{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:28:52Z","timestamp":1792891732041,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Odontology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s10266-019-00470-2","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T09:03:25Z","timestamp":1573117405000},"page":"350-357","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["IL-10 secreting B cells regulate periodontal immune response during periodontitis"],"prefix":"10.1007","volume":"108","author":[{"given":"Tie","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-7348","authenticated-orcid":false,"given":"Xiaoping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"issue":"1","key":"470_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12221","volume":"75","author":"J Slots","year":"2017","unstructured":"Slots J. Periodontitis: facts, fallacies and the future. Periodontol 2000. 2017;75(1):7\u201323.","journal-title":"Periodontol 2000."},{"issue":"1","key":"470_CR2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/prd.12222","volume":"75","author":"JL Ebersole","year":"2017","unstructured":"Ebersole JL, Dawson D 3rd, Emecen-Huja P, et al. The periodontal war: microbes and immunity. Periodontol 2000. 2017;75(1):52\u2013115.","journal-title":"Periodontol 2000."},{"issue":"6","key":"470_CR3","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/omi.12144","volume":"31","author":"L Campbell","year":"2016","unstructured":"Campbell L, Millhouse E, Malcolm J, et al. T cells, teeth and tissue destruction\u2014what do T cells do in periodontal disease? Mol Oral Microbiol. 2016;31(6):445\u201356.","journal-title":"Mol Oral Microbiol."},{"issue":"2","key":"470_CR4","doi-asserted-by":"publisher","first-page":"672","DOI":"10.4103\/0975-7406.163602","volume":"7","author":"B Karthikeyan","year":"2015","unstructured":"Karthikeyan B, Talwar Arun KV, et al. Evaluation of transcription factor that regulates T helper 17 and regulatory T cells function in periodontal health and disease. J Pharm Bioallied Sci. 2015;7(2):672\u20136.","journal-title":"J Pharm Bioallied Sci."},{"issue":"8","key":"470_CR5","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1073\/pnas.1615065114","volume":"114","author":"D Lukas","year":"2017","unstructured":"Lukas D, Yogev N, Kel JM, et al. TGF-\u03b2 inhibitor Smad7 regulates dendritic cell-induced autoimmunity. Proc Natl Acad Sci USA. 2017;114(8):1480\u20139.","journal-title":"Proc Natl Acad Sci USA."},{"issue":"46","key":"470_CR6","doi-asserted-by":"publisher","first-page":"18525","DOI":"10.1073\/pnas.1302829110","volume":"110","author":"AJ Glowacki","year":"2013","unstructured":"Glowacki AJ, Yoshizawa S, Jhunjhunwala S, et al. Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes. Proc Natl Acad Sci USA. 2013;110(46):18525\u201330.","journal-title":"Proc Natl Acad Sci USA."},{"issue":"6","key":"470_CR7","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1111\/jcpe.12238","volume":"41","author":"WC Cheng","year":"2014","unstructured":"Cheng WC, Hughes FJ, Taams LS. The presence, function and regulation of IL-17 and Th17 cells in periodontitis. J Clin Periodontol. 2014;41(6):541\u20139.","journal-title":"J Clin Periodontol."},{"issue":"2","key":"470_CR8","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1902\/jop.2014.140293","volume":"86","author":"A Mitani","year":"2015","unstructured":"Mitani A, Niedbala W, Fujimura T, et al. Increased expression of interleukin (IL)-35 and IL-17, but not IL-27, in gingival tissues with chronic periodontitis. J Periodontol. 2015;86(2):301\u20139.","journal-title":"J Periodontol."},{"issue":"7","key":"470_CR9","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1111\/clr.12886","volume":"28","author":"MKS Teixeira","year":"2017","unstructured":"Teixeira MKS, Lira-Junior R, Telles DM, et al. Th17-related cytokines in mucositis: is there any difference between peri-implantitis and periodontitis patients? Clin Oral Implants Res. 2017;28(7):816\u201322.","journal-title":"Clin Oral Implants Res."},{"issue":"11","key":"470_CR10","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1016\/j.ajpath.2015.07.017","volume":"185","author":"KW Kim","year":"2015","unstructured":"Kim KW, Kim HR, Kim BM, et al. Th17 cytokines regulate osteoclastogenesis in rheumatoid arthritis. Am J Pathol. 2015;185(11):3011\u201324.","journal-title":"Am J Pathol."},{"issue":"10","key":"470_CR11","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1093\/intimm\/dxv046","volume":"27","author":"JM Lykken","year":"2015","unstructured":"Lykken JM, Candando KM, Tedder TF. Regulatory B10 cell development and function. Int Immunol. 2015;27(10):471\u20137.","journal-title":"Int Immunol."},{"issue":"4","key":"470_CR12","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.4049\/jimmunol.1401329","volume":"194","author":"TF Tedder","year":"2015","unstructured":"Tedder TF. B10 cells: a functionally defined regulatory B cell subset. J Immunol. 2015;194(4):1395\u2013401.","journal-title":"J Immunol."},{"key":"470_CR13","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.cellimm.2016.09.010","volume":"310","author":"Y Qin","year":"2016","unstructured":"Qin Y, Zhang M, Jiang RM, et al. B10 cells play a role in the immune modulation of pro- and anti-inflammatory immune responses in mouse islet allograft rejection. Cell Immunol. 2016;310:184\u201392.","journal-title":"Cell Immunol."},{"key":"470_CR14","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.clim.2017.04.013","volume":"184","author":"A Mavropoulos","year":"2017","unstructured":"Mavropoulos A, Liaskos C, Simopoulou T, et al. IL-10-producing regulatory B cells (B10 cells), IL-17\u2009+\u2009T cells and autoantibodies in systemic sclerosis. Clin Immunol. 2017;184:26\u201332.","journal-title":"Clin Immunol."},{"issue":"8","key":"470_CR15","doi-asserted-by":"publisher","first-page":"914","DOI":"10.3389\/fimmu.2017.00914","volume":"3","author":"Y Zheng","year":"2017","unstructured":"Zheng Y, Ge W, Ma Y, et al. miR-155 regulates IL-10-producing CD24hiCD27\u2009+\u2009B cells and impairs their function in patients with Crohn\u2019s disease. Front Immunol. 2017;3(8):914.","journal-title":"Front Immunol."},{"issue":"9","key":"470_CR16","doi-asserted-by":"publisher","first-page":"e00335\u201317","DOI":"10.1128\/IAI.00335-17","volume":"85","author":"Y Wang","year":"2017","unstructured":"Wang Y, Yu X, Lin J, et al. B10 Cells Alleviate periodontal bone loss in experimental periodontitis. Infect Immun. 2017;85(9):e00335\u201317.","journal-title":"Infect Immun."},{"issue":"289","key":"470_CR17","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jneuroim.2015.10.023","volume":"15","author":"JR Sheng","year":"2015","unstructured":"Sheng JR, Quan S, Soliven B. IL-10 derived from CD1dhiCD5+ B cells regulates experimental autoimmune myasthenia gravis. J Neuroimmunol. 2015;15(289):130\u20138.","journal-title":"J Neuroimmunol."},{"issue":"3","key":"470_CR18","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1600-0765.2011.01442.x","volume":"47","author":"I Aoyama","year":"2012","unstructured":"Aoyama I, Calenic B, Imai T, et al. Oral malodorous compound causes caspase-8 and -9 mediated programmed cell death in osteoblasts. J Periodontal Res. 2012;47(3):365\u201373.","journal-title":"J Periodontal Res."},{"issue":"5","key":"470_CR19","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00005-017-0472-8","volume":"65","author":"M N\u0119dzi-G\u00f3ra","year":"2017","unstructured":"N\u0119dzi-G\u00f3ra M, Kowalski J, G\u00f3rska R. The immune response in periodontal tissues. Arch Immunol Ther Exp (Warsz). 2017;65(5):421\u20139.","journal-title":"Arch Immunol Ther Exp (Warsz)."},{"issue":"1","key":"470_CR20","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/08916934.2016.1261841","volume":"50","author":"M Zouali","year":"2017","unstructured":"Zouali M. The emerging roles of B cells as partners and targets in periodontitis. Autoimmunity. 2017;50(1):61\u201370.","journal-title":"Autoimmunity."},{"issue":"6","key":"470_CR21","first-page":"40","volume":"95","author":"NB Astashina","year":"2016","unstructured":"Astashina NB, Sergeeva ES, et al. Evaluating the effectiveness of the new mouthguard design in athletes involved in power sports. Stomatologiia (Mosk). 2016;95(6):40\u20133.","journal-title":"Stomatologiia (Mosk)."},{"issue":"5","key":"470_CR22","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1038\/mi.2015.136","volume":"9","author":"N Dutzan","year":"2016","unstructured":"Dutzan N, Konkel JE, Greenwell-Wild T, et al. Characterization of the human immune cell network at the gingival barrier. Mucosal Immunol. 2016;9(5):1163\u201372.","journal-title":"Mucosal Immunol."},{"issue":"11","key":"470_CR23","doi-asserted-by":"publisher","first-page":"160230","DOI":"10.1098\/rsob.160230","volume":"6","author":"V Sigl","year":"2016","unstructured":"Sigl V, Jones LP, Penninger JM. RANKL\/RANK: from bone loss to the prevention of breast cancer. Open Biol. 2016;6(11):160230.","journal-title":"Open Biol."},{"issue":"10","key":"470_CR24","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1177\/0022034513500306","volume":"92","author":"BF Boyce","year":"2013","unstructured":"Boyce BF. Advances in the regulation of osteoclasts and osteoclast functions. J Dent Res. 2013;92(10):860\u20137.","journal-title":"J Dent Res."},{"issue":"3","key":"470_CR25","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1600-051X.2011.01810.x","volume":"39","author":"GN Belibasakis","year":"2012","unstructured":"Belibasakis GN, Bostanci N. The RANKL-OPG system in clinical periodontology. J Clin Periodontol. 2012;39(3):239\u201348.","journal-title":"J Clin Periodontol."},{"issue":"5","key":"470_CR26","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3389\/fphys.2017.00338","volume":"8","author":"B Sojod","year":"2017","unstructured":"Sojod B, Chateau D, Mueller CG, et al. RANK\/RANKL\/OPG signalization implication in periodontitis: new evidence from a RANK transgenic mouse model. Front Physiol. 2017;8(5):338.","journal-title":"Front Physiol."},{"key":"470_CR27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.coi.2015.03.001","volume":"34","author":"JE Allen","year":"2015","unstructured":"Allen JE, Sutherland TE, R\u00fcckerl D. IL-17 and neutrophils: unexpected players in the type 2 immune response. Curr Opin Immunol. 2015;34:99\u2013106.","journal-title":"Curr Opin Immunol."},{"issue":"3","key":"470_CR28","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.molmed.2016.01.001","volume":"22","author":"A Beringer","year":"2016","unstructured":"Beringer A, Noack M, Miossec P. IL-17 in chronic inflammation: from discovery to targeting. Trends Mol Med. 2016;22(3):230\u201341.","journal-title":"Trends Mol Med."},{"issue":"10","key":"470_CR29","doi-asserted-by":"publisher","first-page":"479","DOI":"10.5483\/BMBRep.2013.46.10.141","volume":"46","author":"Y Lee","year":"2013","unstructured":"Lee Y. The role of interleukin-17 in bone metabolism and inflammatory skeletal diseases. BMB Rep. 2013;46(10):479\u201383.","journal-title":"BMB Rep."},{"issue":"4","key":"470_CR30","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.biochi.2009.12.011","volume":"92","author":"S Kitami","year":"2010","unstructured":"Kitami S, Tanaka H, Kawato T, et al. IL-17A suppresses the expression of bone resorption-related proteinases and osteoclast differentiation via IL-17RA or IL-17RC receptors in RAW264.7 cells. Biochimie. 2010;92(4):398\u2013404.","journal-title":"Biochimie."},{"issue":"Pt B","key":"470_CR31","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.pnpbp.2017.07.023","volume":"79","author":"F Tahmasebinia","year":"2017","unstructured":"Tahmasebinia F, Pourgholaminejad A. The role of Th17 cells in auto-inflammatory neurological disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2017;79(Pt B):408\u201316.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"issue":"3","key":"470_CR32","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3109\/08820139.2016.1138967","volume":"45","author":"XT Chen","year":"2016","unstructured":"Chen XT, Chen LL, Tan JY, et al. Th17 and Th1 lymphocytes are correlated with chronic periodontitis. Immunol Invest. 2016;45(3):243\u201354.","journal-title":"Immunol Invest."},{"key":"470_CR33","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1590\/1807-3107bor-2017.vol31.0103","volume":"31","author":"AO Naufel","year":"2017","unstructured":"Naufel AO, Aguiar MCF, Madeira FM, et al. Treg and Th17 cells in inflammatory periapical disease: a systematic review. Braz Oral Res. 2017;31:e103","journal-title":"Braz Oral Res."},{"issue":"5","key":"470_CR34","first-page":"14","volume":"34","author":"L Lei","year":"2016","unstructured":"Lei L, Zhao C, Qin F, et al. Th17 cells and IL-17 promote the skin and lung inflammation and fibrosis process in a bleomycin-induced murine model of systemic sclerosis. Clin Exp Rheumatol. 2016;34(5):14\u201322.","journal-title":"Clin Exp Rheumatol."},{"issue":"3","key":"470_CR35","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/path.5013","volume":"244","author":"S Singh","year":"2018","unstructured":"Singh S, Maniakis-Grivas G, Singh UK, et al. Interleukin-17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis. J Pathol. 2018;244(3):311\u201322.","journal-title":"J Pathol."},{"issue":"3","key":"470_CR36","doi-asserted-by":"publisher","first-page":"715","DOI":"10.4049\/jimmunol.1600540","volume":"197","author":"R Mahanonda","year":"2016","unstructured":"Mahanonda R, Champaiboon C, Subbalekha K, et al. Human memory B cells in healthy gingiva, gingivitis, and periodontitis. J Immunol. 2016;197(3):715\u201325.","journal-title":"J Immunol."},{"issue":"1","key":"470_CR37","doi-asserted-by":"publisher","first-page":"5127","DOI":"10.1038\/s41467-018-07626-8","volume":"9","author":"W Sun","year":"2018","unstructured":"Sun W, Meednu N, Rosenberg A, et al. B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation. Nat Commun. 2018;9(1):5127.","journal-title":"Nat Commun."},{"issue":"3","key":"470_CR38","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00395-017-0622-5","volume":"112","author":"M Jung","year":"2017","unstructured":"Jung M, Ma Y, Iyer RP, et al. IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation. Basic Res Cardiol. 2017;112(3):33.","journal-title":"Basic Res Cardiol."},{"issue":"6","key":"470_CR39","doi-asserted-by":"publisher","first-page":"6131","DOI":"10.1038\/ncomms7131","volume":"21","author":"B Li","year":"2015","unstructured":"Li B, Gurung P, Malireddi RK, et al. IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis. Nat Commun. 2015;21(6):6131.","journal-title":"Nat Commun."},{"issue":"1","key":"470_CR40","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.intimp.2014.02.038","volume":"20","author":"N Pang","year":"2014","unstructured":"Pang N, Zhang F, Ma X, et al. TGF-\u03b2\/Smad signaling pathway regulates Th17\/Treg balance during Echinococcus multilocularis infection. Int Immunopharmacol. 2014;20(1):248\u201357.","journal-title":"Int Immunopharmacol."},{"issue":"5","key":"470_CR41","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s11011-015-9661-5","volume":"30","author":"J Zhang","year":"2015","unstructured":"Zhang J, Lapato A, Bodhankar S, et al. Treatment with IL-10 producing B cells in combination with E2 ameliorates EAE severity and decreases CNS inflammation in B cell-deficient mice. Metab Brain Dis. 2015;30(5):1117\u201327.","journal-title":"Metab Brain Dis."}],"container-title":["Odontology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-019-00470-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10266-019-00470-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-019-00470-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T20:00:21Z","timestamp":1604606421000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10266-019-00470-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,7]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["470"],"URL":"https:\/\/doi.org\/10.1007\/s10266-019-00470-2","relation":{},"ISSN":["1618-1247","1618-1255"],"issn-type":[{"value":"1618-1247","type":"print"},{"value":"1618-1255","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,7]]},"assertion":[{"value":"12 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}