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Ethical approval was obtained via the Ethics Committee for Animal Experimentation of the State University of Londrina (process number: 15688.2017.30, official letter 112\/2017). All the authors mentioned in the manuscript have agreed for authorship, read, and approved the final version of the manuscript, and given consent for submission and subsequent publication of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"The mice from the sample were kept under controlled conditions to guarantee their welfare: 12\u00a0h light\/dark cycles, temperature set at 22\u2009\u00b1\u20092\u00a0\u00b0C and unlimited access to water and food. Besides, the animals were allocated in a proportion of two females for each male mice, in 30\u00a0cm\u2009\u00d7\u200920\u00a0cm\u2009\u00d7\u200913\u00a0cm polypropylene cages lined with wood shavings. Only two people conducted the treatments and euthanasia out of the research team, as quickly and as comfortably as possible.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of animal welfare"}}]}}