{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:29:33Z","timestamp":1788960573112,"version":"build-2803163510"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Odontology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10266-025-01285-0","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T17:09:57Z","timestamp":1765645797000},"page":"1149-1160","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Platelet-derived concentrates in the immunological management of periodontitis: from dysbiosis to personalized approaches"],"prefix":"10.1007","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-0022","authenticated-orcid":false,"given":"Halil Ata","family":"B\u0131\u00e7ak\u00e7\u0131o\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1171-2228","authenticated-orcid":false,"given":"G\u00fclenay","family":"\u00c7olak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,13]]},"reference":[{"issue":"6","key":"1285_CR1","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41415-022-4113-1","volume":"232","author":"IL Chapple","year":"2022","unstructured":"Chapple IL. Time to take gum disease seriously. Br Dent J. 2022;232(6):360\u20131. https:\/\/doi.org\/10.1038\/s41415-022-4113-1.","journal-title":"Br Dent J"},{"issue":"5","key":"1285_CR2","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1111\/jre.13337","volume":"59","author":"GG Nascimento","year":"2024","unstructured":"Nascimento GG, Alves-Costa S, Romandini M. Burden of severe periodontitis and edentulism in 2021, with projections up to 2050: The Global Burden of Disease 2021 study. J Periodontal Res. 2024;59(5):823\u201367. https:\/\/doi.org\/10.1111\/jre.13337.","journal-title":"J Periodontal Res"},{"issue":"4","key":"1285_CR3","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.14283\/jpad.2024.79","volume":"11","author":"A Villar","year":"2024","unstructured":"Villar A, Paladini S, Cossatis J. Periodontal disease and Alzheimer\u2019s: insights from a systematic literature network analysis. J Prev Alzheimers Dis. 2024;11(4):1148\u201365. https:\/\/doi.org\/10.14283\/jpad.2024.79.","journal-title":"J Prev Alzheimers Dis"},{"issue":"7","key":"1285_CR4","doi-asserted-by":"publisher","first-page":"4078","DOI":"10.1111\/odi.14981","volume":"30","author":"S Ferreira","year":"2024","unstructured":"Ferreira S, Gomes-Filho IS, Costa M, Cruz SSD, Neves CL, Silva C, et al. Periodontitis and systemic parameters in chronic kidney disease: systematic review and meta-analysis. Oral Dis. 2024;30(7):4078\u201386. https:\/\/doi.org\/10.1111\/odi.14981.","journal-title":"Oral Dis"},{"issue":"1","key":"1285_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2017.38","volume":"3","author":"DF Kinane","year":"2017","unstructured":"Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3(1):1\u201314. https:\/\/doi.org\/10.1038\/nrdp.2017.38.","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"1285_CR6","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","volume":"16","author":"RJ Lamont","year":"2018","unstructured":"Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol. 2018;16(12):745\u201359. https:\/\/doi.org\/10.1038\/s41579-018-0089-x.","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"1285_CR7","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2023.2197779","volume":"15","author":"AA Abdulkareem","year":"2023","unstructured":"Abdulkareem AA, Al-Taweel FB, Al-Sharqi AJB, Gul SS, Sha A, Chapple ILC. Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis. J Oral Microbiol. 2023;15(1):2197779. https:\/\/doi.org\/10.1080\/20002297.2023.2197779.","journal-title":"J Oral Microbiol"},{"key":"1285_CR8","doi-asserted-by":"publisher","first-page":"1385436","DOI":"10.3389\/fimmu.2024.1385436","volume":"15","author":"M Zhang","year":"2024","unstructured":"Zhang M, Liu Y, Afzali H, Graves DT. An update on periodontal inflammation and bone loss. Front Immunol. 2024;15:1385436. https:\/\/doi.org\/10.3389\/fimmu.2024.1385436.","journal-title":"Front Immunol"},{"key":"1285_CR9","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1111\/jcpe.12937","volume":"45","author":"S Murakami","year":"2018","unstructured":"Murakami S, Mealey BL, Mariotti A, Chapple IL. Dental plaque-induced gingival conditions. J Clin Periodontol. 2018;45:S17\u201327.","journal-title":"J Clin Periodontol"},{"key":"1285_CR10","doi-asserted-by":"publisher","first-page":"1517154","DOI":"10.3389\/fcimb.2025.1517154","volume":"15","author":"Z Cui","year":"2025","unstructured":"Cui Z, Wang P, Gao W. Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic. Front Cell Infect Microbiol. 2025;15:1517154. https:\/\/doi.org\/10.3389\/fcimb.2025.1517154.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"1285_CR11","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/prd.12393","volume":"87","author":"L Sedghi","year":"2021","unstructured":"Sedghi L, DiMassa V, Harrington A, Lynch SV, Kapila YL. The oral microbiome: role of key organisms and complex networks in oral health and disease. Periodontol 2000. 2021;87(1):107\u201331. https:\/\/doi.org\/10.1111\/prd.12393.","journal-title":"Periodontol 2000"},{"issue":"12","key":"1285_CR12","doi-asserted-by":"publisher","first-page":"6847","DOI":"10.3390\/app15126847","volume":"15","author":"BM Messina","year":"2025","unstructured":"Messina BM, Grippaudo C, Polizzi A, Blasi A, Isola G. The key role of Porphyromonas gingivalis in the pathogenesis of periodontitis linked with systemic diseases. Appl Sci. 2025;15(12):6847. https:\/\/doi.org\/10.3390\/app15126847.","journal-title":"Appl Sci"},{"issue":"1","key":"1285_CR13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2478\/prilozi-2020-0025","volume":"41","author":"J Milutinovic","year":"2020","unstructured":"Milutinovic J, Popovska M, Rusevska B, Nacevski M, Anastasovski S, Ivanovska-Stojanoska M. Evaluation of PRF efficiency in the treatment of infrabony defects. Prilozi. 2020;41(1):79\u201386. https:\/\/doi.org\/10.2478\/prilozi-2020-0025.","journal-title":"Prilozi"},{"issue":"1","key":"1285_CR14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s00784-024-06128-w","volume":"29","author":"T Lipovec","year":"2025","unstructured":"Lipovec T, Kapadia N, Antonoglou GN, Lu EMC, El-Sayed KMF, Nibali L. Autologous platelet concentrates as adjuncts to non-surgical periodontal therapy: a systematic review and meta-analysis. Clin Oral Investig. 2025;29(1):74. https:\/\/doi.org\/10.1007\/s00784-024-06128-w.","journal-title":"Clin Oral Investig"},{"key":"1285_CR15","doi-asserted-by":"publisher","first-page":"1628565","DOI":"10.3389\/fbioe.2025.1628565","volume":"13","author":"Y Li","year":"2025","unstructured":"Li Y, You H, Ou C, Zhu H, Cheng B, Tian J. The evolution of three generations of platelet concentrates products: a leap from classical formulations to the era of extracellular vesicles. Front Bioeng Biotechnol. 2025;13:1628565. https:\/\/doi.org\/10.3389\/fbioe.2025.1628565.","journal-title":"Front Bioeng Biotechnol"},{"issue":"5","key":"1285_CR16","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/s12276-024-01219-w","volume":"56","author":"TS Kim","year":"2024","unstructured":"Kim TS, Moutsopoulos NM. Neutrophils and neutrophil extracellular traps in oral health and disease. Exp Mol Med. 2024;56(5):1055\u201365. https:\/\/doi.org\/10.1038\/s12276-024-01219-w.","journal-title":"Exp Mol Med"},{"key":"1285_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.915081","volume":"13","author":"RA Irwandi","year":"2022","unstructured":"Irwandi RA, Chiesa ST, Hajishengallis G, Papayannopoulos V, Deanfield JE, D\u2019Aiuto F. The roles of neutrophils linking periodontitis and atherosclerotic cardiovascular diseases. Front Immunol. 2022;13:915081. https:\/\/doi.org\/10.3389\/fimmu.2022.915081.","journal-title":"Front Immunol"},{"key":"1285_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015370","author":"B Bassani","year":"2023","unstructured":"Bassani B, Cucchiara M, Butera A, Kayali O, Chiesa A, Palano MT, et al. Neutrophils\u2019 contribution to periodontitis and periodontitis-associated cardiovascular diseases. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms242015370.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"1285_CR19","doi-asserted-by":"publisher","first-page":"578","DOI":"10.4103\/jisp.jisp_75_23","volume":"27","author":"MC Sloniak","year":"2023","unstructured":"Sloniak MC, Lepique AP, Nakao LYS, Villar CC. Alterations in macrophage polarization play a key role in control and development of periodontal diseases. J Indian Soc Periodontol. 2023;27(6):578\u201382. https:\/\/doi.org\/10.4103\/jisp.jisp_75_23.","journal-title":"J Indian Soc Periodontol"},{"key":"1285_CR20","doi-asserted-by":"publisher","first-page":"1423378","DOI":"10.3389\/fimmu.2024.1423378","volume":"15","author":"Y Li","year":"2024","unstructured":"Li Y, Yang Y, Niu Y, Li Y, Hu Z, Sun S, et al. The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis. Front Immunol. 2024;15:1423378. https:\/\/doi.org\/10.3389\/fimmu.2024.1423378.","journal-title":"Front Immunol"},{"key":"1285_CR21","doi-asserted-by":"publisher","DOI":"10.1155\/sci\/9912405","volume":"2025","author":"H Xu","year":"2025","unstructured":"Xu H, Jing H, Miron RJ, Wang Y, Xu D, Zhang X. Platelet-rich fibrin promotes osteoblast recruitment-associated periodontal regeneration via macrophage polarization. Stem Cells Int. 2025;2025:9912405. https:\/\/doi.org\/10.1155\/sci\/9912405.","journal-title":"Stem Cells Int"},{"issue":"1","key":"1285_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02592-4","volume":"22","author":"S Peng","year":"2024","unstructured":"Peng S, Fu H, Li R, Li H, Wang S, Li B, et al. A new direction in periodontitis treatment: biomaterial-mediated macrophage immunotherapy. J Nanobiotechnol. 2024;22(1):359. https:\/\/doi.org\/10.1186\/s12951-024-02592-4.","journal-title":"J Nanobiotechnol"},{"issue":"6","key":"1285_CR23","first-page":"34","volume":"15","author":"S Maheshwari","year":"2021","unstructured":"Maheshwari S, Grover V, Gupta J, Kumar N, Jain A. Effect of non-surgical periodontal therapy on the serum and crevicular fluid interleukin-10 levels in chronic periodontitis: a systematic review and meta-analysis. Int J Health Sci (Qassim). 2021;15(6):34\u201346.","journal-title":"Int J Health Sci (Qassim)"},{"issue":"1","key":"1285_CR24","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1186\/s12967-022-03702-2","volume":"20","author":"H Lee","year":"2022","unstructured":"Lee H, Joo JY, Sohn DH, Kang J, Yu Y, Park HR, et al. Single-cell RNA sequencing reveals rebalancing of immunological response in patients with periodontitis after non-surgical periodontal therapy. J Transl Med. 2022;20(1):504. https:\/\/doi.org\/10.1186\/s12967-022-03702-2.","journal-title":"J Transl Med"},{"issue":"11","key":"1285_CR25","doi-asserted-by":"publisher","first-page":"5442","DOI":"10.4049\/jimmunol.1202339","volume":"189","author":"T Abe","year":"2012","unstructured":"Abe T, Hosur KB, Hajishengallis E, Reis ES, Ricklin D, Lambris JD, et al. Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist. J Immunol. 2012;189(11):5442\u20138. https:\/\/doi.org\/10.4049\/jimmunol.1202339.","journal-title":"J Immunol"},{"issue":"6","key":"1285_CR26","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.chom.2014.05.012","volume":"15","author":"T Maekawa","year":"2014","unstructured":"Maekawa T, Krauss JL, Abe T, Jotwani R, Triantafilou M, Triantafilou K, et al. Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis. Cell Host Microbe. 2014;15(6):768\u201378. https:\/\/doi.org\/10.1016\/j.chom.2014.05.012.","journal-title":"Cell Host Microbe"},{"key":"1285_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11020470","author":"WA Chen","year":"2023","unstructured":"Chen WA, Dou Y, Fletcher HM, Boskovic DS. Local and systemic effects of Porphyromonas gingivalis infection. Microorganisms. 2023. https:\/\/doi.org\/10.3390\/microorganisms11020470.","journal-title":"Microorganisms"},{"key":"1285_CR28","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.92895","author":"X Ye","year":"2024","unstructured":"Ye X, Bai Y, Li M, Ye Y, Chen Y, Liu B, et al. Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care. Elife. 2024. https:\/\/doi.org\/10.7554\/eLife.92895.","journal-title":"Elife"},{"key":"1285_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12101743","author":"T Kikuchi","year":"2022","unstructured":"Kikuchi T, Hayashi JI, Mitani A. Next-generation examination, diagnosis, and personalized medicine in periodontal disease. J Pers Med. 2022. https:\/\/doi.org\/10.3390\/jpm12101743.","journal-title":"J Pers Med"},{"key":"1285_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/9781119406792","volume-title":"Platelet rich fibrin in regenerative dentistry: biological background and clinical indications","author":"RJ Miron","year":"2017","unstructured":"Miron RJ, Choukroun J. Platelet rich fibrin in regenerative dentistry: biological background and clinical indications. Wiley; 2017."},{"issue":"1","key":"1285_CR31","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/prd.12550","volume":"97","author":"E Calciolari","year":"2025","unstructured":"Calciolari E, Dourou M, Akcali A, Donos N. Differences between first- and second-generation autologous platelet concentrates. Periodontol 2000. 2025;97(1):52\u201373. https:\/\/doi.org\/10.1111\/prd.12550.","journal-title":"Periodontol 2000"},{"issue":"7","key":"1285_CR32","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","volume":"21","author":"G Hajishengallis","year":"2021","unstructured":"Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol. 2021;21(7):426\u201340. https:\/\/doi.org\/10.1038\/s41577-020-00488-6.","journal-title":"Nat Rev Immunol"},{"key":"1285_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158370","author":"F Scopelliti","year":"2022","unstructured":"Scopelliti F, Cattani C, Dimartino V, Mirisola C, Cavani A. Platelet derivatives and the immunomodulation of wound healing. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms23158370.","journal-title":"Int J Mol Sci"},{"key":"1285_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.636427","volume":"12","author":"Z Kargarpour","year":"2021","unstructured":"Kargarpour Z, Nasirzade J, Panahipour L, Miron RJ, Gruber R. Liquid PRF reduces the inflammatory response and osteoclastogenesis in murine macrophages. Front Immunol. 2021;12:636427. https:\/\/doi.org\/10.3389\/fimmu.2021.636427.","journal-title":"Front Immunol"},{"issue":"2","key":"1285_CR35","doi-asserted-by":"publisher","DOI":"10.4331\/wjbc.v16.i2.107195","volume":"16","author":"S Mohammadi","year":"2025","unstructured":"Mohammadi S. Innate immunity and wound repair: the platelet-rich fibrin advantage. World J Biol Chem. 2025;16(2):107195. https:\/\/doi.org\/10.4331\/wjbc.v16.i2.107195.","journal-title":"World J Biol Chem"},{"key":"1285_CR36","doi-asserted-by":"publisher","first-page":"1399130","DOI":"10.3389\/fimmu.2024.1399130","volume":"15","author":"E Anitua","year":"2024","unstructured":"Anitua E, Troya M, Alkhraisat MH. Immunoregulatory role of platelet derivatives in the macrophage-mediated immune response. Front Immunol. 2024;15:1399130. https:\/\/doi.org\/10.3389\/fimmu.2024.1399130.","journal-title":"Front Immunol"},{"issue":"1","key":"1285_CR37","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1080\/09537104.2020.1717455","volume":"32","author":"M Fujioka-Kobayashi","year":"2021","unstructured":"Fujioka-Kobayashi M, Schaller B, Mour\u00e3o C, Zhang Y, Sculean A, Miron RJ. Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF). Platelets. 2021;32(1):74\u201381. https:\/\/doi.org\/10.1080\/09537104.2020.1717455.","journal-title":"Platelets"},{"key":"1285_CR38","doi-asserted-by":"publisher","first-page":"228080002412995","DOI":"10.1177\/22808000241299588","volume":"22","author":"P Song","year":"2024","unstructured":"Song P, He D, Ren S, Fan L, Sun J. Platelet-rich fibrin in dentistry. J Appl Biomater Funct Mater. 2024;22:22808000241299588. https:\/\/doi.org\/10.1177\/22808000241299588.","journal-title":"J Appl Biomater Funct Mater"},{"issue":"1","key":"1285_CR39","doi-asserted-by":"publisher","first-page":"6038","DOI":"10.1038\/s41598-021-85736-y","volume":"11","author":"AB Castro","year":"2021","unstructured":"Castro AB, Andrade C, Li X, Pinto N, Teughels W, Quirynen M. Impact of g force and timing on the characteristics of platelet-rich fibrin matrices. Sci Rep. 2021;11(1):6038. https:\/\/doi.org\/10.1038\/s41598-021-85736-y.","journal-title":"Sci Rep"},{"issue":"10","key":"1285_CR40","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3390\/dj13100476","volume":"13","author":"O Bunyatratchata","year":"2025","unstructured":"Bunyatratchata O, Nimlamool W, Sangin S. The impact of centrifugation devices and collection tubes on fibrin characteristics and growth factor release under high- and low-speed protocols. Dent J. 2025;13(10):476. https:\/\/doi.org\/10.3390\/dj13100476.","journal-title":"Dent J"},{"issue":"1","key":"1285_CR41","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40729-016-0052-4","volume":"2","author":"H Masuki","year":"2016","unstructured":"Masuki H, Okudera T, Watanebe T, Suzuki M, Nishiyama K, Okudera H, et al. Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF). Int J Implant Dent. 2016;2(1):19. https:\/\/doi.org\/10.1186\/s40729-016-0052-4.","journal-title":"Int J Implant Dent"},{"issue":"1","key":"1285_CR42","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1186\/s12903-024-04301-x","volume":"24","author":"B Karc\u0131","year":"2024","unstructured":"Karc\u0131 B, Savas HB. Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study. BMC Oral Health. 2024;24(1):527. https:\/\/doi.org\/10.1186\/s12903-024-04301-x.","journal-title":"BMC Oral Health"},{"issue":"5","key":"1285_CR43","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1007\/s00784-021-03825-8","volume":"25","author":"RJ Miron","year":"2021","unstructured":"Miron RJ, Moraschini V, Fujioka-Kobayashi M, Zhang Y, Kawase T, Cosgarea R, et al. Use of platelet-rich fibrin for the treatment of periodontal intrabony defects: a systematic review and meta-analysis. Clin Oral Investig. 2021;25(5):2461\u201378. https:\/\/doi.org\/10.1007\/s00784-021-03825-8.","journal-title":"Clin Oral Investig"},{"issue":"4","key":"1285_CR44","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s10266-024-00949-7","volume":"112","author":"F Silva","year":"2024","unstructured":"Silva F, Chauca-Baja\u00f1a L, Caponio VCA, Cueva KAS, Velasquez-Ron B, Pad\u00edn-Iruegas ME, et al. Regeneration of periodontal intrabony defects using platelet-rich fibrin (PRF): a systematic review and network meta-analysis. Odontology. 2024;112(4):1047\u201368. https:\/\/doi.org\/10.1007\/s10266-024-00949-7.","journal-title":"Odontology"},{"issue":"1","key":"1285_CR45","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1186\/s12903-025-06019-w","volume":"25","author":"T \u00c7a\u011f\u0131ran G\u00fcrb\u00fcz","year":"2025","unstructured":"\u00c7a\u011f\u0131ran G\u00fcrb\u00fcz T, Merac\u0131 YB. The clinical efficacy of injectable platelet-rich fibrin (i-PRF) as an adjunct to nonsurgical periodontal therapy in smokers with periodontitis. BMC Oral Health. 2025;25(1):618. https:\/\/doi.org\/10.1186\/s12903-025-06019-w.","journal-title":"BMC Oral Health"},{"key":"1285_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract15070127","author":"M Tanady","year":"2025","unstructured":"Tanady M, Tadjoedin FM, Masulili SLC, Harsas NA, Widaryono A. Beneficial effect of platelet-rich fibrin as an adjunct to nonsurgical therapy after subgingival professional mechanical plaque removal for periodontitis: a systematic review and meta-analysis. Clin Pract. 2025. https:\/\/doi.org\/10.3390\/clinpract15070127.","journal-title":"Clin Pract"},{"issue":"6","key":"1285_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0304970","volume":"19","author":"D Ozkal Eminoglu","year":"2024","unstructured":"Ozkal Eminoglu D, Arabaci T, Oztas Sahiner GA. The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study. PLoS ONE. 2024;19(6):e0304970. https:\/\/doi.org\/10.1371\/journal.pone.0304970.","journal-title":"PLoS ONE"},{"issue":"3","key":"1285_CR48","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.ijom.2018.07.007","volume":"48","author":"J Canellas","year":"2019","unstructured":"Canellas J, Medeiros PJD, Figueredo C, Fischer RG, Ritto FG. Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2019;48(3):395\u2013414. https:\/\/doi.org\/10.1016\/j.ijom.2018.07.007.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"11","key":"1285_CR49","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s00784-024-06002-9","volume":"28","author":"K Zwittnig","year":"2024","unstructured":"Zwittnig K, Kirnbauer B, Truschnegg A, Jakse N, Wolf A, Sokolowski A, et al. Effectiveness of platelet-rich fibrin in third molar extractions: a randomized controlled split-mouth study. Clin Oral Investig. 2024;28(11):615. https:\/\/doi.org\/10.1007\/s00784-024-06002-9.","journal-title":"Clin Oral Investig"},{"key":"1285_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2025.06.007","author":"B \u00d6hrnell Malekzadeh","year":"2025","unstructured":"\u00d6hrnell Malekzadeh B, \u00d6hrnell LO, Widmark G, Beigi RM, Ivanoff CJ. Effects of platelet-rich fibrin on outcomes following mandibular third molar removal: a randomized controlled clinical trial. Int J Oral Maxillofac Surg. 2025. https:\/\/doi.org\/10.1016\/j.ijom.2025.06.007.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"1","key":"1285_CR51","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1186\/s12903-021-01925-1","volume":"21","author":"BK Csif\u00f3-Nagy","year":"2021","unstructured":"Csif\u00f3-Nagy BK, S\u00f3lyom E, Bogn\u00e1r VL, Nevelits A, D\u0151ri F. Efficacy of a new-generation platelet-rich fibrin in the treatment of periodontal intrabony defects: a randomized clinical trial. BMC Oral Health. 2021;21(1):580. https:\/\/doi.org\/10.1186\/s12903-021-01925-1.","journal-title":"BMC Oral Health"},{"issue":"3","key":"1285_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2021.101545","volume":"21","author":"TAV Pham","year":"2021","unstructured":"Pham TAV. Intrabony defect treatment with platelet-rich fibrin, guided tissue regeneration and open-flap debridement: a randomized controlled trial. J Evid Based Dent Pract. 2021;21(3):101545. https:\/\/doi.org\/10.1016\/j.jebdp.2021.101545.","journal-title":"J Evid Based Dent Pract"},{"issue":"1","key":"1285_CR53","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1186\/s12903-024-05115-7","volume":"24","author":"W Saleh","year":"2024","unstructured":"Saleh W, Abdelhaleem M, Elmeadawy S. Assessing the effectiveness of advanced platelet rich fibrin in treating gingival recession: a systematic review and meta-analysis. BMC Oral Health. 2024;24(1):1400. https:\/\/doi.org\/10.1186\/s12903-024-05115-7.","journal-title":"BMC Oral Health"},{"issue":"1","key":"1285_CR54","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1186\/s12903-025-05922-6","volume":"25","author":"E Giammarinaro","year":"2025","unstructured":"Giammarinaro E, Baldini N, Covani U, Menini M, Pesce P, Marconcini S. Does platelet-rich fibrin enhance the outcomes of peri-implant soft tissues? A systematic review. BMC Oral Health. 2025;25(1):615. https:\/\/doi.org\/10.1186\/s12903-025-05922-6.","journal-title":"BMC Oral Health"},{"key":"1285_CR55","doi-asserted-by":"publisher","first-page":"1568889","DOI":"10.3389\/fdmed.2025.1568889","volume":"6","author":"L Deterville","year":"2025","unstructured":"Deterville L, Lasserre JF, Toma S. A prospective evaluation of subgingival irrigation with i-PRF following non-surgical treatment of peri-implantitis. Front Dent Med. 2025;6:1568889. https:\/\/doi.org\/10.3389\/fdmed.2025.1568889.","journal-title":"Front Dent Med"},{"key":"1285_CR56","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15325","author":"S Iao","year":"2025","unstructured":"Iao S, Ouyang X, Qiao J, Liu J, Liu W, Zhong J. Growth factors release in concentrated growth factor and advanced platelet-rich fibrin sticky bone. Oral Dis. 2025. https:\/\/doi.org\/10.1111\/odi.15325.","journal-title":"Oral Dis"},{"key":"1285_CR57","doi-asserted-by":"publisher","DOI":"10.2174\/0118742106390467250617115216","author":"MH Salama","year":"2025","unstructured":"Salama MH, Bilal AM, Hosny MM, Abozaid HM, Hashem AH, Borhamy A-LG, et al. Efficacy of sticky bone with repeated injectable platelet-rich fibrin application in the management of periodontal intrabony defects: randomized controlled clinical trial. Open Dent J. 2025. https:\/\/doi.org\/10.2174\/0118742106390467250617115216.","journal-title":"Open Dent J"},{"issue":"11","key":"1285_CR58","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1902\/jop.2017.130710","volume":"88","author":"GK Patel","year":"2017","unstructured":"Patel GK, Gaekwad SS, Gujjari SK, S CV. Platelet-rich fibrin in regeneration of intrabony defects: a randomized controlled trial. J Periodontol. 2017;88(11):1192\u20139. https:\/\/doi.org\/10.1902\/jop.2017.130710.","journal-title":"J Periodontol"},{"issue":"2","key":"1285_CR59","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/jcpe.13063","volume":"46","author":"D Polak","year":"2019","unstructured":"Polak D, Clemer-Shamai N, Shapira L. Incorporating antibiotics into platelet-rich fibrin: a novel antibiotics slow-release biological device. J Clin Periodontol. 2019;46(2):241\u20137. https:\/\/doi.org\/10.1111\/jcpe.13063.","journal-title":"J Clin Periodontol"},{"key":"1285_CR60","doi-asserted-by":"publisher","first-page":"1301430","DOI":"10.3389\/fbioe.2023.1301430","volume":"11","author":"H Li","year":"2023","unstructured":"Li H, Xia T, Zeng H, Qiu Y, Wei Y, Cheng Y, et al. Liquid platelet-rich fibrin produced via horizontal centrifugation decreases the inflammatory response and promotes chondrocyte regeneration in vitro. Front Bioeng Biotechnol. 2023;11:1301430. https:\/\/doi.org\/10.3389\/fbioe.2023.1301430.","journal-title":"Front Bioeng Biotechnol"},{"key":"1285_CR61","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-025-02568-y","author":"M Foroughi","year":"2025","unstructured":"Foroughi M, Torabinejad M, Angelov N, Ojcius DM, Parang K, Ravnan M, et al. Bridging oral and systemic health: exploring pathogenesis, biomarkers, and diagnostic innovations in periodontal disease. Infection. 2025. https:\/\/doi.org\/10.1007\/s15010-025-02568-y.","journal-title":"Infection"},{"issue":"3","key":"1285_CR62","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3390\/medsci13030159","volume":"13","author":"CM Ardila","year":"2025","unstructured":"Ardila CM, Vivares-Builes AM, Yadalam PK. Artificial intelligence models for diagnosis of periodontitis using non-invasive biological markers: a systematic review and meta-analysis of patient-based studies. Med Sci. 2025;13(3):159. https:\/\/doi.org\/10.3390\/medsci13030159.","journal-title":"Med Sci"},{"key":"1285_CR63","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2340\/aos.v84.43344","volume":"84","author":"X Xie","year":"2025","unstructured":"Xie X, Xu J, Li Y, Tang L, Awuti G. Efficacy of nonsurgical periodontal treatment on patients with periodontitis and type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis. Acta Odontol Scand. 2025;84:201\u201311. https:\/\/doi.org\/10.2340\/aos.v84.43344.","journal-title":"Acta Odontol Scand"},{"issue":"1","key":"1285_CR64","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1186\/s12903-024-04433-0","volume":"24","author":"R Meng","year":"2024","unstructured":"Meng R, Xu J, Fan C, Liao H, Wu Z, Zeng Q. Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis. BMC Oral Health. 2024;24(1):692. https:\/\/doi.org\/10.1186\/s12903-024-04433-0.","journal-title":"BMC Oral Health"},{"issue":"5","key":"1285_CR65","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/jcpe.12067","volume":"40","author":"L Chambrone","year":"2013","unstructured":"Chambrone L, Foz AM, Guglielmetti MR, Pannuti CM, Artese HP, Feres M, et al. Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate. J Clin Periodontol. 2013;40(5):443\u201356. https:\/\/doi.org\/10.1111\/jcpe.12067.","journal-title":"J Clin Periodontol"},{"issue":"1","key":"1285_CR66","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau3333","volume":"5","author":"SS Dominy","year":"2019","unstructured":"Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, et al. Porphyromonas gingivalis in Alzheimer\u2019s disease brains: evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5(1):eaau3333. https:\/\/doi.org\/10.1126\/sciadv.aau3333.","journal-title":"Sci Adv"},{"issue":"1","key":"1285_CR67","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/prd.12521","volume":"94","author":"RJ Miron","year":"2024","unstructured":"Miron RJ, Fujioka-Kobayashi M, Sculean A, Zhang Y. Optimization of platelet-rich fibrin. Periodontol 2000. 2024;94(1):79\u201391. https:\/\/doi.org\/10.1111\/prd.12521.","journal-title":"Periodontol 2000"},{"key":"1285_CR68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111531","author":"ES Louren\u00e7o","year":"2024","unstructured":"Louren\u00e7o ES, Rocha NRS, de Lima Barbosa R, Mello-Machado RC, de Souza Lima VH, Leite PEC, et al. Investigating the biological efficacy of albumin-enriched platelet-rich fibrin (Alb-PRF): a study on cytokine dynamics and osteoblast behavior. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms252111531.","journal-title":"Int J Mol Sci"},{"issue":"11","key":"1285_CR69","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.3390\/medicina60111897","volume":"60","author":"A Stefanescu","year":"2024","unstructured":"Stefanescu A, Coco\u0219 DI, Topor G, Lupu FC, Forna-Agop D, Earar K. Assessing the effectiveness of A-PRF+ for treating periodontal defects: a prospective interventional pilot study involving smokers. Medicina (Kaunas). 2024;60(11):1897. https:\/\/doi.org\/10.3390\/medicina60111897.","journal-title":"Medicina (Kaunas)"},{"key":"1285_CR70","doi-asserted-by":"publisher","DOI":"10.3390\/medicina61061066","author":"GS Chatzopoulos","year":"2025","unstructured":"Chatzopoulos GS, Koidou VP, Tsalikis L, Kaklamanos EG. Clinical applications of artificial intelligence in periodontology: a scoping review. Medicina (Kaunas). 2025. https:\/\/doi.org\/10.3390\/medicina61061066.","journal-title":"Medicina (Kaunas)"},{"issue":"2","key":"1285_CR71","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/dmfr\/twae070","volume":"54","author":"YH Khubrani","year":"2025","unstructured":"Khubrani YH, Thomas D, Slator PJ, White RD, Farnell DJJ. Detection of periodontal bone loss and periodontitis from 2D dental radiographs via machine learning and deep learning: systematic review employing APPRAISE-AI and meta-analysis. Dentomaxillofac Radiol. 2025;54(2):89\u2013108. https:\/\/doi.org\/10.1093\/dmfr\/twae070.","journal-title":"Dentomaxillofac Radiol"},{"key":"1285_CR72","doi-asserted-by":"publisher","first-page":"1085251","DOI":"10.3389\/fdmed.2023.1085251","volume":"4","author":"H Ding","year":"2023","unstructured":"Ding H, Wu J, Zhao W, Matinlinna JP, Burrow MF, Tsoi JKH. Artificial intelligence in dentistry: a review. Front Dent Med. 2023;4:1085251. https:\/\/doi.org\/10.3389\/fdmed.2023.1085251.","journal-title":"Front Dent Med"},{"key":"1285_CR73","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11175070","author":"K Zwittnig","year":"2022","unstructured":"Zwittnig K, Kirnbauer B, Jakse N, Schlenke P, Mischak I, Ghanaati S, et al. Growth factor release within liquid and solid PRF. J Clin Med. 2022. https:\/\/doi.org\/10.3390\/jcm11175070.","journal-title":"J Clin Med"},{"key":"1285_CR74","doi-asserted-by":"publisher","first-page":"1525505","DOI":"10.3389\/fdmed.2024.1525505","volume":"5","author":"D Rokaya","year":"2024","unstructured":"Rokaya D, Jaghsi AA, Jagtap R, Srimaneepong V. Artificial intelligence in dentistry and dental biomaterials. Front Dent Med. 2024;5:1525505. https:\/\/doi.org\/10.3389\/fdmed.2024.1525505.","journal-title":"Front Dent Med"},{"key":"1285_CR75","doi-asserted-by":"publisher","first-page":"1578635","DOI":"10.3389\/fimmu.2025.1578635","volume":"16","author":"Z Tang","year":"2025","unstructured":"Tang Z, Jin L, Yang Y. The dual role of IL-17 in periodontitis regulating immunity and bone homeostasis. Front Immunol. 2025;16:1578635. https:\/\/doi.org\/10.3389\/fimmu.2025.1578635.","journal-title":"Front Immunol"}],"container-title":["Odontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-025-01285-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10266-025-01285-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-025-01285-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:16:41Z","timestamp":1782800201000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10266-025-01285-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,13]]},"references-count":75,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["1285"],"URL":"https:\/\/doi.org\/10.1007\/s10266-025-01285-0","relation":{},"ISSN":["1618-1247","1618-1255"],"issn-type":[{"value":"1618-1247","type":"print"},{"value":"1618-1255","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,13]]},"assertion":[{"value":"15 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable. This article is a narrative review and does not involve human participants or animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}