinity of gastric H(+),K(+)-ATPase is affected by both lipid composition and the beta-subunit. Biochim Biophys Acta 1480:182\u2013190","journal-title":"Biochim Biophys Acta"},{"key":"503_CR32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1152\/physrev.1995.75.1.155","volume":"75","author":"SJ Hersey","year":"1995","unstructured":"Hersey SJ, Sachs G (1995) Gastric acid secretion. Physiol Rev 75:155\u2013189","journal-title":"Physiol Rev"},{"key":"503_CR33","doi-asserted-by":"crossref","first-page":"C922","DOI":"10.1152\/ajpcell.2001.281.3.C922","volume":"281","author":"K Higashi","year":"2001","unstructured":"Higashi K, Fujita A, Inanobe A, Tanemoto M, Doi K, Kubo T, Kurachi Y (2001) An inwardly rectifying K(+) channel, Kir4.1, expressed in astrocytes surrounds synapses and blood vessels in brain. Am J Physiol Cell Physiol 281:C922\u2013C931","journal-title":"Am J Physiol Cell Physiol"},{"key":"503_CR34","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1152\/ajplegacy.1969.216.4.961","volume":"216","author":"DK Kasbekar","year":"1969","unstructured":"Kasbekar DK, Ridley HA, Forte JG (1969) Pentagastrin and acetylcholine relation to histamine in H+ secretion by gastric mucosa. Am J Physiol 216:961\u2013967","journal-title":"Am J Physiol"},{"key":"503_CR35","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1016\/S0021-9258(18)83580-3","volume":"264","author":"DJ Keeling","year":"1989","unstructured":"Keeling DJ, Taylor AG, Schudt C (1989) The binding of a K+ competitive ligand, 2-methyl,8-(phenylmethoxy)imidazo(1,2-a)pyridine 3-acetonitrile, to the gastric (H+ + K+)-ATPase. J Biol Chem 264:5545\u20135551","journal-title":"J Biol Chem"},{"key":"503_CR36","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0006-2952(91)90690-7","volume":"42","author":"DJ Keeling","year":"1991","unstructured":"Keeling DJ, Malcolm RC, Laing SM, Ife RJ, Leach CA (1991) SK&F 96067 is a reversible, lumenally acting inhibitor of the gastric (H+ + K+)-ATPase. Biochem Pharmacol 42:123\u2013130","journal-title":"Biochem Pharmacol"},{"key":"503_CR37","doi-asserted-by":"crossref","first-page":"G1242","DOI":"10.1152\/ajpgi.00165.2003","volume":"285","author":"P Kirchhoff","year":"2003","unstructured":"Kirchhoff P, Wagner CA, Gaetzschmann F, Radebold K, Geibel JP (2003) Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands. Am J Physiol Gastrointest Liver Physiol 285:G1242\u2013G1248","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"503_CR38","doi-asserted-by":"publisher","first-page":"11604","DOI":"10.1074\/jbc.274.17.11604","volume":"274","author":"JB Koenderink","year":"1999","unstructured":"Koenderink JB, Swarts HG, Hermsen HP, De Pont JJ (1999) The beta-subunits of Na+,K+-ATPase and gastric H+,K+-ATPase have a high preference for their own alpha-subunit and affect the K+ affinity of these enzymes. J Biol Chem 274:11604\u201311610","journal-title":"J Biol Chem"},{"key":"503_CR39","doi-asserted-by":"publisher","first-page":"16417","DOI":"10.1074\/jbc.M400020200","volume":"279","author":"JB Koenderink","year":"2004","unstructured":"Koenderink JB, Swarts HG, Willems PH, Krieger E, De Pont JJ (2004) A conformation-specific interhelical salt bridge in the K+ binding site of gastric H,K-ATPase. J Biol Chem 279:16417\u201316424","journal-title":"J Biol Chem"},{"key":"503_CR40","doi-asserted-by":"publisher","first-page":"4041","DOI":"10.1074\/jbc.275.6.4041","volume":"275","author":"N Lambrecht","year":"2000","unstructured":"Lambrecht N, Munson K, Vagin O, Sachs G (2000) Comparison of covalent with reversible inhibitor binding sites of the gastric H,K-ATPase by site-directed mutagenesis. J Biol Chem 275:4041\u20134048","journal-title":"J Biol Chem"},{"key":"503_CR41","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1152\/physiolgenomics.00212.2004","volume":"21","author":"NW Lambrecht","year":"2005","unstructured":"Lambrecht NW, Yakubov I, Scott D, Sachs G (2005) Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion. Physiol Genomics 21:81\u201391","journal-title":"Physiol Genomics"},{"key":"503_CR42","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1172\/JCI10897","volume":"106","author":"MP Lee","year":"2000","unstructured":"Lee MP, Ravenel JD, Hu RJ, Lustig LR, Tomaselli G, Berger RD, Brandenburg SA, Litzi TJ, Bunton TE, Limb C, Francis H, Gorelikow M, Gu H, Washington K, Argani P, Goldenring JR, Coffey RJ, Feinberg AP (2000) Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J Clin Invest 106:1447\u20131455","journal-title":"J Clin Invest"},{"key":"503_CR46","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/316696a0","volume":"316","author":"DH Maclennan","year":"1985","unstructured":"Maclennan DH, Brandl CJ, Korczak B, Green NM (1985) Amino-acid sequence of a Ca2+ + Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence. Nature 316:696\u2013700","journal-title":"Nature"},{"key":"503_CR47","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0167-4889(88)90106-1","volume":"972","author":"DH Malinowska","year":"1988","unstructured":"Malinowska DH, Sachs G, Cuppoletti J (1988) Gastric H+ secretion: histamine (cAMP-mediated) activation of protein phosphorylation. Biochim Biophys Acta 972:95\u2013109","journal-title":"Biochim Biophys Acta"},{"key":"503_CR48","doi-asserted-by":"crossref","first-page":"C191","DOI":"10.1152\/ajpcell.1995.268.1.C191","volume":"268","author":"DH Malinowska","year":"1995","unstructured":"Malinowska DH, Kupert EY, Bahinski A, Sherry AM, Cuppoletti J (1995) Cloning, functional expression, and characterization of a PKA-activated gastric Cl- channel. Am J Physiol 268:C191\u2013C200","journal-title":"Am J Physiol"},{"key":"503_CR43","doi-asserted-by":"publisher","first-page":"C495","DOI":"10.1152\/ajpcell.00386.2003","volume":"286","author":"DH Malinowska","year":"2004","unstructured":"Malinowska DH, Sherry AM, Tewari KP, Cuppoletti J (2004) Gastric parietal cell secretory membrane contains PKA- and acid-activated Kir2.1 K+ channels. Am J Physiol Cell Physiol 286:C495\u2013C506","journal-title":"Am J Physiol Cell Physiol"},{"key":"503_CR49","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0248-4900(90)90349-8","volume":"69","author":"P Mangeat","year":"1990","unstructured":"Mangeat P, Gusdinar T, Sahuquet A, Hanzel DK, Forte JG, Magous R (1990) Acid secretion and membrane reorganization in single gastric parietal cell in primary culture. Biol Cell 69:223\u2013231","journal-title":"Biol Cell"},{"key":"503_CR44","first-page":"G1273","volume":"276","author":"N McDaniel","year":"1999","unstructured":"McDaniel N, Lytle C (1999) Parietal cells express high levels of Na-K-2Cl cotransporter on migrating into the gastric gland neck. Am J Physiol 276:G1273\u2013G1278","journal-title":"Am J Physiol"},{"key":"503_CR45","doi-asserted-by":"publisher","first-page":"G550","DOI":"10.1152\/ajpgi.00095.2005","volume":"289","author":"N McDaniel","year":"2005","unstructured":"McDaniel N, Pace AJ, Spiegel S, Engelhardt R, Koller BH, Seidler U, Lytle C (2005) Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen. Am J Physiol Gastrointest Liver Physiol 289:G550\u2013G560","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"503_CR50","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1016\/S0021-9258(19)34079-7","volume":"265","author":"J Mendlein","year":"1990","unstructured":"Mendlein J, Sachs G (1990) Interaction of a K(+)-competitive inhibitor, a substituted imidazo[1,2a] pyridine, with the phospho- and dephosphoenzyme forms of H+, K(+)-ATPase. J Biol Chem 265:5030\u20135036","journal-title":"J Biol Chem"},{"key":"503_CR51","doi-asserted-by":"crossref","first-page":"15590","DOI":"10.1016\/S0021-9258(18)55438-7","volume":"265","author":"J Mendlein","year":"1990","unstructured":"Mendlein J, Ditmars ML, Sachs G (1990) Calcium binding to the H+,K(+)-ATPase. Evidence for a divalent cation site that is occupied during the catalytic cycle. J Biol Chem 265:15590\u201315598","journal-title":"J Biol Chem"},{"key":"503_CR52","doi-asserted-by":"publisher","first-page":"9803","DOI":"10.1021\/bi025819z","volume":"41","author":"M Mense","year":"2002","unstructured":"Mense M, Rajendran V, Blostein R, Caplan MJ (2002) Extracellular domains, transmembrane segments, and intracellular domains interact to determine the cation selectivity of Na,K- and gastric H,K-ATPase. Biochemistry 41:9803\u20139812","journal-title":"Biochemistry"},{"key":"503_CR53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1242\/jeb.203.1.161","volume":"203","author":"K Munson","year":"2000","unstructured":"Munson K, Lambrecht N, Shin JM, Sachs G (2000) Analysis of the membrane domain of the gastric H(+)\/K(+)-ATPase. J Exp Biol 203:161\u2013170","journal-title":"J Exp Biol"},{"key":"503_CR54","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1023\/A:1018895405362","volume":"43","author":"L Nyberg","year":"1998","unstructured":"Nyberg L, Pratha V, Hogan DL, Rapier RC, Koss MA, Isenberg JI (1998) Human proximal duodenal alkaline secretion is mediated by Cl-\/HCO3- exchange and. Dig Dis Sci 43:1205\u20131210","journal-title":"Dig Dis Sci"},{"key":"503_CR55","doi-asserted-by":"crossref","first-page":"C30","DOI":"10.1152\/ajpcell.1987.253.1.C30","volume":"253","author":"AM Paradiso","year":"1987","unstructured":"Paradiso AM, Tsien RY, Demarest JR, Machen TE (1987) Na-H and Cl-HCO3 exchange in rabbit oxyntic cells using fluorescence microscopy. Am J Physiol 253:C30\u2013C36","journal-title":"Am J Physiol"},{"key":"503_CR56","doi-asserted-by":"crossref","first-page":"G1207","DOI":"10.1152\/ajpgi.00137.2002","volume":"283","author":"S Petrovic","year":"2002","unstructured":"Petrovic S, Wang Z, Ma L, Seidler U, Forte JG, Shull GE, Soleimani M (2002) Colocalization of the apical Cl-\/HCO3- exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells. Am J Physiol Gastrointest Liver Physiol 283:G1207\u2013G1216","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"503_CR57","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1097\/00001756-200206120-00012","volume":"13","author":"M Raap","year":"2002","unstructured":"Raap M, Biedermann B, Braun P, Milenkovic I, Skatchkov SN, Bringmann A, Reichenbach A (2002) Diversity of Kir channel subunit mRNA expressed by retinal glial cells of the guinea-pig. Neuroreport 13:1037\u20131040","journal-title":"Neuroreport"},{"key":"503_CR58","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1016\/S0021-9258(20)65138-9","volume":"257","author":"EC Rabon","year":"1982","unstructured":"Rabon EC, McFall TL, Sachs G (1982) The gastric [H,K]ATPase:H+\/ATP stoichiometry. J Biol Chem 257:6296\u20136299","journal-title":"J Biol Chem"},{"key":"503_CR59","first-page":"G850","volume":"259","author":"WW Reenstra","year":"1990","unstructured":"Reenstra WW, Forte JG (1990) Characterization of K+ and Cl- conductances in apical membrane vesicles from stimulated rabbit oxyntic cells. Am J Physiol 259:G850\u2013G858","journal-title":"Am J Physiol"},{"key":"503_CR60","first-page":"F951","volume":"271","author":"D Riccardi","year":"1996","unstructured":"Riccardi D, Lee WS, Lee K, Segre GV, Brown EM, Hebert SC (1996) Localization of the extracellular Ca(2+)-sensing receptor and PTH\/PTHrP receptor in rat kidney. Am J Physiol 271:F951\u2013F956","journal-title":"Am J Physiol"},{"key":"503_CR61","first-page":"G662","volume":"277","author":"MJ Rutten","year":"1999","unstructured":"Rutten MJ, Bacon KD, Marlink KL, Stoney M, Meichsner CL, Lee FP, Hobson SA, Rodland KD, Sheppard BC, Trunkey DD, Deveney KE, Deveney CW (1999) Identification of a functional Ca2+-sensing receptor in normal human gastric mucous epithelial cells. Am J Physiol 277:G662\u2013G670","journal-title":"Am J Physiol"},{"key":"503_CR62","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1592\/phco.23.13.68S.31931","volume":"23","author":"G Sachs","year":"2003","unstructured":"Sachs G (2003) Physiology of the parietal cell and therapeutic implications. Pharmacotherapy 23:68S\u201373S","journal-title":"Pharmacotherapy"},{"key":"503_CR63","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev.physiol.59.1.243","volume":"59","author":"G Sachs","year":"1997","unstructured":"Sachs G, Zeng N, Prinz C (1997) Physiology of isolated gastric endocrine cells. Annu Rev Physiol 59:243\u2013256","journal-title":"Annu Rev Physiol"},{"key":"503_CR64","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/316691a0","volume":"316","author":"GE Shull","year":"1985","unstructured":"Shull GE, Schwartz A, Lingrel JB (1985) Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA. Nature 316:691\u2013695","journal-title":"Nature"},{"key":"503_CR65","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0005-2736(84)90278-5","volume":"774","author":"AT Skrabanja","year":"1984","unstructured":"Skrabanja AT, De Pont JJ, Bonting SL (1984) The H+\/ATP transport ratio of the (K+ + H+)-ATPase of pig gastric membrane vesicles. Biochim Biophys Acta 774:91\u201395","journal-title":"Biochim Biophys Acta"},{"key":"503_CR66","first-page":"G589","volume":"245","author":"A Smolka","year":"1983","unstructured":"Smolka A, Helander HF, Sachs G (1983) Monoclonal antibodies against gastric H+ + K+ ATPase. Am J Physiol 245:G589\u2013G596","journal-title":"Am J Physiol"},{"key":"503_CR67","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/BF01870404","volume":"123","author":"S Supplisson","year":"1991","unstructured":"Supplisson S, Loo DD, Sachs G (1991) Diversity of K+ channels in the basolateral membrane of resting Necturus oxyntic cells. J Membr Biol 123:209\u2013221","journal-title":"J Membr Biol"},{"key":"503_CR68","doi-asserted-by":"publisher","first-page":"29764","DOI":"10.1074\/jbc.271.47.29764","volume":"271","author":"HG Swarts","year":"1996","unstructured":"Swarts HG, Klaassen CH, de BM, Fransen JA, De Pont JJ (1996) Role of negatively charged residues in the fifth and sixth transmembrane domains of the catalytic subunit of gastric H+,K+-ATPase. J Biol Chem 271:29764\u201329772","journal-title":"J Biol Chem"},{"key":"503_CR69","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1093\/emboj\/17.11.3029","volume":"17","author":"HG Swarts","year":"1998","unstructured":"Swarts HG, Hermsen HP, Koenderink JB, Schuurmans Stekhoven FM, De Pont JJ (1998) Constitutive activation of gastric H+,K+-ATPase by a single mutation. EMBO J 17:3029\u20133035","journal-title":"EMBO J"},{"key":"503_CR70","doi-asserted-by":"crossref","first-page":"G953","DOI":"10.1152\/ajpgi.00399.2001","volume":"282","author":"H Thangarajah","year":"2002","unstructured":"Thangarajah H, Wong A, Chow DC, Crothers JM Jr, Forte JG (2002) Gastric H-K-ATPase and acid-resistant surface proteins. Am J Physiol Gastrointest Liver Physiol 282:G953\u2013G961","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"503_CR71","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1091\/mbc.2.9.727","volume":"2","author":"HA Thomas","year":"1991","unstructured":"Thomas HA, Machen TE (1991) Regulation of Cl\/HCO3 exchange in gastric parietal cells. Cell Regul 2:727\u2013737","journal-title":"Cell Regul"},{"key":"503_CR72","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1254\/jjp.82.21","volume":"82","author":"Y Tsukimi","year":"2000","unstructured":"Tsukimi Y, Ushiro T, Yamazaki T, Ishikawa H, Hirase J, Narita M, Nishigaito T, Banno K, Ichihara T, Tanaka H (2000) Studies on the mechanism of action of the gastric H+,K(+)-ATPase inhibitor SPI-447. Jpn J Pharmacol 82:21\u201328","journal-title":"Jpn J Pharmacol"},{"key":"503_CR73","doi-asserted-by":"publisher","first-page":"7480","DOI":"10.1021\/bi0105328","volume":"40","author":"O Vagin","year":"2001","unstructured":"Vagin O, Munson K, Lambrecht N, Karlish SJ, Sachs G (2001) Mutational analysis of the K+-competitive inhibitor site of gastric H,K-ATPase. Biochemistry 40:7480\u20137490","journal-title":"Biochemistry"},{"key":"503_CR74","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1749-6632.2003.tb07147.x","volume":"986","author":"O Vagin","year":"2003","unstructured":"Vagin O, Munson K, Denevich S, Sachs G (2003) Inhibition kinetics of the gastric H,K-ATPase by K-competitive inhibitor SCH28080 as a tool for investigating the luminal ion pathway. Ann NY Acad Sci 986:111\u2013115","journal-title":"Ann NY Acad Sci"},{"key":"503_CR75","doi-asserted-by":"publisher","first-page":"39026","DOI":"10.1074\/jbc.M405453200","volume":"279","author":"O Vagin","year":"2004","unstructured":"Vagin O, Turdikulova S, Sachs G (2004) The H,K-ATPase beta subunit as a model to study the role of N-glycosylation in membrane trafficking and apical sorting. J Biol Chem 279:39026\u201339034","journal-title":"J Biol Chem"},{"key":"503_CR76","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1111\/j.1365-2036.2004.01957.x","volume":"19","author":"N Vakil","year":"2004","unstructured":"Vakil N (2004) Review article: new pharmacological agents for the treatment of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 19:1041\u20131049","journal-title":"Aliment Pharmacol Ther"},{"key":"503_CR77","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1080\/003655298750026679","volume":"33","author":"HL Waldum","year":"1998","unstructured":"Waldum HL, Brenna E, Sandvik AK (1998) Maximal gastric acid secretion in man: a concept that needs precision. Scand J Gastroenterol 33:1009\u20131015","journal-title":"Scand J Gastroenterol"},{"key":"503_CR78","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1046\/j.1365-2826.2000.00447.x","volume":"12","author":"I Wulfsen","year":"2000","unstructured":"Wulfsen I, Hauber HP, Schiemann D, Bauer CK, Schwarz JR (2000) Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3\/B6 cells and rat pituitary. J Neuroendocrinol 12:263\u2013272","journal-title":"J Neuroendocrinol"},{"key":"503_CR79","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1146\/annurev.physiol.65.072302.114200","volume":"65","author":"X Yao","year":"2003","unstructured":"Yao X, Forte JG (2003) Cell biology of acid secretion by the parietal cell. Annu Rev Physiol 65:103\u2013131","journal-title":"Annu Rev Physiol"},{"key":"503_CR80","first-page":"474","volume":"25","author":"D Yan","year":"2004","unstructured":"Yan D, Hu YD, Li S, Cheng MS (2004) A model of 3D-structure of H+, K+-ATPase catalytic subunit derived by homology modeling. Acta Pharmacol Sin, 25:474\u2013479","journal-title":"Acta Pharmacol Sin,"},{"key":"503_CR81","doi-asserted-by":"crossref","first-page":"C662","DOI":"10.1152\/ajpcell.00085.2003","volume":"285","author":"R Zhou","year":"2003","unstructured":"Zhou R, Watson C, Fu C, Yao X, Forte JG (2003) Myosin II is present in gastric parietal cells and required for lamellipodial dynamics associated with cell activation. Am J Physiol Cell Physiol 285:C662\u2013C673","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Reviews of Physiology, Biochemistry and Pharmacology"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10254-005-0003-0.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T02:08:39Z","timestamp":1628906919000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10254-005-0003-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"ISBN":["9783540311232","9783540331469"],"references-count":81,"URL":"https:\/\/doi.org\/10.1007\/s10254-005-0003-0","relation":{},"subject":[],"published":{"date-parts":[[2006]]}}}