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Inform. med."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chest X-ray is one of the main diagnostic tools in emergency medicine, yet its limited ability to capture fine anatomical details can result in missed or delayed diagnoses. To address this, we introduce XVertNet, a novel deep-learning framework designed to enhance vertebral structure visualization in X-ray images significantly. Our framework introduces two key innovations: (1) an unsupervised learning architecture that eliminates reliance on manually labeled training data\u2014a persistent bottleneck in medical imaging, and (2) a dynamic self-tuned internal guidance mechanism featuring an adaptive feedback loop for real-time image optimization. Extensive validation across four major public datasets revealed that XVertNet outperforms state-of-the-art enhancement methods, as demonstrated by improvements in evaluation measures such as entropy, the Tenengrad criterion, LPC-SI, TMQI, and PIQE. Furthermore, clinical validation conducted by two board-certified clinicians confirmed that the enhanced images enabled more sensitive examination of vertebral structural changes. The unsupervised nature of XVertNet facilitates immediate clinical deployment without requiring additional training overhead. This innovation represents a transformative advancement in emergency radiology, providing a scalable and time-efficient solution to enhance diagnostic accuracy in high-pressure clinical environments.<\/jats:p>","DOI":"10.1007\/s10278-025-01592-6","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T17:14:22Z","timestamp":1753463662000},"page":"1441-1458","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["XVertNet: Unsupervised Contrast Enhancement of Vertebral Structures with Dynamic Self-Tuning Guidance and Multi-Stage Analysis"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9091-3366","authenticated-orcid":false,"given":"Ella","family":"Eidlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assaf","family":"Hoogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hila","family":"Rozen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Badarne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6648-9441","authenticated-orcid":false,"given":"Nathan S.","family":"Netanyahu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"1592_CR1","doi-asserted-by":"crossref","unstructured":"J. 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The dataset used is publicly available dataset(s) and approval has been obtained from the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images in the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}