{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T16:06:02Z","timestamp":1749917162039,"version":"3.37.3"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Odontology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s10266-020-00503-1","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T10:03:00Z","timestamp":1583402580000},"page":"653-660","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bone metabolism of the jaw in response to bisphosphonate: a quantitative analysis of bone scintigraphy images"],"prefix":"10.1007","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9040-4065","authenticated-orcid":false,"given":"Fumi","family":"Nakai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Ohbayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"issue":"10","key":"503_CR1","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","volume":"72","author":"SL Ruggiero","year":"2014","unstructured":"Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, et al. American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw\u20132014 update. J Oral Maxillofac Surg. 2014;72(10):1938\u201356. https:\/\/doi.org\/10.1016\/j.joms.2014.04.031.","journal-title":"J Oral Maxillofac Surg"},{"issue":"9","key":"503_CR2","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","volume":"61","author":"RE Marx","year":"2003","unstructured":"Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61(9):1115\u20137.","journal-title":"J Oral Maxillofac Surg"},{"issue":"22","key":"503_CR3","doi-asserted-by":"publisher","first-page":"4253","DOI":"10.1200\/JCO.2003.99.132","volume":"21","author":"CA Migliorati","year":"2003","unstructured":"Migliorati CA. Bisphosphanates and oral cavity avascular bone necrosis. J Clin Oncol. 2003;21(22):4253\u20134. https:\/\/doi.org\/10.1200\/JCO.2003.99.132.","journal-title":"J Clin Oncol"},{"issue":"5","key":"503_CR4","first-page":"262","volume":"6","author":"T Kaneta","year":"2016","unstructured":"Kaneta T, Ogawa M, Daisaki H, Nawata S, Yoshida K, Inoue T. SUV measurement of normal vertebrae using SPECT\/CT with Tc-99m methylene diphosphonate. Am J Nuclear Med Mol Imag. 2016;6(5):262\u20138.","journal-title":"Am J Nuclear Med Mol Imag"},{"issue":"9","key":"503_CR5","doi-asserted-by":"publisher","first-page":"e108429","DOI":"10.1371\/journal.pone.0108429","volume":"9","author":"AZ Win","year":"2014","unstructured":"Win AZ, Aparici CM. Normal SUV values measured from NaF18-PET\/CT bone scan studies. PloS ONE. 2014;9(9):e108429. https:\/\/doi.org\/10.1371\/journal.pone.0108429.","journal-title":"PloS ONE"},{"issue":"3","key":"503_CR6","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1007\/s10266-016-0279-9","volume":"105","author":"Y Ohbayashi","year":"2017","unstructured":"Ohbayashi Y, Nakai F, Iwasaki A, Ogawa T, Yamamoto Y, Nishiyama Y, et al. The utility of bone scintigraphy in the assessment of mandibular metabolism during long-term bisphosphonate administration. Odontology. 2017;105(3):382\u201390. https:\/\/doi.org\/10.1007\/s10266-016-0279-9.","journal-title":"Odontology"},{"issue":"4","key":"503_CR7","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00784-015-1563-8","volume":"20","author":"C Thomas","year":"2016","unstructured":"Thomas C, Spanidis M, Engel C, Roos FC, Frees S, Neisius A, et al. Bone scintigraphy predicts bisphosphonate-induced osteonecrosis of the jaw (BRONJ) in patients with metastatic castration-resistant prostate cancer (mCRPC). Clin Oral Investig. 2016;20(4):753\u20138. https:\/\/doi.org\/10.1007\/s00784-015-1563-8.","journal-title":"Clin Oral Investig"},{"issue":"7","key":"503_CR8","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.joms.2009.03.005","volume":"67","author":"FS O'Ryan","year":"2009","unstructured":"O'Ryan FS, Khoury S, Liao W, Han MM, Hui RL, Baer D, et al. Intravenous bisphosphonate-related osteonecrosis of the jaw: bone scintigraphy as an early indicator. J Oral Maxillofac. 2009;67(7):1363\u201372. https:\/\/doi.org\/10.1016\/j.joms.2009.03.005.","journal-title":"J Oral Maxillofac"},{"issue":"3","key":"503_CR9","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s13139-012-0144-x","volume":"46","author":"CM Hong","year":"2012","unstructured":"Hong CM, Ahn BC, Choi SY, Kim DH, Lee SW, Kwon TG, et al. Implications of three-phase bone scintigraphy for the diagnosis of bisphosphonate-related osteonecrosis of the jaw. Nuclear Med Mol Imag. 2012;46(3):162\u20138. https:\/\/doi.org\/10.1007\/s13139-012-0144-x.","journal-title":"Nuclear Med Mol Imag"},{"issue":"4","key":"503_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.coms.2015.06.002","volume":"27","author":"MR Allen","year":"2015","unstructured":"Allen MR. Medication-related osteonecrosis of the jaw: basic and translational science updates. Oral Maxillofac Surg Clin N Am. 2015;27(4):497\u2013508. https:\/\/doi.org\/10.1016\/j.coms.2015.06.002.","journal-title":"Oral Maxillofac Surg Clin N Am"},{"issue":"10","key":"503_CR11","doi-asserted-by":"publisher","first-page":"753","DOI":"10.7326\/0003-4819-144-10-200605160-00009","volume":"144","author":"SB Woo","year":"2006","unstructured":"Woo SB, Hellstein JW, Kalmar JR. Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann Intern Med. 2006;144(10):753\u201361.","journal-title":"Ann Intern Med"},{"issue":"3","key":"503_CR12","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.bone.2007.04.196","volume":"41","author":"IR Reid","year":"2007","unstructured":"Reid IR, Bolland MJ, Grey AB. Is bisphosphonate-associated osteonecrosis of the jaw caused by soft tissue toxicity? Bone. 2007;41(3):318\u201320. https:\/\/doi.org\/10.1016\/j.bone.2007.04.196.","journal-title":"Bone"},{"issue":"2","key":"503_CR13","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1302\/0301-620X.61B2.438276","volume":"61","author":"RA Khan","year":"1979","unstructured":"Khan RA, Hughes S, Lavender P, Leon M, Spyrou N. Autoradiography of technetium-labelled diphosphonate in rat bone. J Bone Joint Surg Br. 1979;61(2):221\u20134.","journal-title":"J Bone Joint Surg Br"},{"issue":"12","key":"503_CR14","first-page":"1185","volume":"21","author":"MD Francis","year":"1980","unstructured":"Francis MD, Ferguson DL, Tofe AJ, Bevan JA, Michaels SE. Comparative evaluation of three diphosphonates: in vitro adsorption (C-14 labeled) and in vivo osteogenic uptake (Tc-99m complexed). J Nucl Med. 1980;21(12):1185\u20139.","journal-title":"J Nucl Med"},{"issue":"1","key":"503_CR15","doi-asserted-by":"publisher","first-page":"90","DOI":"10.2106\/00004623-198062010-00013","volume":"62","author":"SB Christensen","year":"1980","unstructured":"Christensen SB, Arnold CC. Distribution of 99mTc-phosphate compounds in osteoarthritic femoral heads. J Bone Joint Surg Am. 1980;62(1):90\u20136.","journal-title":"J Bone Joint Surg Am"},{"issue":"2","key":"503_CR16","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0030-4220(93)90100-I","volume":"75","author":"D Kanishi","year":"1993","unstructured":"Kanishi D. 99mTc-MDP accumulation mechanisms in bone. Oral Surg Oral Med Oral Pathol. 1993;75(2):239\u201346.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"3","key":"503_CR17","first-page":"237","volume":"22","author":"SB Christensen","year":"1981","unstructured":"Christensen SB, Krogsgaard OW. Localization of Tc-99m MDP in epiphyseal growth plates of rats. J Nucl Med. 1981;22(3):237\u201345.","journal-title":"J Nucl Med"},{"issue":"11","key":"503_CR18","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/BF00261010","volume":"11","author":"TJ Savelkoul","year":"1986","unstructured":"Savelkoul TJ, Visser WJ, Oldenburg SJ, Duursma SA. A micro-autoradiographical study of the localization of 99mTc(Sn)-MDP and 99mTc-MDP in undecalcified bone sections. Eur J Nucl Med. 1986;11(11):459\u201362.","journal-title":"Eur J Nucl Med"},{"issue":"736","key":"503_CR19","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1259\/0007-1285-62-736-318","volume":"62","author":"RS Budd","year":"1989","unstructured":"Budd RS, Hodgson GS, Hare WS. The relation of radionuclide uptake by bone to the rate of calcium mineralization II: patient studies using 99Tcm-MDP. Br J Radiol. 1989;62(736):318\u201320. https:\/\/doi.org\/10.1259\/0007-1285-62-736-318.","journal-title":"Br J Radiol"},{"issue":"4","key":"503_CR20","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3109\/17453678909149310","volume":"60","author":"GS Lausten","year":"1989","unstructured":"Lausten GS, Christensen SB. Distribution of 99mTc-phosphate compounds in osteonecrotic femoral heads. Acta Orthop Scand. 1989;60(4):419\u201323.","journal-title":"Acta Orthop Scand"},{"issue":"2","key":"503_CR21","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s00198-012-2006-x","volume":"24","author":"T Puri","year":"2013","unstructured":"Puri T, Frost ML, Curran KM, Siddique M, Moore AE, Cook GJ, et al. Differences in regional bone metabolism at the spine and hip: a quantitative study using (18)F-fluoride positron emission tomography. Osteop Int. 2013;24(2):633\u20139. https:\/\/doi.org\/10.1007\/s00198-012-2006-x.","journal-title":"Osteop Int"},{"issue":"2","key":"503_CR22","first-page":"118","volume":"3","author":"C Cheng","year":"2013","unstructured":"Cheng C, Heiss C, Dimitrakopoulou-Strauss A, Govindarajan P, Schlewitz G, Pan L, et al. Evaluation of bone remodeling with (18)F-fluoride and correlation with the glucose metabolism measured by (18)F-FDG in lumbar spine with time in an experimental nude rat model with osteoporosis using dynamic PET-CT. Am J Nuclear Med Mol Imag. 2013;3(2):118\u201328.","journal-title":"Am J Nuclear Med Mol Imag"},{"issue":"5","key":"503_CR23","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1002\/jbmr.305","volume":"26","author":"ML Frost","year":"2011","unstructured":"Frost ML, Siddique M, Blake GM, Moore AE, Schleyer PJ, Dunn JT, et al. Differential effects of teriparatide on regional bone formation using (18)F-fluoride positron emission tomography. J Bone Miner Res. 2011;26(5):1002\u2013111. https:\/\/doi.org\/10.1002\/jbmr.305.","journal-title":"J Bone Miner Res"},{"issue":"10","key":"503_CR24","doi-asserted-by":"publisher","first-page":"e379","DOI":"10.1097\/RLU.0b013e31828d30c0","volume":"38","author":"N Kobayashi","year":"2013","unstructured":"Kobayashi N, Inaba Y, Tateishi U, Yukizawa Y, Ike H, Inoue T, et al. New application of 18F-fluoride PET for the detection of bone remodelling in early-stage osteoarthritis of the hip. Clin Nuclear Med. 2013;38(10):e379\u2013e383383. https:\/\/doi.org\/10.1097\/RLU.0b013e31828d30c0.","journal-title":"Clin Nuclear Med"},{"issue":"1","key":"503_CR25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cpet.2018.08.007","volume":"14","author":"AG Austin","year":"2019","unstructured":"Austin AG, Raynor WY, Reilly CC, Zadeh MZ, Werner TJ, Zhuang H, et al. Evolving role of MR imaging and PET in assessing osteoporosis. PET Clin. 2019;14(1):31\u201341. https:\/\/doi.org\/10.1016\/j.cpet.2018.08.007.","journal-title":"PET Clin"},{"issue":"1","key":"503_CR26","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jpor.2011.04.002","volume":"56","author":"H Suenaga","year":"2012","unstructured":"Suenaga H, Yokoyama M, Yamaguchi K, Sasaki K. Bone metabolism of residual ridge beneath the denture base of an RPD observed using NaF-PET\/CT. J Prosthodont Res. 2012;56(1):42\u20136. https:\/\/doi.org\/10.1016\/j.jpor.2011.04.002.","journal-title":"J Prosthodont Res"},{"issue":"2","key":"503_CR27","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1210\/edrv.21.2.0395","volume":"21","author":"SC Manolagas","year":"2000","unstructured":"Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endoc Rev. 2000;21(2):115\u201337. https:\/\/doi.org\/10.1210\/edrv.21.2.0395.","journal-title":"Endoc Rev"},{"issue":"4","key":"503_CR28","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1172\/JCI113725","volume":"82","author":"R Civitelli","year":"1988","unstructured":"Civitelli R, Gonnelli S, Zacchei F, Bigazzi S, Vattimo A, Avioli LV, et al. Bone turnover in postmenopausal osteoporosis effect of calcitonin treatment. J Clin Invest. 1988;82(4):1268\u201374. https:\/\/doi.org\/10.1172\/JCI113725.","journal-title":"J Clin Invest"},{"issue":"1","key":"503_CR29","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/BF02408600","volume":"30","author":"A Caniggia","year":"1980","unstructured":"Caniggia A, Vattimo A. Kinetics of 99mtechnetium-tin-methylene-diphosphonate in normal subjects and pathological conditions: a simple index of bone metabolism. Calcif Tissue Int. 1980;30(1):5\u201313.","journal-title":"Calcif Tissue Int"},{"issue":"9","key":"503_CR30","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1007\/BF00281861","volume":"13","author":"MW Davie","year":"1987","unstructured":"Davie MW, Britton JM, Haddaway M, McCall IW. 99mTc-MDP retention in osteoporosis: relationship to other indices of bone cell activity and response to calcium and vitamin D therapy. Eur J Nucl Med. 1987;13(9):462\u20136.","journal-title":"Eur J Nucl Med"},{"issue":"11","key":"503_CR31","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1359\/JBMR.040818","volume":"19","author":"ML Frost","year":"2004","unstructured":"Frost ML, Fogelman I, Blake GM, Marsden PK, Cook G Jr. Dissociation between global markers of bone formation and direct measurement of spinal bone formation in osteoporosis. J Bone Min Res. 2004;19(11):1797\u2013804. https:\/\/doi.org\/10.1359\/JBMR.040818.","journal-title":"J Bone Min Res"},{"issue":"7","key":"503_CR32","first-page":"1155","volume":"35","author":"O Israel","year":"1994","unstructured":"Israel O, Lubushitzky R, Frenkel A, Iosilevsky G, Bettman L, Gips S, et al. Bone turnover in cortical and trabecular bone in normal women and in women with osteoporosis. J Nucl Med. 1994;35(7):1155\u20138.","journal-title":"J Nucl Med"},{"issue":"9","key":"503_CR33","first-page":"1478","volume":"41","author":"V Carnevale","year":"2000","unstructured":"Carnevale V, Dicembrino F, Frusciante V, Chiodini I, Minisola S, Scillitani A. Different patterns of global and regional skeletal uptake of 99mTc-methylene diphosphonate with age: relevance to the pathogenesis of bone loss. J Nucl Med. 2000;41(9):1478\u201383.","journal-title":"J Nucl Med"},{"issue":"11","key":"503_CR34","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.2967\/jnumed.109.062570","volume":"50","author":"K Uchida","year":"2009","unstructured":"Uchida K, Nakajima H, Miyazaki T, Yayama T, Kawahara H, Kobayashi S, et al. Effects of alendronate on bone metabolism in glucocorticoid-induced osteoporosis measured by 18F-fluoride PET: a prospective study. J Nucl Med. 2009;50(11):1808\u201314. https:\/\/doi.org\/10.2967\/jnumed.109.062570.","journal-title":"J Nucl Med"},{"issue":"3","key":"503_CR35","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1148\/radiol.2016152294","volume":"280","author":"MS Suh","year":"2016","unstructured":"Suh MS, Lee WW, Kim YK, Yun PY, Kim SE. Maximum Standardized Uptake Value of (99m)Tc Hydroxymethylene diphosphonate SPECT\/CT for the evaluation of temporomandibular joint disorder. Radiology. 2016;280(3):890\u20136. https:\/\/doi.org\/10.1148\/radiol.2016152294.","journal-title":"Radiology"}],"container-title":["Odontology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-020-00503-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10266-020-00503-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-020-00503-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T01:10:50Z","timestamp":1614906650000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10266-020-00503-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,5]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["503"],"URL":"https:\/\/doi.org\/10.1007\/s10266-020-00503-1","relation":{},"ISSN":["1618-1247","1618-1255"],"issn-type":[{"type":"print","value":"1618-1247"},{"type":"electronic","value":"1618-1255"}],"subject":[],"published":{"date-parts":[[2020,3,5]]},"assertion":[{"value":"6 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee [the Kagawa University Ethical Committee (H24\u2013#106)] and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}