{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:09:21Z","timestamp":1788854961448,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Odontology"],"DOI":"10.1007\/s10266-026-01558-2","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:48:09Z","timestamp":1788853689000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of injectable platelet-rich fibrin with guided tissue regeneration and bone grafting in the management of alveolar bone defects in patients with chronic periodontitis and baseline vitamin D deficiency"],"prefix":"10.1007","author":[{"given":"Jie","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Min","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Hua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"3","key":"1558_CR1","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.molmed.2014.11.004","volume":"21","author":"RJ Lamont","year":"2015","unstructured":"Lamont RJ, Hajishengallis G. Polymicrobial synergy and dysbiosis in inflammatory disease. Trends Mol Med. 2015;21(3):172\u201383. https:\/\/doi.org\/10.1016\/j.molmed.2014.11.004.","journal-title":"Trends Mol Med"},{"issue":"1","key":"1558_CR2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/prd.12431","volume":"89","author":"K Parsegian","year":"2022","unstructured":"Parsegian K, Randall D, Curtis M, Ioannidou E. Association between periodontitis and chronic kidney disease. Periodontol 2000. 2022;89(1):114\u201324. https:\/\/doi.org\/10.1111\/prd.12431.","journal-title":"Periodontol 2000"},{"issue":"4","key":"1558_CR3","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/jre.12634","volume":"54","author":"Y Wang","year":"2019","unstructured":"Wang Y, Zhen Z, Liu HN, et al. Periodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes. J Periodontal Res. 2019;54(4):339\u201348. https:\/\/doi.org\/10.1111\/jre.12634.","journal-title":"J Periodontal Res"},{"issue":"3","key":"1558_CR4","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.3390\/nu7032044","volume":"7","author":"PO Lang","year":"2015","unstructured":"Lang PO, Aspinall R. Can we translate vitamin D immunomodulating effect on innate and adaptive immunity to vaccine response? Nutrients. 2015;7(3):2044\u201360. https:\/\/doi.org\/10.3390\/nu7032044. Published 2015 Mar 20.","journal-title":"Nutrients"},{"issue":"4","key":"1558_CR5","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/MNH.0b013e3282ff64a3","volume":"17","author":"DD Bikle","year":"2008","unstructured":"Bikle DD. Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hypertens. 2008;17(4):348\u201352. https:\/\/doi.org\/10.1097\/MNH.0b013e3282ff64a3.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"1558_CR6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bonr.2018.03.004","volume":"8","author":"M Chakhtoura","year":"2018","unstructured":"Chakhtoura M, Rahme M, Chamoun N, El-Hajj Fuleihan G. Vitamin D in the Middle East and North Africa. Bone Rep. 2018;8:135\u201346. https:\/\/doi.org\/10.1016\/j.bonr.2018.03.004. Published 2018 Mar 17.","journal-title":"Bone Rep"},{"issue":"24","key":"1558_CR7","doi-asserted-by":"publisher","first-page":"9751","DOI":"10.1073\/pnas.87.24.9751","volume":"87","author":"J Liao","year":"1990","unstructured":"Liao J, Ozono K, Sone T, McDonnell DP, Pike JW. Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A. 1990;87(24):9751\u20135. https:\/\/doi.org\/10.1073\/pnas.87.24.9751.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"1558_CR8","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1371\/journal.pmed.0040103","volume":"4","author":"H Li","year":"2007","unstructured":"Li H, Stampfer MJ, Hollis JB, et al. A prospective study of plasma vitamin D metabolites, vitamin D receptor polymorphisms, and prostate cancer. PLoS Med. 2007;4(3):e103. https:\/\/doi.org\/10.1371\/journal.pmed.0040103.","journal-title":"PLoS Med"},{"issue":"6","key":"1558_CR9","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/odi.12659","volume":"23","author":"J Du","year":"2017","unstructured":"Du J, Li R, Yu F, et al. Experimental study on 1,25(OH)2 D3 amelioration of oral lichen planus through regulating NF-\u03baB signaling pathway. Oral Dis. 2017;23(6):770\u20138. https:\/\/doi.org\/10.1111\/odi.12659.","journal-title":"Oral Dis"},{"issue":"5","key":"1558_CR10","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.identj.2023.06.004","volume":"73","author":"Y Li","year":"2023","unstructured":"Li Y, Wang J, Cai Y, Chen H. Association of serum Vitamin D with periodontal disease. Int Dent J. 2023;73(5):777\u201383. https:\/\/doi.org\/10.1016\/j.identj.2023.06.004.","journal-title":"Int Dent J"},{"issue":"2","key":"1558_CR11","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/jre.12207","volume":"50","author":"GN Antonoglou","year":"2015","unstructured":"Antonoglou GN, Knuuttila M, Niemel\u00e4 O, et al. Low serum level of 1,25(OH)2 D is associated with chronic periodontitis. J Periodontal Res. 2015;50(2):274\u201380. https:\/\/doi.org\/10.1111\/jre.12207.","journal-title":"J Periodontal Res"},{"issue":"7","key":"1558_CR12","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","volume":"96","author":"MF Holick","year":"2011","unstructured":"Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911\u201330. https:\/\/doi.org\/10.1210\/jc.2011-0385.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1558_CR13","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1056\/NEJMra070553","volume":"357","author":"MF Holick","year":"2007","unstructured":"Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266\u201381. https:\/\/doi.org\/10.1056\/NEJMra070553.","journal-title":"N Engl J Med"},{"issue":"2","key":"1558_CR14","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/jre.13083","volume":"58","author":"EM Lu","year":"2023","unstructured":"Lu EM. The role of vitamin D in periodontal health and disease. J Periodontal Res. 2023;58(2):213\u201324. https:\/\/doi.org\/10.1111\/jre.13083.","journal-title":"J Periodontal Res"},{"issue":"8","key":"1558_CR15","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1177\/0022034511407771","volume":"90","author":"JD Bashutski","year":"2011","unstructured":"Bashutski JD, Eber RM, Kinney JS, et al. The impact of vitamin D status on periodontal surgery outcomes. J Dent Res. 2011;90(8):1007\u201312. https:\/\/doi.org\/10.1177\/0022034511407771.","journal-title":"J Dent Res"},{"issue":"1","key":"1558_CR16","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00068-017-0767-9","volume":"44","author":"J Choukroun","year":"2018","unstructured":"Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients\u2019 own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg. 2018;44(1):87\u201395. https:\/\/doi.org\/10.1007\/s00068-017-0767-9.","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"3","key":"1558_CR17","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.prosdent.2018.03.027","volume":"121","author":"R Shah","year":"2019","unstructured":"Shah R, Gowda TM, Thomas R, Kumar T, Mehta DS. Biological activation of bone grafts using injectable platelet-rich fibrin. J Prosthet Dent. 2019;121(3):391\u20133. https:\/\/doi.org\/10.1016\/j.prosdent.2018.03.027.","journal-title":"J Prosthet Dent"},{"key":"1558_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/prd.12626","volume":"00","author":"N Farshidfar","year":"2025","unstructured":"Farshidfar N, Amiri MA, Estrin NE, et al. Platelet-rich plasma (PRP) versus injectable platelet-rich fibrin (i-PRF): a systematic review across all fields of medicine. Periodontol 2000. 2025;00:1\u201331. https:\/\/doi.org\/10.1111\/prd.12626.","journal-title":"Periodontol 2000"},{"issue":"1","key":"1558_CR19","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1177\/0885328220914407","volume":"35","author":"S Kyyak","year":"2020","unstructured":"Kyyak S, Blatt S, Pabst A, Thiem D, Al-Nawas B, K\u00e4mmerer PW. Combination of an allogenic and a xenogenic bone substitute material with injectable platelet-rich fibrin\u2014a comparative in vitro study. J Biomater Appl. 2020;35(1):83\u201396. https:\/\/doi.org\/10.1177\/0885328220914407.","journal-title":"J Biomater Appl"},{"issue":"3","key":"1558_CR20","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1016\/j.tripleo.2005.07.011","volume":"101","author":"J Choukroun","year":"2006","unstructured":"Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e56\u201360. https:\/\/doi.org\/10.1016\/j.tripleo.2005.07.011.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"1558_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/ma14216430","author":"M Wang","year":"2021","unstructured":"Wang M, Zhang X, Li Y, Mo A. Lateral ridge augmentation with guided bone regeneration using particulate bone substitutes and injectable platelet-rich fibrin in a digital workflow: 6 month results of a prospective cohort study based on cone-beam computed tomography data. Material (Basel). 2021;14(21):6430. https:\/\/doi.org\/10.3390\/ma14216430. Published 2021 Oct 27."},{"issue":"Suppl 20","key":"1558_CR22","doi-asserted-by":"publisher","first-page":"S162","DOI":"10.1111\/jcpe.12946","volume":"45","author":"PN Papapanou","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Clin Periodontol. 2018;45(Suppl 20):S162\u201370. https:\/\/doi.org\/10.1111\/jcpe.12946.","journal-title":"J Clin Periodontol"},{"issue":"1","key":"1558_CR23","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cden.2021.09.002","volume":"66","author":"A Stavropoulos","year":"2022","unstructured":"Stavropoulos A, Bertl K, Sculean A, Kantarci A. Regenerative periodontal therapy in intrabony defects and long-term tooth prognosis. Dent Clin North Am. 2022;66(1):103\u20139. https:\/\/doi.org\/10.1016\/j.cden.2021.09.002.","journal-title":"Dent Clin North Am"},{"issue":"4","key":"1558_CR24","doi-asserted-by":"publisher","first-page":"S1080","DOI":"10.1093\/ajcn\/87.4.1080S","volume":"87","author":"MF Holick","year":"2008","unstructured":"Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87(4):S1080\u20136. https:\/\/doi.org\/10.1093\/ajcn\/87.4.1080S.","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"1558_CR25","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3290\/j.ohpd.a44323","volume":"18","author":"P Dragonas","year":"2020","unstructured":"Dragonas P, El-Sioufi I, Bobetsis YA, Madianos PN. Association of vitamin D with periodontal disease: a narrative review. Oral Health Prev Dent. 2020;18(2):103\u201314. https:\/\/doi.org\/10.3290\/j.ohpd.a44323. Published 2020 Apr 3.","journal-title":"Oral Health Prev Dent"},{"issue":"5","key":"1558_CR26","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1111\/odi.13097","volume":"25","author":"MM Meghil","year":"2019","unstructured":"Meghil MM, Hutchens L, Raed A, et al. The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: a pilot study. Oral Dis. 2019;25(5):1403\u201313. https:\/\/doi.org\/10.1111\/odi.13097.","journal-title":"Oral Dis"},{"issue":"3","key":"1558_CR27","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.jormas.2020.07.007","volume":"122","author":"JK Dayashankara Rao","year":"2021","unstructured":"Dayashankara Rao JK, Bhatnagar A, Pandey R, et al. A comparative evaluation of iliac crest bone graft with and without injectable and advanced platelet rich fibrin in secondary alveolar bone grafting for cleft alveolus in unilateral cleft lip and palate patients: a randomized prospective study. J Stomatol Oral Maxillofac Surg. 2021;122(3):241\u20137. https:\/\/doi.org\/10.1016\/j.jormas.2020.07.007.","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"1558_CR28","doi-asserted-by":"publisher","unstructured":"Sezgin Y, Uraz A, Taner IL, \u00c7ulhao\u011flu R. Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral. Braz Oral Res. 2017;31:e15. https:\/\/doi.org\/10.1590\/1807-3107BOR-2017.vol31.0015. Published 2017 Jan 26.","DOI":"10.1590\/1807-3107BOR-2017.vol31.0015"},{"issue":"2","key":"1558_CR29","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jobcr.2018.07.001","volume":"9","author":"A Bhargava","year":"2019","unstructured":"Bhargava A, Rastogi P, Lal N, Singhal R, Khatoon S, Ali Mahdi A. Relationship between VITAMIN D and chronic periodontitis. J Oral Biol Craniofac Res. 2019;9(2):177\u20139. https:\/\/doi.org\/10.1016\/j.jobcr.2018.07.001.","journal-title":"J Oral Biol Craniofac Res"},{"issue":"11","key":"1558_CR30","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1002\/JPER.20-0860","volume":"92","author":"K Liu","year":"2021","unstructured":"Liu K, Huang Z, Chen Z, Han B, Ouyang X. Treatment of periodontal intrabony defects using bovine porous bone mineral and guided tissue regeneration with\/without platelet-rich fibrin: a randomized controlled clinical trial. J Periodontol. 2021;92(11):1546\u201353. https:\/\/doi.org\/10.1002\/JPER.20-0860.","journal-title":"J Periodontol"},{"issue":"11","key":"1558_CR31","first-page":"7312","volume":"12","author":"Z Mu","year":"2020","unstructured":"Mu Z, He Q, Xin L, et al. Effects of injectable platelet rich fibrin on bone remodeling in combination with DBBM in maxillary sinus elevation: a randomized preclinical study. Am J Transl Res. 2020;12(11):7312\u201325. Published 2020 Nov 15.","journal-title":"Am J Transl Res"},{"issue":"4","key":"1558_CR32","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/jcpe.13247","volume":"47","author":"ZB Ozsagir","year":"2020","unstructured":"Ozsagir ZB, Saglam E, Sen Yilmaz B, Choukroun J, Tunali M. Injectable platelet-rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: a randomized controlled clinical trial. J Clin Periodontol. 2020;47(4):489\u201399. https:\/\/doi.org\/10.1111\/jcpe.13247.","journal-title":"J Clin Periodontol"},{"issue":"6","key":"1558_CR33","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1007\/s10753-015-0209-y","volume":"38","author":"Y Hosokawa","year":"2015","unstructured":"Hosokawa Y, Hosokawa I, Shindo S, Ozaki K, Matsuo T. Calcitriol suppressed inflammatory reactions in IL-1\u03b2-stimulated human periodontal ligament cells. Inflammation. 2015;38(6):2252\u20138. https:\/\/doi.org\/10.1007\/s10753-015-0209-y.","journal-title":"Inflammation"}],"container-title":["Odontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-026-01558-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10266-026-01558-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-026-01558-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:48:10Z","timestamp":1788853690000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10266-026-01558-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":33,"alternative-id":["1558"],"URL":"https:\/\/doi.org\/10.1007\/s10266-026-01558-2","relation":{"references":[{"id-type":"doi","id":"10.3390\/ma14216430IF:","asserted-by":"subject"}]},"ISSN":["1618-1247","1618-1255"],"issn-type":[{"value":"1618-1247","type":"print"},{"value":"1618-1255","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"7 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki (as was revised in 2013). The study was approved by Ethics Committee of the School and Hospital of Stomatology, Zunyi Medical University (Approval Number: 2024-13). Written informed consent was obtained from all participants.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}