{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:20:02Z","timestamp":1790796002496,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Children's Hospital of Philadelphia Cardiac Center"},{"name":"Dysautonomia International"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Auton Res"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s10286-019-00622-y","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T04:03:41Z","timestamp":1564977821000},"page":"19-28","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Orthostatic heart rate does not predict symptomatic burden in pediatric patients with chronic orthostatic intolerance"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0428-7681","authenticated-orcid":false,"given":"Jeffrey R.","family":"Boris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bernadzikowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"622_CR1","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.1161\/CIRCULATIONAHA.104.497594","volume":"111","author":"SR Raj","year":"2005","unstructured":"Raj SR, Black BK, Biaggioni I, Harris PA, Robertson D (2005) Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome. Circulation 111:2734\u20132740","journal-title":"Circulation"},{"key":"622_CR2","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1007\/s10286-006-0373-0","volume":"16","author":"RD Hoeldtke","year":"2006","unstructured":"Hoeldtke RD, Bryner KD, Hoeldtke ME, Hobbs G (2006) Treatment of postural tachycardia syndrome: a comparison of octreotide and midodrine. Clin Auton Res 16:390\u2013395","journal-title":"Clin Auton Res"},{"key":"622_CR3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.jpeds.2011.08.054","volume":"160","author":"W Singer","year":"2012","unstructured":"Singer W, Sletten DM, Opfer-Gehrking TL, Brands CK, Fischer PR, Low PA (2012) Postural tachycardia in children and adolescents: what is abnormal? J Pediatr 160:222\u2013226","journal-title":"J Pediatr"},{"key":"622_CR4","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1016\/j.hrthm.2015.03.029","volume":"12","author":"RS Sheldon","year":"2015","unstructured":"Sheldon RS, Grubb BP 2nd, Olshansky B et al (2015) 2015 Heart Rhythm Society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm 12:e41\u2013e63","journal-title":"Heart Rhythm"},{"key":"622_CR5","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","volume":"42","author":"PA Harris","year":"2009","unstructured":"Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG (2009) Research electronic data capture (REDCap)\u2014a metadata-drive methodology and workflow process for providing translational research informatics support. J Biomed Inform 42:377\u2013381","journal-title":"J Biomed Inform"},{"issue":"1","key":"622_CR6","doi-asserted-by":"publisher","first-page":"e20171673","DOI":"10.1542\/peds.2017-1673","volume":"141","author":"Julian M. Stewart","year":"2017","unstructured":"Stewart JM, Boris JR, Chelimsky G et al (2018) Pediatric disorders of orthostatic intolerance. Pediatrics 141(1):e20171673. \nhttps:\/\/doi.org\/10.1542\/peds.2017-1673","journal-title":"Pediatrics"},{"key":"622_CR7","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nrneurol.2011.187","volume":"8","author":"CJ Mathias","year":"2011","unstructured":"Mathias CJ, Low DA, Iodice V, Owens AP, Kirbis M, Grahame R (2011) Postural tachycardia syndrome\u2014current experience and concepts. Nat Rev Neurol 8:22\u201334","journal-title":"Nat Rev Neurol"},{"key":"622_CR8","first-page":"3684","volume":"J127","author":"L Jiawei","year":"2014","unstructured":"Jiawei L, Qingyou Z, Hongjun H, Hongfang J, Junbao D (2014) Clinical features and management of postural tachycardia syndrome in children: a single-center experience. Chin Med J127:3684\u20133689","journal-title":"Chin Med"},{"key":"622_CR9","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1017\/S1047951117002888","volume":"28","author":"JR Boris","year":"2018","unstructured":"Boris JR, Bernadzikowski T (2018) Demographics of a large paediatric postural orthostatic tachycardia syndrome program. Cardiol Young 28:668\u2013674","journal-title":"Cardiol Young"},{"key":"622_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3324-9","volume-title":"Density estimation for statistics and data analysis","author":"BW Silverman","year":"1986","unstructured":"Silverman BW (1986) Density estimation for statistics and data analysis. Chapman and Hall, London"},{"key":"622_CR11","unstructured":"Landgraf AJ, Lee Y (2015) Dimensionality reduction for binary data through the projection of natural parameters.\u00a0\narXiv:1510.06112"},{"key":"622_CR12","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.jpeds.2010.09.004","volume":"158","author":"JM Stewart","year":"2011","unstructured":"Stewart JM, Clarke D (2011) \u201cHe\u2019s dizzy when he stands up\u201d. An introduction to initial orthostatic hypotension. J Pediatr 158:499\u2013504","journal-title":"J Pediatr"},{"key":"622_CR13","doi-asserted-by":"publisher","first-page":"e0136512","DOI":"10.1371\/journal.pone.0136512","volume":"10","author":"T Langhagen","year":"2015","unstructured":"Langhagen T, Albers L, Heinen F et al (2015) Period prevalence of dizziness and vertigo in adolescents. PLoS One 10:e0136512","journal-title":"PLoS One"},{"key":"622_CR14","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/S0002-9149(03)00127-9","volume":"91","author":"KS Ganzeboom","year":"2003","unstructured":"Ganzeboom KS, Colman N, Reitsma JB, Shen WK, Wieling W (2003) Prevalence and triggers of syncope in medical students. Am J Cardiol 91:1006\u20131008","journal-title":"Am J Cardiol"},{"key":"622_CR15","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1042\/cs0930205","volume":"93","author":"CCE De Jong-deVos van Steenwijk","year":"1997","unstructured":"De Jong-deVos van Steenwijk CCE, Wieling W, Harms MPM, Wesseling KH (1997) Variability of near-fainting responses in healthy 6\u201316-year-old subjects. Clin Sci (Lond) 93:205\u2013211","journal-title":"Clin Sci (Lond)"},{"key":"622_CR16","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1055\/s-2004-817727","volume":"23","author":"R Freeman","year":"2003","unstructured":"Freeman R (2003) Treatment of orthostatic hypotension. Semin Neurol 23:435\u2013442","journal-title":"Semin Neurol"},{"key":"622_CR17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/01.HDX.0000050416.53995.43","volume":"5","author":"WH Frishman","year":"2003","unstructured":"Frishman WH, Azer V, Sica D (2003) Drug treatment of orthostatic hypotension and vasovagal syncope. Heart Dis 5:49\u201364","journal-title":"Heart Dis"},{"key":"622_CR18","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1080\/14017431.2017.1355068","volume":"51","author":"M Ruzieh","year":"2017","unstructured":"Ruzieh M, Batizy L, Dasa O, Oostra C, Grubb B (2017) The role of autoantibodies in the syndromes of orthostatic intolerance: a systematic review. Scan Cardiovasc J 51:243\u2013247","journal-title":"Scan Cardiovasc J"},{"key":"622_CR19","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/acn3.524","volume":"5","author":"M Watari","year":"2018","unstructured":"Watari M, Nakane S, Mukaino A et al (2018) Autoimmune postural orthostatic tachycardia syndrome. Ann Clin Transl Neurol 5:486\u2013492","journal-title":"Ann Clin Transl Neurol"},{"key":"622_CR20","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008351","author":"X Yu","year":"2018","unstructured":"Yu X, Li H, Murphy TA et al (2018) Angiotensin II type 1 receptor autoantibodies in postural tachycardia syndrome. J Am Heart Assoc. \nhttps:\/\/doi.org\/10.1161\/JAHA.117.008351","journal-title":"J Am Heart Assoc"},{"key":"622_CR21","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1177\/0883073809359539","volume":"25","author":"JE Skinner","year":"2010","unstructured":"Skinner JE, Driscoll SW, Porter CJ et al (2010) Orthostatic heart rate and blood pressure in adolescents: reference ranges. J Child Neurol 25:1210\u20131215","journal-title":"J Child Neurol"},{"key":"622_CR22","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jpeds.2015.03.039","volume":"167","author":"G Chelimsky","year":"2015","unstructured":"Chelimsky G, Kovacic K, Nugent M, Mueller A, Simpson P, Chelimsky TC (2015) Comorbid conditions do not differ in children and young adults with functional disorders with or without postural tachycardia syndrome. J Pediatr 167:120\u2013124","journal-title":"J Pediatr"},{"key":"622_CR23","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1016\/j.clinph.2014.02.014","volume":"125","author":"CT Ives","year":"2014","unstructured":"Ives CT, Kimpinski K (2014) Higher heart rate increments on head-up tilt in control subjects are not associated with autonomic dysfunction. Clin Neurophysiol 125:2109\u20132114","journal-title":"Clin Neurophysiol"},{"key":"622_CR24","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s10286-013-0199-5","volume":"23","author":"AJ Parsaik","year":"2013","unstructured":"Parsaik AJ, Singer W, Allison TG et al (2013) Orthostatic intolerance without postural tachycardia: how much dysautonomia? Clin Auton Res 23:181\u2013188","journal-title":"Clin Auton Res"},{"key":"622_CR25","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1042\/CS20120276","volume":"124","author":"WB Plash","year":"2013","unstructured":"Plash WB, Diedrich A, Biaggioni I et al (2013) Diagnosing postural tachycardia syndrome: comparison of tilt testing compared with standing haemodynamics. Clin Sci (Lond) 124:109\u2013114","journal-title":"Clin Sci (Lond)"},{"key":"622_CR26","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/clc.4960180908","volume":"18","author":"JB Berkowitz","year":"1995","unstructured":"Berkowitz JB, Auld D, Hulse JE, Campbell RM (1995) Tilt table evaluation for control pediatric patients: comparison with symptomatic patients. Clin Cardiol 18:521\u2013525","journal-title":"Clin Cardiol"},{"key":"622_CR27","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1093\/eurheartj\/ehl164","volume":"27","author":"M Brignole","year":"2006","unstructured":"Brignole M, Sutton R, Menozzi C et al (2006) Lack of correlation between the responses to tilt testing and adenosine triphosphate test and the mechanism of spontaneous neurally mediated syncope. Eur Heart J 27:2232\u20132239","journal-title":"Eur Heart J"}],"container-title":["Clinical Autonomic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-019-00622-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10286-019-00622-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10286-019-00622-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T19:17:53Z","timestamp":1596482273000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10286-019-00622-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,5]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["622"],"URL":"https:\/\/doi.org\/10.1007\/s10286-019-00622-y","relation":{},"ISSN":["0959-9851","1619-1560"],"issn-type":[{"value":"0959-9851","type":"print"},{"value":"1619-1560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,5]]},"assertion":[{"value":"13 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}