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To induce periodontitis, 42 rats were injected with 3\u00a0\u00b5L of a 10\u00a0mg\/mL lipopolysaccharide (LPS) for\u00a04\u00a0weeks and divided into 3 categories: untreated Periodontitis, Exosomes treated (single dose 200\u00a0\u00b5g exosomes), and exosomes loaded NCUR treated group (200\u00a0\u00b5g exosomes loaded with 200\u00a0\u00b5g NCUR). In addition, 14 rats were injected PBS to serve as control. Rats were sacrificed between 2 and 4 weeks. Rats were allocated in 7 groups; (Group I (Control), Group II (Periodontitis 2\u00a0weeks), Group III (Periodontitis\u2009+\u2009exosomes 2 weeks), Group IV (Periodontitis\u2009+\u2009loaded exosomes 2\u00a0weeks), Group V (Periodontitis 4\u00a0weeks), Group VI (Periodontitis\u2009+\u2009exosomes 4\u00a0weeks) and Group VII (Periodontitis\u2009+\u2009loaded exosomes 4\u00a0weeks). The specimens were prepared for histological, histochemical and ELISA analysis. Histological examination of Group I showed normal structure of periodontium. Groups II and V illustrated reduction in periodontal ligament and different stainability of cementum and bone. Group III revealed disordered periodontal fibers and irregular outlines of cementum and bone. The periodontal fibers in Groups IV and VII were obliquely oriented, and the cementum and bone were consistently stained. Group VI explored dense periodontal ligament. Cementum and alveolar bone showed regular outlines. Masson's trichrome statistical results showed group VI has highest mean. Group V has the greatest IL-1\u03b2 mean. NCUR-loaded exosomes were found to be more effective in decreasing inflammation and stimulating tissue regeneration in experimental periodontitis.<\/jats:p>","DOI":"10.1007\/s10266-025-01161-x","type":"journal-article","created":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:57:16Z","timestamp":1754197036000},"page":"800-814","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prospective effect of mesenchymal exosomes versus nanocurcumin-loaded mesenchymal exosomes on induced periodontitis in albino rats"],"prefix":"10.1007","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0576-5099","authenticated-orcid":false,"given":"Nehad M.","family":"Abd-elmonsif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Gamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona El","family":"Deeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany A.","family":"Rabea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,3]]},"reference":[{"key":"1161_CR1","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.actbio.2019.03.021","volume":"89","author":"JRJ Chew","year":"2019","unstructured":"Chew JRJ, Chuah SJ, Teo KYW, Zhang S, Lai RC, Fu JH, Lim LP, Lim SK, Toh WS. 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