{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:51:37Z","timestamp":1791967897708,"version":"4.3.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Odontology"],"DOI":"10.1007\/s10266-026-01577-z","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:17:22Z","timestamp":1791940642000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of high-sucrose intake on the salivary glands of growing rats: histological analysis and assessment of gene and protein expression"],"prefix":"10.1007","author":[{"given":"Orie","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0331-403X","authenticated-orcid":false,"given":"Takao","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Shimomura-Kuroki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"1577_CR1","volume-title":"Sugars intake for adults and children","author":"World Health Organization","year":"2015","unstructured":"World Health Organization. Sugars intake for adults and children. Geneva (CH): World Health Organization; 2015. https:\/\/www.who.int\/publications\/i\/item\/9789241549028."},{"key":"1577_CR2","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/s41415-021-3775-4","volume":"231","author":"N Pitts","year":"2021","unstructured":"Pitts N, Twetman S, Fisher J, Marsh P. Understanding dental caries as a non-communicable disease. Br Dent J. 2021;231:749\u201353. https:\/\/doi.org\/10.1038\/s41415-021-3775-4.","journal-title":"Br Dent J"},{"key":"1577_CR3","doi-asserted-by":"publisher","unstructured":"Keyes PH. 1960. The infectious and transmissible nature of experimental dental caries. Findings and implications. Arch Oral Biol. 1960;1:304\u201320. https:\/\/doi.org\/10.1016\/0003-9969(60)90091-1","DOI":"10.1016\/0003-9969(60)90091-1"},{"key":"1577_CR4","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1093\/eurpub\/ckaa147","volume":"31","author":"M Valenzuela","year":"2021","unstructured":"Valenzuela M, Waterhouse B, Aggarwal V, Bloor K, Doran T. Effect of sugar-sweetened beverages on oral health: A systematic review and meta-analysis. Eur J Public Health. 2021;31:122\u20139. https:\/\/doi.org\/10.1093\/eurpub\/ckaa147.","journal-title":"Eur J Public Health"},{"key":"1577_CR5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41368-022-00186-0","volume":"14","author":"J Zou","year":"2022","unstructured":"Zou J, Du Q, Ge L, Wang J, Wang X, Li Y, Song G, Zhao W, Chen X, Jiang B, Mei Y, Huang Y, Deng S, Zhang H, Li Y, Zhou X. Expert consensus on early childhood caries management. Int J Oral Sci. 2022;14:35. https:\/\/doi.org\/10.1038\/s41368-022-00186-0.","journal-title":"Int J Oral Sci"},{"key":"1577_CR6","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1177\/0022034520917398","volume":"99","author":"E Bernab\u00e9","year":"2020","unstructured":"Bernab\u00e9 E, Ballantyne H, Longbottom C, Pitts N. Early introduction of sugar-sweetened beverages and caries trajectories from age 12 to 48 months. J Dent Res. 2020;99:898\u2013906. https:\/\/doi.org\/10.1177\/0022034520917398.","journal-title":"J Dent Res"},{"issue":"8","key":"1577_CR7","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1111\/apa.15905","volume":"110","author":"M Hanson","year":"2021","unstructured":"Hanson M, Aagaard-Hansen J. Developmental Origins of Health and Disease: Towards a combined bio-social life-course perspective. Acta Paediatr. 2021;110(8):2306\u20139. https:\/\/doi.org\/10.1111\/apa.15905.","journal-title":"Acta Paediatr"},{"key":"1577_CR8","doi-asserted-by":"publisher","unstructured":"Silva M, Riggs E, Kilpatrick N. 2019. Getting ahead of the oral health game: It starts before we\u2019re born? Aust Dent J. 2019;64:S4\u20139. https:\/\/doi.org\/10.1111\/adj.12672","DOI":"10.1111\/adj.12672"},{"key":"1577_CR9","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.prosdent.2021.05.009","volume":"127","author":"H Uchida","year":"2022","unstructured":"Uchida H, Ovitt C. Novel impacts of saliva with regard to oral health. J Prosthet Dent. 2022;127:383\u201391. https:\/\/doi.org\/10.1016\/j.prosdent.2021.05.009.","journal-title":"J Prosthet Dent"},{"key":"1577_CR10","doi-asserted-by":"publisher","first-page":"4234","DOI":"10.3390\/cimb46050258","volume":"46","author":"R Antonelli","year":"2024","unstructured":"Antonelli R, Massei V, Ferrari E, Gallo M, Pertinhez TA, Vescovi P, Pizzi S, Meleti M. Salivary diagnosis of dental caries: A systematic review. Curr Issues Mol Biol. 2024;46:4234\u201350. https:\/\/doi.org\/10.3390\/cimb46050258.","journal-title":"Curr Issues Mol Biol"},{"key":"1577_CR11","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1007\/s00018-020-03741-2","volume":"78","author":"A Suzuki","year":"2021","unstructured":"Suzuki A, Ogata K, Iwata J. Cell signaling regulation in salivary gland development. Cell Mol Life Sci. 2021;78:3299\u2013315. https:\/\/doi.org\/10.1007\/s00018-020-03741-2.","journal-title":"Cell Mol Life Sci"},{"key":"1577_CR12","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1152\/physrev.00015.2021","volume":"102","author":"A Chibly","year":"2022","unstructured":"Chibly A, Aure M, Patel V, Hoffman M. Salivary gland function, development, and regeneration. Physiol Rev. 2022;102:1495\u2013552. https:\/\/doi.org\/10.1152\/physrev.00015.2021.","journal-title":"Physiol Rev"},{"key":"1577_CR13","doi-asserted-by":"publisher","first-page":"e0205372","DOI":"10.1371\/journal.pone.0205372","volume":"13","author":"A El Sadik","year":"2018","unstructured":"El Sadik A, Mohamed E, El Zainy A. Postnatal changes in the development of rat submandibular glands in offspring of diabetic mothers: Biochemical, histological and ultrastructural study. PLoS ONE. 2018;13:e0205372. https:\/\/doi.org\/10.1371\/journal.pone.0205372.","journal-title":"PLoS ONE"},{"key":"1577_CR14","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.3390\/nu10101530","volume":"10","author":"M Maciejczyk","year":"2018","unstructured":"Maciejczyk M, Matczuk J, \u017bendzian-Piotrowska M, Nikli\u0144ska W, Fejfer K, Szarmach I, \u0141adny JR, Zieniewska I, Zalewska A. Eight-week consumption of high-sucrose diet has a pro-oxidant effect and alters the function of the salivary glands of rats. Nutrients. 2018;10:1530. https:\/\/doi.org\/10.3390\/nu10101530.","journal-title":"Nutrients"},{"key":"1577_CR15","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.tice.2017.01.011","volume":"49","author":"S Takahashi","year":"2017","unstructured":"Takahashi S, Uekita H, Taniwaki H, Domon T. Acinar cell response to liquid diet during rats\u2019 growth period differs in submandibular and sublingual glands from that in parotid glands. Tissue Cell. 2017;49:275\u201384. https:\/\/doi.org\/10.1016\/j.tice.2017.01.011.","journal-title":"Tissue Cell"},{"key":"1577_CR16","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/jhn.12338","volume":"29","author":"K Newens","year":"2016","unstructured":"Newens K, Walton J. A review of sugar consumption from nationally representative dietary surveys across the world. J Hum Nutr Diet. 2016;29:225\u201340. https:\/\/doi.org\/10.1111\/jhn.12338.","journal-title":"J Hum Nutr Diet"},{"key":"1577_CR17","doi-asserted-by":"publisher","unstructured":"Kim J, Shin S, Cheon Y, Kim H, Park G, Kim H, et al. Effect of Echinochrome A on Submandibular Gland Dysfunction in Ovariectomized Rats. Mar Drugs. 2022;20(12). https:\/\/doi.org\/10.3390\/md20120729.","DOI":"10.3390\/md20120729"},{"issue":"10","key":"1577_CR18","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1093\/ibd\/izaa190","volume":"26","author":"M Majster","year":"2020","unstructured":"Majster M, Lira-Junior R, H\u00f6\u00f6g C, Almer S, Bostr\u00f6m E. Salivary and Serum Inflammatory Profiles Reflect Different Aspects of Inflammatory Bowel Disease Activity. Inflamm Bowel Dis. 2020;26(10):1588\u201396. https:\/\/doi.org\/10.1093\/ibd\/izaa190.","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"1577_CR19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.job.2024.07.004","volume":"66","author":"H Sakazume","year":"2024","unstructured":"Sakazume H, Morita T, Yamaguchi H, Tanaka A. Intracellular signaling pathways involved in the regulation of gene expression by pilocarpine. J Oral Biosci. 2024;66(4):81\u20137. https:\/\/doi.org\/10.1016\/j.job.2024.07.004.","journal-title":"J Oral Biosci"},{"key":"1577_CR20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"K Livak","year":"2001","unstructured":"Livak K, Schmittgen T. Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2013\u2206\u2206Ct method. Methods. 2001;25:402\u20138. https:\/\/doi.org\/10.1006\/meth.2001.1262.","journal-title":"Methods"},{"key":"1577_CR21","doi-asserted-by":"crossref","unstructured":"Gr\u00e4tz C, Bui M, Thaqi G, Kirchner B, Loewe R, Pfaffl M. Obtaining Reliable RT-qPCR Results in Molecular Diagnostics-MIQE Goals and Pitfalls for Transcriptional Biomarker Discovery. Life(Basel). 2022;12(3).","DOI":"10.3390\/life12030386"},{"issue":"5","key":"1577_CR22","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1177\/002215540104900513","volume":"49","author":"J Leinonen","year":"2001","unstructured":"Leinonen J, Parkkila S, Kaunisto K, Koivunen P, Rajaniemi H. Secretion of carbonic anhydrase isoenzyme VI (CA VI) from human and rat lingual serous von Ebner\u2019s glands. J Histochem Cytochem. 2001;49(5):657\u201362. https:\/\/doi.org\/10.1177\/002215540104900513.","journal-title":"J Histochem Cytochem"},{"key":"1577_CR23","doi-asserted-by":"publisher","first-page":"1675415","DOI":"10.3389\/fvets.2025.1675415","volume":"12","author":"M Matas-Quintanilla","year":"2026","unstructured":"Matas-Quintanilla M, L\u00f3pez-Balibrea R, Miller I, Guti\u00e9rrez A. Porcine salivary carbonic anhydrase VI is involved in the pathogenesis of disease. Front Vet Sci. 2026;12:1675415. https:\/\/doi.org\/10.3389\/fvets.2025.1675415.","journal-title":"Front Vet Sci"},{"issue":"5","key":"1577_CR24","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1513\/AnnalsATS.201512-797OC","volume":"13","author":"O Sibila","year":"2016","unstructured":"Sibila O, Garcia-Bellmunt L, Giner J, Rodrigo-Troyano A, Suarez-Cuartin G, Torrego A, et al. Airway Mucin 2 Is Decreased in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization. Ann Am Thorac Soc. 2016;13(5):636\u201342. https:\/\/doi.org\/10.1513\/AnnalsATS.201512-797OC.","journal-title":"Ann Am Thorac Soc"},{"key":"1577_CR25","first-page":"201","volume":"93","author":"F Jacoby","year":"1959","unstructured":"Jacoby F, Leeson CR. The postnatal development of the rat submaxillary gland. J Anat. 1959;93:201\u201316. https:\/\/pubmed.ncbi.nlm.nih.gov\/13641119\/.","journal-title":"J Anat"},{"key":"1577_CR26","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1677\/joe.0.1400357","volume":"140","author":"M Hiramatsu","year":"1994","unstructured":"Hiramatsu M, Kashimata M, Takayama F, Minami N. Developmental changes in and hormonal modulation of epidermal growth-factor concentration in the rat submandibular gland. J Endocrinol. 1994;140:357\u201363. https:\/\/doi.org\/10.1677\/joe.0.1400357.","journal-title":"J Endocrinol"},{"key":"1577_CR27","first-page":"624","volume":"4","author":"P Sengupta","year":"2013","unstructured":"Sengupta P. The laboratory rat: Relating its age with human\u2019s. Int J Prev Med. 2013;4:624\u201330.","journal-title":"Int J Prev Med"},{"key":"1577_CR28","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s12903-020-01182-8","volume":"20","author":"A Pineda","year":"2020","unstructured":"Pineda A, P\u00e9rez A, Garc\u00eda-Godoy F. Salivary parameters and oral health status amongst adolescents in Mexico. BMC Oral Health. 2020;20:190. https:\/\/doi.org\/10.1186\/s12903-020-01182-8.","journal-title":"BMC Oral Health"},{"key":"1577_CR29","doi-asserted-by":"publisher","first-page":"6572381","DOI":"10.1155\/2018\/6572381","volume":"2018","author":"E Kubala","year":"2018","unstructured":"Kubala E, Strzelecka P, Grzegocka M, Lietz-Kijak D, Gronwald H, Skomro P, et al. A Review of Selected Studies That Determine the Physical and Chemical Properties of Saliva in the Field of Dental Treatment. Biomed Res Int. 2018;2018:6572381. https:\/\/doi.org\/10.1155\/2018\/6572381.","journal-title":"Biomed Res Int"},{"key":"1577_CR30","doi-asserted-by":"publisher","first-page":"638","DOI":"10.3390\/nu9060638","volume":"9","author":"A Burgeiro","year":"2017","unstructured":"Burgeiro A, Cerqueira MG, Varela-Rodr\u00edguez BM, Nunes S, Neto P, Pereira FC, Reis F, Carvalho E. Glucose and lipid dysmetabolism in a rat model of prediabetes induced by a high-sucrose diet. Nutrients. 2017;9:638. https:\/\/doi.org\/10.3390\/nu9060638.","journal-title":"Nutrients"},{"key":"1577_CR31","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00394-011-0228-x","volume":"51","author":"A Sheludiakova","year":"2012","unstructured":"Sheludiakova A, Rooney K, Boakes R. Metabolic and behavioural effects of sucrose and fructose\/glucose drinks in the rat. Eur J Nutr. 2012;51:445\u201354. https:\/\/doi.org\/10.1007\/s00394-011-0228-x.","journal-title":"Eur J Nutr"},{"key":"1577_CR32","doi-asserted-by":"publisher","first-page":"e010330","DOI":"10.1136\/bmjopen-2015-010330","volume":"6","author":"J Boulton","year":"2016","unstructured":"Boulton J, Hashem KM, Jenner KH, Lloyed-Williams F, Bromley H, Capewell S. How much sugar is hidden in drinks marketed to children? A survey of fruit juices, juice drinks and smoothies. BMJ Open. 2016;6:e010330. https:\/\/doi.org\/10.1136\/bmjopen-2015-010330.","journal-title":"BMJ Open"},{"key":"1577_CR33","doi-asserted-by":"publisher","first-page":"9","DOI":"10.7762\/cnr.2015.4.1.9","volume":"4","author":"S Park","year":"2015","unstructured":"Park S, Lin M, Onufrak S, Li R. Association of sugar-sweetened beverage intake during infancy with dental caries in 6-year-olds. Clin Nutr Res. 2015;4:9\u201317. https:\/\/doi.org\/10.7762\/cnr.2015.4.1.9.","journal-title":"Clin Nutr Res"},{"key":"1577_CR34","doi-asserted-by":"publisher","first-page":"118748","DOI":"10.1016\/j.lfs.2020.118748","volume":"265","author":"S Li","year":"2021","unstructured":"Li S, Wu C, Zhang B, Qiu L, Chen W, Yuan Y, et al. Nerve growth factor protects salivary glands from irradiation-induced damage. Life Sci. 2021;265:118748. https:\/\/doi.org\/10.1016\/j.lfs.2020.118748.","journal-title":"Life Sci"},{"issue":"3","key":"1577_CR35","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1111\/odi.14087","volume":"29","author":"J Liu","year":"2023","unstructured":"Liu J, Liu P, Wei L, Li W, Li B, Cheng Y. Oxidative-antioxidant imbalance in chronic sialadenitis of submandibular gland in human and rat. Oral Dis. 2023;29(3):1005\u201316. https:\/\/doi.org\/10.1111\/odi.14087.","journal-title":"Oral Dis"},{"key":"1577_CR36","doi-asserted-by":"publisher","first-page":"3685683","DOI":"10.1155\/2020\/3695683","volume":"2020","author":"H Araujo","year":"2020","unstructured":"Araujo H, Nakamune A, Garcia W, Pessan J, Antoniali C. Carious lesion severity induces higher antioxidant system activity and consequently reduces oxidative damage in children\u2019s saliva. Oxid Med Cell Longev. 2020;2020:3685683. https:\/\/doi.org\/10.1155\/2020\/3695683.","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"1577_CR37","doi-asserted-by":"publisher","first-page":"493","DOI":"10.4103\/jisppd.jisppd_315_25","volume":"43","author":"C James Reshma, Nagarathna","year":"2025","unstructured":"James Reshma, Nagarathna C. Salivary carbonic anhydrase \u2165 as a biomarker for caries susceptibility in pre-school children and its associated Streptococcus mutans of white spot lesions: A cross-sectional Study. J Indian Soc Pedod Prev. 2025;43(4):493\u20138. https:\/\/doi.org\/10.4103\/jisppd.jisppd_315_25.","journal-title":"J Indian Soc Pedod Prev"},{"key":"1577_CR38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.archoralbio.2005.04.007","volume":"51","author":"M Kimoto","year":"2006","unstructured":"Kimoto M, Kishino M, Yura Y, Ogawa Y. A role of salivary carbonic anhydrase vi in dental plaque. Arch Oral Biol. 2006;51:117\u201322. https:\/\/doi.org\/10.1016\/j.archoralbio.2005.04.007.","journal-title":"Arch Oral Biol"},{"key":"1577_CR39","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1159\/000470849","volume":"51","author":"D Picco","year":"2017","unstructured":"Picco D, Lopes L, Marques M, Line S, Parisotto T, dos Santos M. Children with a higher activity of carbonic anhydrase vi in saliva are more likely to develop dental caries. Caries Res. 2017;51:394\u2013401. https:\/\/doi.org\/10.1159\/000470849.","journal-title":"Caries Res"},{"key":"1577_CR40","doi-asserted-by":"publisher","first-page":"1516025","DOI":"10.3389\/froh.2025.1516025","volume":"6","author":"C Robertsson","year":"2025","unstructured":"Robertsson C, Davies J, Svens\u00e4ter G, Nord A, Norrstr\u00f6m N, Wickstr\u00f6m C. MUC5B modulation of early oral biofilm glucose metabolism. Front Oral Health. 2025;6:1516025. https:\/\/doi.org\/10.3389\/froh.2025.1516025.","journal-title":"Front Oral Health"},{"key":"1577_CR41","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/odi.12784","volume":"24","author":"T Cavallari","year":"2018","unstructured":"Cavallari T, Salomao H, Moys\u00e9s ST, Moys\u00e9s SY, Werneck R. The impact of muc5b gene on dental caries. Oral Dis. 2018;24:372\u20136. https:\/\/doi.org\/10.1111\/odi.12784.","journal-title":"Oral Dis"},{"key":"1577_CR42","doi-asserted-by":"publisher","first-page":"226","DOI":"10.2334\/josnusd.18-0293","volume":"62","author":"J Shimomura-Kuroki","year":"2020","unstructured":"Shimomura-Kuroki J, Nashida T, Miyagawa Y, Morita T, Hayashi-Sakai S. Analysis of salivary factors related to the oral health status in children. J Oral Sci. 2020;62:226\u201330. https:\/\/doi.org\/10.2334\/josnusd.18-0293.","journal-title":"J Oral Sci"},{"issue":"5","key":"1577_CR43","doi-asserted-by":"publisher","first-page":"323","DOI":"10.17796\/1053-4625-45.5.6","volume":"45","author":"A Ahmad","year":"2021","unstructured":"Ahmad A, Kumar D, Singh A, Anand S, Agarwal N, Ahmad R. A Comparative Quantitative Assessment of Salivary Iga and Alpha Amylase in Caries Free and Caries Active Children. J Clin Pediatr Dent. 2021;45(5):323\u20139. https:\/\/doi.org\/10.17796\/1053-4625-45.5.6.","journal-title":"J Clin Pediatr Dent"}],"container-title":["Odontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-026-01577-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10266-026-01577-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10266-026-01577-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:23:28Z","timestamp":1791966208000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10266-026-01577-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":43,"alternative-id":["1577"],"URL":"https:\/\/doi.org\/10.1007\/s10266-026-01577-z","relation":{},"ISSN":["1618-1247","1618-1255"],"issn-type":[{"value":"1618-1247","type":"print"},{"value":"1618-1255","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"3 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal research was conducted in accordance with the approval from the Laboratory Animal Committee of The Nippon Dental University School of Life Dentistry at Niigata (approval number: 255).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}