{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:15:37Z","timestamp":1792782937262,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Tokat Gaziosmanpa\u015fa University Scientific Research Projects Coordination Unit","id":[{"id":"https:\/\/ror.org\/01rpe9k96","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Tokat Gaziosmanpasa University","id":[{"id":"https:\/\/ror.org\/01rpe9k96","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Odontology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pit and fissure sealants (PFS) are effective in preventing occlusal caries. This randomized split-mouth clinical study aimed to compare the 18-month clinical performance of the bioactive resin-based PFS (BioCoat\u2122) with a fluoride-containing conventional resin-based PFS (Fissurit FX) and to assess the influence of patient-related factors on material success. Sixty-three pediatric patients (aged 7\u20139) requiring non-invasive PFS were included. BioCoat\u2122 (Group 1) and Fissurit FX (Group 2) were applied to contralateral mandibular permanent first molars. Clinical evaluations were performed at 3rd, 6th, 9th, 12th, and 18th months using modified USPHS criteria. Kaplan\u2013Meier survival analysis and logistic regression were applied. At 18\u00a0months, success rates were 90.2% for BioCoat\u2122 and 88.2% for Fissurit FX, with no statistically significant difference between groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). Both materials showed similar performance in marginal discoloration\u2013adaptation, retention and secondary caries (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). Median survival times were 17.72\u00a0months (BioCoat\u2122) and 17.49\u00a0months (Fissurit FX), showing no significant difference (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.744). No significant effect of patient-related factors on material success was determined (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). BioCoat\u2122 demonstrated comparable long-term clinical performance to Fissurit FX. Its bioactive properties may provide additional preventive benefits, supporting its safe use in pediatric dentistry.\n                  <\/jats:p>","DOI":"10.1007\/s10266-026-01332-4","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T17:34:26Z","timestamp":1770053666000},"page":"2637-2647","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical performance of BioCoat\u2122 and Fissurit FX: a randomized 18-month split-mouth study"],"prefix":"10.1007","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3772-4976","authenticated-orcid":false,"given":"Esra","family":"Erg\u00fcn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-1778","authenticated-orcid":false,"given":"Canan","family":"Bayraktar Nahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"1332_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1472-6831-6-S1-S14","volume":"1","author":"PD Marsh","year":"2006","unstructured":"Marsh PD. Dental plaque as a biofilm and a microbial community implications for health and disease. BMC Oral Health. 2006;1:14.","journal-title":"BMC Oral Health"},{"key":"1332_CR2","doi-asserted-by":"publisher","first-page":"726","DOI":"10.26719\/emhj.20.050","volume":"266","author":"S Kale","year":"2020","unstructured":"Kale S, Kakodkar P, Shetiya S, Abdulkader R. Prevalence of dental caries among children aged 5\u201315 years from 9 countries in the eastern mediterranean region: a meta-analysis. East Mediterr Health J. 2020;266:726\u201335.","journal-title":"East Mediterr Health J"},{"key":"1332_CR3","first-page":"393","volume":"245","author":"RJ Simonsen","year":"2002","unstructured":"Simonsen RJ. Pit and fissure sealant: review of the literature. 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(2018) How to achieve both retention and prevention with BioCoat. https:\/\/www.dentalproductsreport.com\/view\/how-achieve-both-retention-and-prevention-biocoat, 2018"},{"key":"1332_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.51847\/61lbclcDSe","volume":"94","author":"KH Alfakhri","year":"2021","unstructured":"Alfakhri KH, Aldosari RS, Alturki IB, Alhussain BS. Resin-based sealants vs glass ionomer sealants: a systematic review to determine the clinical efficacy and longevity. Ann Dent Spec. 2021;94:1\u20135.","journal-title":"Ann Dent Spec"},{"key":"1332_CR8","first-page":"83","volume":"45","author":"Z Tarle","year":"2018","unstructured":"Tarle Z. Bioaktivni dentalni kompozitni materijali. Rad HAZU Med Znan. 2018;45:83\u201399.","journal-title":"Rad HAZU Med Znan"},{"key":"1332_CR9","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.3390\/polym16131855","volume":"613","author":"JW Choi","year":"2024","unstructured":"Choi JW, Han AR, Yang SY. Ion release and apatite formation of resin based pit and fissure sealants containing 45s5 bioactive glass. Polymers. 2024;613:1855.","journal-title":"Polymers"},{"key":"1332_CR10","unstructured":"Premier Dental Products Company. BioCoat Brochure. 2017. https:\/\/www.premierdentalco.com\/wpcontent\/uploads\/2017\/04\/BioCoat_Brochure.pdfAccessed September 4, 2025."},{"key":"1332_CR11","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.3390\/ma15041369","volume":"154","author":"A AlQahtani","year":"2022","unstructured":"AlQahtani A, AlDlaigan Y, Almahdy A. Microtensile bond strength of bioactive pit and fissure sealants bonded to primary and permanent teeth. Materials. 2022;154:1369.","journal-title":"Materials"},{"key":"1332_CR12","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1166\/jbt.2022.3158","volume":"1211","author":"A AlQahtani","year":"2022","unstructured":"AlQahtani A, AlDlaigan Y, Almahdy A. 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