{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:54:34Z","timestamp":1791888874016,"version":"4.3.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Odontology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s10266-020-00502-2","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T16:02:42Z","timestamp":1582646562000},"page":"646-652","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of non-surgical periodontal treatment on salivary expression of cytokines related to bone metabolism"],"prefix":"10.1007","volume":"108","author":[{"given":"Tatiane F. C. S. B.","family":"Beiler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Martins","family":"de Mello Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Cardoso","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hamlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Ipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0222-9231","authenticated-orcid":false,"given":"Carlos Marcelo","family":"da Silva Figueredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"issue":"34","key":"502_CR1","first-page":"22","volume":"2004","author":"GC Armitage","year":"2000","unstructured":"Armitage GC. The complete periodontal examination. Periodontol. 2000;2004(34):22\u201333.","journal-title":"Periodontol"},{"key":"502_CR2","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1902\/jop.1999.70.12.1457","volume":"70","author":"CM Figueredo","year":"1999","unstructured":"Figueredo CM, Ribeiro MS, Fischer RG, Gustafsson A. Increased interleukin-1beta concentration in gingival crevicular fluid as a characteristic of periodontitis. J Periodontol. 1999;70:1457\u201363.","journal-title":"J Periodontol"},{"key":"502_CR3","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1902\/jop.2015.150399","volume":"87","author":"UK Gursoy","year":"2016","unstructured":"Gursoy UK, Liukkonen J, Jula A, et al. Associations between salivary bone metabolism markers and periodontal breakdown. J Periodontol. 2016;87:367\u201375.","journal-title":"J Periodontol"},{"key":"502_CR4","doi-asserted-by":"publisher","first-page":"e20180671","DOI":"10.1590\/1678-7757-2018-0671","volume":"27","author":"CD Borges","year":"2019","unstructured":"Borges CD, Ricoldi MS, Messora MR, et al. Clinical attachment loss and molecular profile of inflamed sites before treatment. J Appl Oral Sci. 2019;27:e20180671.","journal-title":"J Appl Oral Sci."},{"key":"502_CR5","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.metabol.2014.10.021","volume":"64","author":"J Upadhyay","year":"2015","unstructured":"Upadhyay J, Farr OM, Mantzoros CS. The role of leptin in regulating bone metabolism. Metabolism. 2015;64:105\u201313.","journal-title":"Metabolism."},{"key":"502_CR6","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1210\/er.2017-00226","volume":"39","author":"IR Reid","year":"2018","unstructured":"Reid IR, Baldock PA, Cornish J. Effects of leptin on the skeleton. Endocr Rev. 2018;39:938\u201359.","journal-title":"Endocr Rev"},{"key":"502_CR7","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s00774-014-0569-7","volume":"33","author":"XX Chen","year":"2015","unstructured":"Chen XX, Yang T. Roles of leptin in bone metabolism and bone diseases. J Bone Miner Metab. 2015;33:474\u201385.","journal-title":"J Bone Miner Metab"},{"key":"502_CR8","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/jcb.10156","volume":"85","author":"JO Gordeladze","year":"2002","unstructured":"Gordeladze JO, Drevon CA, Syversen U, Reseland JE. Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: impact on differentiation markers, apoptosis, and osteoclastic signalling. J Cell Biochem. 2002;85:825\u201336.","journal-title":"J Cell Biochem"},{"key":"502_CR9","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.it.2004.02.009","volume":"25","author":"G Matarese","year":"2004","unstructured":"Matarese G, La Cava A. The intricate interface between immune system and metabolism. Trends Immunol. 2004;25:193\u2013200.","journal-title":"Trends Immunol"},{"key":"502_CR10","first-page":"R204","volume":"274","author":"R Faggioni","year":"1998","unstructured":"Faggioni R, Fantuzzi G, Fuller J, Dinarello CA, Feingold KR. Grunfeld C IL-1 beta mediates leptin induction during inflammation. Am J Physiol. 1998;274:R204\u20138.","journal-title":"Am J Physiol"},{"key":"502_CR11","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3892\/etm.2014.1724","volume":"8","author":"C Reis","year":"2014","unstructured":"Reis C, da Costa AV, Guimar\u00e3es JT, et al. Clinical improvement following therapy for periodontitis: association with a decrease in IL-1 and IL-6. Exp Ther Med. 2014;8:323\u20137.","journal-title":"Exp Ther Med"},{"key":"502_CR12","first-page":"1748584","volume":"5","author":"T Hokari","year":"2018","unstructured":"Hokari T, Morozumi T, Komatsu Y, et al. Effects of antimicrobial photodynamic therapy and local administration of minocycline on clinical, microbiological, and inflammatory markers of periodontal pockets: a pilot study. Int J Dent. 2018;5:1748584.","journal-title":"Int J Dent"},{"key":"502_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18311\/jade\/2018\/20883","volume":"4","author":"M Abiramidevi","year":"2018","unstructured":"Abiramidevi M, Nagappan V, Prasad PAK. Saliva\u2014a tool for diagnosis in periodontitis. J Acad Dent. 2018;4:1\u20137.","journal-title":"J Acad Dent."},{"issue":"50","key":"502_CR14","first-page":"52","volume":"2009","author":"WV Giannobile","year":"2000","unstructured":"Giannobile WV, Beikler T, Kinney JS, Ramseier CA, Morelli T, Wong DT. Saliva as a diagnostic tool for periodontal disease: current state and future directions Periodontol. 2000;2009(50):52\u201364.","journal-title":"Saliva as a diagnostic tool for periodontal disease: current state and future directions Periodontol"},{"key":"502_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","volume":"4","author":"GC Armitage","year":"1999","unstructured":"Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999;4:1\u20136.","journal-title":"Ann Periodontol."},{"key":"502_CR16","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1749-6632.1993.tb18343.x","volume":"20","author":"M Navazesh","year":"1993","unstructured":"Navazesh M. Methods for collecting saliva. Ann N Y Acad Sci. 1993;20:72\u20137.","journal-title":"Ann N Y Acad Sci"},{"key":"502_CR17","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1111\/j.1600-051X.2011.01706.x","volume":"38","author":"WM Sexton","year":"2012","unstructured":"Sexton WM, Lin Y, Kryscio RJ, Dawson DR, Ebersole JL, Miller CS. Salivary biomarkers of periodontal disease in response to treatment. J Clin Periodontol. 2012;38:434\u201341.","journal-title":"J Clin Periodontol"},{"key":"502_CR18","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/jre.12404","volume":"52","author":"F \u00d6ng\u00f6z Dede","year":"2017","unstructured":"\u00d6ng\u00f6z Dede F, Balli U, Bozkurt Do\u011fan \u015e, G\u00fcven B. Interleukin-32 levels in gingival crevicular fluid and saliva of patients with chronic periodontitis after periodontal treatment. J Periodontal Res. 2017;52:397\u2013407.","journal-title":"J Periodontal Res"},{"key":"502_CR19","doi-asserted-by":"publisher","first-page":"e033","DOI":"10.1590\/1807-3107bor-2019.vol33.0033","volume":"33","author":"RA Yoshida","year":"2019","unstructured":"Yoshida RA, Gorj\u00e3o R, Mayer MPA, et al. Inflammatory markers in the saliva of cerebral palsy individuals with gingivitis after periodontal treatment. Braz Oral Res. 2019;33:e033.","journal-title":"Braz Oral Res."},{"key":"502_CR20","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3109\/00016357.2015.1030768","volume":"73","author":"P Purwar","year":"2015","unstructured":"Purwar P, Khan MA, Gupta A, et al. The effects of periodontal therapy on serum and salivary leptin levels in chronic periodontitis patients with normal body mass index. Acta Odontol Scand. 2015;73:633\u201341.","journal-title":"Acta Odontol Scand"},{"key":"502_CR21","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/jcpe.12451","volume":"42","author":"F Graziani","year":"2015","unstructured":"Graziani F, Cei S, Orlandi M, et al. Acute-phase response following full-mouth versus quadrant non-surgical periodontal treatment: a randomized clinical trial. J Clin Periodontol. 2015;42:843\u201352.","journal-title":"J Clin Periodontol"},{"key":"502_CR22","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/jre.12328","volume":"51","author":"G Torumtay","year":"2016","unstructured":"Torumtay G, K\u0131rz\u0131o\u011flu FY, \u00d6zt\u00fcrk Tongu\u00e7 M, Kale B, Calapo\u011flu M, Orhan H. Effects of periodontal treatment on inflammation and oxidative stress markers in patients with metabolic syndrome. J Periodontal Res. 2016;51:489\u201398.","journal-title":"J Periodontal Res"},{"key":"502_CR23","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/j.1600-0765.2011.01345.x","volume":"46","author":"S Lossd\u00f6rfer","year":"2011","unstructured":"Lossd\u00f6rfer S, Kraus D, Abuduwali N, J\u00e4ger A. Intermittent administration of PTH(1-34) regulates the osteoblastic differentiation of human periodontal ligament cells via protein kinase C- and protein kinase A-dependent pathways in vitro. J Periodontal Res. 2011;46:318\u201326.","journal-title":"J Periodontal Res"},{"key":"502_CR24","first-page":"E193","volume":"12","author":"P Bullon","year":"2007","unstructured":"Bullon P, Chandler L, Segura Egea JJ, Perez Cano R, Martinez Sahuquillo A. Osteocalcin in serum, saliva and gingival crevicular fluid: their relation with periodontal treatment outcome in postmenopausal women. Med Oral Patol Oral Cir Bucal. 2007;12:E193\u20137.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"502_CR25","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1902\/jop.2015.150270","volume":"86","author":"U Balli","year":"2015","unstructured":"Balli U, Aydogdu A, Dede FO, Turer CC, Guven B. Gingival crevicular fluid levels of sclerostin, osteoprotegerin, and receptor activator of nuclear factor-\u03baB ligand in periodontitis. J Periodontol. 2015;86:1396\u2013404.","journal-title":"J Periodontol"}],"container-title":["Odontology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-020-00502-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10266-020-00502-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-020-00502-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:56:53Z","timestamp":1614128213000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10266-020-00502-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,25]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["502"],"URL":"https:\/\/doi.org\/10.1007\/s10266-020-00502-2","relation":{},"ISSN":["1618-1247","1618-1255"],"issn-type":[{"value":"1618-1247","type":"print"},{"value":"1618-1255","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,25]]},"assertion":[{"value":"3 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethics Committee of the Pedro Ernesto University Hospital (number: 1.207.487).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants signed informed consent. All procedures performed in the study were following the 1964 Helsinki Declaration and its later amendments.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}