{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:56:42Z","timestamp":1790891802049,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Odontology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10266-026-01314-6","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T17:30:36Z","timestamp":1768239036000},"page":"1791-1800","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical efficacy of bioactive glass in periodontal regeneration: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6346-4502","authenticated-orcid":false,"given":"Nazanin","family":"Jafari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0222-3035","authenticated-orcid":false,"given":"Amin","family":"Tamadon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-3541","authenticated-orcid":false,"given":"Madina A.","family":"Kurmanalina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3600-8840","authenticated-orcid":false,"given":"Nadiar M.","family":"Mussin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9282-1778","authenticated-orcid":false,"given":"Nader","family":"Tanideh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9304-6945","authenticated-orcid":false,"given":"Ramazon","family":"Safarzoda Sharoffidin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"issue":"1","key":"1314_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38","volume":"3","author":"DF Kinane","year":"2017","unstructured":"Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3(1):17038. https:\/\/doi.org\/10.1038\/nrdp.2017.38.","journal-title":"Nat Rev Dis Primers"},{"issue":"10","key":"1314_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/bdjteam.2015.163","volume":"2","author":"L Winning","year":"2015","unstructured":"Winning L, Linden GJ. Periodontitis and systemic disease. BDJ Team. 2015;2(10):15163. https:\/\/doi.org\/10.1038\/bdjteam.2015.163.","journal-title":"BDJ Team"},{"issue":"11","key":"1314_CR3","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1002\/JPER.22-0059","volume":"93","author":"N Andere","year":"2022","unstructured":"Andere N, Castro Dos Santos NC, Araujo CF, et al. Open flap debridement compared to repeated applications of photodynamic therapy in the treatment of residual pockets: a randomized clinical trial. J Periodontol. 2022;93(11):1671\u201381. https:\/\/doi.org\/10.1002\/JPER.22-0059.","journal-title":"J Periodontol"},{"issue":"21","key":"1314_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800457","volume":"7","author":"C Vaquette","year":"2018","unstructured":"Vaquette C, Pilipchuk SP, Bartold PM, et al. Tissue engineered constructs for periodontal regeneration: current status and future perspectives. Adv Healthc Mater. 2018;7(21):e1800457. https:\/\/doi.org\/10.1002\/adhm.201800457.","journal-title":"Adv Healthc Mater"},{"issue":"5","key":"1314_CR5","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1039\/d2tb02505a","volume":"11","author":"OD Abodunrin","year":"2023","unstructured":"Abodunrin OD, El Mabrouk K, Bricha M. A review on borate bioactive glasses (BBG): effect of doping elements, degradation, and applications. J Mater Chem B. 2023;11(5):955\u201373. https:\/\/doi.org\/10.1039\/d2tb02505a.","journal-title":"J Mater Chem B"},{"issue":"3","key":"1314_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/dj13030092","volume":"13","author":"E Bud","year":"2025","unstructured":"Bud E, Pop SI, Bud A, et al. Bony defect regeneration in periodontitis: a systematic review of the literature regarding the use of enamel matrix derivative proteins. Dent J. 2025;13(3):92. https:\/\/doi.org\/10.3390\/dj13030092.","journal-title":"Dent J"},{"issue":"4","key":"1314_CR7","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1902\/jop.2011.110347","volume":"83","author":"K Sohrabi","year":"2012","unstructured":"Sohrabi K, Saraiya V, Laage TA, et al. An evaluation of bioactive glass in the treatment of periodontal defects: a meta-analysis of randomized controlled clinical trials. J Periodontol. 2012;83(4):453\u201364. https:\/\/doi.org\/10.1902\/jop.2011.110347.","journal-title":"J Periodontol"},{"issue":"1","key":"1314_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-02898-z","volume":"23","author":"C Motta","year":"2023","unstructured":"Motta C, Cavagnetto D, Amoroso F, et al. Bioactive glass for periodontal regeneration: a systematic review. BMC Oral Health. 2023;23(1):264. https:\/\/doi.org\/10.1186\/s12903-023-02898-z.","journal-title":"BMC Oral Health"},{"key":"1314_CR9","doi-asserted-by":"crossref","unstructured":"Nandi SK, Mahato A, Kundu B, et al. Doped bioactive glass materials in bone regeneration. In: Advanced Techniques in Bone Regeneration. (Zorzi R, de Miranda JB. eds.) IntechOpen: London; 2016; pp. 275.","DOI":"10.5772\/63266"},{"issue":"20","key":"1314_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/ma14206123","volume":"14","author":"CW Cheah","year":"2021","unstructured":"Cheah CW, Al-Namnam NM, Lau MN, et al. Synthetic material for bone, periodontal, and dental tissue regeneration: where are we now, and where are we heading next? Materials. 2021;14(20):6123. https:\/\/doi.org\/10.3390\/ma14206123.","journal-title":"Materials"},{"issue":"18","key":"1314_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ma14185440","volume":"14","author":"M Cannio","year":"2021","unstructured":"Cannio M, Bellucci D, Roether JA, et al. Bioactive glass applications: a literature review of human clinical trials. Materials. 2021;14(18):5440. https:\/\/doi.org\/10.3390\/ma14185440.","journal-title":"Materials"},{"issue":"4","key":"1314_CR12","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1902\/jop.1999.70.4.384","volume":"70","author":"CR Anderegg","year":"1999","unstructured":"Anderegg CR, Alexander DC, Freidman M. A bioactive glass particulate in the treatment of molar furcation invasions. J Periodontol. 1999;70(4):384\u20137. https:\/\/doi.org\/10.1902\/jop.1999.70.4.384.","journal-title":"J Periodontol"},{"issue":"3","key":"1314_CR13","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1902\/jop.2007.060263","volume":"78","author":"T Dybvik","year":"2007","unstructured":"Dybvik T, Leknes KN, Boe OE, et al. Bioactive ceramic filler in the treatment of severe osseous defects: 12-month results. J Periodontol. 2007;78(3):403\u201310. https:\/\/doi.org\/10.1902\/jop.2007.060263.","journal-title":"J Periodontol"},{"issue":"1","key":"1314_CR14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.4103\/2229-5194.134999","volume":"4","author":"SEM El-Haddad","year":"2014","unstructured":"El-Haddad SEM, Abd-El Razzak M, Saudi H, et al. Evaluation of bioactive glass and autogenous bone in the treatment of Grade II furcation involvement: a randomized controlled trial. J Interdiscip Dent. 2014;4(1):13\u201323. https:\/\/doi.org\/10.4103\/2229-5194.134999.","journal-title":"J Interdiscip Dent"},{"issue":"6","key":"1314_CR15","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1902\/jop.1998.69.6.698","volume":"69","author":"SJ Froum","year":"1998","unstructured":"Froum SJ, Weinberg MA, Tarnow D. Comparison of bioactive glass synthetic bone graft particles and open debridement in the treatment of human periodontal defects. a clinical study. J Periodontol. 1998;69(6):698\u2013709. https:\/\/doi.org\/10.1902\/jop.1998.69.6.698.","journal-title":"J Periodontol"},{"issue":"3","key":"1314_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00784-006-0052-5","volume":"10","author":"B Kuru","year":"2006","unstructured":"Kuru B, Yilmaz S, Argin K, et al. Enamel matrix derivative alone or in combination with a bioactive glass in wide intrabony defects. Clin Oral Investig. 2006;10(3):227\u201334. https:\/\/doi.org\/10.1007\/s00784-006-0052-5.","journal-title":"Clin Oral Investig"},{"issue":"12","key":"1314_CR17","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1902\/jop.1998.69.12.1346","volume":"69","author":"MM Ong","year":"1998","unstructured":"Ong MM, Eber RM, Korsnes MI, et al. Evaluation of a bioactive glass alloplast in treating periodontal intrabony defects. J Periodontol. 1998;69(12):1346\u201354. https:\/\/doi.org\/10.1902\/jop.1998.69.12.1346.","journal-title":"J Periodontol"},{"issue":"6","key":"1314_CR18","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1902\/jop.2001.72.6.730","volume":"72","author":"JS Park","year":"2001","unstructured":"Park JS, Suh JJ, Choi SH, et al. Effects of pretreatment clinical parameters on bioactive glass implantation in intrabony periodontal defects. J Periodontol. 2001;72(6):730\u201340. https:\/\/doi.org\/10.1902\/jop.2001.72.6.730.","journal-title":"J Periodontol"},{"issue":"5","key":"1314_CR19","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/j.1708-8240.2000.tb00231.x","volume":"12","author":"ES Rosenberg","year":"2000","unstructured":"Rosenberg ES, Fox GK, Cohen C. Bioactive glass granules for regeneration of human periodontal defects. J Esthet Restor Dent. 2000;12(5):248\u201357. https:\/\/doi.org\/10.1111\/j.1708-8240.2000.tb00231.x.","journal-title":"J Esthet Restor Dent"},{"issue":"37","key":"1314_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3126\/kumj.v10i1.6906","volume":"10","author":"KV Satyanarayana","year":"2012","unstructured":"Satyanarayana KV, Anuradha BR, Srikanth G, et al. Clinical evaluation of intrabony defects in localized aggressive periodontitis patients with and without bioglass- an in-vivo study. Kathmandu Univ Med J. 2012;10(37):11\u20135. https:\/\/doi.org\/10.3126\/kumj.v10i1.6906.","journal-title":"Kathmandu Univ Med J"},{"issue":"6","key":"1314_CR21","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/j.1600-051X.2007.01084.x","volume":"34","author":"A Sculean","year":"2007","unstructured":"Sculean A, Pietruska M, Arweiler NB, et al. Four-year results of a prospective-controlled clinical study evaluating healing of intra-bony defects following treatment with an enamel matrix protein derivative alone or combined with a bioactive glass. J Clin Periodontol. 2007;34(6):507\u201313. https:\/\/doi.org\/10.1111\/j.1600-051X.2007.01084.x.","journal-title":"J Clin Periodontol"},{"issue":"2","key":"1314_CR22","doi-asserted-by":"publisher","first-page":"e239","DOI":"10.4317\/medoral.16.e239","volume":"16","author":"R Subbaiah","year":"2011","unstructured":"Subbaiah R, Thomas B. Efficacy of a bioactive alloplast, in the treatment of human periodontal osseous defects-a clinical study. Med Oral Patol Oral Cir Bucal. 2011;16(2):e239\u201344. https:\/\/doi.org\/10.4317\/medoral.16.e239.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"6","key":"1314_CR23","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/j.1600-051x.1997.tb00205.x","volume":"24","author":"JS Zamet","year":"1997","unstructured":"Zamet JS, Darbar UR, Griffiths GS, et al. Particulate bioglass as a grafting material in the treatment of periodontal intrabony defects. J Clin Periodontol. 1997;24(6):410\u20138. https:\/\/doi.org\/10.1111\/j.1600-051x.1997.tb00205.x.","journal-title":"J Clin Periodontol"},{"key":"1314_CR24","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","author":"MJ Page","year":"2020","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2020. https:\/\/doi.org\/10.1136\/bmj.n71.","journal-title":"BMJ"}],"container-title":["Odontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-026-01314-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10266-026-01314-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-026-01314-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:15:09Z","timestamp":1790889309000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10266-026-01314-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["1314"],"URL":"https:\/\/doi.org\/10.1007\/s10266-026-01314-6","relation":{},"ISSN":["1618-1247","1618-1255"],"issn-type":[{"value":"1618-1247","type":"print"},{"value":"1618-1255","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"assertion":[{"value":"6 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}