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An electronic search of MEDLINE, Cochrane, and PubMed databases was performed, selecting exclusively randomized clinical trials where the following were measured: probing depth reduction (PD), clinical attachment level gain (CAL), and radiographic bone fill (RBF).\u00a0Out of 284 selected articles, 32 were chosen based on inclusion criteria. The use of platelet-rich fibrin (PRF)\u2009+\u2009open flap debridement (OFD), PRF\u2009+\u2009metformin, PRF\u2009+\u2009platelet-rich plasma (PRP), and PRF\u2009+\u2009OFD\/bone graft (BG) significantly reduced PD and improved CAL and RBF. However, the combination of PRF\u2009+\u2009BG, PRF\u2009+\u2009metformin, and PRF\u2009+\u2009STATINS reduced CAL. The intervention of PRF combined with different treatments such as metformin, OFD, PRP, BG, and STATINS has a significant impact on improving PD and CAL. The use of PRF significantly improved the regeneration of periodontal bone defects compared to other treatments.<\/jats:p>","DOI":"10.1007\/s10266-024-00949-7","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T13:02:10Z","timestamp":1716296530000},"page":"1047-1068","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Regeneration of periodontal intrabony defects using platelet-rich fibrin (PRF): a systematic review and network meta-analysis"],"prefix":"10.1007","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8389-086X","authenticated-orcid":false,"given":"F\u00e1bio Fran\u00e7a Vieira e","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-951X","authenticated-orcid":false,"given":"Luis","family":"Chauca-Baja\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-5921","authenticated-orcid":false,"given":"Vito Carlo Alberto","family":"Caponio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-3548","authenticated-orcid":false,"given":"Kareelend Andreina Segura","family":"Cueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-3941","authenticated-orcid":false,"given":"Byron","family":"Velasquez-Ron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-7768","authenticated-orcid":false,"given":"Maria Elena","family":"Pad\u00edn-Iruegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lays Lamolha","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9180-4703","authenticated-orcid":false,"given":"Alejandro Ismael","family":"Lorenzo-Pouso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4033-3638","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Su\u00e1rez-Pe\u00f1aranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-9868","authenticated-orcid":false,"given":"Mario","family":"P\u00e9rez-Say\u00e1ns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"issue":"1","key":"949_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/prd.12296","volume":"83","author":"MA Curtis","year":"2020","unstructured":"Curtis MA, Diaz PI, Van Dyke TE. 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