{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:45:47Z","timestamp":1793310347476,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"PLGA\/WK fiber membrane composite stem cell membrane containing Sema3A calcium alginate microspheres for bone regeneration in osteoporotic rats","award":["2024AAC03624"],"award-info":[{"award-number":["2024AAC03624"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Odontology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10266-025-01231-0","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T02:33:10Z","timestamp":1761359590000},"page":"1654-1664","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["miR-155 rs767649 polymorphism contributes to dental caries susceptibility of Chinese Han children"],"prefix":"10.1007","volume":"114","author":[{"given":"Qi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamei","family":"Gai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"issue":"4","key":"1231_CR1","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1177\/0300060519828450","volume":"47","author":"XP Hu","year":"2019","unstructured":"Hu XP, Song TZ, Zhu YY, Wu LL, Zhang X, Zhou JY, et al. Association of ENAM, TUFT1, MMP13, IL1B, IL10 and IL1RN gene polymorphism and dental caries susceptibility in Chinese children. J Int Med Res. 2019;47(4):1696\u2013704.","journal-title":"J Int Med Res"},{"key":"1231_CR2","doi-asserted-by":"publisher","first-page":"911110","DOI":"10.3389\/froh.2022.911110","volume":"3","author":"SM Susarla","year":"2022","unstructured":"Susarla SM, Trimble M, Sokal-Gutierrez K. Cross-sectional analysis of oral healthcare vs. general healthcare utilization in five low- and middle-income countries. Front Oral Health. 2022;3:911110.","journal-title":"Front Oral Health"},{"key":"1231_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.637394","volume":"11","author":"F Li","year":"2021","unstructured":"Li F, Fu D, Tao D, Feng X, Wong MCM, Xu W, et al. Dynamic observation of the effect of maternal caries on the oral microbiota of infants aged 12\u201324 months. Front Cell Infect Microbiol. 2021;11:637394.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"1231_CR4","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s12884-025-07426-1","volume":"25","author":"AT Tefera","year":"2025","unstructured":"Tefera AT, Berhe S, Seifu S, Solomon M, Ayichew Z, Adane A, et al. The magnitude of untreated dental caries and its predictors among pregnant women attending antenatal care at health facilities in Gondar town, Northwest Ethiopia. BMC Pregnancy Childbirth. 2025;25(1):300.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"1231_CR5","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.pop.2013.10.011","volume":"41","author":"H Silk","year":"2014","unstructured":"Silk H. Diseases of the mouth. Prim Care. 2014;41(1):75\u201390.","journal-title":"Prim Care"},{"key":"1231_CR6","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2017.vol31.0041","volume":"31","author":"A Lips","year":"2017","unstructured":"Lips A, Antunes LS, Antunes LA, Pintor AVB, Santos D, Bachinski R, et al. Salivary protein polymorphisms and risk of dental caries: a systematic review. Braz Oral Res. 2017;31:e41.","journal-title":"Braz Oral Res"},{"issue":"2","key":"1231_CR7","doi-asserted-by":"publisher","first-page":"226","DOI":"10.4103\/0973-029X.325119","volume":"25","author":"N Thampan","year":"2021","unstructured":"Thampan N, Ramya R, Swarnalakshmi R, Rajkumar K, Savithri S, Divyalakshmi G. Analysis of ENAM gene single-nucleotide polymorphism rs3796704 with caries susceptibility in young adult Tamil population. J Oral Maxillofac Pathol JOMFP. 2021;25(2):226\u201331.","journal-title":"J Oral Maxillofac Pathol JOMFP"},{"issue":"1","key":"1231_CR8","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1177\/0022034515605281","volume":"95","author":"G Yildiz","year":"2016","unstructured":"Yildiz G, Ermis RB, Calapoglu NS, Celik EU, T\u00fcrel GY. Gene\u2013environment interactions in the etiology of dental caries. J Dent Res. 2016;95(1):74\u20139.","journal-title":"J Dent Res"},{"key":"1231_CR9","doi-asserted-by":"publisher","first-page":"1402583","DOI":"10.3389\/fendo.2024.1402583","volume":"15","author":"S Corrao","year":"2024","unstructured":"Corrao S, Pollicino C, Maggio D, Torres A, Argano C. Tirzepatide against obesity and insulin-resistance: pathophysiological aspects and clinical evidence. Front Endocrinol. 2024;15:1402583.","journal-title":"Front Endocrinol"},{"key":"1231_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.archoralbio.2018.04.010","volume":"92","author":"DSB Oliveira","year":"2018","unstructured":"Oliveira DSB, Segato RAB, Oliveira S, Dutra ALT, Santos ASD, Praxedes ADN, et al. Association between genetic polymorphisms in DEFB1 and microRNA202 with caries in two groups of Brazilian children. Arch Oral Biol. 2018;92:1\u20137.","journal-title":"Arch Oral Biol"},{"issue":"3","key":"1231_CR11","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1159\/000458537","volume":"51","author":"A Lips","year":"2017","unstructured":"Lips A, Antunes LS, Antunes LA, Abreu JGB, Barreiros D, Oliveira DSB, et al. Genetic polymorphisms in DEFB1 and miRNA202 are involved in salivary human \u03b2-defensin 1 levels and caries experience in children. Caries Res. 2017;51(3):209\u201315.","journal-title":"Caries Res"},{"key":"1231_CR12","doi-asserted-by":"publisher","first-page":"7437281","DOI":"10.1155\/2022\/7437281","volume":"2022","author":"J Hu","year":"2022","unstructured":"Hu J, Huang S, Liu X, Zhang Y, Wei S, Hu X. miR-155: an important role in inflammation response. J Immunol Res. 2022;2022:7437281.","journal-title":"J Immunol Res"},{"issue":"3","key":"1231_CR13","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.tube.2015.03.006","volume":"95","author":"H Iwai","year":"2015","unstructured":"Iwai H, Funatogawa K, Matsumura K, Kato-Miyazawa M, Kirikae F, Kiga K, et al. MicroRNA-155 knockout mice are susceptible to Mycobacterium tuberculosis infection. Tuberculosis (Edinb). 2015;95(3):246\u201350.","journal-title":"Tuberculosis (Edinb)"},{"key":"1231_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111258","volume":"140","author":"P Guo","year":"2020","unstructured":"Guo P, Qiao F, Huang D, Wu Q, Chen T, Badawy S, et al. MiR-155-5p plays as a \u201cjanus\u201d in the expression of inflammatory cytokines induced by T-2 toxin. Food Chem Toxicol. 2020;140:111258.","journal-title":"Food Chem Toxicol"},{"issue":"8","key":"1231_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237004","volume":"15","author":"NH Al-Rawi","year":"2020","unstructured":"Al-Rawi NH, Al-Marzooq F, Al-Nuaimi AS, Hachim MY, Hamoudi R. Salivary microRNA 155, 146a\/b and 203: A pilot study for potentially non-invasive diagnostic biomarkers of periodontitis and diabetes mellitus. PLoS ONE. 2020;15(8):e0237004.","journal-title":"PLoS ONE"},{"key":"1231_CR16","doi-asserted-by":"publisher","first-page":"39","DOI":"10.4103\/1735-3327.344162","volume":"19","author":"A Mogharehabed","year":"2022","unstructured":"Mogharehabed A, Yaghini J, Aminzadeh A, Rahaiee M. Comparative evaluation of microRNA-155 expression level and its correlation with tumor necrotizing factor \u03b1 and interleukin 6 in patients with chronic periodontitis. Dental Res J. 2022;19:39.","journal-title":"Dental Res J"},{"issue":"7","key":"1231_CR17","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1111\/iej.13923","volume":"56","author":"Y Jiang","year":"2023","unstructured":"Jiang Y, He Y, Chen Y, Zeng J, Huang W, Huang L, et al. Overexpression of MicroRNA-155 aggravates pulpitis by targeting kinesin superfamily proteins-5C based on illumina high-throughput sequencing. Int Endod J. 2023;56(7):837\u201353.","journal-title":"Int Endod J"},{"issue":"37","key":"1231_CR18","doi-asserted-by":"publisher","first-page":"60303","DOI":"10.18632\/oncotarget.11206","volume":"7","author":"J Ji","year":"2016","unstructured":"Ji J, Xu M, Tu J, Zhao Z, Gao J, Chen M, et al. MiR-155 and its functional variant rs767649 contribute to the susceptibility and survival of hepatocellular carcinoma. Oncotarget. 2016;7(37):60303\u20139.","journal-title":"Oncotarget"},{"issue":"1","key":"1231_CR19","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3390\/ijms24010271","volume":"24","author":"C Avgeros","year":"2022","unstructured":"Avgeros C, Patsatsi A, Dimitriadis D, Malousi A, Koletsa T, Papathemeli D, et al. Dysregulation of plasma miR-146a and miR-155 expression profile in mycosis fungoides is associated with rs2910164 and rs767649 polymorphisms. Int J Mol Sci. 2022;24(1):271.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1231_CR20","first-page":"247","volume":"8","author":"SE Ayoub","year":"2019","unstructured":"Ayoub SE, Shaker OG, Abdelwahed MY, Ahmed NA, Abdelhameed HG, Bosilah AH, et al. Association of microRNA-155rs767649 polymorphism with susceptibility to preeclampsia. Int J Mol Cell Med. 2019;8(4):247\u201357.","journal-title":"Int J Mol Cell Med"},{"issue":"11","key":"1231_CR21","volume":"15","author":"MA Elghouneimy","year":"2023","unstructured":"Elghouneimy MA, Ramadan MA, Farrag EA, Ibrahim HF, Khirala SK, Seliem N, et al. Impact of miR-155 rs767649 polymorphism on rheumatoid arthritis activity in Egyptian patients. Cureus. 2023;15(11):e49297.","journal-title":"Cureus"},{"key":"1231_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2025.106219","volume":"173","author":"H Fu","year":"2025","unstructured":"Fu H, Li X, Xie Z, Jiang Y, Qin H. MicroRNA-155 rs767649 polymorphism is associated with susceptibility to peri-implantitis. Arch Oral Biol. 2025;173:106219.","journal-title":"Arch Oral Biol"},{"issue":"11","key":"1231_CR23","doi-asserted-by":"publisher","first-page":"300060521106017","DOI":"10.1177\/03000605211060175","volume":"49","author":"Y Luo","year":"2021","unstructured":"Luo Y, Zhang H, Zeng X, Xu W, Wang X, Zhang Y, et al. Nomogram prediction of caries risk among schoolchildren age 7 years based on a cohort study in Shanghai. J Int Med Res. 2021;49(11):3000605211060175.","journal-title":"J Int Med Res"},{"issue":"1","key":"1231_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2024.111214","volume":"86","author":"L Mathews","year":"2025","unstructured":"Mathews L, Appukuttan D, Victor DJ, Venkadassalapathy S, Subramanian S, Prakash PSG. Role of miRNA-155 in macrophage polarisation in stage III\/IV periodontitis with type II diabetes mellitus: an analytical case\u2013control study. Hum Immunol. 2025;86(1):111214.","journal-title":"Hum Immunol"},{"issue":"9","key":"1231_CR25","doi-asserted-by":"publisher","first-page":"8575","DOI":"10.1007\/s11033-022-07690-w","volume":"49","author":"B Li","year":"2022","unstructured":"Li B, Guo L, He Y, Tu X, Zhong J, Guan H, et al. MicroRNA-155 expression is associated with pulpitis progression by targeting SHIP1. Mol Biol Rep. 2022;49(9):8575\u201386.","journal-title":"Mol Biol Rep"},{"issue":"3","key":"1231_CR26","first-page":"1425","volume":"25","author":"SR Mohammed","year":"2021","unstructured":"Mohammed SR, Shaker OG, Mohammed AA, Fouad NA, Hussein HA, Ahmed NA, et al. Impact of miR-155 (rs767649 A>T) and miR-146a (rs57095329 A>G) polymorphisms in system lupus erythematosus susceptibility in an Egyptian cohort. Eur Rev Med Pharmacol Sci. 2021;25(3):1425\u201335.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1231_CR27","doi-asserted-by":"publisher","first-page":"32","DOI":"10.4103\/jrms.jrms_960_21","volume":"28","author":"S Iranparast","year":"2023","unstructured":"Iranparast S, Tahmasebi-Birgani M, Motamedfar A, Amari A, Ghafourian M. miR-155 rs767649 T>A gene polymorphism is associated with downregulation of miR-155 expression, suppressor of cytokine signaling-1 overexpression, and low probability of metastatic tumor at the time of breast cancer diagnosis. J Res Med Sci. 2023;28:32.","journal-title":"J Res Med Sci"},{"issue":"7","key":"1231_CR28","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1089\/jir.2019.0001","volume":"39","author":"OG Shaker","year":"2019","unstructured":"Shaker OG, Abdelaleem OO, Fouad NA, Ali A, Ahmed TI, Ibrahem EG, et al. Association between miR-155, Its polymorphism and ischemia-modified albumin in patients with rheumatoid arthritis. J Interferon Cytokine Res. 2019;39(7):428\u201337.","journal-title":"J Interferon Cytokine Res"},{"issue":"2","key":"1231_CR29","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3390\/genes14020431","volume":"14","author":"Y Ali","year":"2023","unstructured":"Ali Y, Chen Y, Islam ZU, Aman A, Almutairi MM, Alouffi A, et al. MIR149 rs2292832 and MIR499 rs3746444 genetic variants associated with the risk of rheumatoid arthritis. Genes (Basel). 2023;14(2):431.","journal-title":"Genes (Basel)"},{"key":"1231_CR30","doi-asserted-by":"publisher","first-page":"5593608","DOI":"10.1155\/2021\/5593608","volume":"2021","author":"V Spallone","year":"2021","unstructured":"Spallone V, Ciccacci C, Latini A, Borgiani P. What is in the field for genetics and epigenetics of diabetic neuropathy: the role of microRNAs. J Diabetes Res. 2021;2021:5593608.","journal-title":"J Diabetes Res"},{"issue":"14","key":"1231_CR31","doi-asserted-by":"publisher","first-page":"7569","DOI":"10.3390\/ijms25147569","volume":"25","author":"J Torres-Torres","year":"2024","unstructured":"Torres-Torres J, Espino YSS, Martinez-Portilla R, Borboa-Olivares H, Estrada-Gutierrez G, Acevedo-Gallegos S, et al. A narrative review on the pathophysiology of preeclampsia. Int J Mol Sci. 2024;25(14):7569.","journal-title":"Int J Mol Sci"},{"issue":"9","key":"1231_CR32","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1002\/kjm2.12229","volume":"36","author":"X Fu","year":"2020","unstructured":"Fu X, He HD, Li CJ, Li N, Jiang SY, Ge HW, et al. MicroRNA-155 deficiency attenuates inflammation and oxidative stress in experimental autoimmune prostatitis in a TLR4-dependent manner. Kaohsiung J Med Sci. 2020;36(9):712\u201320.","journal-title":"Kaohsiung J Med Sci"},{"issue":"13","key":"1231_CR33","doi-asserted-by":"publisher","first-page":"6318","DOI":"10.1128\/JVI.00635-10","volume":"84","author":"Q Yin","year":"2010","unstructured":"Yin Q, Wang X, Fewell C, Cameron J, Zhu H, Baddoo M, et al. MicroRNA miR-155 inhibits bone morphogenetic protein (BMP) signaling and BMP-mediated Epstein-Barr virus reactivation. J Virol. 2010;84(13):6318\u201327.","journal-title":"J Virol"},{"key":"1231_CR34","doi-asserted-by":"publisher","first-page":"875987","DOI":"10.3389\/fdmed.2022.875987","volume":"3","author":"M Socorro","year":"2022","unstructured":"Socorro M, Hoskere P, Roberts C, Lukashova L, Verdelis K, Beniash E, et al. Deficiency of mineralization-regulating transcription factor Trps1 compromises quality of dental tissues and increases susceptibility to dental caries. Front Dent Med. 2022;3:875987.","journal-title":"Front Dent Med"},{"issue":"5","key":"1231_CR35","first-page":"276","volume":"12","author":"M Ahmed Ali","year":"2020","unstructured":"Ahmed Ali M, Gamil Shaker O, Mohamed Eid H, Elsayed Mahmoud E, Mahmoud Ezzat E, Nady GS. Relationship between miR-155 and miR-146a polymorphisms and susceptibility to multiple sclerosis in an Egyptian cohort. Biomed Rep. 2020;12(5):276\u201384.","journal-title":"Biomed Rep"},{"key":"1231_CR36","doi-asserted-by":"publisher","first-page":"1469852","DOI":"10.3389\/fmedt.2024.1469852","volume":"6","author":"J Jundaeng","year":"2024","unstructured":"Jundaeng J, Chamchong R, Nithikathkul C. Artificial intelligence-powered innovations in periodontal diagnosis: a new era in dental healthcare. Front Med Technol. 2024;6:1469852.","journal-title":"Front Med Technol"},{"key":"1231_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-023-6114-0","author":"C Osnes","year":"2023","unstructured":"Osnes C, Davda K, Hyde TP, Khalid S, Dillon S, Archer N, et al. Current challenges for 3D printing complete dentures: experiences from a multi-centre clinical trial. Br Dent J. 2023. https:\/\/doi.org\/10.1038\/s41415-023-6114-0.","journal-title":"Br Dent J"},{"issue":"3","key":"1231_CR38","first-page":"140","volume":"46","author":"Z Kaufman","year":"2025","unstructured":"Kaufman Z, Paranhos KS, de Carle LF, Kang M. Combining digital technology and traditional principles to optimize complete removable denture treatment. Compend Contin Educ Dent (Jamesburg, NJ, 1995). 2025;46(3):140\u20135.","journal-title":"Compend Contin Educ Dent (Jamesburg, NJ, 1995)"},{"issue":"6","key":"1231_CR39","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.sdentj.2024.03.014","volume":"36","author":"HMH Negm","year":"2024","unstructured":"Negm HMH, Farag AF, Taha R. Polymorphisms in ENAM, AMBN, and KLK4 predispose Egyptian adults to dental caries: a cross-sectional study. Saudi Dent J. 2024;36(6):915\u20139.","journal-title":"Saudi Dent J"}],"container-title":["Odontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-025-01231-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10266-025-01231-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-025-01231-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:16:31Z","timestamp":1782800191000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10266-025-01231-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,25]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["1231"],"URL":"https:\/\/doi.org\/10.1007\/s10266-025-01231-0","relation":{},"ISSN":["1618-1247","1618-1255"],"issn-type":[{"value":"1618-1247","type":"print"},{"value":"1618-1255","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,25]]},"assertion":[{"value":"6 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have declared no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The authors state that they have obtained Affiliated Hospital Group of Guangdong Medical University Panyu He Xian Memorial Hospital review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}