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Sound third molars were selected and stored in 0.01% thymol solution, and part of them was subjected to a pH-cycling protocol to induce controlled demineralization. The experimental groups were: SD, ADD, BAG\u2009+\u2009SD, and BAG\u2009+\u2009ADD. Microtensile bond strength (n\u2009=\u20098) was assessed after 24\u00a0h and six months. Nanoleakage (n\u2009=\u20093), micropermeability (n\u2009=\u20093), Knoop microhardness (n\u2009=\u20093 after 24\u00a0h and three months), and FT-IR spectroscopy (n\u2009=\u20093 immediately and after 30\u00a0days) were also performed. All specimens were stored in artificial saliva at 37\u00a0\u00b0C with monthly renewal. Data were analyzed using ANOVA and Tukey\u2019s test (p\u2009&lt;\u20090.05). The BAG\u2009+\u2009ADD group maintained bond strength after 6\u00a0months (p\u2009=\u20090.887). BAG reduced nanoleakage in both SD and ADD. Micropermeability showed no fluorescein uptake in SD, and reduced absorption in ADD when treated with BAG. After 3\u00a0months, BAG\u2009+\u2009ADD significantly increased microhardness at all tested depths, while BAG\u2009+\u2009SD showed improvements at 70\u00a0\u00b5m and 100\u00a0\u00b5m (p\u2009=\u20090.006 and p\u2009=\u20090.015, respectively) FT-IR analysis showed phosphate and carbonate bands in BAG-containing adhesives, with increased definition after 30\u00a0days, indicating time-dependent ion release and apatite maturation. Incorporation of BAG into a self-etch adhesive (Clearfil SE Bond) preserved long-term bond strength, enhanced dentin microhardness, promoted mineral precipitation at the adhesive interface, and improved hybrid layer, sealing\u2014particularly in artificially demineralized dentin.<\/jats:p>","DOI":"10.1007\/s10266-026-01326-2","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T14:46:57Z","timestamp":1770302817000},"page":"2591-2603","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic effects of a 45S5 bioactive glass\u2013modified self-etch adhesive on sound and artificially demineralized dentin: mechanical, interfacial, and chemical analyses"],"prefix":"10.1007","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7474-1505","authenticated-orcid":false,"given":"Ana Laura Mendes","family":"Mota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2993-534X","authenticated-orcid":false,"given":"Marcelo Victor Sidou","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-6752","authenticated-orcid":false,"given":"Mateus Soares","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2174-2263","authenticated-orcid":false,"given":"Victoria Patr\u00edcio","family":"de Oliveira Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4010-0474","authenticated-orcid":false,"given":"Juliano Sartori","family":"Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6808-092X","authenticated-orcid":false,"given":"S\u00e9rgio Lima","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"1326_CR1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jdsr.2011.03.002","volume":"47","author":"M Nakajima","year":"2011","unstructured":"Nakajima M, Kunawarote S, Prasansuttiporn T, Tagami J. 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