{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:09:49Z","timestamp":1786500589169,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T00:00:00Z","timestamp":1503100800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Auton Res"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s10286-017-0456-0","type":"journal-article","created":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T00:49:44Z","timestamp":1503103784000},"page":"379-383","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Etiology of Primary Hyperhidrosis: A Systematic Review"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5921-2479","authenticated-orcid":false,"given":"Moshe","family":"Hashmonai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan E. P.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cliff P.","family":"Connery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Perin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Licht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,19]]},"reference":[{"key":"456_CR1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0190-9622(89)70081-5","volume":"20","author":"K Sato","year":"1989","unstructured":"Sato K, Kang WH, Saga K, Sato KT (1989) Biology of sweat glands and their disorders. II. Disorders of sweat gland function. J Am Acad Dermatol 20:713\u2013726","journal-title":"J Am Acad Dermatol"},{"key":"456_CR2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000446786","volume":"51","author":"T Fujimoto","year":"2016","unstructured":"Fujimoto T (2016) Pathophysiology and treatment of hyperhidrosis. Curr Probl Dermatol 51:86\u201393","journal-title":"Curr Probl Dermatol"},{"key":"456_CR3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00000658-197707000-00006","volume":"186","author":"R Adar","year":"1977","unstructured":"Adar R, Kurchin A, Zweig A, Mozes M (1977) Palmar hyperhidrosis and its surgical treatment: a report of 100 cases. Ann Surg 186:34\u201341","journal-title":"Ann Surg"},{"key":"456_CR4","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1097\/00029330-200712020-00011","volume":"120","author":"X Li","year":"2007","unstructured":"Li X, Chen R, Tu YR, Lin M, Lai FC, Li YP, Chen JF, Ye JG (2007) Epidemiological survey of primary hyperhidrosis in adolescents. Chin Med J (Engl) 120:2215\u20132217","journal-title":"Chin Med J (Engl)"},{"key":"456_CR5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jaad.2003.12.040","volume":"51","author":"DR Strutton","year":"2004","unstructured":"Strutton DR, Kowalski JW, Glaser DA, Strang PE (2004) US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: Results from a national survey. J Am Acad Dermatol 51:241\u2013248","journal-title":"J Am Acad Dermatol"},{"key":"456_CR6","doi-asserted-by":"crossref","first-page":"772","DOI":"10.3346\/jkms.2010.25.5.772","volume":"25","author":"EJ Park","year":"2010","unstructured":"Park EJ, Han KR, Choi H, Kim DW, Kim C (2010) An epidemiological study of hyperhidrosis patients visiting the Ajou university hospital hyperhidrosis center in Korea. J Korean Med Sci 25:772\u2013775","journal-title":"J Korean Med Sci"},{"key":"456_CR7","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1346-8138.2009.00732.x","volume":"36","author":"N Yamashita","year":"2009","unstructured":"Yamashita N, Tamada Y, Kawada M, Mizutani K, Watanabe D, Matsumoto Y (2009) Analysis of family history of palmoplantar hyperhidrosis in Japan. J Dermatol 36:628\u2013631","journal-title":"J Dermatol"},{"key":"456_CR8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1590\/abd1806-4841.20153859","volume":"90","author":"SO Lima","year":"2015","unstructured":"Lima SO, Neto JM, Menezes LMS, Aragao JFB, Santos de Almeida KB, Santana VR (2015) Research of primary hyperhidrosis in students of medicine of the State of Sergipe, Brazil. An Bras Dermatol 90:661\u2013665","journal-title":"An Bras Dermatol"},{"key":"456_CR9","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1468-3083.2009.03131.x","volume":"23","author":"D Karimian-Teherani","year":"2009","unstructured":"Karimian-Teherani D, Panhofer P, Ringhofer C, Jakesz R, Prager M, Zacherl J, Bischof G, Neumayer C (2009) New epidemiological aspects of patients with severe hyperhidrosis presenting for sympathetic surgery. J Eur Acad Dermatol Venereol 23:651\u2013655","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"456_CR10","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1067\/mva.2002.119507","volume":"35","author":"KM Ro","year":"2002","unstructured":"Ro KM, Cantor RM, Lange KL, Ahn SS (2002) Palmar hyperhidrosis: evidence of genetic transmission. J Vasc Surg 35:382\u2013386","journal-title":"J Vasc Surg"},{"key":"456_CR11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s10286-003-0082-x","volume":"13","author":"H Kaufmann","year":"2003","unstructured":"Kaufmann H, Saadia D, Polin C, Hague S, Singleton A, Singleton A (2003) Primary hyperhidrosis: evidence for autosomal dominant inheritance. Clin Auton Res 13:96\u201398","journal-title":"Clin Auton Res"},{"key":"456_CR12","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/bjd.13383","volume":"172","author":"J Chen","year":"2015","unstructured":"Chen J, Lin M, Chen X, Cao Z, Tan Z, Xiong W, Tu Y, Yang J (2015) A novel locus for primary focal hyperhidrosis mapped on chromosome 2q31.1. Br J Dermatol 172:1150\u20131153","journal-title":"Br J Dermatol"},{"key":"456_CR13","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/ajmg.a.31127","volume":"140A","author":"I Higashimoto","year":"2006","unstructured":"Higashimoto I, Yoshiura K-I, Hirakawa N, Higashimoto K, Soejima H, Totoki T, Mukai T, Niikawa N (2006) Primary palmar hyperhidrosis locus maps to 14q11.2-q13. Am J Med Gen 140A:567\u2013572","journal-title":"Am J Med Gen"},{"key":"456_CR14","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.avsg.2013.11.004","volume":"28","author":"FRG Oliveira de","year":"2014","unstructured":"de Oliveira FRG, de Moura NB Jr, de Campos JRM, Wolosker N, Parra ER, Capelozzi VL, P\u00eago-Fernandes P (2014) Morphometric analysis of thoracic ganglion neurons in subjects with and without primary palmar hyperhidrosis. Ann Vasc Surg 28:1023\u20131029","journal-title":"Ann Vasc Surg"},{"key":"456_CR15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.athoracsur.2012.10.068","volume":"95","author":"NB Moura de Jr","year":"2013","unstructured":"de Moura NB Jr, das-Neves-Pereira JC, de Oliveira FRG, Jatene FB, Parra ER, Capelozzi VL, Wolosker N, de Campos JRM (2013) Expression of acetylcholine and its receptor in human sympathetic ganglia in primary hyperhidrosis. Ann Thorac Surg 95:465\u2013471","journal-title":"Ann Thorac Surg"},{"key":"456_CR16","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.jocn.2011.12.032","volume":"19","author":"Y Tu","year":"2012","unstructured":"Tu Y, Luo R, Li X, Lin M, Qiu M (2012) Hypermyelination and overexpression of neuregulin-1 in thoracic sympathetic nerves in patients with primary palmar hyperhidrosis. J Clin Neurosci 19:1651\u20131653","journal-title":"J Clin Neurosci"},{"key":"456_CR17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0300-2896(03)75337-X","volume":"39","author":"J Moya","year":"2003","unstructured":"Moya J, Ramos R, Prat J, Morera R, Bernat R, Villalonga R, Ferrer R (2003) Cambios anatomopat\u00f3logicos observados en los ganglios simp\u00e1ticos de pacientes intervenidos de hiperhidrosis palmar-axilar. Estudio de 55 muestras. Arch Bronconeumol 39:115\u2013117","journal-title":"Arch Bronconeumol"},{"key":"456_CR18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11010-006-9177-8","volume":"290","author":"S Karaca","year":"2006","unstructured":"Karaca S, Kulac M, Uz E, Mollaoglu H, Yilmaz HR (2006) Erythrocyte oxidant\/antioxidant status in essential hyperhidrosis. Mol Cell Biochem 290:131\u2013135","journal-title":"Mol Cell Biochem"},{"key":"456_CR19","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/j.1365-4632.2007.03243.x","volume":"46","author":"S Karaca","year":"2007","unstructured":"Karaca S, Kulac M, Uz E, Barutcu I, Yilmaz HR (2007) Is nitric oxide involved in the pathophysiology of essential hyperhidrosis? Int J Dermatol 46:1027\u20131030","journal-title":"Int J Dermatol"},{"key":"456_CR20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.autneu.2011.11.007","volume":"167","author":"M Marinis de","year":"2012","unstructured":"de Marinis M, Colaizzo E, Petrelli RAN, Santilli V (2012) Alterations in cardiovascular autonomic function tests in idiopathic hyperhidrosis. Auton Neurosci 167:34\u201338","journal-title":"Auton Neurosci"},{"key":"456_CR21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000008207","volume":"44","author":"P Birner","year":"2000","unstructured":"Birner P, Heinzl H, Schindl M, Pumprla J, Schnider P (2000) Cardiac autonomic function in patients suffering from primary focal hyperhidrosis. Eur Neurol 44:112\u2013116","journal-title":"Eur Neurol"},{"key":"456_CR22","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/mus.880180820","volume":"18","author":"T-K Lin","year":"1995","unstructured":"Lin T-K, Chee EC-Y, Chen H-J, Cheng M-H (1995) Abnormal sympathetic skin response in patients with palmar hyperhidrosis. Muscle Nerve 18:917\u2013919","journal-title":"Muscle Nerve"},{"key":"456_CR23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0165-1838(97)00014-3","volume":"64","author":"S Iwase","year":"1997","unstructured":"Iwase S, Ikeda T, Kitazawa H, Hakusui S, Sugenoya J, Mano T (1997) Altered response in cutaneous sympathetic outflow to mental and thermal stimuli in primary palmoplantar hyperhidrosis. J Auton Nerv Syst 64:65\u201373","journal-title":"J Auton Nerv Syst"},{"key":"456_CR24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/jnnp.2009.203687","volume":"82","author":"P Schestatsky","year":"2011","unstructured":"Schestatsky P, Callejas MA, Valls-Sol\u00e9 J (2011) Abnormal modulation of electrodermal activity by thermoalgesic stimuli in patients with primary palmar hyperhidrosis. J Neurol Neurosurg Psychiatry 82:92\u201396","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"456_CR25","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/S1388-2457(00)00394-1","volume":"111","author":"D Manca","year":"2000","unstructured":"Manca D, Valls-Sol\u00e9 J, Callejas MA (2000) Excitability recovery curve of the sympathetic skin response in healthy volunteers and patients with palmar hyperhidrosis. Clin Neurophysiol 111:1767\u20131770","journal-title":"Clin Neurophysiol"},{"key":"456_CR26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1477-7525-11-5","volume":"11","author":"M Ak","year":"2013","unstructured":"Ak M, Dincer D, Haciomeroglu B, Akarsu S, Cinar A, Lapsekili N (2013) Temperament and character properties of primary focal hyperhidrosis patients. Health and Quality of Life Outcomes 11:5. doi: 10.1186\/1477-7525-11-5","journal-title":"Health and Quality of Life Outcomes"},{"key":"456_CR27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000099589","volume":"214","author":"S Karaca","year":"2007","unstructured":"Karaca S, Emul M, Kulac M, Yuksel S, Ozbulut O, Guler O, Gecici O (2007) Temperament and character profile in patients with essential hyperhidrosis. Dermatology 214:240\u2013245","journal-title":"Dermatology"},{"key":"456_CR28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-2230.1998.00268.x","volume":"23","author":"OS Kwon","year":"1998","unstructured":"Kwon OS, Kim BS, Cho KH, Kwon JS, Shin MS, Youn JI, Chung JH (1998) Essential hyperhidrosis: no evidence of abnormal personality features. Clin Exp Dermatol 23:45\u201346","journal-title":"Clin Exp Dermatol"},{"key":"456_CR29","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1046\/j.1365-2133.2002.04857.x","volume":"147","author":"RA Ruchinskas","year":"2002","unstructured":"Ruchinskas RA, Narayan RK, Meagher RJ, Furukawa S (2002) The relationship of psychopathology and hyperhidrosis. Br J Dermatol 147:733\u2013735","journal-title":"Br J Dermatol"},{"key":"456_CR30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.clindermatol.2003.12.029","volume":"22","author":"OP Kreyden","year":"2004","unstructured":"Kreyden OP, Scheidegger EP (2004) Anatomy of sweat glands, pharmacology of botulinum toxin, and distinctive syndromes associated with hyperhidrosis. Clin Dermatol 22:40\u201344","journal-title":"Clin Dermatol"},{"key":"456_CR31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1365-2230.2003.01162.x","volume":"28","author":"A Lonsdale-Eccles","year":"2003","unstructured":"Lonsdale-Eccles A, Leonard N, Lawrence C (2003) Axillary hyperhidrosis: eccrine or apocrine? Clin Exp Dermatol 28:2\u20137","journal-title":"Clin Exp Dermatol"},{"key":"456_CR32","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/j.1365-2133.2007.07917.x","volume":"156","author":"DL Bovell","year":"2007","unstructured":"Bovell DL, Corbett AD, Holmes S, MacDonald A, Harker M (2007) The absence of apoeccrine glands in the human axilla has disease pathogenic implications, including axillary hyperhidrosis. Br J Dermatol 156:1278\u20131286","journal-title":"Br J Dermatol"},{"key":"456_CR33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1055\/s-2004-817724","volume":"23","author":"WP Cheshire","year":"2003","unstructured":"Cheshire WP, Freeman MB (2003) Disorders of sweating. Sem Neurol 23:399\u2013406","journal-title":"Disorders of sweating. Sem Neurol"},{"key":"456_CR34","doi-asserted-by":"crossref","first-page":"R203","DOI":"10.1152\/ajpregu.1983.245.2.R203","volume":"14","author":"K Sato","year":"1983","unstructured":"Sato K, Sato F (1983) Individual variations in structure and function of human eccrine sweat glands. Am J Physiol (Regulatory Integrative Comp Physiol) 14:R203\u2013R208","journal-title":"Am J Physiol (Regulatory Integrative Comp Physiol)"},{"key":"456_CR35","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1600-0625.2011.01361.x","volume":"20","author":"DL Bovell","year":"2011","unstructured":"Bovell DL, MacDonald A, Meyer BA, Corbett AD, MacLaren WM, Holmes S, Harker M (2011) The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis. Exp Dermatol 20:1017\u20131020","journal-title":"Exp Dermatol"}],"container-title":["Clinical Autonomic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10286-017-0456-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-017-0456-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-017-0456-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T11:54:19Z","timestamp":1570017259000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10286-017-0456-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,19]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["456"],"URL":"https:\/\/doi.org\/10.1007\/s10286-017-0456-0","relation":{},"ISSN":["0959-9851","1619-1560"],"issn-type":[{"value":"0959-9851","type":"print"},{"value":"1619-1560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,19]]}}}