{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:55:24Z","timestamp":1793912124502,"version":"4.8.0"},"reference-count":121,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE26924"],"award-info":[{"award-number":["R01DE26924"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE26924"],"award-info":[{"award-number":["R01DE26924"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103638"],"award-info":[{"award-number":["P20GM103638"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32-GM008359"],"award-info":[{"award-number":["T32-GM008359"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Odontology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s10266-019-00439-1","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T12:02:31Z","timestamp":1562155351000},"page":"153-165","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Estrogen signaling impacts temporomandibular joint and periodontal disease pathology"],"prefix":"10.1007","volume":"108","author":[{"given":"Jennifer L.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela M.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Kister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5743-9231","authenticated-orcid":false,"given":"Sunil","family":"Wadhwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"issue":"7","key":"439_CR1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/odi.12428","volume":"22","author":"LJ Jin","year":"2016","unstructured":"Jin LJ, et al. Global burden of oral diseases: emerging concepts, management and interplay with systemic health. Oral Dis. 2016;22(7):609\u201319.","journal-title":"Oral Dis"},{"issue":"2","key":"439_CR2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.nwh.2017.02.010","volume":"21","author":"JL Kessler","year":"2017","unstructured":"Kessler JL. A literature review on women\u2019s oral health across the life span. Nurs Womens Health. 2017;21(2):108\u201321.","journal-title":"Nurs Womens Health"},{"issue":"9","key":"439_CR3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/joor.12661","volume":"45","author":"CH Bueno","year":"2018","unstructured":"Bueno CH, et al. Gender differences in temporomandibular disorders in adult populational studies: a systematic review and meta-analysis. J Oral Rehabil. 2018;45(9):720\u20139.","journal-title":"J Oral Rehabil"},{"issue":"Pt A","key":"439_CR4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.steroids.2014.12.010","volume":"99","author":"JA Cauley","year":"2015","unstructured":"Cauley JA. Estrogen and bone health in men and women. Steroids. 2015;99(Pt A):11\u20135.","journal-title":"Steroids"},{"key":"439_CR5","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.3389\/fphys.2018.01834","volume":"9","author":"N Chidi-Ogbolu","year":"2018","unstructured":"Chidi-Ogbolu N, Baar K. Effect of estrogen on musculoskeletal performance and injury risk. Front Physiol. 2018;9:1834.","journal-title":"Front Physiol"},{"issue":"11 Suppl","key":"439_CR6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jpain.2011.09.001","volume":"12","author":"R Ohrbach","year":"2011","unstructured":"Ohrbach R, et al. Clinical findings and pain symptoms as potential risk factors for chronic TMD: descriptive data and empirically identified domains from the OPPERA case-control study. J Pain. 2011;12(11 Suppl):27\u201345.","journal-title":"J Pain."},{"issue":"4","key":"439_CR7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.tripleo.2011.04.021","volume":"112","author":"D Manfredini","year":"2011","unstructured":"Manfredini D, et al. Research diagnostic criteria for temporomandibular disorders: a systematic review of axis I epidemiologic findings. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(4):453\u201362.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"3","key":"439_CR8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/10454411970080030401","volume":"8","author":"L LeResche","year":"1997","unstructured":"LeResche L. Epidemiology of temporomandibular disorders: implications for the investigation of etiologic factors. Crit Rev Oral Biol Med. 1997;8(3):291\u2013305.","journal-title":"Crit Rev Oral Biol Med"},{"issue":"1\u20132","key":"439_CR9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0304-3959(96)03230-7","volume":"69","author":"L LeResche","year":"1997","unstructured":"LeResche L, et al. Use of exogenous hormones and risk of temporomandibular disorder pain. Pain. 1997;69(1\u20132):153\u201360.","journal-title":"Pain"},{"issue":"3","key":"439_CR10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000047881","volume":"169","author":"MP Warren","year":"2001","unstructured":"Warren MP, Fried JL. Temporomandibular disorders and hormones in women. Cells Tissues Organs. 2001;169(3):187\u201392.","journal-title":"Cells Tissues Organs"},{"issue":"12 Suppl","key":"439_CR11","first-page":"T20.e1-3","volume":"14","author":"GD Slade","year":"2013","unstructured":"Slade GD, et al. Signs and symptoms of first-onset TMD and sociodemographic predictors of its development: the OPPERA prospective cohort study. J Pain. 2013;14(12 Suppl):T20.e1-3\u201332.e1-3.","journal-title":"J Pain."},{"issue":"10","key":"439_CR12","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1177\/0022034516653743","volume":"95","author":"GD Slade","year":"2016","unstructured":"Slade GD, et al. Painful temporomandibular disorder: decade of discovery from OPPERA studies. J Dent Res. 2016;95(10):1084\u201392.","journal-title":"J Dent Res"},{"issue":"1","key":"439_CR13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1034\/j.1600-0528.2002.300108.x","volume":"30","author":"TV Macfarlane","year":"2002","unstructured":"Macfarlane TV, et al. Oro-facial pain in the community: prevalence and associated impact. Commun Dent Oral Epidemiol. 2002;30(1):52\u201360.","journal-title":"Commun Dent Oral Epidemiol"},{"issue":"4","key":"439_CR14","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/ejp.755","volume":"20","author":"A Lovgren","year":"2016","unstructured":"Lovgren A, et al. Temporomandibular pain and jaw dysfunction at different ages covering the lifespan\u2014a population based study. Eur J Pain. 2016;20(4):532\u201340.","journal-title":"Eur J Pain"},{"issue":"9 Suppl","key":"439_CR15","doi-asserted-by":"crossref","first-page":"T93","DOI":"10.1016\/j.jpain.2016.06.002","volume":"17","author":"W Maixner","year":"2016","unstructured":"Maixner W, et al. Overlapping chronic pain conditions: implications for diagnosis and classification. J Pain. 2016;17(9 Suppl):T93\u2013107.","journal-title":"J Pain"},{"issue":"1","key":"439_CR16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.11607\/jop.1151","volume":"28","author":"E Schiffman","year":"2014","unstructured":"Schiffman E, et al. Diagnostic criteria for temporomandibular disorders (DC\/TMD) for clinical and research applications: recommendations of the international RDC\/TMD Consortium Network* and Orofacial Pain Special Interest Groupdagger. J Oral Facial Pain Headache. 2014;28(1):6\u201327.","journal-title":"J Oral Facial Pain Headache"},{"issue":"2","key":"439_CR17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1179\/crn.2012.015","volume":"30","author":"L Guarda-Nardini","year":"2012","unstructured":"Guarda-Nardini L, et al. Age-related differences in temporomandibular disorder diagnoses. Cranio. 2012;30(2):103\u20139.","journal-title":"Cranio"},{"issue":"2","key":"439_CR18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/ger.12245","volume":"34","author":"K Back","year":"2017","unstructured":"Back K, et al. Relation between osteoporosis and radiographic and clinical signs of osteoarthritis\/arthrosis in the temporomandibular joint: a population-based, cross-sectional study in an older Swedish population. Gerodontology. 2017;34(2):187\u201394.","journal-title":"Gerodontology"},{"issue":"2","key":"439_CR19","first-page":"42","volume":"13","author":"O Jagur","year":"2011","unstructured":"Jagur O, et al. Relationship between radiographic changes in the temporomandibular joint and bone mineral density: a population based study. Stomatologija. 2011;13(2):42\u20138.","journal-title":"Stomatologija"},{"issue":"3","key":"439_CR20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tripleo.2005.04.010","volume":"100","author":"E Dervis","year":"2005","unstructured":"Dervis E. Oral implications of osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(3):349\u201356.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"6","key":"439_CR21","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/oxfordjournals.aje.a009142","volume":"145","author":"KM Brett","year":"1997","unstructured":"Brett KM, Madans JH. Use of postmenopausal hormone replacement therapy: estimates from a nationally representative cohort study. Am J Epidemiol. 1997;145(6):536\u201345.","journal-title":"Am J Epidemiol"},{"issue":"3","key":"439_CR22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2344\/0003-3006(2007)54[109:IRFFTF]2.0.CO;2","volume":"54","author":"MD Martin","year":"2007","unstructured":"Martin MD, et al. Intubation risk factors for temporomandibular joint\/facial pain. Anesth Prog. 2007;54(3):109\u201314.","journal-title":"Anesth Prog"},{"issue":"1","key":"439_CR23","first-page":"e100","volume":"30","author":"VR Lora","year":"2016","unstructured":"Lora VR, et al. Prevalence of temporomandibular disorders in postmenopausal women and relationship with pain and HRT. Braz Oral Res. 2016;30(1):e100.","journal-title":"Braz Oral Res"},{"issue":"3","key":"439_CR24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1179\/crn.2008.028","volume":"26","author":"A Nekora-Azak","year":"2008","unstructured":"Nekora-Azak A, et al. Estrogen replacement therapy among postmenopausal women and its effects on signs and symptoms of temporomandibular disorders. Cranio. 2008;26(3):211\u20135.","journal-title":"Cranio"},{"issue":"3","key":"439_CR25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.14219\/jada.archive.2001.0174","volume":"132","author":"JP Hatch","year":"2001","unstructured":"Hatch JP, et al. Is use of exogenous estrogen associated with temporomandibular signs and symptoms? J Am Dent Assoc. 2001;132(3):319\u201326.","journal-title":"J Am Dent Assoc"},{"issue":"1","key":"439_CR26","first-page":"3","volume":"26","author":"VA Mayoral","year":"2013","unstructured":"Mayoral VA, Espinosa IA, Montiel AJ. Association between signs and symptoms of temporomandibular disorders and pregnancy (case control study). Acta Odontol Latinoam. 2013;26(1):3\u20137.","journal-title":"Acta Odontol Latinoam"},{"issue":"2","key":"439_CR27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.11607\/ofph.1906","volume":"32","author":"N Ivkovi\u0107","year":"2018","unstructured":"Ivkovi\u0107 N, et al. Relationship between symptoms of temporomandibular disorders and estrogen levels in women with different menstrual status. J Oral Facial Pain Headache. 2018;32(2):151\u20138.","journal-title":"J Oral Facial Pain Headache"},{"issue":"3","key":"439_CR28","first-page":"193","volume":"19","author":"L LeResche","year":"2005","unstructured":"LeResche L, et al. Musculoskeletal orofacial pain and other signs and symptoms of temporomandibular disorders during pregnancy: a prospective study. J Orofac Pain. 2005;19(3):193\u2013201.","journal-title":"J Orofac Pain"},{"issue":"9","key":"439_CR29","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1016\/j.pain.2011.05.005","volume":"152","author":"JA Turner","year":"2011","unstructured":"Turner JA, et al. Targeting temporomandibular disorder pain treatment to hormonal fluctuations: a randomized clinical trial. Pain. 2011;152(9):2074\u201384.","journal-title":"Pain"},{"issue":"3","key":"439_CR30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1089\/ten.teb.2017.0341","volume":"24","author":"AJ Almarza","year":"2018","unstructured":"Almarza AJ, et al. Preclinical animal models for temporomandibular joint tissue engineering. Tissue Eng Part B Rev. 2018;24(3):171\u20138.","journal-title":"Tissue Eng Part B Rev"},{"issue":"3\u20134","key":"439_CR31","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1089\/ten.tea.2014.0250","volume":"21","author":"CM Juran","year":"2015","unstructured":"Juran CM, Dolwick MF, McFetridge PS. Engineered microporosity: enhancing the early regenerative potential of decellularized temporomandibular joint discs. Tissue Eng Part A. 2015;21(3\u20134):829\u201339.","journal-title":"Tissue Eng Part A"},{"issue":"6","key":"439_CR32","first-page":"125","volume":"96","author":"L Rees","year":"1954","unstructured":"Rees L. The structure and function of the mandibular joint. Br Dent J. 1954;96(6):125\u201333.","journal-title":"Br Dent J"},{"issue":"8\u20139","key":"439_CR33","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0003-9969(96)00040-4","volume":"41","author":"T Nakano","year":"1996","unstructured":"Nakano T, Scott PG. Changes in the chemical composition of the bovine temporomandibular joint disc with age. Arch Oral Biol. 1996;41(8\u20139):845\u201353.","journal-title":"Arch Oral Biol"},{"issue":"2","key":"439_CR34","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bjoms.2005.05.002","volume":"44","author":"AJ Almarza","year":"2006","unstructured":"Almarza AJ, et al. Biochemical analysis of the porcine temporomandibular joint disc. Br J Oral Maxillofac Surg. 2006;44(2):124\u20138.","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"1","key":"439_CR35","first-page":"28","volume":"5","author":"T Shengyi","year":"1991","unstructured":"Shengyi T, Xu Y. Biomechanical properties and collagen fiber orientation of TMJ discs in dogs: part 1. Gross anatomy and collagen fiber orientation of the discs. J Craniomandib Disord Facial Oral Pain. 1991;5(1):28\u201334.","journal-title":"J Craniomandib Disord Facial Oral Pain"},{"issue":"2","key":"439_CR36","first-page":"95","volume":"11","author":"AM Minarelli","year":"1997","unstructured":"Minarelli AM, Del Santo JM, Liberti EA. The structure of the human temporomandibular joint disc: a scanning electron microscopy study. J Orofac Pain. 1997;11(2):95\u2013100.","journal-title":"J Orofac Pain"},{"issue":"9","key":"439_CR37","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0003-9969(89)90082-4","volume":"34","author":"T Nakano","year":"1989","unstructured":"Nakano T, Scott PG. A quantitative chemical study of glycosaminoglycans in the articular disc of the bovine temporomandibular joint. Arch Oral Biol. 1989;34(9):749\u201357.","journal-title":"Arch Oral Biol"},{"issue":"1","key":"439_CR38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.matbio.2004.11.006","volume":"24","author":"MS Detamore","year":"2005","unstructured":"Detamore MS, et al. Quantitative analysis and comparative regional investigation of the extracellular matrix of the porcine temporomandibular joint disc. Matrix Biol. 2005;24(1):45\u201357.","journal-title":"Matrix Biol"},{"issue":"2","key":"439_CR39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3109\/00016359209012753","volume":"50","author":"S Axelsson","year":"1992","unstructured":"Axelsson S, Holmlund A, Hjerpe A. Glycosaminoglycans in normal and osteoarthrotic human temporomandibular joint disks. Acta Odontol Scand. 1992;50(2):113\u20139.","journal-title":"Acta Odontol Scand"},{"issue":"5","key":"439_CR40","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1089\/ten.2006.12.1183","volume":"12","author":"KD Allen","year":"2006","unstructured":"Allen KD, Athanasiou KA. Tissue engineering of the TMJ disc: a review. Tissue Eng. 2006;12(5):1183\u201396.","journal-title":"Tissue Eng"},{"issue":"2","key":"439_CR41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.joms.2005.10.009","volume":"64","author":"MS Detamore","year":"2006","unstructured":"Detamore MS, et al. Cell type and distribution in the porcine temporomandibular joint disc. J Oral Maxillofac Surg. 2006;64(2):243\u20138.","journal-title":"J Oral Maxillofac Surg"},{"issue":"16","key":"439_CR42","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1016\/j.jbiomech.2016.09.033","volume":"49","author":"GJ Wright","year":"2016","unstructured":"Wright GJ, et al. Tensile biomechanical properties of human temporomandibular joint disc: effects of direction, region and sex. J Biomech. 2016;49(16):3762\u20139.","journal-title":"J Biomech"},{"issue":"2","key":"439_CR43","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s10439-017-1963-9","volume":"46","author":"GJ Wright","year":"2018","unstructured":"Wright GJ, et al. Electrical conductivity method to determine sexual dimorphisms in human temporomandibular disc fixed charge density. Ann Biomed Eng. 2018;46(2):310\u20137.","journal-title":"Ann Biomed Eng"},{"issue":"8","key":"439_CR44","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/j.0022-0337.2008.72.8.tb04569.x","volume":"72","author":"S Wadhwa","year":"2008","unstructured":"Wadhwa S, Kapila S. TMJ disorders: future innovations in diagnostics and therapeutics. J Dent Educ. 2008;72(8):930\u201347.","journal-title":"J Dent Educ"},{"issue":"12","key":"439_CR45","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1177\/0022034515598135","volume":"94","author":"Y Jing","year":"2015","unstructured":"Jing Y, et al. Chondrocytes directly transform into bone cells in mandibular condyle growth. J Dent Res. 2015;94(12):1668\u201375.","journal-title":"J Dent Res"},{"issue":"4","key":"439_CR46","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/(SICI)1097-0185(199808)251:4<439::AID-AR3>3.0.CO;2-N","volume":"251","author":"HU Luder","year":"1998","unstructured":"Luder HU. Age changes in the articular tissue of human mandibular condyles from adolescence to old age: a semiquantitative light microscopic study. Anat Rec. 1998;251(4):439\u201347.","journal-title":"Anat Rec"},{"issue":"1","key":"439_CR47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00418-003-0544-1","volume":"120","author":"A Gepstein","year":"2003","unstructured":"Gepstein A, et al. Association of metalloproteinases, tissue inhibitors of matrix metalloproteinases, and proteoglycans with development, aging, and osteoarthritis processes in mouse temporomandibular joint. Histochem Cell Biol. 2003;120(1):23\u201332.","journal-title":"Histochem Cell Biol"},{"issue":"Pt 3","key":"439_CR48","first-page":"507","volume":"129","author":"M Silbermann","year":"1979","unstructured":"Silbermann M, Livne E. Age-related degenerative changes in the mouse mandibular joint. J Anat. 1979;129(Pt 3):507\u201320.","journal-title":"J Anat"},{"issue":"2","key":"439_CR49","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/eos.12119","volume":"122","author":"JS McDaniel","year":"2014","unstructured":"McDaniel JS, et al. Transcriptional regulation of proteoglycan 4 by 17beta-estradiol in immortalized baboon temporomandibular joint disc cells. Eur J Oral Sci. 2014;122(2):100\u20138.","journal-title":"Eur J Oral Sci"},{"issue":"8","key":"439_CR50","first-page":"925","volume":"78","author":"S Kapila","year":"1998","unstructured":"Kapila S, Xie Y. Targeted induction of collagenase and stromelysin by relaxin in unprimed and beta-estradiol-primed diarthrodial joint fibrocartilaginous cells but not in synoviocytes. Lab Invest. 1998;78(8):925\u201338.","journal-title":"Lab Invest"},{"issue":"1","key":"439_CR51","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1186\/ar1451","volume":"7","author":"T Naqvi","year":"2005","unstructured":"Naqvi T, et al. Relaxin\u2019s induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants. Arthritis Res Ther. 2005;7(1):R1\u201311.","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"439_CR52","doi-asserted-by":"crossref","first-page":"R98","DOI":"10.1186\/ar1978","volume":"8","author":"G Hashem","year":"2006","unstructured":"Hashem G, et al. Relaxin and beta-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss. Arthritis Res Ther. 2006;8(4):R98.","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"439_CR53","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.joms.2005.12.006","volume":"64","author":"RM Talwar","year":"2006","unstructured":"Talwar RM, et al. Effects of estrogen on chondrocyte proliferation and collagen synthesis in skeletally mature articular cartilage. J Oral Maxillofac Surg. 2006;64(4):600\u20139.","journal-title":"J Oral Maxillofac Surg"},{"issue":"9","key":"439_CR54","first-page":"1413","volume":"116","author":"P Cheng","year":"2003","unstructured":"Cheng P, et al. Effects of estradiol on proliferation and metabolism of rabbit mandibular condylar cartilage cells in vitro. Chin Med J (Engl). 2003;116(9):1413\u20137.","journal-title":"Chin Med J (Engl)"},{"issue":"2","key":"439_CR55","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0278-2391(00)90337-9","volume":"58","author":"T Yasuoka","year":"2000","unstructured":"Yasuoka T, et al. Effect of estrogen replacement on temporomandibular joint remodeling in ovariectomized rats. J Oral Maxillofac Surg. 2000;58(2):189\u201396.","journal-title":"J Oral Maxillofac Surg"},{"issue":"11","key":"439_CR56","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/j.joca.2014.07.003","volume":"22","author":"J Chen","year":"2014","unstructured":"Chen J, et al. Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth. Osteoarthr Cartil. 2014;22(11):1861\u20138.","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"439_CR57","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1038\/s41598-018-26937-w","volume":"8","author":"JL Robinson","year":"2018","unstructured":"Robinson JL, et al. Estrogen promotes mandibular condylar fibrocartilage chondrogenesis and inhibits degeneration via estrogen receptor alpha in female mice. Sci Rep. 2018;8(1):8527.","journal-title":"Sci Rep"},{"issue":"11","key":"439_CR58","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.ijom.2015.06.025","volume":"44","author":"SR Figueroba","year":"2015","unstructured":"Figueroba SR, et al. Dependence of cytokine levels on the sex of experimental animals: a pilot study on the effect of oestrogen in the temporomandibular joint synovial tissues. Int J Oral Maxillofac Surg. 2015;44(11):1368\u201375.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"3\u20134","key":"439_CR59","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/03008207.2016.1268604","volume":"58","author":"SP Grogan","year":"2017","unstructured":"Grogan SP, et al. Relevance of meniscal cell regional phenotype to tissue engineering. Connect Tissue Res. 2017;58(3\u20134):259\u201370.","journal-title":"Connect Tissue Res"},{"issue":"5","key":"439_CR60","doi-asserted-by":"crossref","first-page":"R93","DOI":"10.1186\/ar2293","volume":"9","author":"NJ Gunja","year":"2007","unstructured":"Gunja NJ, Athanasiou KA. Passage and reversal effects on gene expression of bovine meniscal fibrochondrocytes. Arthritis Res Ther. 2007;9(5):R93.","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"439_CR61","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0092-8674(95)90201-5","volume":"83","author":"M Beato","year":"1995","unstructured":"Beato M, Herrlich P, Schutz G. Steroid hormone receptors: many actors in search of a plot. Cell. 1995;83(6):851\u20137.","journal-title":"Cell"},{"issue":"8","key":"439_CR62","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2174\/138920206779315737","volume":"7","author":"M Marino","year":"2006","unstructured":"Marino M, Galluzzo P, Ascenzi P. Estrogen signaling multiple pathways to impact gene transcription. Curr Genomics. 2006;7(8):497\u2013508.","journal-title":"Curr Genomics"},{"issue":"8","key":"439_CR63","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1210\/me.2004-0390","volume":"19","author":"ER Levin","year":"2005","unstructured":"Levin ER. Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol. 2005;19(8):1951\u20139.","journal-title":"Mol Endocrinol"},{"issue":"6","key":"439_CR64","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1210\/endo.142.6.8221","volume":"142","author":"SC Manolagas","year":"2001","unstructured":"Manolagas SC, Kousteni S. Perspective: nonreproductive sites of action of reproductive hormones. Endocrinology. 2001;142(6):2200\u20134.","journal-title":"Endocrinology"},{"issue":"5","key":"439_CR65","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0030-4220(87)90025-9","volume":"64","author":"SB Milam","year":"1987","unstructured":"Milam SB, et al. Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon. Oral Surg Oral Med Oral Pathol. 1987;64(5):527\u201332.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"5","key":"439_CR66","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.joca.2008.09.015","volume":"17","author":"W Wang","year":"2009","unstructured":"Wang W, Hayami T, Kapila S. Female hormone receptors are differentially expressed in mouse fibrocartilages. Osteoarthr Cartil. 2009;17(5):646\u201354.","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"439_CR67","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.archoralbio.2009.01.018","volume":"54","author":"SB Yu","year":"2009","unstructured":"Yu SB, et al. The effects of age and sex on the expression of oestrogen and its receptors in rat mandibular condylar cartilages. Arch Oral Biol. 2009;54(5):479\u201385.","journal-title":"Arch Oral Biol"},{"issue":"9","key":"439_CR68","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1177\/0022034518767108","volume":"97","author":"N Ahmad","year":"2018","unstructured":"Ahmad N, et al. 17beta-estradiol induces MMP-9 and MMP-13 in TMJ fibrochondrocytes via estrogen receptor alpha. J Dent Res. 2018;97(9):1023\u201330.","journal-title":"J Dent Res"},{"issue":"Suppl 1","key":"439_CR69","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/ocr.12155","volume":"20","author":"JL Robinson","year":"2017","unstructured":"Robinson JL, et al. Estrogen receptor alpha mediates mandibular condylar cartilage growth in male mice. Orthod Craniofac Res. 2017;20(Suppl 1):167\u201371.","journal-title":"Orthod Craniofac Res"},{"issue":"8","key":"439_CR70","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1002\/jbmr.3434","volume":"33","author":"A Vinel","year":"2018","unstructured":"Vinel A, et al. Respective role of membrane and nuclear estrogen receptor (ER) \u03b1 in the mandible of growing mice: implications for ER\u03b1 modulation. J Bone Miner Res. 2018;33(8):1520\u201331.","journal-title":"J Bone Miner Res"},{"issue":"5","key":"439_CR71","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/jbmr.1835","volume":"28","author":"Y Kamiya","year":"2013","unstructured":"Kamiya Y, et al. Increased mandibular condylar growth in mice with estrogen receptor beta deficiency. J Bone Miner Res. 2013;28(5):1127\u201334.","journal-title":"J Bone Miner Res"},{"issue":"4","key":"439_CR72","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.joca.2016.11.008","volume":"25","author":"JL Robinson","year":"2017","unstructured":"Robinson JL, et al. Sex differences in the estrogen-dependent regulation of temporomandibular joint remodeling in altered loading. Osteoarthr Cartil. 2017;25(4):533\u201343.","journal-title":"Osteoarthr Cartil"},{"key":"439_CR73","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bone.2018.03.008","volume":"111","author":"T Ye","year":"2018","unstructured":"Ye T, et al. Differential effects of high-physiological oestrogen on the degeneration of mandibular condylar cartilage and subchondral bone. Bone. 2018;111:9\u201322.","journal-title":"Bone"},{"issue":"5","key":"439_CR74","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10753-010-9256-6","volume":"34","author":"KE Torres-Chavez","year":"2011","unstructured":"Torres-Chavez KE, et al. Sexual dimorphism on cytokines expression in the temporomandibular joint: the role of gonadal steroid hormones. Inflammation. 2011;34(5):487\u201398.","journal-title":"Inflammation"},{"issue":"10","key":"439_CR75","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1177\/0022034513501323","volume":"92","author":"XD Wang","year":"2013","unstructured":"Wang XD, et al. Estrogen aggravates iodoacetate-induced temporomandibular joint osteoarthritis. J Dent Res. 2013;92(10):918\u201324.","journal-title":"J Dent Res"},{"issue":"8","key":"439_CR76","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/odi.12905","volume":"24","author":"XT Xue","year":"2018","unstructured":"Xue XT, et al. Sexual dimorphism of estrogen-sensitized synoviocytes contributes to gender difference in temporomandibular joint osteoarthritis. Oral Dis. 2018;24(8):1503\u201313.","journal-title":"Oral Dis"},{"issue":"10","key":"439_CR77","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0278-2391(96)90352-3","volume":"54","author":"T Okuda","year":"1996","unstructured":"Okuda T, et al. The effect of ovariectomy on the temporomandibular joints of growing rats. J Oral Maxillofac Surg. 1996;54(10):1201\u201310.","journal-title":"J Oral Maxillofac Surg"},{"issue":"1","key":"439_CR78","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1474-4422(16)30293-9","volume":"16","author":"KG Vetvik","year":"2017","unstructured":"Vetvik KG, MacGregor EA. Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. Lancet Neurol. 2017;16(1):76\u201387.","journal-title":"Lancet Neurol"},{"issue":"1","key":"439_CR79","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s10194-018-0922-7","volume":"19","author":"Z Delaruelle","year":"2018","unstructured":"Delaruelle Z, et al. Male and female sex hormones in primary headaches. J Headache Pain. 2018;19(1):117.","journal-title":"J Headache Pain"},{"issue":"5","key":"439_CR80","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/00016357.2015.1136678","volume":"74","author":"K Kim","year":"2016","unstructured":"Kim K, Wojczynska A, Lee JY. The incidence of osteoarthritic change on computed tomography of Korean temporomandibular disorder patients diagnosed by RDC\/TMD; a retrospective study. Acta Odontol Scand. 2016;74(5):337\u201342.","journal-title":"Acta Odontol Scand"},{"issue":"3","key":"439_CR81","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1259\/dmfr\/59263880","volume":"38","author":"K Alexiou","year":"2009","unstructured":"Alexiou K, Stamatakis H, Tsiklakis K. Evaluation of the severity of temporomandibular joint osteoarthritic changes related to age using cone beam computed tomography. Dentomaxillofac Radiol. 2009;38(3):141\u20137.","journal-title":"Dentomaxillofac Radiol"},{"issue":"3","key":"439_CR82","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3109\/00016358909007693","volume":"47","author":"G Agerberg","year":"1989","unstructured":"Agerberg G, Bergenholtz A. Craniomandibular disorders in adult populations of West Bothnia, Sweden. Acta Odontol Scand. 1989;47(3):129\u201340.","journal-title":"Acta Odontol Scand"},{"issue":"2","key":"439_CR83","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1677\/joe.0.1740167","volume":"174","author":"MK Lindberg","year":"2002","unstructured":"Lindberg MK, et al. Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. J Endocrinol. 2002;174(2):167\u201378.","journal-title":"J Endocrinol"},{"issue":"7","key":"439_CR84","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/art.38576","volume":"66","author":"S Wang","year":"2014","unstructured":"Wang S, et al. Identification of \u03b12-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis. Arthritis Rheum. 2014;66(7):1843\u201353.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"439_CR85","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41467-018-08046-4","volume":"10","author":"CB Herber","year":"2019","unstructured":"Herber CB, et al. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nat Commun. 2019;10(1):163.","journal-title":"Nat Commun"},{"key":"439_CR86","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bone.2017.10.003","volume":"106","author":"JS Coogan","year":"2018","unstructured":"Coogan JS, et al. Determination of sex differences of human cadaveric mandibular condyles using statistical shape and trait modeling. Bone. 2018;106:35\u201341.","journal-title":"Bone"},{"key":"439_CR87","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jmbbm.2017.03.012","volume":"71","author":"DG Kim","year":"2017","unstructured":"Kim DG, et al. Sex dependent mechanical properties of the human mandibular condyle. J Mech Behav Biomed Mater. 2017;71:184\u201391.","journal-title":"J Mech Behav Biomed Mater"},{"issue":"6","key":"439_CR88","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.joca.2016.12.027","volume":"25","author":"LR Iwasaki","year":"2017","unstructured":"Iwasaki LR, et al. TMJ energy densities in healthy men and women. Osteoarthr Cartil. 2017;25(6):846\u20139.","journal-title":"Osteoarthr Cartil"},{"issue":"9499","key":"439_CR89","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","volume":"366","author":"BL Pihlstrom","year":"2005","unstructured":"Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366(9499):1809\u201320.","journal-title":"Lancet"},{"issue":"34","key":"439_CR90","first-page":"9","volume":"2004","author":"GC Armitage","year":"2000","unstructured":"Armitage GC. Periodontal diagnoses and classification of periodontal diseases. Periodontol. 2000;2004(34):9\u201321.","journal-title":"Periodontol"},{"issue":"5","key":"439_CR91","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/jcpe.12053","volume":"40","author":"E Figuero","year":"2013","unstructured":"Figuero E, et al. Effect of pregnancy on gingival inflammation in systemically healthy women: a systematic review. J Clin Periodontol. 2013;40(5):457\u201373.","journal-title":"J Clin Periodontol"},{"issue":"11","key":"439_CR92","first-page":"ZE01","volume":"10","author":"I Ali","year":"2016","unstructured":"Ali I, et al. Oral health and oral contraceptive\u2014is it a shadow behind broad day light? A systematic review. J Clin Diagn Res. 2016;10(11):ZE01\u20136.","journal-title":"J Clin Diagn Res."},{"issue":"2","key":"439_CR93","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","volume":"25","author":"SS Socransky","year":"1998","unstructured":"Socransky SS, et al. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998;25(2):134\u201344.","journal-title":"J Clin Periodontol"},{"issue":"6","key":"439_CR94","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.2041-1014.2012.00663.x","volume":"27","author":"G Hajishengallis","year":"2012","unstructured":"Hajishengallis G, Lamont RJ. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol Oral Microbiol. 2012;27(6):409\u201319.","journal-title":"Mol Oral Microbiol"},{"issue":"1","key":"439_CR95","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1600-0757.2011.00398.x","volume":"61","author":"PS Kumar","year":"2013","unstructured":"Kumar PS. Sex and the subgingival microbiome: do female sex steroids affect periodontal bacteria? Periodontol 2000. 2013;61(1):103\u201324.","journal-title":"Periodontol 2000."},{"key":"439_CR96","first-page":"623427","volume":"2015","author":"M Wu","year":"2015","unstructured":"Wu M, Chen SW, Jiang SY. Relationship between gingival inflammation and pregnancy. Mediat Inflamm. 2015;2015:623427.","journal-title":"Mediat Inflamm"},{"issue":"2","key":"439_CR97","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jogn.2018.12.003","volume":"48","author":"I Yang","year":"2019","unstructured":"Yang I, et al. Characterizing the subgingival microbiome of pregnant African american women. J Obstet Gynecol Neonatal Nurs. 2019;48(2):140\u2013152. \nhttps:\/\/doi.org\/10.1016\/j.jogn.2018.12.003","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"key":"439_CR98","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.3389\/fmicb.2018.02360","volume":"9","author":"P Balan","year":"2018","unstructured":"Balan P, et al. Keystone species in pregnancy gingivitis: a snapshot of oral microbiome during pregnancy and postpartum period. Front Microbiol. 2018;9:2360.","journal-title":"Front Microbiol"},{"issue":"6","key":"439_CR99","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1600-0897.2010.00836.x","volume":"63","author":"G Mor","year":"2010","unstructured":"Mor G, Cardenas I. The immune system in pregnancy: a unique complexity. Am J Reprod Immunol. 2010;63(6):425\u201333.","journal-title":"Am J Reprod Immunol"},{"issue":"2","key":"439_CR100","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cellimm.2015.01.018","volume":"294","author":"S Kovats","year":"2015","unstructured":"Kovats S. Estrogen receptors regulate innate immune cells and signaling pathways. Cell Immunol. 2015;294(2):63\u20139.","journal-title":"Cell Immunol"},{"key":"439_CR101","first-page":"4897890","volume":"2016","author":"M Wu","year":"2016","unstructured":"Wu M, et al. Sex hormones enhance gingival inflammation without affecting IL-1\u03b2 and TNF-\u03b1 in periodontally healthy women during pregnancy. Mediat Inflamm. 2016;2016:4897890.","journal-title":"Mediat Inflamm"},{"issue":"1","key":"439_CR102","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00784-012-0674-8","volume":"17","author":"RA Bieri","year":"2013","unstructured":"Bieri RA, et al. Gingival fluid cytokine expression and subgingival bacterial counts during pregnancy and postpartum: a case series. Clin Oral Investig. 2013;17(1):19\u201328.","journal-title":"Clin Oral Investig"},{"issue":"5","key":"439_CR103","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1902\/jop.2012.120137","volume":"84","author":"MJ LaMonte","year":"2013","unstructured":"LaMonte MJ, et al. Five-year changes in periodontal disease measures among postmenopausal females: the Buffalo Osteoperio study. J Periodontol. 2013;84(5):572\u201384.","journal-title":"J Periodontol"},{"issue":"6","key":"439_CR104","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s11914-016-0330-3","volume":"14","author":"CJ Wang","year":"2016","unstructured":"Wang CJ, McCauley LK. Osteoporosis and periodontitis. Curr Osteoporos Rep. 2016;14(6):284\u201391.","journal-title":"Curr Osteoporos Rep"},{"issue":"4","key":"439_CR105","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1902\/jop.2015.140533","volume":"86","author":"Y Wang","year":"2015","unstructured":"Wang Y, et al. Association of serum 17beta-estradiol concentration, hormone therapy, and alveolar crest height in postmenopausal women. J Periodontol. 2015;86(4):595\u2013605.","journal-title":"J Periodontol"},{"issue":"3","key":"439_CR106","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/jbmr.3014","volume":"32","author":"S Ucer","year":"2017","unstructured":"Ucer S, et al. The effects of aging and sex steroid deficiency on the murine skeleton are independent and mechanistically distinct. J Bone Miner Res. 2017;32(3):560\u201374.","journal-title":"J Bone Miner Res"},{"key":"439_CR107","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3729","author":"J Farr","year":"2019","unstructured":"Farr J, et al. Independent roles of estrogen deficiency and cellular senescence in the pathogenesis of osteoporosis: evidence in young adult mice and older humans. J Bone Miner Res. 2019. \nhttps:\/\/doi.org\/10.1002\/jbmr.3729","journal-title":"J Bone Miner Res"},{"issue":"1","key":"439_CR108","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","volume":"15","author":"G Hajishengallis","year":"2015","unstructured":"Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15(1):30\u201344.","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"439_CR109","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/10454411010120020301","volume":"12","author":"MA Taubman","year":"2001","unstructured":"Taubman MA, Kawai T. Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption. Crit Rev Oral Biol Med. 2001;12(2):125\u201335.","journal-title":"Crit Rev Oral Biol Med"},{"issue":"10","key":"439_CR110","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1902\/jop.2005.76.10.1675","volume":"76","author":"G Brunetti","year":"2005","unstructured":"Brunetti G, et al. T cells support osteoclastogenesis in an in vitro model derived from human periodontitis patients. J Periodontol. 2005;76(10):1675\u201380.","journal-title":"J Periodontol"},{"issue":"12","key":"439_CR111","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1210\/endo.142.12.8536","volume":"142","author":"S Khosla","year":"2001","unstructured":"Khosla S. Minireview: the OPG\/RANKL\/RANK system. Endocrinology. 2001;142(12):5050\u20135.","journal-title":"Endocrinology"},{"issue":"4","key":"439_CR112","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1034\/j.1600-0765.2003.00615.x","volume":"38","author":"T Crotti","year":"2003","unstructured":"Crotti T, et al. Receptor activator NF kappaB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis. J Periodontal Res. 2003;38(4):380\u20137.","journal-title":"J Periodontal Res"},{"issue":"3","key":"439_CR113","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2353\/ajpath.2006.060180","volume":"169","author":"T Kawai","year":"2006","unstructured":"Kawai T, et al. B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease. Am J Pathol. 2006;169(3):987\u201398.","journal-title":"Am J Pathol"},{"issue":"10","key":"439_CR114","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nm1096-1132","volume":"2","author":"DE Hughes","year":"1996","unstructured":"Hughes DE, et al. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta. Nat Med. 1996;2(10):1132\u20136.","journal-title":"Nat Med"},{"issue":"10","key":"439_CR115","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1172\/JCI11468","volume":"106","author":"BL Riggs","year":"2000","unstructured":"Riggs BL. The mechanisms of estrogen regulation of bone resorption. J Clin Investig. 2000;106(10):1203\u20134 (Comment).","journal-title":"J Clin Investig"},{"issue":"1","key":"439_CR116","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bone.2008.02.017","volume":"43","author":"P D\u2019Amelio","year":"2008","unstructured":"D\u2019Amelio P, et al. Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis. Bone. 2008;43(1):92\u2013100.","journal-title":"Bone"},{"issue":"10","key":"439_CR117","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI11066","volume":"106","author":"S Cenci","year":"2000","unstructured":"Cenci S, et al. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Investig. 2000;106(10):1229\u201337.","journal-title":"J Clin Investig"},{"issue":"10","key":"439_CR118","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1034\/j.1600-051x.2000.027010778.x","volume":"27","author":"M Ronderos","year":"2000","unstructured":"Ronderos M, et al. Associations of periodontal disease with femoral bone mineral density and estrogen replacement therapy: cross-sectional evaluation of US adults from NHANES III. J Clin Periodontol. 2000;27(10):778\u201386.","journal-title":"J Clin Periodontol"},{"key":"439_CR119","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13059","author":"JDP Chaves","year":"2019","unstructured":"Chaves JDP, et al. Sex hormone replacement therapy in periodontology\u2014a systematic review. Oral Dis. 2019. \nhttps:\/\/doi.org\/10.1111\/odi.13059","journal-title":"Oral Dis"},{"issue":"8","key":"439_CR120","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1902\/jop.2012.120434","volume":"84","author":"D J\u00f6nsson","year":"2013","unstructured":"J\u00f6nsson D, et al. Beneficial effects of hormone replacement therapy on periodontitis are vitamin D associated. J Periodontol. 2013;84(8):1048\u201357.","journal-title":"J Periodontol"},{"key":"439_CR121","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.archoralbio.2015.02.007","volume":"60","author":"I Polur","year":"2015","unstructured":"Polur I, et al. Oestrogen receptor beta mediates decreased occlusal loading induced inhibition of chondrocyte maturation in female mice. Archives of Oral Biol. 2015;60:818\u2013824. \nhttps:\/\/doi.org\/10.1016\/j.archoralbio.2015.02.007","journal-title":"Archives of Oral Biol"}],"container-title":["Odontology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-019-00439-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10266-019-00439-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-019-00439-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T19:50:51Z","timestamp":1593633051000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10266-019-00439-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,3]]},"references-count":121,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["439"],"URL":"https:\/\/doi.org\/10.1007\/s10266-019-00439-1","relation":{},"ISSN":["1618-1247","1618-1255"],"issn-type":[{"value":"1618-1247","type":"print"},{"value":"1618-1255","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,3]]},"assertion":[{"value":"26 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}