{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:22:26Z","timestamp":1789143746148,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560178"],"award-info":[{"award-number":["81560178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Odontology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s10266-024-00911-7","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T20:01:41Z","timestamp":1711396901000},"page":"1113-1122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlation between PD-1\/PD-L1 and RANKL\/OPG in chronic apical periodontitis model of Sprague-Dawley rats"],"prefix":"10.1007","volume":"112","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burlen","family":"Jieensi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shutao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4851-3625","authenticated-orcid":false,"given":"Yishan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"issue":"3","key":"911_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/00016357.2018.1521005","volume":"77","author":"PH Braz-Silva","year":"2019","unstructured":"Braz-Silva PH, Bergamini ML, Mardegan AP, De Rosa CS, Hasseus B, Jonasson P. Inflammatory profile of chronic apical periodontitis: a literature review. Acta Odontol Scand. 2019;77(3):173\u201380.","journal-title":"Acta Odontol Scand"},{"key":"911_CR2","doi-asserted-by":"crossref","unstructured":"Fouad AF, Khan AA. Etiology and pathogenesis of pulpitis and apical periodontitis. Essential Endodontology: Prevention and Treatment of Apical Periodontitis. 2019:59\u201390.","DOI":"10.1002\/9781119272014.ch3"},{"key":"911_CR3","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.3389\/fcimb.2021.798367","volume":"11","author":"X Sun","year":"2022","unstructured":"Sun X, Yang Z, Nie Y, Hou B. Microbial communities in the extraradicular and intraradicular infections associated with persistent apical periodontitis. Front Cell Infect Microbiol. 2022;11:1391.","journal-title":"Front Cell Infect Microbiol"},{"key":"911_CR4","doi-asserted-by":"crossref","unstructured":"Silva T, Garlet GP, Fukada SY, Silva JSd, Cunha FdQ. Chemokines in oral inflammatory diseases: apical periodontitis and periodontal disease. Journal of dental research. 2007;86(4):306\u201319.","DOI":"10.1177\/154405910708600403"},{"issue":"03","key":"911_CR5","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1055\/s-0040-1712718","volume":"14","author":"DE Ramadan","year":"2020","unstructured":"Ramadan DE, Hariyani N, Indrawati R, Ridwan RD, Diyatri I. Cytokines and chemokines in periodontitis. European journal of dentistry. 2020;14(03):483\u201395.","journal-title":"European journal of dentistry"},{"issue":"2","key":"911_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41368-019-0049-y","volume":"11","author":"H Davanian","year":"2019","unstructured":"Davanian H, Gaiser RA, Silfverberg M, Hugerth LW, Sobkowiak MJ, Lu L, et al. Mucosal-associated invariant T cells and oral microbiome in persistent apical periodontitis. Int J Oral Sci. 2019;11(2):16. https:\/\/doi.org\/10.1038\/s41368-019-0049-y.","journal-title":"Int J Oral Sci"},{"issue":"6","key":"911_CR7","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1111\/odi.13450","volume":"27","author":"L Wei","year":"2021","unstructured":"Wei L, Xu M, Xiong H. An update of knowledge on the regulatory role of Treg cells in apical periodontitis. Oral Dis. 2021;27(6):1356\u201365.","journal-title":"Oral Dis"},{"issue":"2","key":"911_CR8","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3897\/folmed.62.e39599","volume":"62","author":"T Karteva","year":"2020","unstructured":"Karteva T, Manchorova-Veleva N. The role of the immune response in chronic marginal and apical periodontitis. Folia Med. 2020;62(2):238\u201343.","journal-title":"Folia Med"},{"key":"911_CR9","doi-asserted-by":"crossref","unstructured":"Bergamini ML, Mardegan AP, De Rosa CS, Palmieri M, Sarmento DJdS, Hiraki KRN et al. Presence of Langerhans cells, regulatory T cells (Treg) and mast cells in asymptomatic apical periodontitis. Brazilian oral research. 2020;34.","DOI":"10.1590\/1807-3107bor-2020.vol34.0108"},{"issue":"7077","key":"911_CR10","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nature04444","volume":"439","author":"DL Barber","year":"2006","unstructured":"Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006;439(7077):682\u20137.","journal-title":"Nature"},{"issue":"4","key":"911_CR11","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrclinonc.2016.168","volume":"14","author":"A Goodman","year":"2017","unstructured":"Goodman A, Patel SP, Kurzrock R. PD-1\u2013PD-L1 immune-checkpoint blockade in B-cell lymphomas. Nat Rev Clin Oncol. 2017;14(4):203\u201320. https:\/\/doi.org\/10.1038\/nrclinonc.2016.168.","journal-title":"Nat Rev Clin Oncol"},{"key":"911_CR12","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1007\/s12264-021-00683-y","volume":"37","author":"J Zhao","year":"2021","unstructured":"Zhao J, Roberts A, Wang Z, Savage J, Ji R-R. Emerging role of PD-1 in the central nervous system and brain diseases. Neurosci Bull. 2021;37:1188\u2013202.","journal-title":"Neurosci Bull"},{"issue":"1","key":"911_CR13","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1097\/COC.0000000000000239","volume":"39","author":"EI Buchbinder","year":"2016","unstructured":"Buchbinder EI, Desai A. CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition. Am J Clin Oncol. 2016;39(1):98.","journal-title":"Am J Clin Oncol"},{"issue":"1","key":"911_CR14","doi-asserted-by":"publisher","first-page":"5532","DOI":"10.3402\/jom.v2i0.5532","volume":"2","author":"M Kajiya","year":"2010","unstructured":"Kajiya M, Giro G, Taubman MA, Han X, Mayer MP, Kawai T. Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease. J Oral Microbiol. 2010;2(1):5532.","journal-title":"J Oral Microbiol"},{"issue":"3","key":"911_CR15","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4103\/2230-8210.83401","volume":"15","author":"SS Kohli","year":"2011","unstructured":"Kohli SS, Kohli VS. Role of RANKL\u2013RANK\/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications. Indian journal of endocrinology and metabolism. 2011;15(3):175.","journal-title":"Indian journal of endocrinology and metabolism"},{"issue":"3","key":"911_CR16","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.tripleo.2005.10.054","volume":"102","author":"R Menezes","year":"2006","unstructured":"Menezes R, Bramante CM, da Silva Paiva KB, Letra A, Carneiro E, Fernando Zambuzzi W, et al. Receptor activator NF\u03baB-ligand and osteoprotegerin protein expression in human periapical cysts and granulomas. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2006;102(3):404\u20139. https:\/\/doi.org\/10.1016\/j.tripleo.2005.10.054.","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"},{"key":"911_CR17","unstructured":"Fan R, Sun B, Zhang C-f, XUAN W, WANG Q-q, YIN X-z. Receptor activator of nuclear factor kappa B ligand and osteoprotegerin expression in chronic apical periodontitis: possible association with inflammatory cells. Chinese Medical Journal. 2011;124(14):2162\u20136."},{"key":"911_CR18","doi-asserted-by":"crossref","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method. methods. 2001;25(4):402\u20138.","DOI":"10.1006\/meth.2001.1262"},{"issue":"1","key":"911_CR19","first-page":"3","volume":"4","author":"RJR Delgado","year":"2019","unstructured":"Delgado RJR, Pinheiro CR, Gasparoto TH, Sipert CR, De Moraes IG, Garcia RB, et al. Programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in chronic apical periodontitis. European endodontic journal. 2019;4(1):3.","journal-title":"European endodontic journal"},{"key":"911_CR20","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2017-0512","volume":"26","author":"D Barreiros","year":"2018","unstructured":"Barreiros D, Pucinelli CM, Oliveira KMH, Paula-Silva FWG, Nelson Filho P, Silva L, et al. Immunohistochemical and mRNA expression of RANK, RANKL, OPG, TLR2 and MyD88 during apical periodontitis progression in mice. J Appl Oral Sci. 2018;26: e20170512. https:\/\/doi.org\/10.1590\/1678-7757-2017-0512.","journal-title":"J Appl Oral Sci"},{"issue":"4","key":"911_CR21","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/dj7040114","volume":"7","author":"L Fiorillo","year":"2019","unstructured":"Fiorillo L, Cervino G, Laino L, D\u2019Amico C, Mauceri R, Tozum TF, et al. Porphyromonas gingivalis, periodontal and systemic implications: a systematic review. Dentistry journal. 2019;7(4):114.","journal-title":"Dentistry journal"},{"issue":"3\u20134","key":"911_CR22","doi-asserted-by":"publisher","first-page":"296","DOI":"10.5466\/ijoms.18.296","volume":"18","author":"Y Ogawa","year":"2020","unstructured":"Ogawa Y, Kobayashi R, Kono T, Toda M, Okada H, Kurita-Ochiai T, et al. Involvement of Fusobacterium Nucleatum in Bone Resorption and Periodontal Tissue Inflammation. International Journal of Oral-Medical Sciences. 2020;18(3\u20134):296\u2013302.","journal-title":"International Journal of Oral-Medical Sciences"},{"issue":"1","key":"911_CR23","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jdsr.2020.04.002","volume":"56","author":"C Bailly","year":"2020","unstructured":"Bailly C. The implication of the PD-1\/PD-L1 checkpoint in chronic periodontitis suggests novel therapeutic opportunities with natural products. Jpn Dent Sci Rev. 2020;56(1):90\u20136. https:\/\/doi.org\/10.1016\/j.jdsr.2020.04.002.","journal-title":"Jpn Dent Sci Rev"},{"key":"911_CR24","doi-asserted-by":"publisher","unstructured":"Kajiya M, Giro G, Taubman MA, Han X, Mayer MP, Kawai T. Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease. J Oral Microbiol. 2010;2. doi:https:\/\/doi.org\/10.3402\/jom.v2i0.5532.","DOI":"10.3402\/jom.v2i0.5532"},{"issue":"2","key":"911_CR25","first-page":"135","volume":"23","author":"J-W Huang","year":"2017","unstructured":"Huang J-W. PD-1 and PD-1L expression in peripheral blood T lymphocytes of patients with chronic periodontitis and their correlation with the degree of inflammation. Journal of Hainan Medical University. 2017;23(2):135\u20138.","journal-title":"Journal of Hainan Medical University"},{"issue":"3","key":"911_CR26","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1189\/jlb.3MA0717-283","volume":"103","author":"CM Weyand","year":"2018","unstructured":"Weyand CM, Berry GJ, Goronzy JJ. The immunoinhibitory PD-1\/PD-L1 pathway in inflammatory blood vessel disease. J Leukoc Biol. 2018;103(3):565\u201375.","journal-title":"J Leukoc Biol"},{"key":"911_CR27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3389\/fcimb.2019.00207","volume":"9","author":"G Sch\u00f6nrich","year":"2019","unstructured":"Sch\u00f6nrich G, Raftery MJ. The PD-1\/PD-L1 axis and virus infections: a delicate balance. Front Cell Infect Microbiol. 2019;9:207.","journal-title":"Front Cell Infect Microbiol"},{"key":"911_CR28","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s00262-006-0272-1","volume":"56","author":"C Blank","year":"2007","unstructured":"Blank C, Mackensen A. Contribution of the PD-L1\/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion. Cancer Immunol Immunother. 2007;56:739\u201345.","journal-title":"Cancer Immunol Immunother"},{"key":"911_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114215","volume":"159","author":"X Liu","year":"2023","unstructured":"Liu X, Yang L, Tan X. PD-1\/PD-L1 pathway: A double-edged sword in periodontitis. Biomed Pharmacother. 2023;159: 114215.","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"911_CR30","doi-asserted-by":"publisher","first-page":"366","DOI":"10.7518\/hxkq.2015.04.009","volume":"33","author":"W Yuan","year":"2015","unstructured":"Yuan W, Wang X, Zhang J, Zhou W, Feng Y, Chen J, et al. Programmed death ligand 1 negatively regulates inflammatory response of chronic periodontitis. Hua Xi Kou Qiang Yi Xue Za Zhi. 2015;33(4):366\u20139. https:\/\/doi.org\/10.7518\/hxkq.2015.04.009.","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"911_CR31","doi-asserted-by":"publisher","unstructured":"Sun X, Li B, Abula D, Wang L, Wang B, Wang Q et al. 01% Nano-silver mediates PD-1\/PD-L1 pathway and alleviates chronic apical periodontitis in rats. Odontology. 2023;111(1):154\u201364. https:\/\/doi.org\/10.1007\/s10266-022-00735-3.","DOI":"10.1007\/s10266-022-00735-3"},{"issue":"3","key":"911_CR32","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.joen.2011.12.029","volume":"38","author":"MJ Silva","year":"2012","unstructured":"Silva MJ, Kajiya M, AlShwaimi E, Sasaki H, Hong J, Ok P, et al. Bacteria-reactive immune response may induce RANKL-expressing T cells in the mouse periapical bone loss lesion. J Endodont. 2012;38(3):346\u201350.","journal-title":"J Endodont"},{"key":"911_CR33","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00774-020-01162-6","volume":"39","author":"N Udagawa","year":"2021","unstructured":"Udagawa N, Koide M, Nakamura M, Nakamichi Y, Yamashita T, Uehara S, et al. Osteoclast differentiation by RANKL and OPG signaling pathways. J Bone Miner Metab. 2021;39:19\u201326.","journal-title":"J Bone Miner Metab"},{"issue":"2","key":"911_CR34","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.jtbi.2009.09.021","volume":"262","author":"P Pivonka","year":"2010","unstructured":"Pivonka P, Zimak J, Smith DW, Gardiner BS, Dunstan CR, Sims NA, et al. Theoretical investigation of the role of the RANK\u2013RANKL\u2013OPG system in bone remodeling. J Theor Biol. 2010;262(2):306\u201316.","journal-title":"J Theor Biol"},{"key":"911_CR35","doi-asserted-by":"publisher","first-page":"773946","DOI":"10.3389\/fimmu.2022.773946","volume":"13","author":"SR Greisen","year":"2022","unstructured":"Greisen SR, Kragstrup TW, Thomsen JS, H\u00f8rslev-Pedersen K, Hetland ML, Stengaard-Pedersen K, et al. The programmed death-1 pathway counter-regulates inflammation-induced osteoclast activity in clinical and experimental settings. Front Immunol. 2022;13:773946. https:\/\/doi.org\/10.3389\/fimmu.2022.773946.","journal-title":"Front Immunol"}],"container-title":["Odontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-024-00911-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10266-024-00911-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-024-00911-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T10:07:12Z","timestamp":1726826832000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10266-024-00911-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["911"],"URL":"https:\/\/doi.org\/10.1007\/s10266-024-00911-7","relation":{},"ISSN":["1618-1247","1618-1255"],"issn-type":[{"value":"1618-1247","type":"print"},{"value":"1618-1255","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,25]]},"assertion":[{"value":"29 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal experiments were approved by the Animal Experimental Ethics Committee of Xinjiang Medical University (Approval No. IACUC-20190225\u201301).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}